MetaADEDB 2.0 @ LMMD
sibutramine
(UNAANXDKBXWMLN-UHFFFAOYSA-N)
Structure
SMILES
CC(CC(C1(CCC1)c1ccc(cc1)Cl)N(C)C)C
Type(s)
Approved; Illicit; Investigational; Withdrawn
ATC code(s)
A08AA10
Molecular Formula:
C17H26ClN
Molecular Weight:
279.848
Log P:
4.7380
Hydrogen Bond Acceptor:
1
Hydrogen Bond Donor:
0
TPSA:
3.24
CAS Number(s):
106650-56-0
Synonym(s)
1.
sibutramine
2.
(R)-DDMS
3.
BTS 54 524
4.
BTS 54524
5.
BTS-54524
6.
Meridia
7.
N-1-(1-(4-chlorophenyl)cyclobutyl)-3-methylbutyl-N,N-dimethylamine HCl
8.
Reductil
9.
di-desmethylsibutramine
10.
didesmethylsibutramine
11.
mono-desmethylsibutramine
12.
sibutramine hydrochloride
External Link(s)
MeSHC058254
PubChem Compound5210
BindingDB84742
ChEBI9137
CHEMBLCHEMBL1419
DrugBankDB01105
DrugCentral2440
IUPHAR/BPS Guide to PHARMACOLOGY2586
KEGGcpd:C07247
dr:D08513
Therapeutic Target DatabaseD08KVZ
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1DizzinessFAERS: 427838152CTD
OFFSIDES
SIDER
US FAERS
2FatigueFAERS: 4OFFSIDES
US FAERS
3ErythemaFAERS: 3US FAERS
4HeadacheFAERS: 3

View details

10492502
18788006
19588440
27838152
 		CTD
SIDER
US FAERS
5MalaiseFAERS: 3SIDER
US FAERS
6PalpitationsFAERS: 3SIDER
US FAERS
7TachycardiaFAERS: 318788006CTD
SIDER
US FAERS
8UrticariaFAERS: 3SIDER
US FAERS
9Abdominal discomfortFAERS: 2OFFSIDES
US FAERS
10Acute myocardial infarctionFAERS: 2US FAERS
11Cardiac ArrestFAERS: 2SIDER
US FAERS
12CatatoniaFAERS: 2OFFSIDES
US FAERS
13Cerebrovascular accidentFAERS: 2SIDER
US FAERS
14ChorioretinitisFAERS: 2OFFSIDES
US FAERS
15Drug exposure during pregnancyFAERS: 2US FAERS
16Drug ineffectiveFAERS: 2OFFSIDES
US FAERS
17Lack of satietyFAERS: 2OFFSIDES
US FAERS
18LymphadenitisFAERS: 2US FAERS
19Lymphatic obstructionFAERS: 2OFFSIDES
US FAERS
20NauseaFAERS: 2SIDER
US FAERS
21PainFAERS: 2SIDER
US FAERS
22Product quality issueFAERS: 2US FAERS
23Pulmonary EmbolismFAERS: 2US FAERS
24SomnolenceFAERS: 2SIDER
US FAERS
25Activities of daily living impairedFAERS: 1US FAERS
26Acute Coronary SyndromeFAERS: 1SIDER
US FAERS
27AgitationFAERS: 1SIDER
US FAERS
28AnxietyFAERS: 1OFFSIDES
SIDER
US FAERS
29ApathyFAERS: 1SIDER
US FAERS
30AppendicitisFAERS: 1US FAERS
31ArteriosclerosisFAERS: 1US FAERS
32Atrial FlutterFAERS: 1US FAERS
33Blood pressure fluctuationFAERS: 1OFFSIDES
US FAERS
34Cerebral disorderFAERS: 1US FAERS
35Chest PainFAERS: 1OFFSIDES
SIDER
US FAERS
36ConstipationFAERS: 1

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10492502
12119986
19588440
27838152
 		CTD
SIDER
US FAERS
37DemyelinationFAERS: 1US FAERS
38Depressed moodFAERS: 1US FAERS
39DysphoniaFAERS: 1OFFSIDES
US FAERS
40Ejection Fraction DecreasedFAERS: 1US FAERS
41Electrocardiogram abnormalFAERS: 1SIDER
US FAERS
42Feeling abnormalFAERS: 1OFFSIDES
SIDER
US FAERS
43Gastrointestinal toxicityFAERS: 1US FAERS
44GlaucomaFAERS: 1SIDER
US FAERS
45HungerFAERS: 1US FAERS
46HypokinesiaFAERS: 1US FAERS
47Jealous delusionFAERS: 1US FAERS
48LymphadenopathyFAERS: 1SIDER
US FAERS
49MastocytomaFAERS: 1US FAERS
50Muscle strainFAERS: 1OFFSIDES
US FAERS
51Myocardial InfarctionFAERS: 1

