riociguat
(WXXSNCNJFUAIDG-UHFFFAOYSA-N)
Structure
- SMILES
- COC(=O)N(c1c(N)nc(nc1N)c1nn(c2c1cccn2)Cc1ccccc1F)C
- Type(s)
- Approved
- ATC code(s)
- C02KX05
- Molecular Formula:
- C20H19FN8O2
- Molecular Weight:
- 422.416
- Log P:
- 3.6051
- Hydrogen Bond Acceptor:
- 10
- Hydrogen Bond Donor:
- 2
- TPSA:
- 138.07
- CAS Number(s):
- 625115-55-1; 1304478-72-5
Synonym(s)
1.
riociguat
2.
Adempas
3.
BAY 63-2521
4.
BAY-63-2521
External Link(s)
Adverse Drug Event(s)
| Name | Number of Reports | Reference(s) | Data Source | |
|---|---|---|---|---|
| 1 | Dizziness | FAERS: 159 Canada Vigilance: 70 | Canada Vigilance SIDER US FAERS | |
| 2 | Hypotension | FAERS: 150 Canada Vigilance: 46 | Canada Vigilance SIDER US FAERS | |
| 3 | Headache | FAERS: 141 Canada Vigilance: 27 | Canada Vigilance SIDER US FAERS | |
| 4 | Nausea | FAERS: 115 Canada Vigilance: 25 | Canada Vigilance SIDER US FAERS | |
| 5 | Fatigue | FAERS: 88 Canada Vigilance: 47 | Canada Vigilance US FAERS | |
| 6 | Peripheral swelling | FAERS: 83 Canada Vigilance: 33 | Canada Vigilance US FAERS | |
| 7 | Pneumonia | FAERS: 82 Canada Vigilance: 20 | Canada Vigilance US FAERS | |
| 8 | Vomiting | FAERS: 78 Canada Vigilance: 11 | Canada Vigilance SIDER US FAERS | |
| 9 | Syncope | FAERS: 52 Canada Vigilance: 9 | Canada Vigilance US FAERS | |
| 10 | Chest Pain | FAERS: 49 Canada Vigilance: 11 | Canada Vigilance US FAERS | |
| 11 | Malaise | FAERS: 49 Canada Vigilance: 33 | Canada Vigilance US FAERS | |
| 12 | Drug dose omission | FAERS: 47 | US FAERS | |
| 13 | Dyspepsia | FAERS: 47 Canada Vigilance: 13 | Canada Vigilance SIDER US FAERS | |
| 14 | Asthenia | FAERS: 46 Canada Vigilance: 32 | Canada Vigilance US FAERS | |
| 15 | Constipation | FAERS: 41 Canada Vigilance: 7 | Canada Vigilance SIDER US FAERS | |
| 16 | Feeling abnormal | FAERS: 37 Canada Vigilance: 19 | Canada Vigilance US FAERS | |
| 17 | Pulmonary Hypertension | FAERS: 36 Canada Vigilance: 7 | Canada Vigilance US FAERS | |
| 18 | Product use issue | FAERS: 32 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 19 | Abdominal Pain | FAERS: 31 Canada Vigilance: 3 | Canada Vigilance SIDER US FAERS | |
| 20 | Pulmonary arterial hypertension | FAERS: 29 | US FAERS | |
| 21 | Product dose omission | FAERS: 26 Canada Vigilance: 22 | Canada Vigilance US FAERS | |
| 22 | Drug ineffective | FAERS: 24 Canada Vigilance: 7 | Canada Vigilance US FAERS | |
| 23 | Nasopharyngitis | FAERS: 23 Canada Vigilance: 23 | Canada Vigilance US FAERS | |
| 24 | Abdominal discomfort | FAERS: 22 Canada Vigilance: 9 | Canada Vigilance US FAERS | |
| 25 | Adverse event | FAERS: 22 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 26 | Joint swelling | FAERS: 22 Canada Vigilance: 8 | Canada Vigilance US FAERS | |
| 27 | Pain | FAERS: 22 Canada Vigilance: 7 | Canada Vigilance US FAERS | |
| 28 | Urinary tract infection | FAERS: 22 Canada Vigilance: 5 | Canada Vigilance US FAERS | |
| 29 | Weight decreased | FAERS: 22 Canada Vigilance: 8 | Canada Vigilance US FAERS | |
| 30 | Arthralgia | FAERS: 21 Canada Vigilance: 5 | Canada Vigilance US FAERS | |
| 31 | Dehydration | FAERS: 21 Canada Vigilance: 4 | Canada Vigilance US FAERS | |
| 32 | Influenza | FAERS: 21 Canada Vigilance: 6 | Canada Vigilance US FAERS | |
| 33 | Respiratory Failure | FAERS: 21 | US FAERS | |
| 34 | Palpitations | FAERS: 20 Canada Vigilance: 9 | Canada Vigilance SIDER US FAERS | |
