selexipag
(QXWZQTURMXZVHJ-UHFFFAOYSA-N)
Structure
- SMILES
- O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C
- Type(s)
- Approved
- ATC code(s)
- B01AC27
- Molecular Formula:
- C26H32N4O4S
- Molecular Weight:
- 496.622
- Log P:
- 5.3697
- Hydrogen Bond Acceptor:
- 8
- Hydrogen Bond Donor:
- 1
- TPSA:
- 109.87
- CAS Number(s):
- 475086-01-2
Synonym(s)
1.
selexipag
2.
2-(4-((5,6-diphenylpyrazin-2-yl)(isopropyl)amino)butoxy)-N-(methylsulfonyl)acetamide
3.
ACT 293987
4.
ACT-293987
5.
ACT293987
6.
NS-304
7.
Uptravi
External Link(s)
Adverse Drug Event(s)
| Name | Number of Reports | Reference(s) | Data Source | |
|---|---|---|---|---|
| 1 | Headache | FAERS: 201 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 2 | Nausea | FAERS: 119 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 3 | Pneumonia | FAERS: 86 | US FAERS | |
| 4 | Myalgia | FAERS: 64 | US FAERS | |
| 5 | Pain | FAERS: 63 | US FAERS | |
| 6 | Vomiting | FAERS: 60 | US FAERS | |
| 7 | Malaise | FAERS: 57 | US FAERS | |
| 8 | Fatigue | FAERS: 56 | US FAERS | |
| 9 | Asthenia | FAERS: 45 | US FAERS | |
| 10 | Dizziness | FAERS: 42 | US FAERS | |
| 11 | Arthralgia | FAERS: 39 | US FAERS | |
| 12 | Flushing | FAERS: 34 | US FAERS | |
| 13 | Back Pain | FAERS: 33 | US FAERS | |
| 14 | Nasopharyngitis | FAERS: 32 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 15 | Pulmonary arterial hypertension | FAERS: 32 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 16 | Hypotension | FAERS: 29 | US FAERS | |
| 17 | Peripheral swelling | FAERS: 28 | US FAERS | |
| 18 | Abdominal discomfort | FAERS: 26 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 19 | Influenza | FAERS: 25 | US FAERS | |
| 20 | Disease Progression | FAERS: 23 | US FAERS | |
| 21 | Musculoskeletal Pain | FAERS: 21 | US FAERS | |
| 22 | Product dose omission | FAERS: 21 | US FAERS | |
| 23 | Weight decreased | FAERS: 21 | US FAERS | |
| 24 | Bronchitis | FAERS: 19 | US FAERS | |
| 25 | Feeling abnormal | FAERS: 19 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 26 | Syncope | FAERS: 19 | US FAERS | |
| 27 | Drug dose omission | FAERS: 16 | US FAERS | |
| 28 | Pulmonary Hypertension | FAERS: 16 | US FAERS | |
| 29 | Unevaluable event | FAERS: 16 | US FAERS | |
| 30 | Dehydration | FAERS: 14 | US FAERS | |
| 31 | Blood potassium increased | FAERS: 13 | US FAERS | |
| 32 | Chest Pain | FAERS: 13 | US FAERS | |
| 33 | Neck Pain | FAERS: 13 | US FAERS | |
| 34 | Palpitations | FAERS: 13 | US FAERS | |
| 35 | Adverse event | FAERS: 11 | US FAERS | |
| 36 | Oxygen consumption increased | FAERS: 11 | US FAERS | |
| 37 | Urinary tract infection | FAERS: 11 | US FAERS | |
| 38 | Bone pain | FAERS: 10 | US FAERS | |
| 39 | Anxiety | FAERS: 9 | US FAERS | |