View details

17978302
18788006
20446231
27838152
 		CTD
SIDER
US FAERS
52Panic DisorderFAERS: 1OFFSIDES
US FAERS
53Product formulation issueFAERS: 1US FAERS
54PyelonephritisFAERS: 1OFFSIDES
US FAERS
55QuadriplegiaFAERS: 1US FAERS
56Spina BifidaFAERS: 1US FAERS
57Spousal AbuseFAERS: 1US FAERS
58SyncopeFAERS: 1SIDER
US FAERS
59TremorFAERS: 1SIDER
US FAERS
60Ventricular hypokinesiaFAERS: 1OFFSIDES
US FAERS
61VomitingFAERS: 1SIDER
US FAERS
62nervous system disorderFAERS: 1US FAERS
63Abdominal PainSIDER
64Abdominal massOFFSIDES
65Abdominal wall infectionOFFSIDES
66Abnormal cervical smearOFFSIDES
67Abnormal ejaculationSIDER
68Abnormal visionSIDER
69AbscessOFFSIDES
SIDER
70AcneSIDER
71Actinic keratosisOFFSIDES
72Acute interstitial nephritisSIDER
73Acute nephritisSIDER
74Acute psychosisOFFSIDES
75Acute sinusitisOFFSIDES
76AdenitisOFFSIDES
77AkathisiaSIDER
78Alanine Aminotransferase IncreasedSIDER
79AlbuminuriaSIDER
80Alcohol IntoleranceSIDER
81Allergy to arthropod stingOFFSIDES
82AlopeciaSIDER
83AlveoloplastyOFFSIDES
84AmblyopiaSIDER
85AmenorrheaOFFSIDES
86AmnesiaSIDER
87Amphetamines positiveOFFSIDES
88Anaphylactic shockSIDER
89Anaphylactoid ReactionSIDER
90AngerSIDER
91Angina PectorisSIDER
92AngioedemaSIDER
93Anorexia10492502CTD
SIDER
94Aortic RuptureOFFSIDES
95Arterial thrombosisOFFSIDES
96ArthralgiaSIDER
97ArthritisSIDER
98ArthropathySIDER
99Aspartate Aminotransferase IncreasedSIDER
100AsphyxiaOFFSIDES
101AstheniaSIDER
102AsthmaSIDER
103AtaxiaSIDER
104Atrial FibrillationSIDER
105Atrial tachycardiaOFFSIDES
106Auditory and visual hallucinationsSIDER
107AuraOFFSIDES
108AutomatismOFFSIDES
109Back PainSIDER
110Bacteria urine identifiedOFFSIDES
111Benign Prostatic HyperplasiaOFFSIDES
112BereavementOFFSIDES
113BiopsyOFFSIDES
114Bipolar Disorder11874219CTD
115Bladder painSIDER
116Blood alkaline phosphatase increasedSIDER
117Blood chloride increasedOFFSIDES
118Blood cholesterol abnormalOFFSIDES
119Blood cholesterolOFFSIDES
120Blood creatinine increasedSIDER
121Blood urea increasedSIDER
122Blurred visionOFFSIDES
123Bone painSIDER
124BradycardiaSIDER
125Breast MicrocalcificationOFFSIDES
126BronchitisSIDER
127BruxismOFFSIDES
128BursitisSIDER
129CalcinosisOFFSIDES
130CarcinomaSIDER
131Cardiac FlutterOFFSIDES
132Cardiotoxicity26259608CTD
133CataractSIDER
134Catheter placementOFFSIDES
135CellulitisSIDER
136CheilitisSIDER
137Chest discomfortSIDER
138Chest pressureSIDER
139Chest tightnessSIDER
140ChillsSIDER
141Choking sensationOFFSIDES
142CholecystitisOFFSIDES
SIDER
143CholelithiasisSIDER
144ChorioamnionitisOFFSIDES
145Circumoral paresthesiaSIDER
146Circumstance or information capable of leading to medication errorOFFSIDES
147Coagulation factor VII level increasedOFFSIDES
148ColitisSIDER
149Completed SuicideSIDER
150Complications of maternal exposure to therapeutic drugsOFFSIDES
151Congenital tricuspid valve incompetenceOFFSIDES
152ConjunctivitisSIDER
153Conversion disorderOFFSIDES
154Cramps of lower extremitiesSIDER
155Creatinine increasedSIDER
156CystitisSIDER
157DehydrationSIDER
158Dental cariesSIDER
159Depressed Level of ConsciousnessOFFSIDES
