MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Mefloquine

(XEEQGYMUWCZPDN-DOMZBBRYSA-N)

Structure

SMILES: O[C@@H](c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)[C@H]1CCCCN1
Molecular Formula:: C17H16F6N2O
Molecular Weight:: 378.312
Log P:: 4.7767
Hydrogen Bond Acceptor:: 3
Hydrogen Bond Donor:: 2
TPSA:: 45.15
CAS Number(s):: 51742-86-0; 51742-87-1; 53230-10-7

Synonym(s)

Mefloquine

Lariam

Mefloquine Hydrochloride

Mephloquine

Ro-21-5998-001

WR-142,490

WR-177,602

Ro 21 5998 001

Ro215998001

10.

WR 142,490

11.

WR 177,602

12.

WR142,490

13.

WR177,602

External Link(s)

MeSH	D015767
PubChem Compound	40692
BindingDB	79170 50151865
ChEBI	63687
CHEMBL	CHEMBL172
DrugCentral	1665
KEGG	cpd:C07633 dr:D04895
Therapeutic Target Database	D0GQ7K
ZINC	897085

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Anxiety	FAERS: 49 Canada Vigilance: 6		Canada Vigilance OFFSIDES SIDER US FAERS
2	Dizziness	FAERS: 32 Canada Vigilance: 2	View details 1603191 2811953 8780466 8846489 9080886 9248763 12879977	CTD OFFSIDES SIDER Canada Vigilance US FAERS
3	Nausea	FAERS: 20 Canada Vigilance: 1	View details 1916870 2811953 8780466 8846489 11801224	CTD OFFSIDES SIDER Canada Vigilance US FAERS
4	Headache	FAERS: 19 Canada Vigilance: 1	View details 8161647 8780466 11801224 12962582	CTD SIDER Canada Vigilance US FAERS
5	Paranoia	FAERS: 19 Canada Vigilance: 1		Canada Vigilance OFFSIDES SIDER US FAERS
6	Vertigo	FAERS: 14 Canada Vigilance: 1	2811953 8161647 11801224	CTD SIDER Canada Vigilance US FAERS
7	Anger	FAERS: 13		OFFSIDES US FAERS
8	Tinnitus	FAERS: 13 Canada Vigilance: 1	10687269 17983978	CTD OFFSIDES SIDER Canada Vigilance US FAERS
9	Amnesia	FAERS: 11		OFFSIDES US FAERS
10	Asthenia	FAERS: 11		OFFSIDES SIDER US FAERS
11	Fatigue	FAERS: 10		OFFSIDES SIDER US FAERS
12	Feeling abnormal	FAERS: 10		OFFSIDES SIDER US FAERS
13	Palpitations	FAERS: 10 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
14	Impaired work ability	FAERS: 9 Canada Vigilance: 1		Canada Vigilance OFFSIDES US FAERS
15	Memory impairment	FAERS: 9 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
16	Myalgia	FAERS: 7		SIDER US FAERS
17	Syncope	FAERS: 6 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
18	Vomiting	FAERS: 6	View details 1916870 8846489 12962582 15893244	CTD SIDER US FAERS
19	Malaise	FAERS: 5		SIDER US FAERS
20	Mood swings	FAERS: 5		SIDER US FAERS
21	Restlessness	FAERS: 5		US FAERS
22	Tremor	FAERS: 5		SIDER US FAERS
23	Arthralgia	FAERS: 4		SIDER US FAERS
24	Chest Pain	FAERS: 4		OFFSIDES SIDER US FAERS
25	Chest discomfort	FAERS: 4		US FAERS
26	Cold sweat	FAERS: 4		OFFSIDES US FAERS
27	Personality Change	FAERS: 4		US FAERS
28	Photophobia	FAERS: 4 Canada Vigilance: 1		Canada Vigilance US FAERS
29	Post-Traumatic Stress Disorder	FAERS: 4 Canada Vigilance: 1		Canada Vigilance US FAERS
30	Stress	FAERS: 4		OFFSIDES US FAERS