| 40 | Atrial Fibrillation | FAERS: 9 | US FAERS | |
| 41 | Hypoxia | FAERS: 9 | US FAERS | |
| 42 | Swelling | FAERS: 9 | US FAERS | |
| 43 | Tremor | FAERS: 9 | US FAERS | |
| 44 | Abdominal Pain | FAERS: 8 | US FAERS | |
| 45 | Alopecia | FAERS: 8 | US FAERS | |
| 46 | Ascites | FAERS: 8 | US FAERS | |
| 47 | Chest discomfort | FAERS: 8 | US FAERS | |
| 48 | Fluid overload | FAERS: 8 | US FAERS | |
| 49 | General physical health deterioration | FAERS: 8 | US FAERS | |
| 50 | Productive Cough | FAERS: 8 | US FAERS | |
| 51 | Right ventricular failure | FAERS: 8 | US FAERS | |
| 52 | Cardiac Arrest | FAERS: 7 | US FAERS | |
| 53 | Disease complication | FAERS: 7 | US FAERS | |
| 54 | Hypersomnia | FAERS: 7 | US FAERS | |
| 55 | Memory impairment | FAERS: 7 | US FAERS | |
| 56 | Pruritus | FAERS: 7 | US FAERS | |
| 57 | Respiratory Failure | FAERS: 7 | US FAERS | |
| 58 | Sinusitis | FAERS: 7 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 59 | Constipation | FAERS: 6 | US FAERS | |
| 60 | Dyspepsia | FAERS: 6 | US FAERS | |
| 61 | Hospice Care | FAERS: 6 | US FAERS | |
| 62 | Infection | FAERS: 6 | US FAERS | |
| 63 | Sepsis | FAERS: 6 | US FAERS | |
| 64 | Stress | FAERS: 6 | US FAERS | |
| 65 | Therapy non-responder | FAERS: 6 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 66 | Tinnitus | FAERS: 6 | US FAERS | |
| 67 | Asthma | FAERS: 5 | US FAERS | |
| 68 | Bedridden | FAERS: 5 | US FAERS | |
| 69 | Blood glucose abnormal | FAERS: 5 | US FAERS | |
| 70 | Cerebrovascular accident | FAERS: 5 | US FAERS | |
| 71 | Concomitant disease aggravated | FAERS: 5 | US FAERS | |
| 72 | Flatulence | FAERS: 5 | US FAERS | |
| 73 | Incorrect dose administered | FAERS: 5 | US FAERS | |
| 74 | Intestinal Obstruction | FAERS: 5 | US FAERS | |
| 75 | Overdose | FAERS: 5 | US FAERS | |
| 76 | Photophobia | FAERS: 5 | US FAERS | |
| 77 | Somnolence | FAERS: 5 | US FAERS | |
| 78 | Thrombosis | FAERS: 5 | US FAERS | |
| 79 | Accidental overdose | FAERS: 4 | US FAERS | |
| 80 | Blood glucose increased | FAERS: 4 | US FAERS | |
| 81 | Blood potassium decreased | FAERS: 4 | US FAERS | |
| 82 | Blood sodium decreased | FAERS: 4 | US FAERS | |
| 83 | Burning sensation | FAERS: 4 | US FAERS | |
| 84 | Carbon dioxide increased | FAERS: 4 | US FAERS | |
| 85 | Cellulitis | FAERS: 4 | US FAERS | |
| 86 | Chills | FAERS: 4 | US FAERS | |
| 87 | Drug ineffective | FAERS: 4 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 88 | Epistaxis | FAERS: 4 | US FAERS | |
| 89 | Facial Pain | FAERS: 4 | US FAERS | |
| 90 | Inappropriate schedule of drug administration | FAERS: 4 | US FAERS | |
| 91 | Lethargy | FAERS: 4 | US FAERS | |
| 92 | Limb discomfort | FAERS: 4 | US FAERS | |