| 35 | Swelling | FAERS: 20 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 36 | General physical health deterioration | FAERS: 19 Canada Vigilance: 4 | Canada Vigilance US FAERS | |
| 37 | Intestinal Obstruction | FAERS: 18 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 38 | Epistaxis | FAERS: 17 Canada Vigilance: 7 | Canada Vigilance SIDER US FAERS | |
| 39 | Acute kidney injury | FAERS: 16 | US FAERS | |
| 40 | Chest discomfort | FAERS: 16 Canada Vigilance: 8 | Canada Vigilance US FAERS | |
| 41 | Back Pain | FAERS: 15 Canada Vigilance: 10 | Canada Vigilance US FAERS | |
| 42 | Sepsis | FAERS: 15 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 43 | Tachycardia | FAERS: 15 | US FAERS | |
| 44 | Atrial Fibrillation | FAERS: 14 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 45 | Cerebrovascular accident | FAERS: 14 Canada Vigilance: 4 | Canada Vigilance US FAERS | |
| 46 | Ascites | FAERS: 13 | US FAERS | |
| 47 | Flatulence | FAERS: 12 | US FAERS | |
| 48 | Hypoxia | FAERS: 12 | US FAERS | |
| 49 | Product availability issue | FAERS: 12 | US FAERS | |
| 50 | Pulmonary endarterectomy | FAERS: 12 Canada Vigilance: 6 | Canada Vigilance US FAERS | |
| 51 | Thrombosis | FAERS: 12 Canada Vigilance: 5 | Canada Vigilance US FAERS | |
| 52 | Blood potassium decreased | FAERS: 11 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 53 | Pericardial effusion | FAERS: 11 | US FAERS | |
| 54 | Right ventricular failure | FAERS: 11 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 55 | Therapy cessation | FAERS: 11 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 56 | Unevaluable event | FAERS: 11 | US FAERS | |
| 57 | Flushing | FAERS: 10 | US FAERS | |
| 58 | Intentional product use issue | FAERS: 10 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 59 | Lethargy | FAERS: 10 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 60 | Myalgia | FAERS: 10 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 61 | Presyncope | FAERS: 10 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 62 | Pulmonary Embolism | FAERS: 10 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 63 | Somnolence | FAERS: 10 Canada Vigilance: 4 | Canada Vigilance US FAERS | |
| 64 | Wrong technique in product usage process | FAERS: 10 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 65 | Anxiety | FAERS: 9 Canada Vigilance: 6 | Canada Vigilance US FAERS | |
| 66 | Endarterectomy | FAERS: 9 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 67 | Fluid overload | FAERS: 9 | US FAERS | |
| 68 | Gastroenteritis | FAERS: 9 | SIDER US FAERS | |
| 69 | Incorrect dose administered | FAERS: 9 Canada Vigilance: 4 | Canada Vigilance US FAERS | |
| 70 | Myocardial Infarction | FAERS: 9 | US FAERS | |
| 71 | Productive Cough | FAERS: 9 Canada Vigilance: 8 | Canada Vigilance US FAERS | |
| 72 | Alopecia | FAERS: 8 | US FAERS | |
| 73 | Cardiac Arrest | FAERS: 8 | US FAERS | |
| 74 | Product supply issue | FAERS: 8 | US FAERS | |
| 75 | Pruritus | FAERS: 8 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 76 | Rehabilitation therapy | FAERS: 8 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 77 | Vertigo | FAERS: 8 | US FAERS | |
| 78 | Wheezing | FAERS: 8 | US FAERS | |
| 79 | Gout | FAERS: 7 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 80 | Hypersensitivity | FAERS: 7 | US FAERS | |
| 81 | Intentional product misuse | FAERS: 7 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 82 | Oxygen supplementation | FAERS: 7 | US FAERS | |
| 83 | Pulmonary thrombosis | FAERS: 7 Canada Vigilance: 4 | Canada Vigilance US FAERS | |