31	Activities of daily living impaired	FAERS: 3		OFFSIDES US FAERS
32	Agitation	FAERS: 3		SIDER US FAERS
33	Alopecia	FAERS: 3		SIDER US FAERS
34	Crying	FAERS: 3 Canada Vigilance: 2		Canada Vigilance OFFSIDES US FAERS
35	Depressed mood	FAERS: 3		OFFSIDES US FAERS
36	Disorientation	FAERS: 3		US FAERS
37	Hypersomnia	FAERS: 3		US FAERS
38	Hypervigilance	FAERS: 3		OFFSIDES US FAERS
39	Hypotension	FAERS: 3		SIDER US FAERS
40	Toxicity to various agents	FAERS: 3		US FAERS
41	Abasia	FAERS: 2		OFFSIDES US FAERS
42	Anorexia	FAERS: 2	8846489 12962582	CTD OFFSIDES US FAERS
43	Apathy	FAERS: 2		OFFSIDES US FAERS
44	Chills	FAERS: 2 Canada Vigilance: 1	8202114	CTD SIDER Canada Vigilance US FAERS
45	Deafness	FAERS: 2		OFFSIDES SIDER US FAERS
46	Delirium	FAERS: 2	8094856 8202114	CTD US FAERS
47	Delusion of reference	FAERS: 2		US FAERS
48	Depressed Level of Consciousness	FAERS: 2		OFFSIDES US FAERS
49	Discomfort	FAERS: 2		SIDER US FAERS
50	Drug prescribing error	FAERS: 2		OFFSIDES US FAERS
51	Emotional disorder	FAERS: 2		OFFSIDES SIDER US FAERS
52	Hyperacusis	FAERS: 2		US FAERS
53	Lethargy	FAERS: 2		US FAERS
54	Mental impairment	FAERS: 2		OFFSIDES US FAERS
55	Middle insomnia	FAERS: 2		OFFSIDES US FAERS
56	Nervousness	FAERS: 2		US FAERS
57	Night sweats	FAERS: 2 Canada Vigilance: 1		Canada Vigilance US FAERS
58	Obsessive-Compulsive Disorder	FAERS: 2		US FAERS
59	Polyneuropathy	FAERS: 2		OFFSIDES US FAERS
60	Poor quality sleep	FAERS: 2		OFFSIDES SIDER US FAERS
61	Pregnancy	FAERS: 2		SIDER US FAERS
62	Pruritus	FAERS: 2	9248763 10457122	CTD SIDER US FAERS
63	Sinus bradycardia	FAERS: 2		US FAERS
64	Skin Ulcer	FAERS: 2	16242740	CTD US FAERS
65	Urticaria	FAERS: 2	10457122	CTD SIDER US FAERS
66	Visual Impairment	FAERS: 2		SIDER US FAERS
67	Weight decreased	FAERS: 2		US FAERS
68	Abdominal discomfort	FAERS: 1		OFFSIDES US FAERS
69	Adverse event	FAERS: 1		US FAERS
70	Alanine aminotransferase decreased	FAERS: 1		US FAERS
71	Anencephaly	FAERS: 1		US FAERS
72	Angina Pectoris	FAERS: 1		US FAERS
73	Arthropathy	FAERS: 1		US FAERS
74	Back Pain	FAERS: 1		US FAERS
75	Bedridden	FAERS: 1		US FAERS
76	Belligerence	FAERS: 1		US FAERS
77	Bipolar Disorder	FAERS: 1	11394195 16752027 19295181	CTD OFFSIDES US FAERS
78	Blood cholesterol increased	FAERS: 1		US FAERS
79	Bradycardia	FAERS: 1		OFFSIDES SIDER US FAERS
80	Burning sensation	FAERS: 1		US FAERS
81	Completed Suicide	FAERS: 1		OFFSIDES SIDER US FAERS
82	Constipation	FAERS: 1		US FAERS
83	Conversion disorder	FAERS: 1		OFFSIDES US FAERS
84	Creutzfeldt-Jakob disease	FAERS: 1		OFFSIDES US FAERS
85	Cyclothymic Disorder	FAERS: 1		US FAERS
86	Dermatitis	FAERS: 1		SIDER US FAERS
87	Drug dispensing error	FAERS: 1		OFFSIDES US FAERS
88	Dysphemia	FAERS: 1		OFFSIDES US FAERS
89	Ear discomfort	FAERS: 1		US FAERS
90	Early retirement	FAERS: 1		US FAERS
91	Eczema	FAERS: 1		US FAERS
92	Emotional poverty	FAERS: 1		US FAERS
93	Euphoric mood	FAERS: 1		US FAERS
