MetaADEDB 2.0 @ LMMD
Cefazolin
(MLYYVTUWGNIJIB-BXKDBHETSA-N)
Structure
SMILES
O=C(N[C@@H]1C(=O)N2[C@@H]1SCC(=C2C(=O)O)CSc1nnc(s1)C)Cn1cnnn1
Type(s)
Approved
ATC code(s)
J01DB04
Molecular Formula:
C14H14N8O4S3
Molecular Weight:
454.507
Log P:
-0.3073
Hydrogen Bond Acceptor:
15
Hydrogen Bond Donor:
2
TPSA:
234.93
CAS Number(s):
25953-19-9; 27164-46-1
Synonym(s)
1.
Cefazolin
2.
Cephazolin
3.
Ancef
4.
Cefamedin
5.
Cefamezine
6.
Cefazolin Sodium
7.
Cephamezine
8.
Cephazolin Sodium
9.
Gramaxin
10.
Kefzol
11.
Sodium Cephazolin
12.
Totacef
13.
Cephazolin, Sodium
14.
Sodium, Cefazolin
15.
Sodium, Cephazolin
External Link(s)
MeSHD002437
PubChem Compound33255
BindingDB50292238
50370587
ChEBI474053
CHEMBLCHEMBL1435
DrugBankDB01327
DrugCentral530
KEGGcpd:C06880
dr:D02299
Therapeutic Target DatabaseD09KDN
ZINC3830405
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Incision site infectionFAERS: 49US FAERS
2UrticariaFAERS: 31
Canada Vigilance: 2		11792017CTD
SIDER
Canada Vigilance
US FAERS
3HypotensionFAERS: 29
Canada Vigilance: 3		Canada Vigilance
SIDER
US FAERS
4InfectionFAERS: 26OFFSIDES
US FAERS
5NauseaFAERS: 25
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
SIDER
US FAERS
6Anaphylactic shockFAERS: 23SIDER
US FAERS
7PruritusFAERS: 20
Canada Vigilance: 3		Canada Vigilance
SIDER
US FAERS
8VomitingFAERS: 20
Canada Vigilance: 3		Canada Vigilance
SIDER
US FAERS
9ErythemaFAERS: 14
Canada Vigilance: 4		Canada Vigilance
OFFSIDES
US FAERS
10ShockFAERS: 13SIDER
US FAERS
11Poor quality drug administeredFAERS: 12US FAERS
12HypersensitivityFAERS: 11
Canada Vigilance: 2		Canada Vigilance
SIDER
US FAERS
13Pharmaceutical product complaintFAERS: 11US FAERS
14Abdominal PainFAERS: 9
Canada Vigilance: 3		Canada Vigilance
OFFSIDES
SIDER
US FAERS
15FlushingFAERS: 9US FAERS
16TachycardiaFAERS: 9
Canada Vigilance: 2		Canada Vigilance
US FAERS
17ThrombocytopeniaFAERS: 9SIDER
US FAERS
18treatment failureFAERS: 9US FAERS
19Acute kidney injuryFAERS: 8US FAERS
20AngioedemaFAERS: 8US FAERS
21ChillsFAERS: 8
Canada Vigilance: 3		Canada Vigilance
US FAERS
22NeutropeniaFAERS: 8
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
23Toxic Epidermal NecrolysisFAERS: 8SIDER
US FAERS
24Feeling abnormalFAERS: 7SIDER
US FAERS
25Medication ErrorFAERS: 7US FAERS
26ProteinuriaFAERS: 73172294CTD
US FAERS
27Status EpilepticusFAERS: 7US FAERS
28BradycardiaFAERS: 6OFFSIDES
US FAERS
29DysarthriaFAERS: 6US FAERS
30EosinophiliaFAERS: 6SIDER
US FAERS
31Kounis SyndromeFAERS: 6US FAERS
32SepsisFAERS: 6US FAERS
33Blood creatinine increasedFAERS: 5OFFSIDES
SIDER
US FAERS
34Clostridium difficile infectionFAERS: 5
Canada Vigilance: 4		Canada Vigilance
US FAERS
35Depressed Level of ConsciousnessFAERS: 5OFFSIDES
US FAERS
36Electrocardiogram ST segment abnormalFAERS: 5US FAERS