| 84 | Respiratory distress | FAERS: 7 | US FAERS | |
| 85 | Tremor | FAERS: 7 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 86 | Unresponsive to stimuli | FAERS: 7 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 87 | Blood count abnormal | FAERS: 6 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 88 | Depressed mood | FAERS: 6 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 89 | Device related infection | FAERS: 6 | US FAERS | |
| 90 | Disease Progression | FAERS: 6 | US FAERS | |
| 91 | Feeling Cold | FAERS: 6 Canada Vigilance: 6 | Canada Vigilance US FAERS | |
| 92 | Hospice Care | FAERS: 6 | US FAERS | |
| 93 | Inappropriate schedule of drug administration | FAERS: 6 | US FAERS | |
| 94 | Musculoskeletal Pain | FAERS: 6 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 95 | Respiratory arrest | FAERS: 6 | US FAERS | |
| 96 | intensive care | FAERS: 6 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 97 | Aphasia | FAERS: 5 | US FAERS | |
| 98 | Blood pressure fluctuation | FAERS: 5 Canada Vigilance: 13 | Canada Vigilance US FAERS | |
| 99 | Burning sensation | FAERS: 5 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 100 | Erythema | FAERS: 5 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 101 | Gastritis | FAERS: 5 Canada Vigilance: 1 | Canada Vigilance SIDER US FAERS | |
| 102 | Mechanical ventilation | FAERS: 5 | US FAERS | |
| 103 | Oropharyngeal pain | FAERS: 5 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 104 | Sinusitis | FAERS: 5 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 105 | Traumatic fracture | FAERS: 5 | US FAERS | |
| 106 | Accidental exposure to product by child | FAERS: 4 | US FAERS | |
| 107 | Blood glucose decreased | FAERS: 4 | US FAERS | |
| 108 | Blood potassium increased | FAERS: 4 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 109 | Blood urine present | FAERS: 4 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 110 | Choking | FAERS: 4 | US FAERS | |
| 111 | Clostridium difficile infection | FAERS: 4 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 112 | Cold sweat | FAERS: 4 | US FAERS | |
| 113 | Critical Illness | FAERS: 4 | US FAERS | |
| 114 | Cystitis | FAERS: 4 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 115 | Drug administered to patient of inappropriate age | FAERS: 4 | US FAERS | |
| 116 | Dysphonia | FAERS: 4 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 117 | Dysuria | FAERS: 4 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 118 | Emotional disorder | FAERS: 4 | US FAERS | |
| 119 | Gastric Dilatation | FAERS: 4 | US FAERS | |
| 120 | Hernia | FAERS: 4 | US FAERS | |
| 121 | Inflammation | FAERS: 4 | US FAERS | |
| 122 | Laceration | FAERS: 4 | US FAERS | |
| 123 | Limb discomfort | FAERS: 4 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 124 | Limb injury | FAERS: 4 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 125 | Loss of personal independence in daily activities | FAERS: 4 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 126 | Nervousness | FAERS: 4 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 127 | Product prescribing issue | FAERS: 4 | US FAERS | |
| 128 | Pulmonary pain | FAERS: 4 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 129 | Urticaria | FAERS: 4 | US FAERS | |
| 130 | Visual Impairment | FAERS: 4 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 131 | Acute respiratory failure | FAERS: 3 | US FAERS | |