| 93 | Loss of personal independence in daily activities | FAERS: 4 | US FAERS | |
| 94 | Paracentesis | FAERS: 4 | US FAERS | |
| 95 | Unresponsive to stimuli | FAERS: 4 | US FAERS | |
| 96 | Wheezing | FAERS: 4 | US FAERS | |
| 97 | Ammonia increased | FAERS: 3 | US FAERS | |
| 98 | Ankle Fracture | FAERS: 3 | US FAERS | |
| 99 | Cardiac Flutter | FAERS: 3 | US FAERS | |
| 100 | Cholecystitis | FAERS: 3 | US FAERS | |
| 101 | Clostridium difficile infection | FAERS: 3 | US FAERS | |
| 102 | Colitis | FAERS: 3 | US FAERS | |
| 103 | Crying | FAERS: 3 | US FAERS | |
| 104 | Device breakage | FAERS: 3 | US FAERS | |
| 105 | Device related sepsis | FAERS: 3 | US FAERS | |
| 106 | Disorientation | FAERS: 3 | US FAERS | |
| 107 | Drug titration error | FAERS: 3 | US FAERS | |
| 108 | Erythema | FAERS: 3 | US FAERS | |
| 109 | Hypersensitivity | FAERS: 3 | US FAERS | |
| 110 | Joint stiffness | FAERS: 3 | US FAERS | |
| 111 | Lymphoma | FAERS: 3 | US FAERS | |
| 112 | Nephrolithiasis | FAERS: 3 | US FAERS | |
| 113 | Restless Legs Syndrome | FAERS: 3 | US FAERS | |
| 114 | Retching | FAERS: 3 | US FAERS | |
| 115 | Scleroderma | FAERS: 3 | US FAERS | |
| 116 | Sinus headache | FAERS: 3 | US FAERS | |
| 117 | Terminal state | FAERS: 3 | US FAERS | |
| 118 | Transplant | FAERS: 3 | US FAERS | |
| 119 | Trismus | FAERS: 3 | US FAERS | |
| 120 | Urinary Incontinence | FAERS: 3 | US FAERS | |
| 121 | Vitreous floaters | FAERS: 3 | US FAERS | |
| 122 | Abasia | FAERS: 2 | US FAERS | |
| 123 | Acute kidney injury | FAERS: 2 | US FAERS | |
| 124 | Acute respiratory failure | FAERS: 2 | US FAERS | |
| 125 | Arthritis | FAERS: 2 | US FAERS | |
| 126 | Aspartate Aminotransferase Increased | FAERS: 2 | US FAERS | |
| 127 | Blindness | FAERS: 2 | US FAERS | |
| 128 | Blood alkaline phosphatase increased | FAERS: 2 | US FAERS | |
| 129 | Blood glucose decreased | FAERS: 2 | US FAERS | |
| 130 | Brachytherapy | FAERS: 2 | US FAERS | |
| 131 | Breast tenderness | FAERS: 2 | US FAERS | |
| 132 | Cholelithiasis | FAERS: 2 | US FAERS | |
| 133 | Cyanosis | FAERS: 2 | US FAERS | |
| 134 | Cystitis | FAERS: 2 | US FAERS | |
| 135 | Dry skin | FAERS: 2 | US FAERS | |
| 136 | Dysgeusia | FAERS: 2 | US FAERS | |
| 137 | Eating disorder symptom | FAERS: 2 | US FAERS | |
| 138 | Feeling jittery | FAERS: 2 | US FAERS | |
| 139 | Frustration tolerance decreased | FAERS: 2 | US FAERS | |
| 140 | Head discomfort | FAERS: 2 | US FAERS | |
| 141 | Hepatic Encephalopathy | FAERS: 2 | US FAERS | |
| 142 | Hepatitis | FAERS: 2 | US FAERS | |
| 143 | Hip surgery | FAERS: 2 | US FAERS | |
| 144 | Hyperacusis | FAERS: 2 | US FAERS | |
| 145 | Immune thrombocytopenic purpura | FAERS: 2 | US FAERS | |
| 146 | Incontinence | FAERS: 2 | US FAERS | |