94	Eye irritation	FAERS: 1		US FAERS
95	Flatulence	FAERS: 1		US FAERS
96	Formication	FAERS: 1		OFFSIDES US FAERS
97	Frustration	FAERS: 1		OFFSIDES US FAERS
98	Hallucinations, mixed	FAERS: 1		OFFSIDES US FAERS
99	Hyperthyroidism	FAERS: 1		US FAERS
100	Imminent abortion	FAERS: 1		US FAERS
101	Impaired driving ability	FAERS: 1		US FAERS
102	Inappropriate schedule of drug administration	FAERS: 1		US FAERS
103	Incorrect dose administered	FAERS: 1		US FAERS
104	Influenza	FAERS: 1		US FAERS
105	Initial insomnia	FAERS: 1		OFFSIDES US FAERS
106	Insulin C-peptide increased	FAERS: 1		US FAERS
107	Intentional product misuse	FAERS: 1		US FAERS
108	Jealous delusion	FAERS: 1		US FAERS
109	Medication Error	FAERS: 1		US FAERS
110	Musculoskeletal stiffness	FAERS: 1		OFFSIDES US FAERS
111	Myocardial Infarction	FAERS: 1		US FAERS
112	Neck Pain	FAERS: 1		US FAERS
113	Neuroglycopenia	FAERS: 1		US FAERS
114	Neuropsychiatric syndrome	FAERS: 1		US FAERS
115	Oral pain	FAERS: 1		US FAERS
116	Pain	FAERS: 1		US FAERS
117	Panic Disorder	FAERS: 1	1807186	CTD OFFSIDES US FAERS
118	Pharmaceutical product complaint	FAERS: 1		OFFSIDES US FAERS
119	Polydipsia	FAERS: 1		US FAERS
120	Post procedural complication	FAERS: 1		US FAERS
121	Postural Orthostatic Tachycardia Syndrome	FAERS: 1	20860911	CTD US FAERS
122	Presyncope	FAERS: 1		US FAERS
123	Purulence	FAERS: 1		US FAERS
124	Rash erythematous	FAERS: 1		US FAERS
125	Retinal pigmentation	FAERS: 1		US FAERS
126	Shock	FAERS: 1	12712918	CTD SIDER US FAERS
127	Sleep Talking	FAERS: 1		US FAERS
128	Somnolence	FAERS: 1		SIDER US FAERS
129	Sudden death	FAERS: 1		US FAERS
130	Suicide attempt	FAERS: 1		US FAERS
131	Swelling	FAERS: 1		US FAERS
132	Tachycardia	FAERS: 1	20860911	CTD SIDER US FAERS
133	Unevaluable event	FAERS: 1		OFFSIDES US FAERS
134	Ventricular Fibrillation	FAERS: 1		US FAERS
135	Verbigeration	FAERS: 1		US FAERS
136	Violence-related symptom	FAERS: 1		OFFSIDES US FAERS
137	insulinoma	FAERS: 1		US FAERS
138	nervous system disorder	FAERS: 1		SIDER US FAERS
139	Abdominal Pain			OFFSIDES SIDER
140	Abnormal sleep-related event			OFFSIDES
141	Abnormal vision			OFFSIDES
142	Achalasia microcephaly		10532181	CTD
143	Acid reflux			OFFSIDES
144	Acquired diaphragmatic eventration			OFFSIDES
145	Acute Coronary Syndrome			OFFSIDES
146	Adjustment disorder with depressed mood			OFFSIDES
147	Agranulocytosis			SIDER
148	Agraphia			OFFSIDES
149	Alcohol consumption			OFFSIDES
150	Alcohol poisoning			OFFSIDES
151	Amenorrhea			OFFSIDES
152	Anaphylactic shock			SIDER
153	Angioedema			OFFSIDES
154	Angiotensin converting enzyme increased			OFFSIDES
155	Anhedonia			OFFSIDES
156	Anhidrosis			OFFSIDES
157	Anosmia			OFFSIDES
158	Anxiety Disorders		1867351 8202114 9394947	CTD
159	Aphagia			SIDER
160	Arthropod bite			SIDER
161	Asthma			OFFSIDES
162	Ataxia			OFFSIDES SIDER
163	Atrial Flutter		8957602	CTD
164	Atrial tachycardia			OFFSIDES