37MyalgiaFAERS: 5US FAERS
38Rash erythematousFAERS: 5US FAERS
39ArthralgiaFAERS: 4US FAERS
40Cardiac ArrestFAERS: 4
Canada Vigilance: 5		Canada Vigilance
US FAERS
41Chest PainFAERS: 4OFFSIDES
US FAERS
42Chest discomfortFAERS: 4
Canada Vigilance: 2		Canada Vigilance
US FAERS
43Cold sweatFAERS: 4US FAERS
44Disease ProgressionFAERS: 4US FAERS
45PainFAERS: 4OFFSIDES
SIDER
US FAERS
46Respiratory arrestFAERS: 4US FAERS
47Septic ShockFAERS: 4OFFSIDES
US FAERS
48SneezingFAERS: 4US FAERS
49SyncopeFAERS: 4SIDER
US FAERS
50pseudomembranous colitisFAERS: 4SIDER
US FAERS
51Alanine Aminotransferase IncreasedFAERS: 3OFFSIDES
US FAERS
52Aspartate Aminotransferase IncreasedFAERS: 3SIDER
US FAERS
53AstheniaFAERS: 3SIDER
US FAERS
54Atrial FibrillationFAERS: 3US FAERS
55BronchospasmFAERS: 3US FAERS
56CellulitisFAERS: 3OFFSIDES
US FAERS
57Disease complicationFAERS: 3US FAERS
58Disseminated Intravascular CoagulationFAERS: 3OFFSIDES
US FAERS
59EpistaxisFAERS: 3OFFSIDES
US FAERS
60HeadacheFAERS: 3SIDER
US FAERS
61HypoxiaFAERS: 3OFFSIDES
US FAERS
62Injection site painFAERS: 3US FAERS
63Lip swellingFAERS: 3US FAERS
64MalaiseFAERS: 3US FAERS
65OliguriaFAERS: 3OFFSIDES
US FAERS
66Peripheral swellingFAERS: 3
Canada Vigilance: 1		Canada Vigilance
US FAERS
67Positron emission tomogram abnormalFAERS: 3US FAERS
68Procedural complicationFAERS: 3US FAERS
69Product quality issueFAERS: 3US FAERS
70Respiratory distressFAERS: 3US FAERS
71Therapeutic product contaminationFAERS: 3US FAERS
72TremorFAERS: 3US FAERS
73Unresponsive to stimuliFAERS: 3OFFSIDES
US FAERS
74Urinary RetentionFAERS: 3US FAERS
75Weight decreasedFAERS: 3US FAERS
76WheezingFAERS: 3US FAERS
77Abdominal AbscessFAERS: 2US FAERS
78Anaphylactoid ReactionFAERS: 2
Canada Vigilance: 2		Canada Vigilance
US FAERS
79Angina PectorisFAERS: 2US FAERS
80AphoniaFAERS: 2US FAERS
81AscitesFAERS: 2US FAERS
82Back PainFAERS: 2US FAERS
83Bone marrow depressionFAERS: 2US FAERS
84Burning sensationFAERS: 2US FAERS
85Clostridium colitisFAERS: 2OFFSIDES
US FAERS
86ConjunctivitisFAERS: 2US FAERS
87Coronary Artery DiseaseFAERS: 2US FAERS
88DehydrationFAERS: 2OFFSIDES
US FAERS
89Drug ineffectiveFAERS: 2US FAERS
90DysplasiaFAERS: 2US FAERS
91FatigueFAERS: 2SIDER
US FAERS
92FlatulenceFAERS: 2SIDER
US FAERS
93Hepatic congestionFAERS: 2US FAERS
94HepatotoxicityFAERS: 2US FAERS
95HyperkinesiaFAERS: 2SIDER
US FAERS
96Hypertensive crisisFAERS: 2US FAERS
97Infusion site erythemaFAERS: 2US FAERS
98Infusion site painFAERS: 2US FAERS
99LeukopeniaFAERS: 2SIDER
US FAERS
100Myocardial InfarctionFAERS: 2US FAERS
101No adverse eventFAERS: 2US FAERS
102PancytopeniaFAERS: 2SIDER
US FAERS
103PneumoniaFAERS: 2US FAERS
104Postoperative infectionFAERS: 2SIDER
US FAERS
105Product use in unapproved indicationFAERS: 2