| 132 | Amnesia | FAERS: 3 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 133 | Angioplasty | FAERS: 3 | US FAERS | |
| 134 | Ankle Fracture | FAERS: 3 | US FAERS | |
| 135 | Bronchitis | FAERS: 3 Canada Vigilance: 7 | Canada Vigilance US FAERS | |
| 136 | Cellulitis | FAERS: 3 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 137 | Chills | FAERS: 3 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 138 | Crying | FAERS: 3 | US FAERS | |
| 139 | Deafness | FAERS: 3 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 140 | Discomfort | FAERS: 3 | US FAERS | |
| 141 | Disorientation | FAERS: 3 | US FAERS | |
| 142 | Drug titration error | FAERS: 3 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 143 | Dysgeusia | FAERS: 3 | US FAERS | |
| 144 | Eructation | FAERS: 3 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 145 | Fracture | FAERS: 3 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 146 | Head discomfort | FAERS: 3 Canada Vigilance: 4 | Canada Vigilance US FAERS | |
| 147 | Hepatic Encephalopathy | FAERS: 3 | US FAERS | |
| 148 | Hydronephrosis | FAERS: 3 | US FAERS | |
| 149 | Inappropriate schedule of product administration | FAERS: 3 Canada Vigilance: 6 | Canada Vigilance US FAERS | |
| 150 | Incorrect product administration duration | FAERS: 3 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 151 | Infection | FAERS: 3 Canada Vigilance: 1 | Canada Vigilance SIDER US FAERS | |
| 152 | Intra-abdominal fluid collection | FAERS: 3 | US FAERS | |
| 153 | Joint injury | FAERS: 3 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 154 | Medical procedure | FAERS: 3 | US FAERS | |
| 155 | Memory impairment | FAERS: 3 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 156 | Neck Pain | FAERS: 3 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 157 | Overdose | FAERS: 3 | US FAERS | |
| 158 | Pneumonitis | FAERS: 3 | US FAERS | |
| 159 | Post procedural complication | FAERS: 3 | US FAERS | |
| 160 | Procedural complication | FAERS: 3 | US FAERS | |
| 161 | Procedural hypotension | FAERS: 3 | US FAERS | |
| 162 | Rales | FAERS: 3 | US FAERS | |
| 163 | Sluggishness | FAERS: 3 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 164 | Sudden death | FAERS: 3 | US FAERS | |
| 165 | Therapy change | FAERS: 3 | US FAERS | |
| 166 | Throat irritation | FAERS: 3 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 167 | Transplant | FAERS: 3 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 168 | Troponin increased | FAERS: 3 | US FAERS | |
| 169 | Abasia | FAERS: 2 | US FAERS | |
| 170 | Abnormal weight gain | FAERS: 2 | US FAERS | |
| 171 | Accidental exposure to product | FAERS: 2 | US FAERS | |
| 172 | Ammonia increased | FAERS: 2 | US FAERS | |
| 173 | Angina Pectoris | FAERS: 2 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 174 | Angioedema | FAERS: 2 | US FAERS | |
| 175 | Anticoagulation drug level increased | FAERS: 2 | US FAERS | |
| 176 | Anuria | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 177 | Arterial thrombosis | FAERS: 2 | US FAERS | |
| 178 | Asphyxia | FAERS: 2 | US FAERS | |
| 179 | Asthma | FAERS: 2 | US FAERS | |
| 180 | Blindness | FAERS: 2 | US FAERS | |
| 181 | Blood iron decreased | FAERS: 2 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 182 | Blood sodium decreased | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 183 | Bradyphrenia | FAERS: 2 | US FAERS | |