165	Atrioventricular Block		20058779	CTD SIDER
166	Aura			OFFSIDES
167	Autoimmune thyroiditis			OFFSIDES
168	Bad dreams			SIDER
169	Blepharospasm			OFFSIDES
170	Blood Glucose			OFFSIDES
171	Blood and lymphatic system disorders			SIDER
172	Blood cholesterol			OFFSIDES
173	Blood creatine phosphokinase increased			OFFSIDES
174	Blood lactate dehydrogenase increased			OFFSIDES
175	Blood potassium decreased			OFFSIDES
176	Blood thyroid stimulating hormone increased			OFFSIDES
177	Blood triglycerides increased			OFFSIDES
178	Blurred vision			OFFSIDES
179	Brain Diseases		17826578	CTD
180	Brain stem syndrome			OFFSIDES
181	Breast Feeding			SIDER
182	Bronchitis			OFFSIDES
183	Bronchopneumonia			OFFSIDES
184	Bruxism			OFFSIDES
185	Bulbar palsy			OFFSIDES
186	Cardiac stress test abnormal			OFFSIDES
187	Cardiovascular insufficiency			OFFSIDES
188	Cataract			SIDER
189	Catatonia			OFFSIDES
190	Cerebral disorder			OFFSIDES
191	Cerebral ventricle dilatation			OFFSIDES
192	Chemical and Drug Induced Liver Injury		11130224 17335720	CTD
193	Choking sensation			OFFSIDES
194	Cholangiolitis			OFFSIDES
195	Cholestasis		15983754	CTD
196	Chondroplasty			OFFSIDES
197	Chronic left ventricular failure			OFFSIDES
198	Chronic sinusitis			OFFSIDES
199	Circumstance or information capable of leading to medication error			OFFSIDES
200	Claustrophobia			OFFSIDES
201	Clumsiness			OFFSIDES
202	Cognition Disorders		2811953 11449039	CTD
203	Colitis			OFFSIDES
204	Collagen-vascular disease			OFFSIDES
205	Confabulation			OFFSIDES
206	Confusion		1603191 11064842 11449039	CTD
207	Corneal Scar			OFFSIDES
208	Decreased Libido			OFFSIDES
209	Dehydration			OFFSIDES
210	Demyelination			OFFSIDES
211	Depressive disorder		View details 1575269 8202114 8256107 8978255 9248763 11064842 11449039 16012293	CTD
212	Diarrhea		9080886 12962582	CTD OFFSIDES
213	Diastolic dysfunction			OFFSIDES
214	Difficulty sleeping			SIDER
215	Diffuse alopecia			SIDER
216	Diplopia			OFFSIDES
217	Disease recurrence			OFFSIDES
218	Dissociative disorder			OFFSIDES
219	Drowning			OFFSIDES
220	Drowsiness			OFFSIDES
221	Drug Eruptions		16242740	CTD
222	Drug Tolerance			OFFSIDES SIDER
223	Drug dose omission			OFFSIDES
224	Drug toxicity			OFFSIDES
225	Drug withdrawal headache			OFFSIDES
226	Dry skin			OFFSIDES
227	Dyspepsia			OFFSIDES SIDER
228	Dysthymic Disorder			OFFSIDES
229	Ear and labyrinth disorders			SIDER
230	Ecchymosis		8161647	CTD
231	Electrocardiogram ST segment abnormal			OFFSIDES
232	Electrocardiogram ST-T change			OFFSIDES
233	Electrocardiogram repolarisation abnormality			OFFSIDES
234	Emotional distress			OFFSIDES
235	Emotional problems			SIDER
236	Endocarditis			OFFSIDES
237	Endolymphatic Hydrops			OFFSIDES
238	Eosinophilic Pneumonia			OFFSIDES
239	Eosinophilic myocarditis			OFFSIDES
240	Epilepsy			OFFSIDES SIDER
241	Erectile dysfunction			OFFSIDES
242	Erythema Multiforme			SIDER
243	Erythema		16242740	CTD SIDER