Canada Vigilance: 1		Canada Vigilance
US FAERS
106Propionibacterium infectionFAERS: 2US FAERS
107Rubber sensitivityFAERS: 2US FAERS
108Serum SicknessFAERS: 2OFFSIDES
US FAERS
109SilicosisFAERS: 2US FAERS
110SplenomegalyFAERS: 2
Canada Vigilance: 3		Canada Vigilance
US FAERS
111Stevens-Johnson SyndromeFAERS: 225811541CTD
OFFSIDES
SIDER
US FAERS
112StuporFAERS: 2US FAERS
113SwellingFAERS: 2US FAERS
114SymblepharonFAERS: 2US FAERS
115Troponin increasedFAERS: 2US FAERS
116Ventricular FibrillationFAERS: 2OFFSIDES
US FAERS
117Acute myocardial infarctionFAERS: 1US FAERS
118Acute respiratory failureFAERS: 1OFFSIDES
US FAERS
119AgitationFAERS: 1SIDER
US FAERS
120Antibiotic level above therapeuticFAERS: 1US FAERS
121Arteriovenous fistulaFAERS: 1US FAERS
122Bacteria blood identifiedFAERS: 1US FAERS
123Blood alkaline phosphatase increasedFAERS: 1OFFSIDES
US FAERS
124Blood cholesterol increasedFAERS: 1US FAERS
125Blood creatine phosphokinase increasedFAERS: 1OFFSIDES
US FAERS
126Blood glucose decreasedFAERS: 1OFFSIDES
US FAERS
127Blood immunoglobulin E increasedFAERS: 1US FAERS
128Blood lactate dehydrogenase increasedFAERS: 1OFFSIDES
SIDER
US FAERS
129Body temperature fluctuationFAERS: 1US FAERS
130Brain scan abnormalFAERS: 1US FAERS
131BursitisFAERS: 1US FAERS
132CardiomegalyFAERS: 1US FAERS
133Cerebral disorderFAERS: 1US FAERS
134CholangitisFAERS: 1US FAERS
135CholestasisFAERS: 1SIDER
US FAERS
136ChorioamnionitisFAERS: 1US FAERS
137Clostridium difficile colitisFAERS: 1US FAERS
138Clostridium test positiveFAERS: 1US FAERS
139ColectomyFAERS: 1US FAERS
140Deafness NeurosensoryFAERS: 1US FAERS
141Device related infectionFAERS: 1OFFSIDES
US FAERS
142DiscomfortFAERS: 1US FAERS
143Disease recurrenceFAERS: 1US FAERS
144DisorientationFAERS: 1US FAERS
145Documented hypersensitivity to administered drugFAERS: 1US FAERS
146Drug administration errorFAERS: 1US FAERS
147Drug level decreasedFAERS: 1US FAERS
148DysgeusiaFAERS: 1US FAERS
149EcchymosisFAERS: 1US FAERS
150Electroencephalogram abnormalFAERS: 1US FAERS
151Endotracheal intubation complicationFAERS: 1OFFSIDES
US FAERS
152ExtravasationFAERS: 1US FAERS
153Febrile NeutropeniaFAERS: 1US FAERS
154Fluid overloadFAERS: 1OFFSIDES
US FAERS
155HepatitisFAERS: 1SIDER
US FAERS
156HyperthyroidismFAERS: 1US FAERS
157HypometabolismFAERS: 1US FAERS
158HypoperfusionFAERS: 1US FAERS
159HypophagiaFAERS: 1OFFSIDES
US FAERS
160HyporeflexiaFAERS: 1US FAERS
161HypoventilationFAERS: 1US FAERS
162Inappropriate schedule of drug administrationFAERS: 1US FAERS
163Incorrect drug administration durationFAERS: 1US FAERS
164Incorrect route of drug administrationFAERS: 1US FAERS
165Inflammatory marker increasedFAERS: 1US FAERS
166Infusion Site ExtravasationFAERS: 1US FAERS