| 184 | Cardiomegaly | FAERS: 2 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 185 | Cerebral Infarction | FAERS: 2 | US FAERS | |
| 186 | Choking sensation | FAERS: 2 | US FAERS | |
| 187 | Clostridium difficile colitis | FAERS: 2 | US FAERS | |
| 188 | Colitis | FAERS: 2 | US FAERS | |
| 189 | Cor pulmonale | FAERS: 2 | US FAERS | |
| 190 | Deep Vein Thrombosis | FAERS: 2 | US FAERS | |
| 191 | Dialysis device insertion | FAERS: 2 | US FAERS | |
| 192 | Drug dispensing error | FAERS: 2 | US FAERS | |
| 193 | Ear discomfort | FAERS: 2 Canada Vigilance: 4 | Canada Vigilance US FAERS | |
| 194 | Epilepsy | FAERS: 2 | US FAERS | |
| 195 | Extra dose administered | FAERS: 2 | US FAERS | |
| 196 | Feeling jittery | FAERS: 2 | US FAERS | |
| 197 | Flank Pain | FAERS: 2 | US FAERS | |
| 198 | Food Poisoning | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 199 | Gait inability | FAERS: 2 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 200 | Gastric ulcer | FAERS: 2 | US FAERS | |
| 201 | Gastrointestinal Pain | FAERS: 2 | SIDER US FAERS | |
| 202 | Hepatic necrosis | FAERS: 2 | US FAERS | |
| 203 | Hypophagia | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 204 | Ileus | FAERS: 2 | US FAERS | |
| 205 | Incorrect product storage | FAERS: 2 | US FAERS | |
| 206 | Incorrect route of drug administration | FAERS: 2 | US FAERS | |
| 207 | Increased tendency to bruise | FAERS: 2 | US FAERS | |
| 208 | Increased viscosity of bronchial secretion | FAERS: 2 | US FAERS | |
| 209 | Infarction | FAERS: 2 | US FAERS | |
| 210 | Limb mass | FAERS: 2 | US FAERS | |
| 211 | Lip swelling | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 212 | Lymphoma | FAERS: 2 | US FAERS | |
| 213 | Malnutrition | FAERS: 2 | US FAERS | |
| 214 | Medication Error | FAERS: 2 | US FAERS | |
| 215 | Menorrhagia | FAERS: 2 | US FAERS | |
| 216 | Musculoskeletal stiffness | FAERS: 2 | US FAERS | |
| 217 | Nephrolithiasis | FAERS: 2 | US FAERS | |
| 218 | Neuralgia | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 219 | Ocular icterus | FAERS: 2 | US FAERS | |
| 220 | Oropharyngeal discomfort | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 221 | Pain of skin | FAERS: 2 | US FAERS | |
| 222 | Pallor | FAERS: 2 | US FAERS | |
| 223 | Peritoneal Dialysis | FAERS: 2 | US FAERS | |
| 224 | Photophobia | FAERS: 2 | US FAERS | |
| 225 | Physical product label issue | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 226 | Pleuritic pain | FAERS: 2 | US FAERS | |
| 227 | Pneumothorax | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 228 | Polyuria | FAERS: 2 | US FAERS | |
| 229 | Product packaging issue | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 230 | Pulmonary congestion | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 231 | Pulmonary function test decreased | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 232 | Rhonchi | FAERS: 2 | US FAERS | |
| 233 | Scleroderma | FAERS: 2 | US FAERS | |
| 234 | Seizure like phenomena | FAERS: 2 | US FAERS | |
| 235 | Skin lesion | FAERS: 2 | US FAERS | |
| 236 | Skin tightness | FAERS: 2 | US FAERS | |
| 237 | Sputum retention | FAERS: 2 | US FAERS | |
| 238 | Tension | FAERS: 2 | US FAERS | |
| 239 | Terminal state | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 240 | Thrombectomy | FAERS: 2 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 241 | Thrombocytosis | FAERS: 2 | US FAERS | |
| 242 | Ulcer | FAERS: 2 | US FAERS | |
| 243 | Upper-airway cough syndrome | FAERS: 2 | US FAERS | |