244	Exfoliative rash			OFFSIDES
245	Exposure to toxic agent			OFFSIDES
246	Fatty Liver		9929030	CTD
247	Febrile infection			OFFSIDES
248	Feeding and Eating Disorders		20964849	CTD
249	Feelings of worthlessness			OFFSIDES
250	Fever		8202114	CTD
251	Flight of ideas			OFFSIDES
252	Flushing			SIDER
253	Foaming at mouth			OFFSIDES
254	Gait Ataxia		12879977	CTD
255	Gastroenteritis			OFFSIDES
256	Gastrointestinal Diseases		8161647	CTD
257	Gastrointestinal Pain			SIDER
258	Gastrointestinal bacterial infection			OFFSIDES
259	Gastrointestinal motility disorder			OFFSIDES
260	General symptom			OFFSIDES
261	Hallucinations		View details 1603191 7705258 7859199 8202114 8560592 8644976 10535096 11064842 11449039 12962582 16752027	CTD
262	Hearing Loss, High-Frequency		10687269	CTD
263	Hearing Loss, Sudden		17983978	CTD
264	Hearing Loss		7855666	CTD
265	Heat Stroke			OFFSIDES
266	Hepatitis		17335720	CTD
267	Homicide			OFFSIDES
268	Hostility			OFFSIDES
269	Hydrocephalus			OFFSIDES
270	Hypereosinophilic syndrome			OFFSIDES
271	Hyperkeratosis			OFFSIDES
272	Hypersensitivity			SIDER
273	Hyperventilation			OFFSIDES
274	Hypesthesia		11505262 16242740	CTD
275	Hypokinesia			OFFSIDES
276	Hyporeflexia			OFFSIDES
277	Hypotension, Orthostatic		8513843	CTD
278	Impaired reasoning	Canada Vigilance: 1		Canada Vigilance
279	Impatience			OFFSIDES
280	Impetigo			OFFSIDES
281	Incoherent			OFFSIDES
282	Incontinence			OFFSIDES
283	Increased bronchial secretion			OFFSIDES
284	Increased upper airway secretion			OFFSIDES
285	Influenza-like symptoms			SIDER
286	Intention tremor			OFFSIDES
287	Intentional self-injury			OFFSIDES
288	Intervertebral Disc Degeneration			OFFSIDES
289	Joint sprain			OFFSIDES
290	Keratitis sicca			OFFSIDES
291	Lactose Intolerance			OFFSIDES
292	Laziness			OFFSIDES
293	Leukocytosis			SIDER
294	Leukopenia			SIDER
295	Lichen Planus			OFFSIDES
296	Liver Failure		9929030	CTD
297	Malaria, Cerebral		8644976	CTD
298	Malaria, Falciparum		View details 1523478 1916870 2811953 7705258 8161647 8202114 8513843 8644976 8846489 9426652 9537268 9973835 11130224 12479545 15215119 15893244 18986553 19295181 19725966 20964849	CTD
299	Malaria, Vivax		8161647 16242740	CTD
300	Malaria		View details 2569094 2694482 7486482 7859199 7935106 7944858 8099690 8287786 8780466 9394947 9882160 10457122 11179947 11449039 12649241 12962582 16012293 17826578 20058779	CTD OFFSIDES
301	Malnutrition			SIDER
302	Memory Disorders		8191092	CTD
303	Mental disorders		View details 2260038 7741814 7944858 8099690 8789977 9241106 9537268 9616091 10085752 12170684 12242605 15705005 17015054 20964849	CTD
304	Merycism			OFFSIDES
305	Mood Disorders		15025750	CTD
306	Mood disorder due to a general medical condition			OFFSIDES
307	Morbid thoughts			OFFSIDES
308	Motion Sickness			OFFSIDES
309	Motor retardation			OFFSIDES
310	Multiple allergies			OFFSIDES
311	Murder			OFFSIDES