167Infusion site pruritusFAERS: 1US FAERS
168Infusion site swellingFAERS: 1US FAERS
169Injection site extravasationFAERS: 1US FAERS
170Injection site massFAERS: 1US FAERS
171Large intestine perforationFAERS: 1US FAERS
172LaryngospasmFAERS: 1US FAERS
173LethargyFAERS: 1OFFSIDES
US FAERS
174LeukocytosisFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
175Livedo ReticularisFAERS: 1US FAERS
176Lupus NephritisFAERS: 1US FAERS
177Maternal exposure during deliveryFAERS: 1US FAERS
178Mechanical ventilation complicationFAERS: 1US FAERS
179Medical device complicationFAERS: 1US FAERS
180Medical device site irritationFAERS: 1US FAERS
181Memory impairmentFAERS: 1US FAERS
182Mental status changesFAERS: 1OFFSIDES
US FAERS
183MyoclonusFAERS: 1US FAERS
184Nephrotic SyndromeFAERS: 1US FAERS
185Oral candidiasisFAERS: 1SIDER
US FAERS
186OsteomyelitisFAERS: 11601755CTD
US FAERS
187PapuleFAERS: 1US FAERS
188Pathogen resistanceFAERS: 1US FAERS
189Peritoneal DialysisFAERS: 1US FAERS
190Peritoneal fluid analysis abnormalFAERS: 1US FAERS
191PeritonitisFAERS: 115877673CTD
US FAERS
192PetechiaeFAERS: 1US FAERS
193PneumoconiosisFAERS: 1US FAERS
194Post procedural complicationFAERS: 1OFFSIDES
US FAERS
195Post procedural dischargeFAERS: 1US FAERS
196Postoperative feverFAERS: 1US FAERS
197PresyncopeFAERS: 1US FAERS
198Product substitution issueFAERS: 1US FAERS
199Renal tubular necrosisFAERS: 1US FAERS
200Respiratory DepressionFAERS: 1US FAERS
201RhinitisFAERS: 1US FAERS
202ScreamingFAERS: 1US FAERS
203Serum sickness-like reactionFAERS: 1SIDER
US FAERS
204Shoulder PainFAERS: 1US FAERS
205Sinus TachycardiaFAERS: 1US FAERS
206Soft Tissue InfectionFAERS: 1US FAERS
207Sterile pyuriaFAERS: 1US FAERS
208Streptococcus test positiveFAERS: 1US FAERS
209Therapy cessationFAERS: 1US FAERS
210Therapy non-responderFAERS: 1US FAERS
211Throat irritationFAERS: 1US FAERS
212TinnitusFAERS: 1US FAERS
213Tryptase increasedFAERS: 1US FAERS
214Upper motor neurone lesionFAERS: 1US FAERS
215Urinary tract infectionFAERS: 1US FAERS
216Vanishing bile duct syndromeFAERS: 1US FAERS
217VasculitisFAERS: 1US FAERS
218Vitamin K DeficiencyFAERS: 1US FAERS
219White blood cell count decreasedFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
220AbasiaOFFSIDES
221Abdominal discomfortOFFSIDES
222Abdominal tendernessOFFSIDES
223AbscessOFFSIDES
224AcidosisOFFSIDES
225Acquired Protein S DeficiencyOFFSIDES
226AgranulocytosisSIDER
227Allergic cystitisOFFSIDES
228AlopeciaOFFSIDES
229Ammonia increasedOFFSIDES
230Anemia, Hemolytic96555CTD
231AneurysmOFFSIDES
232AnhedoniaOFFSIDES
233Anorectal discomfortSIDER
234AnorexiaSIDER
235Anti-erythropoietin antibody positiveOFFSIDES
236AnuriaOFFSIDES
237AnxietyCanada Vigilance: 1Canada Vigilance
OFFSIDES
238ApathyOFFSIDES