160Depression aggravatedSIDER
161DermatitisSIDER
162Device related infectionOFFSIDES
163Diabetes MellitusSIDER
164DiscomfortSIDER
165Disease recurrenceOFFSIDES
166Disturbance in sexual arousalSIDER
167Drug ToleranceOFFSIDES
168Drug addictOFFSIDES
169Drug screen positiveOFFSIDES
170Drug withdrawal headacheOFFSIDES
171Dry skinSIDER
172Duodenal UlcerSIDER
173DysgeusiaSIDER
174DyspepsiaSIDER
175DysphasiaOFFSIDES
176DysuriaSIDER
177Ear discomfortOFFSIDES
178EcchymosisSIDER
179EclampsiaOFFSIDES
180EczemaSIDER
181Electrocardiogram ST-T changeOFFSIDES
182Electromechanical dissociationOFFSIDES
183Elevated moodOFFSIDES
184EmbolismOFFSIDES
185Enlargement abdomenSIDER
186EnteritisSIDER
187EosinophiliaSIDER
188EpididymitisSIDER
189EpilepsySIDER
190EpistaxisSIDER
191Erectile dysfunctionOFFSIDES
SIDER
192EructationSIDER
193Euphoric moodSIDER
194ExophthalmosOFFSIDES
195Eye painSIDER
196Facial paralysisSIDER
197Familial Mediterranean FeverOFFSIDES
198Fatty Liver14502318CTD
199Flank PainOFFSIDES
200Flat affectSIDER
201FlatulenceSIDER
202Food cravingOFFSIDES
203FormicationOFFSIDES
204FurunculosisSIDER
205GamblingOFFSIDES
206Gamma-Glutamyltransferase IncreasedOFFSIDES
SIDER
207GangreneOFFSIDES
208Gastric LavageOFFSIDES
209Gastric ulcerOFFSIDES
SIDER
210GastritisSIDER
211GastroenteritisOFFSIDES
SIDER
212Gastrointestinal PainSIDER
213GingivitisSIDER
214GlomerulonephritisOFFSIDES
215GlossitisSIDER
216GoiterOFFSIDES
217GoutSIDER
218GranulomaOFFSIDES
219Hallucinations, mixedSIDER
220Heart Diseases24038852CTD
221HemicephalalgiaOFFSIDES
222Hepatitis B positiveOFFSIDES
223HerniaOFFSIDES
SIDER
224High density lipoprotein increasedOFFSIDES
225Hip surgeryOFFSIDES
226Hormone level abnormalSIDER
227HostilitySIDER
228HydrothoraxOFFSIDES
229HyperkinesiaSIDER
230HypersensitivitySIDER
231HyperthyroidismSIDER
232HyperventilationSIDER
233HypotensionSIDER
234HypothyroidismSIDER
235Iliac artery stenosisOFFSIDES
236Incision site complicationOFFSIDES
237IncontinenceOFFSIDES
238InfectionSIDER
239InfertilityOFFSIDES
240InflammationSIDER
241InfluenzaSIDER
242Insulin Resistance14502318CTD
243Intention tremorOFFSIDES
244Intestinal ObstructionOFFSIDES
SIDER
245Intracranial AneurysmOFFSIDES
246IritisSIDER
247Lacrimal structural disorderSIDER
248LaryngitisSIDER
249LeukocytosisSIDER
250LeukopeniaSIDER
251Ligament injuryOFFSIDES
252Limb injuryOFFSIDES
253LymphocytosisSIDER
254Malignant HypertensionOFFSIDES
SIDER
255Malignant neoplasm of spinal cordOFFSIDES
256MalnutritionSIDER
257Manic psychosisSIDER
258MediastinitisOFFSIDES
259Metastatic Renal Cell CarcinomaOFFSIDES
260MetrorrhagiaSIDER
261MonocytosisSIDER
262MonoplegiaOFFSIDES
263Mood swingsSIDER
264Mucosal erosionOFFSIDES
265MurderOFFSIDES
266Muscle WeaknessOFFSIDES
267Musculoskeletal discomfortOFFSIDES
SIDER
268MyalgiaSIDER
269MyoclonusSIDER
270MyopathySIDER
271Nasal sinus drainageOFFSIDES
272Neck PainSIDER
273Necrotising granulomatous lymphadenitisOFFSIDES
274Nephritic syndromeSIDER
275NephritisSIDER
276Nervous tensionOFFSIDES
277NervousnessSIDER
278NeuralgiaOFFSIDES
SIDER
279NeuritisSIDER
280NocturiaOFFSIDES
281Obesity