312	Muscle Weakness		16242740	CTD
313	Musculoskeletal discomfort			SIDER
314	Mydriasis		8202114	CTD
315	Myoclonus		12410053	CTD
316	Narcissistic Personality Disorder			OFFSIDES
317	Nerve Degeneration		20562019	CTD
318	Nervous tension			OFFSIDES
319	Neuritis			SIDER
320	Neuropathy			SIDER
321	Nocturia			OFFSIDES
322	Non-cardiac chest pain			OFFSIDES
323	Nystagmus			OFFSIDES
324	Obsessive thoughts			OFFSIDES
325	Occupational exposure to dust			OFFSIDES
326	Ototoxicity			OFFSIDES
327	Overdose			OFFSIDES
328	Parent-child problem			OFFSIDES
329	Paresthesia		1443980 16242740	CTD
330	Partner stress			OFFSIDES
331	Peripheral motor neuropathy			SIDER
332	Physical assault			OFFSIDES
333	Pneumonia			SIDER
334	Poor quality drug administered			OFFSIDES
335	Priapism			OFFSIDES
336	Product contamination			OFFSIDES
337	Productive Cough			OFFSIDES
338	Psoriasis		9882160	CTD
339	Psychiatric symptom			OFFSIDES
340	Psychomotor Agitation		8202114	CTD
341	Psychoses, Substance-Induced		View details 1603191 1867351 2569094 2811953 7705258 7859199 8191092 8202114 8560592 8644976 10535096 10959270 11064842 12237793 12968793 16752027 19295181	CTD
342	Pulse irregular			SIDER
343	Quality of life decreased	Canada Vigilance: 1		Canada Vigilance
344	Reflex Sympathetic Dystrophy			OFFSIDES
345	Respiratory fume inhalation disorder			OFFSIDES
346	Restrictive pulmonary disease			OFFSIDES
347	Rheumatoid factor increased			OFFSIDES
348	Rhinitis			OFFSIDES
349	Rhonchi			OFFSIDES
350	Sarcoidosis			OFFSIDES
351	Schizoaffective Disorder			OFFSIDES
352	Schizophrenia			SIDER
353	Scotoma			OFFSIDES
354	Seizures		View details 1867351 2024874 2811953 7935106 8202114 9973835 10028330 10086156 10743379 11179947 12712918	CTD
355	Sensory integrative dysfunction			OFFSIDES
356	Sexual abuse			OFFSIDES
357	Shoulder Pain			OFFSIDES
358	Sjogren's Syndrome			OFFSIDES
359	Sleep Initiation and Maintenance Disorders		7705258 9143859	CTD
360	Sleep Wake Disorders		View details 1867351 8099690 8644976 8846489 9080886 12962582 16752027 20964849	CTD
361	Sleep disorder due to general medical condition, hypersomnia type			OFFSIDES
362	Snoring			OFFSIDES
363	Sputum culture positive			OFFSIDES
364	Stevens-Johnson Syndrome		10457122 25811541	CTD SIDER
365	Stress at work			OFFSIDES
366	Stupor		8202114	CTD
367	Suicide			SIDER
368	Sweating			SIDER
369	Tardive Dyskinesia			OFFSIDES
370	Telogen effluvium			SIDER
371	Tendinitis			OFFSIDES
372	Theft			OFFSIDES
373	Thrombocytopenia		8161647	CTD SIDER
374	Tobacco user			OFFSIDES
375	Trisomy 21			OFFSIDES
376	Umbilical malformation			OFFSIDES
377	Vasculitis, Leukocytoclastic, Cutaneous		7486482 8340189 10457122	CTD
378	Vestibular Neuronitis			OFFSIDES
379	Vision Disorders		12879977	CTD
380	Visual disturbance			OFFSIDES SIDER
381	Water Pollution			OFFSIDES
382	Weight Gain			OFFSIDES
383	jaundice		15983754	CTD

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