239Apnea10775086CTD
240Arterial bypass operationOFFSIDES
241ArteriosclerosisOFFSIDES
242Arteriovenous fistula thrombosisOFFSIDES
243AsbestosisOFFSIDES
244Aspiration PneumoniaOFFSIDES
245AtelectasisOFFSIDES
246Atrioventricular BlockOFFSIDES
247Bacteremia6366126CTD
248Bacteriuria16983943CTD
249BalanitisOFFSIDES
250Biliary sepsisOFFSIDES
251BlepharospasmOFFSIDES
252Blood GlucoseOFFSIDES
253Blood amylase increasedOFFSIDES
254Blood chloride decreasedOFFSIDES
255Blood electrolytes abnormalOFFSIDES
256Blood parathyroid hormone increasedOFFSIDES
257Blood potassium increasedOFFSIDES
258Blood pressure fluctuationOFFSIDES
259Blood sodiumOFFSIDES
260Blood urea increasedOFFSIDES
SIDER
261Bone density decreasedOFFSIDES
262Breakthrough PainOFFSIDES
263BronchitisOFFSIDES
264Bulbar palsyOFFSIDES
265Carcinoma, Transitional Cell15028437CTD
266Carotid artery aneurysmOFFSIDES
267Catheter related infectionOFFSIDES
268Cerebral atrophyOFFSIDES
269Cervicobrachial syndromeOFFSIDES
270CheilitisSIDER
271Choking sensationOFFSIDES
272Cholecystitis infectiveOFFSIDES
273Coagulation time abnormalOFFSIDES
274ColitisOFFSIDES
SIDER
275ConfabulationOFFSIDES
276Creatinine increasedSIDER
277Culture wound positiveOFFSIDES
278CyanosisCanada Vigilance: 2Canada Vigilance
279CystOFFSIDES
280DemyelinationOFFSIDES
281Dental abscessOFFSIDES
282Dental cariesOFFSIDES
283Denture wearerOFFSIDES
284DermatitisSIDER
285Device connection issueOFFSIDES
286DiarrheaOFFSIDES
287Diastolic dysfunctionOFFSIDES
288DizzinessSIDER
289Drug Eruptions11792017CTD
290Duodenal ulcer perforationOFFSIDES
291DyscheziaOFFSIDES
292DyspepsiaSIDER
293DysuriaOFFSIDES
294Economic problemOFFSIDES
295Ejection Fraction DecreasedOFFSIDES
296EndocarditisOFFSIDES
297Endometrial disorderOFFSIDES
298Enterococcal infectionOFFSIDES
299EpidermolysisOFFSIDES
300Epigastric painSIDER
301Erectile dysfunctionOFFSIDES
302Erythema MultiformeSIDER
303ErythroplasiaOFFSIDES
304Escherichia coli Infections6366126
16983943		CTD
305Escherichia infectionOFFSIDES
306ExcoriationOFFSIDES
307Extracorporeal Membrane OxygenationOFFSIDES
308Failure to ThriveOFFSIDES
309Fever6124751CTD
310FormicationOFFSIDES
311Gamma-Glutamyltransferase IncreasedOFFSIDES
312Gastric ulcerOFFSIDES
313GastroenteritisOFFSIDES
314Gastrointestinal PainSIDER
315Gastrointestinal sounds abnormalOFFSIDES
316General physical health deteriorationOFFSIDES
317Genital erosionOFFSIDES
318Gingival erythemaOFFSIDES
319GlaucomaOFFSIDES
320GlossectomyOFFSIDES
321GranulocytosisOFFSIDES
322Hallucinations, mixedOFFSIDES
323Heart sounds abnormalOFFSIDES
324HeartburnSIDER
325Heparin-induced thrombocytopeniaOFFSIDES
326Hepatic impairmentSIDER
327Hip surgeryOFFSIDES
328Hyperosmolar stateOFFSIDES
329Ileal ulcerOFFSIDES
330ImpetigoOFFSIDES
331Implant site reactionOFFSIDES