| 244 | Urinary Incontinence | FAERS: 2 | US FAERS | |
| 245 | Viral upper respiratory tract infection | FAERS: 2 | US FAERS | |
| 246 | Walking distance test abnormal | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 247 | White blood cell count decreased | FAERS: 2 | US FAERS | |
| 248 | Abdominal tenderness | FAERS: 1 | US FAERS | |
| 249 | Activities of daily living impaired | FAERS: 1 | US FAERS | |
| 250 | Acute myocardial infarction | FAERS: 1 | US FAERS | |
| 251 | Airway secretion clearance therapy | FAERS: 1 | US FAERS | |
| 252 | Alcohol abuse | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 253 | Aortic stent insertion | FAERS: 1 | US FAERS | |
| 254 | Apathy | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 255 | Apparent death | FAERS: 1 | US FAERS | |
| 256 | Application site reaction | FAERS: 1 | US FAERS | |
| 257 | Arteriovenous fistula site complication | FAERS: 1 | US FAERS | |
| 258 | Arthritis | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 259 | Arthropathy | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 260 | Atelectasis | FAERS: 1 | US FAERS | |
| 261 | Atrial Flutter | FAERS: 1 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 262 | Autoimmune hepatitis | FAERS: 1 | US FAERS | |
| 263 | Back disorder | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 264 | Bendopnoea | FAERS: 1 | US FAERS | |
| 265 | Bilevel positive airway pressure | FAERS: 1 | US FAERS | |
| 266 | Biopsy | FAERS: 1 | US FAERS | |
| 267 | Bladder prolapse | FAERS: 1 | US FAERS | |
| 268 | Blood glucose increased | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 269 | Blood magnesium decreased | FAERS: 1 | US FAERS | |
| 270 | Blood pressure inadequately controlled | FAERS: 1 | US FAERS | |
| 271 | Blood thyroid stimulating hormone increased | FAERS: 1 | US FAERS | |
| 272 | Body Temperature | FAERS: 1 | US FAERS | |
| 273 | Bone contusion | FAERS: 1 | US FAERS | |
| 274 | Bone pain | FAERS: 1 | US FAERS | |
| 275 | Bradycardia | FAERS: 1 | US FAERS | |
| 276 | Brain natriuretic peptide abnormal | FAERS: 1 | US FAERS | |
| 277 | Brain natriuretic peptide increased | FAERS: 1 | US FAERS | |
| 278 | Breast discomfort | FAERS: 1 | US FAERS | |
| 279 | Cardiac ablation | FAERS: 1 | US FAERS | |
| 280 | Cardiac discomfort | FAERS: 1 | US FAERS | |
| 281 | Cardiac dysfunction | FAERS: 1 | US FAERS | |
| 282 | Cardiac procedure complication | FAERS: 1 | US FAERS | |
| 283 | Cardiovascular evaluation | FAERS: 1 | US FAERS | |
| 284 | Carpal Tunnel Syndrome | FAERS: 1 | US FAERS | |
| 285 | Cataract | FAERS: 1 | US FAERS | |
| 286 | Catheter site discharge | FAERS: 1 | US FAERS | |
| 287 | Catheter site pruritus | FAERS: 1 | US FAERS | |
| 288 | Cervix carcinoma | FAERS: 1 | US FAERS | |
| 289 | Cholecystitis | FAERS: 1 | US FAERS | |
| 290 | Cholelithiasis | FAERS: 1 | US FAERS | |
| 291 | Cholestasis | FAERS: 1 | US FAERS | |
| 292 | Colectomy | FAERS: 1 | US FAERS | |
| 293 | Complication associated with device | FAERS: 1 | US FAERS | |
| 294 | Complications of transplant surgery | FAERS: 1 | US FAERS | |
| 295 | Concomitant disease progression | FAERS: 1 | US FAERS | |
| 296 | Contraindicated drug prescribed | FAERS: 1 | US FAERS | |
| 297 | Contraindicated product administered | FAERS: 1 | US FAERS | |
| 298 | Creatinine renal clearance decreased | FAERS: 1 | US FAERS | |
| 299 | Cyanosis | FAERS: 1 | US FAERS | |
| 300 | Dementia | FAERS: 1 | US FAERS | |
| 301 | Device battery issue | FAERS: 1 | US FAERS | |