| 147 | Limb injury | FAERS: 2 | US FAERS | |
| 148 | Lower respiratory tract infection | FAERS: 2 | US FAERS | |
| 149 | Medication Error | FAERS: 2 | US FAERS | |
| 150 | Mental impairment | FAERS: 2 | US FAERS | |
| 151 | Mental status changes | FAERS: 2 | US FAERS | |
| 152 | Multiple allergies | FAERS: 2 | US FAERS | |
| 153 | Myocardial Infarction | FAERS: 2 | US FAERS | |
| 154 | No adverse event | FAERS: 2 | US FAERS | |
| 155 | Pallor | FAERS: 2 | US FAERS | |
| 156 | Pericardial effusion | FAERS: 2 | US FAERS | |
| 157 | Pulmonary arterial pressure increased | FAERS: 2 | US FAERS | |
| 158 | Pulmonary function test decreased | FAERS: 2 | US FAERS | |
| 159 | Restlessness | FAERS: 2 | US FAERS | |
| 160 | Sluggishness | FAERS: 2 | US FAERS | |
| 161 | Sneezing | FAERS: 2 | US FAERS | |
| 162 | Stevens-Johnson Syndrome | FAERS: 2 | US FAERS | |
| 163 | Sudden death | FAERS: 2 | US FAERS | |
| 164 | Supraventricular tachycardia | FAERS: 2 | US FAERS | |
| 165 | Tachycardia | FAERS: 2 | US FAERS | |
| 166 | Thirst | FAERS: 2 | US FAERS | |
| 167 | Tooth Extraction | FAERS: 2 | US FAERS | |
| 168 | Walking aid user | FAERS: 2 | US FAERS | |
| 169 | Wrong technique in product usage process | FAERS: 2 | US FAERS | |
| 170 | cancer surgery | FAERS: 2 | US FAERS | |
| 171 | Administration site erythema | FAERS: 1 | US FAERS | |
| 172 | Agitation | FAERS: 1 | US FAERS | |
| 173 | Amputation | FAERS: 1 | US FAERS | |
| 174 | Angina Pectoris | FAERS: 1 | US FAERS | |
| 175 | Angioedema | FAERS: 1 | US FAERS | |
| 176 | Aortic Aneurysm | FAERS: 1 | US FAERS | |
| 177 | Arthropod sting | FAERS: 1 | US FAERS | |
| 178 | Atrial Flutter | FAERS: 1 | US FAERS | |
| 179 | Blood count abnormal | FAERS: 1 | US FAERS | |
| 180 | Blood glucose fluctuation | FAERS: 1 | US FAERS | |
| 181 | Blood magnesium decreased | FAERS: 1 | US FAERS | |
| 182 | Blood pressure fluctuation | FAERS: 1 | US FAERS | |
| 183 | Blood urine present | FAERS: 1 | US FAERS | |
| 184 | Bone contusion | FAERS: 1 | US FAERS | |
| 185 | Brain Abscess | FAERS: 1 | US FAERS | |
| 186 | Brain natriuretic peptide increased | FAERS: 1 | US FAERS | |
| 187 | Cardiac discomfort | FAERS: 1 | US FAERS | |
| 188 | Carotid artery occlusion | FAERS: 1 | US FAERS | |
| 189 | Catheter site thrombosis | FAERS: 1 | US FAERS | |
| 190 | Cerebral Infarction | FAERS: 1 | US FAERS | |
| 191 | Cerebral hypoperfusion | FAERS: 1 | US FAERS | |
| 192 | Chemotherapy | FAERS: 1 | US FAERS | |
| 193 | Chromaturia | FAERS: 1 | US FAERS | |
| 194 | Completed Suicide | FAERS: 1 | US FAERS | |
| 195 | Cyst aspiration | FAERS: 1 | US FAERS | |
| 196 | Delirium | FAERS: 1 | US FAERS | |
| 197 | Dementia | FAERS: 1 | US FAERS | |