332Incorrect drug administration rateOFFSIDES
333IndurationSIDER
334Intervertebral Disc DegenerationOFFSIDES
335Jaw lesion excisionOFFSIDES
336Kidney FailureOFFSIDES
337Klebsiella Infections6366126CTD
338Lactic dehydrogenase activity increasedSIDER
339LightheadednessSIDER
340Lip erosionOFFSIDES
341LipaseOFFSIDES
342Local reactionSIDER
343Loose toothOFFSIDES
344Lymphocyte stimulation test positiveOFFSIDES
345Malignant neoplasm progressionOFFSIDES
346Mallory-Weiss SyndromeOFFSIDES
347Metabolic acidosisOFFSIDES
348MetaplasiaOFFSIDES
349Mucosal erosionOFFSIDES
350Muscle WeaknessOFFSIDES
351Musculoskeletal PainOFFSIDES
352Nephrogenic Diabetes InsipidusOFFSIDES
353Neutrophil count decreasedCanada Vigilance: 1Canada Vigilance
354Nutritional condition abnormalOFFSIDES
355Ocular icterusOFFSIDES
356Oculomucocutaneous syndromeOFFSIDES
357Open reduction of fractureOFFSIDES
358Open woundOFFSIDES
359Oral Cavity FistulaOFFSIDES
360OsteolysisOFFSIDES
361OsteopeniaOFFSIDES
362PallorOFFSIDES
363PancreatitisOFFSIDES
364Perianal abscessOFFSIDES
365Pericardial effusionOFFSIDES
366Peripheral embolismOFFSIDES
367Phlebitis789268
1147583		CTD
SIDER
368Pleural decorticationOFFSIDES
369PneumothoraxOFFSIDES
370PolyuriaOFFSIDES
371Post procedural infectionSIDER
372Progressive supranuclear palsyOFFSIDES
373Propofol Infusion SyndromeOFFSIDES
374Pruritus VulvaeSIDER
375Pseudomonas Infections6366126CTD
376Pulmonary HypertensionOFFSIDES
377Purulent dischargeOFFSIDES
378Pyoderma GangrenosumOFFSIDES
379Rectal fissureOFFSIDES
380Renal Insufficiency6366126CTD
381Respiratory FailureOFFSIDES
382RhonchiOFFSIDES
383Salpingitis6124751CTD
384Seizures

View details

2787643
10576583
15855723
17015947
17877149
 		CTD
385Sick Sinus SyndromeOFFSIDES
386Sinus headacheOFFSIDES
387SinusitisOFFSIDES
388Skeletal injuryOFFSIDES
389Skin ErosionOFFSIDES
390Skin lesionOFFSIDES
391SomnolenceSIDER
392Spinal column stenosisOFFSIDES
393Splenic abscessOFFSIDES
394Staphylococcal Infections789268
6366126		CTD
395Stasis dermatitisOFFSIDES
396StomatitisSIDER
397Streptococcal Infections789268
11706922		CTD
398StressOFFSIDES
399StridorOFFSIDES
400Subcutaneous AbscessOFFSIDES
401SuperinfectionSIDER
402Thoracic cavity drainageOFFSIDES
403ThrombocytosisSIDER
404ThrombophlebitisOFFSIDES
405Thrombosis in deviceOFFSIDES
406Tooth ExtractionOFFSIDES
407Tooth InfectionOFFSIDES
408Tooth LossOFFSIDES
409Urinary tract infection staphylococcalOFFSIDES
410Urine flow decreasedOFFSIDES
411Urine ketone body presentOFFSIDES
412Vascular insufficiencyOFFSIDES
413Vulvovaginal pruritusSIDER
414Walking aid userOFFSIDES
415Wound InfectionOFFSIDES
416Wound infection bacterialOFFSIDES
417effusionOFFSIDES
418prostatitisOFFSIDES
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