| 302 | Device dislocation | FAERS: 1 | US FAERS | |
| 303 | Device leakage | FAERS: 1 | US FAERS | |
| 304 | Diabetic Foot | FAERS: 1 | US FAERS | |
| 305 | Diffuse alveolar damage | FAERS: 1 | US FAERS | |
| 306 | Disability | FAERS: 1 | US FAERS | |
| 307 | Diverticulitis | FAERS: 1 | US FAERS | |
| 308 | Drug Dependence | FAERS: 1 | US FAERS | |
| 309 | Drug dose titration not performed | FAERS: 1 | US FAERS | |
| 310 | Drug effect delayed | FAERS: 1 | US FAERS | |
| 311 | Drug effect incomplete | FAERS: 1 | US FAERS | |
| 312 | Dry skin | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 313 | Dysarthria | FAERS: 1 | US FAERS | |
| 314 | Dysbacteriosis | FAERS: 1 | US FAERS | |
| 315 | Ear congestion | FAERS: 1 | US FAERS | |
| 316 | Early satiety | FAERS: 1 | US FAERS | |
| 317 | Economic problem | FAERS: 1 | US FAERS | |
| 318 | Enteritis | FAERS: 1 | US FAERS | |
| 319 | Eosinophilia | FAERS: 1 | US FAERS | |
| 320 | Epigastric discomfort | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 321 | Erection increased | FAERS: 1 | US FAERS | |
| 322 | Essential Tremor | FAERS: 1 | US FAERS | |
| 323 | Exfoliative rash | FAERS: 1 | US FAERS | |
| 324 | Eye inflammation | FAERS: 1 | US FAERS | |
| 325 | Eye pain | FAERS: 1 | US FAERS | |
| 326 | Facial Pain | FAERS: 1 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 327 | Feelings of worthlessness | FAERS: 1 | US FAERS | |
| 328 | Food Allergy | FAERS: 1 | US FAERS | |
| 329 | Frustration tolerance decreased | FAERS: 1 | US FAERS | |
| 330 | Gastric Antral Vascular Ectasia | FAERS: 1 | US FAERS | |
| 331 | Gastric Stenosis | FAERS: 1 | US FAERS | |
| 332 | Gastric mucosal lesion | FAERS: 1 | US FAERS | |
| 333 | Gastric ulcer helicobacter | FAERS: 1 | US FAERS | |
| 334 | Gastrointestinal inflammation | FAERS: 1 | US FAERS | |
| 335 | Gastrointestinal obstruction | FAERS: 1 | US FAERS | |
| 336 | Gastrointestinal sounds abnormal | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 337 | Gastrointestinal ulcer | FAERS: 1 | US FAERS | |
| 338 | Genital rash | FAERS: 1 | US FAERS | |
| 339 | Grip strength decreased | FAERS: 1 | US FAERS | |
| 340 | Hyperpyrexia | FAERS: 1 | US FAERS | |
| 341 | Hypersomnia | FAERS: 1 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 342 | Hypertensive crisis | FAERS: 1 | US FAERS | |
| 343 | Hyperthyroidism | FAERS: 1 | US FAERS | |
| 344 | Hypertrophy | FAERS: 1 | US FAERS | |
| 345 | Hysterectomy | FAERS: 1 | US FAERS | |
| 346 | Impaired gastric emptying | FAERS: 1 | US FAERS | |
| 347 | Impaired quality of life | FAERS: 1 | US FAERS | |
| 348 | Inability to afford medication | FAERS: 1 | US FAERS | |
| 349 | Incoherent | FAERS: 1 | US FAERS | |
| 350 | Increased bronchial secretion | FAERS: 1 | US FAERS | |
| 351 | Intentional dose omission | FAERS: 1 | US FAERS | |
| 352 | Intervertebral disc compression | FAERS: 1 | US FAERS | |
| 353 | Intestinal Pseudo-Obstruction | FAERS: 1 | US FAERS | |
| 354 | Irritable Bowel Syndrome | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 355 | Lactose Intolerance | FAERS: 1 | US FAERS | |
| 356 | Laryngitis | FAERS: 1 | US FAERS | |
| 357 | Liver Abscess | FAERS: 1 | US FAERS | |
| 358 | Low Cardiac Output Syndrome | FAERS: 1 | US FAERS | |
| 359 | Lower respiratory tract infection | FAERS: 1 Canada Vigilance: 4 | Canada Vigilance US FAERS | |
| 360 | Lymphadenopathy | FAERS: 1 | US FAERS | |
| 361 | Lymphocyte count decreased | FAERS: 1 | US FAERS | |