| 198 | Dental caries | FAERS: 1 | US FAERS | |
| 199 | Depressed mood | FAERS: 1 | US FAERS | |
| 200 | Dialysis device insertion | FAERS: 1 | US FAERS | |
| 201 | Drug administration error | FAERS: 1 | US FAERS | |
| 202 | Drug dose titration not performed | FAERS: 1 | US FAERS | |
| 203 | Dysphonia | FAERS: 1 | US FAERS | |
| 204 | Dysuria | FAERS: 1 | US FAERS | |
| 205 | Ear congestion | FAERS: 1 | US FAERS | |
| 206 | Ear discomfort | FAERS: 1 | US FAERS | |
| 207 | Elective procedure | FAERS: 1 | US FAERS | |
| 208 | Emergency Care | FAERS: 1 | US FAERS | |
| 209 | Endarterectomy | FAERS: 1 | US FAERS | |
| 210 | Extra dose administered | FAERS: 1 | US FAERS | |
| 211 | Eye inflammation | FAERS: 1 | US FAERS | |
| 212 | Eye pain | FAERS: 1 | US FAERS | |
| 213 | Eyelid pain | FAERS: 1 | US FAERS | |
| 214 | Facial paralysis | FAERS: 1 | US FAERS | |
| 215 | Feeding tube user | FAERS: 1 | US FAERS | |
| 216 | Foaming at mouth | FAERS: 1 | US FAERS | |
| 217 | Gait inability | FAERS: 1 | US FAERS | |
| 218 | Gastroenteritis | FAERS: 1 | US FAERS | |
| 219 | Gastrointestinal Pain | FAERS: 1 | US FAERS | |
| 220 | Gastrointestinal perforation | FAERS: 1 | US FAERS | |
| 221 | Gastrostomy | FAERS: 1 | US FAERS | |
| 222 | Hemiplegia | FAERS: 1 | US FAERS | |
| 223 | Hepatitis C | FAERS: 1 | US FAERS | |
| 224 | Hernia | FAERS: 1 | US FAERS | |
| 225 | Hyperthyroidism | FAERS: 1 | US FAERS | |
| 226 | Hypokinesia | FAERS: 1 | US FAERS | |
| 227 | Impaired gastric emptying | FAERS: 1 | US FAERS | |
| 228 | Inappropriate schedule of product administration | FAERS: 1 | US FAERS | |
| 229 | Incoherent | FAERS: 1 | US FAERS | |
| 230 | Intentional dose omission | FAERS: 1 | US FAERS | |
| 231 | Intentional product use issue | FAERS: 1 | US FAERS | |
| 232 | Intercepted product prescribing error | FAERS: 1 | US FAERS | |
| 233 | Joint swelling | FAERS: 1 | US FAERS | |
| 234 | Labile blood pressure | FAERS: 1 | US FAERS | |
| 235 | Laryngitis | FAERS: 1 | US FAERS | |
| 236 | Laziness | FAERS: 1 | US FAERS | |
| 237 | Limb operation | FAERS: 1 | US FAERS | |
| 238 | Lip swelling | FAERS: 1 | US FAERS | |
| 239 | Mastitis | FAERS: 1 | US FAERS | |
| 240 | Medical device removal | FAERS: 1 | US FAERS | |
| 241 | Monoplegia | FAERS: 1 | US FAERS | |
| 242 | Musculoskeletal chest pain | FAERS: 1 | US FAERS | |
| 243 | Neck Dissection | FAERS: 1 | US FAERS | |
| 244 | Neuralgia | FAERS: 1 | US FAERS | |
| 245 | Oropharyngeal pain | FAERS: 1 | US FAERS | |
| 246 | Orthostatic hypertension | FAERS: 1 | US FAERS | |
| 247 | Oxygen supplementation | FAERS: 1 | US FAERS | |
| 248 | Pain of skin | FAERS: 1 | US FAERS | |
| 249 | Pancreatic carcinoma | FAERS: 1 | US FAERS | |
| 250 | Paresis | FAERS: 1 | US FAERS | |