View details

9118819
10492502
11026090
11840225
11916102
12119986
12975638
14502318
15532736
16861099
17404163
18773755
19046740
19357147
19482040
19588440
20002075
20188082
20518802
20671571
21333255
24038852
 		CTD
282OligohydramniosOFFSIDES
283Oral polypectomyOFFSIDES
284OrthopneaOFFSIDES
285OsteoporosisSIDER
286Otitis ExternaSIDER
287Otitis MediaSIDER
288PallorOFFSIDES
289PanniculitisOFFSIDES
290ParanoiaOFFSIDES
291Pelvic PainSIDER
292Pericardial effusionOFFSIDES
293PetechiaeSIDER
294PharyngitisSIDER
295Pharyngolaryngeal PainOFFSIDES
296PhlebitisOFFSIDES
SIDER
297Physical disabilityOFFSIDES
298PneumoniaSIDER
299Postoperative infectionOFFSIDES
300Precancerous skin lesionOFFSIDES
301Pregnancy on oral contraceptiveOFFSIDES
302Pregnancy with implant contraceptiveOFFSIDES
303Prescribed overdoseOFFSIDES
304Proctitis herpesOFFSIDES
305Productive CoughOFFSIDES
306PruritusSIDER
307PsoriasisSIDER
308Pulmonary HypertensionOFFSIDES
309Pulmonary InfarctionOFFSIDES
310Pulmonary congestionOFFSIDES
311PurpuraSIDER
312Rebound hypertensionOFFSIDES
313Reflux laryngitisOFFSIDES
314Renal Artery StenosisOFFSIDES
315Renal massOFFSIDES
316Retinal Vein OcclusionOFFSIDES
317Retrosternal painSIDER
318Rheumatoid ArthritisSIDER
319RhinitisSIDER
320Right ventricular failureSIDER
321Risus sardonicusOFFSIDES
322ScreamingOFFSIDES
323SepsisSIDER
324SepticemiaSIDER
325Serotonin SyndromeSIDER
326ShockSIDER
327Sinus headacheOFFSIDES
328SinusitisOFFSIDES
SIDER
329Skin UlcerSIDER
330Skin hypertrophySIDER
331Skin lesionOFFSIDES
332Skin noduleSIDER
333Sleep Initiation and Maintenance Disorders10492502
12119986		CTD
334SpondylosisOFFSIDES
335StomatitisSIDER
336StressOFFSIDES
337Subcutaneous noduleOFFSIDES
338Submandibular massOFFSIDES
339Sudden deathSIDER
340SuicideSIDER
341Supraventricular tachycardiaOFFSIDES
SIDER
342SweatingSIDER
343Synovial CystOFFSIDES
344TachyphreniaOFFSIDES
345TenosynovitisSIDER
346TensionSIDER
347Therapeutic response unexpectedSIDER
348ThirstSIDER
349ThrombocytopeniaSIDER
350ThrombocytosisSIDER
351ThrombophlebitisOFFSIDES
352TinnitusSIDER
353TorticollisSIDER
354UlcerOFFSIDES
355Ultrasound liver abnormalOFFSIDES
356Unexpected therapeutic effectSIDER
357Unwanted pregnancyOFFSIDES
358Urinary IncontinenceSIDER
359Urinary RetentionSIDER
360Urinary tract infectionSIDER
361Uterine CancerOFFSIDES
362VIIth nerve paralysisSIDER
363Vascular purpuraSIDER
364Vasculitic rashSIDER
365Vasculitis gastrointestinalOFFSIDES
366Vasodilation procedureSIDER
367VasodilationSIDER
368VasospasmOFFSIDES
369Venous InsufficiencyOFFSIDES
370Venous stenosisOFFSIDES
371Venous thrombosis limbOFFSIDES
372Ventricular FibrillationOFFSIDES
SIDER
373VertigoSIDER
374Viral upper respiratory tract infectionOFFSIDES
375Visual ImpairmentSIDER
376Visual disturbanceOFFSIDES
377Weight GainOFFSIDES
378Wolff-Parkinson-White SyndromeOFFSIDES
379Wound InfectionOFFSIDES
380Wound dehiscenceOFFSIDES
381Xerostomia10492502
12119986
19588440		CTD
382YawningSIDER
383colonoscopyOFFSIDES
384furuncleSIDER
385prostatitisOFFSIDES
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