| 251 | Pneumothorax | FAERS: 1 | US FAERS | |
| 252 | Poor peripheral circulation | FAERS: 1 | US FAERS | |
| 253 | Post procedural complication | FAERS: 1 | US FAERS | |
| 254 | Pre-existing condition improved | FAERS: 1 | US FAERS | |
| 255 | Presyncope | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 256 | Product administration error | FAERS: 1 | US FAERS | |
| 257 | Product prescribing error | FAERS: 1 | US FAERS | |
| 258 | Product prescribing issue | FAERS: 1 | US FAERS | |
| 259 | Product supply issue | FAERS: 1 | US FAERS | |
| 260 | Product used for unknown indication | FAERS: 1 | US FAERS | |
| 261 | Pulmonary Embolism | FAERS: 1 | US FAERS | |
| 262 | Pulmonary Fibrosis | FAERS: 1 | US FAERS | |
| 263 | Pulmonary congestion | FAERS: 1 | US FAERS | |
| 264 | Pulmonary endarterectomy | FAERS: 1 | US FAERS | |
| 265 | Pulmonary pain | FAERS: 1 | US FAERS | |
| 266 | Quality of life decreased | FAERS: 1 | US FAERS | |
| 267 | Rectal Prolapse | FAERS: 1 | US FAERS | |
| 268 | Rehabilitation therapy | FAERS: 1 | US FAERS | |
| 269 | Respiratory distress | FAERS: 1 | US FAERS | |
| 270 | Respiratory tract congestion | FAERS: 1 | US FAERS | |
| 271 | Sarcoidosis | FAERS: 1 | US FAERS | |
| 272 | Sensitive skin | FAERS: 1 | US FAERS | |
| 273 | Shunt malfunction | FAERS: 1 | US FAERS | |
| 274 | Splenomegaly | FAERS: 1 | US FAERS | |
| 275 | Squamous cell carcinoma | FAERS: 1 | US FAERS | |
| 276 | Temperature intolerance | FAERS: 1 | US FAERS | |
| 277 | Tension | FAERS: 1 | US FAERS | |
| 278 | Therapy cessation | FAERS: 1 | US FAERS | |
| 279 | Therapy change | FAERS: 1 | US FAERS | |
| 280 | Thrombocytopenia | FAERS: 1 | US FAERS | |
| 281 | Tonsillectomy | FAERS: 1 | US FAERS | |
| 282 | Tooth Infection | FAERS: 1 | US FAERS | |
| 283 | Transplant evaluation | FAERS: 1 | US FAERS | |
| 284 | Troponin increased | FAERS: 1 | US FAERS | |
| 285 | Ulcer | FAERS: 1 | US FAERS | |
| 286 | Urinary Retention | FAERS: 1 | US FAERS | |
| 287 | Urticaria | FAERS: 1 | US FAERS | |
| 288 | Vaginal Discharge | FAERS: 1 | US FAERS | |
| 289 | Vascular device infection | FAERS: 1 | US FAERS | |
| 290 | Vascular graft complication | FAERS: 1 | US FAERS | |
| 291 | Vascular insufficiency | FAERS: 1 | US FAERS | |
| 292 | Venoocclusive disease | FAERS: 1 | US FAERS | |
| 293 | Vertigo | FAERS: 1 | US FAERS | |
| 294 | Volvulus repair | FAERS: 1 | US FAERS | |
| 295 | Vulvovaginal pruritus | FAERS: 1 | US FAERS | |
| 296 | Walking distance test abnormal | FAERS: 1 | US FAERS | |
| 297 | jaundice | FAERS: 1 | US FAERS | |
| 298 | Pulmonary vascular resistance abnormality | Canada Vigilance: 1 | Canada Vigilance |
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