| 362 | Lymphopenia | FAERS: 1 | US FAERS | |
| 363 | Manufacturing product shipping issue | FAERS: 1 | US FAERS | |
| 364 | Maternal exposure during pregnancy | FAERS: 1 | US FAERS | |
| 365 | Medical device discomfort | FAERS: 1 | US FAERS | |
| 366 | Medical device removal | FAERS: 1 | US FAERS | |
| 367 | Medical induction of coma | FAERS: 1 | US FAERS | |
| 368 | Mental impairment | FAERS: 1 | US FAERS | |
| 369 | Mental status changes | FAERS: 1 | US FAERS | |
| 370 | Metabolic acidosis | FAERS: 1 | US FAERS | |
| 371 | Micturition frequency decreased | FAERS: 1 | US FAERS | |
| 372 | Migraine with Aura | FAERS: 1 | US FAERS | |
| 373 | Mineral supplementation | FAERS: 1 | US FAERS | |
| 374 | Multiple allergies | FAERS: 1 | US FAERS | |
| 375 | Muscle strain | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 376 | Muscle tightness | FAERS: 1 | US FAERS | |
| 377 | Mydriasis | FAERS: 1 | US FAERS | |
| 378 | Myelofibrosis | FAERS: 1 | US FAERS | |
| 379 | Nasal discomfort | FAERS: 1 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 380 | Neutrophil count decreased | FAERS: 1 | US FAERS | |
| 381 | Nodule | FAERS: 1 | US FAERS | |
| 382 | Occult blood positive | FAERS: 1 | US FAERS | |
| 383 | Oral fungal infection | FAERS: 1 | US FAERS | |
| 384 | Orthostatic intolerance | FAERS: 1 | US FAERS | |
| 385 | Oxygen saturation abnormal | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 386 | PCO2 increased | FAERS: 1 | US FAERS | |
| 387 | Pancreatitis | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 388 | Paracentesis | FAERS: 1 | US FAERS | |
| 389 | Paranasal sinus hypersecretion | FAERS: 1 | US FAERS | |
| 390 | Pericarditis | FAERS: 1 | US FAERS | |
| 391 | Peritonitis | FAERS: 1 | US FAERS | |
| 392 | Petechiae | FAERS: 1 | US FAERS | |
| 393 | Platelet count abnormal | FAERS: 1 | US FAERS | |
| 394 | Pleurisy | FAERS: 1 | US FAERS | |
| 395 | Polyneuropathy | FAERS: 1 | US FAERS | |
| 396 | Poor quality sleep | FAERS: 1 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 397 | Post-traumatic pain | FAERS: 1 | US FAERS | |
| 398 | Post-tussive vomiting | FAERS: 1 | US FAERS | |
| 399 | Product dosage form issue | FAERS: 1 | US FAERS | |
| 400 | Product use in unapproved indication | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 401 | Pulmonary Eosinophilia | FAERS: 1 | US FAERS | |
| 402 | Pulmonary Fibrosis | FAERS: 1 | US FAERS | |
| 403 | Pulmonary arterial pressure abnormal | FAERS: 1 | US FAERS | |
| 404 | Pulmonary arterial pressure increased | FAERS: 1 | US FAERS | |
| 405 | Rectal Obstruction | FAERS: 1 | US FAERS | |
| 406 | Respiratory tract congestion | FAERS: 1 | US FAERS | |
| 407 | Restless Legs Syndrome | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 408 | Restlessness | FAERS: 1 | US FAERS | |
| 409 | Retching | FAERS: 1 | US FAERS | |
| 410 | Rhinitis | FAERS: 1 | US FAERS | |
| 411 | Scleroderma renal crisis | FAERS: 1 | US FAERS | |
| 412 | Septic Shock | FAERS: 1 | US FAERS | |
| 413 | Shock | FAERS: 1 | US FAERS | |
| 414 | Skin Ulcer | FAERS: 1 | US FAERS | |
| 415 | Skin laceration | FAERS: 1 | US FAERS | |
| 416 | Slow response to stimuli | FAERS: 1 | US FAERS | |
| 417 | Sneezing | FAERS: 1 | US FAERS | |
| 418 | Spinal column injury | FAERS: 1 | US FAERS | |
| 419 | Stress | FAERS: 1 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 420 | Suicide attempt | FAERS: 1 | US FAERS | |
| 421 | Swelling of eyelid | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 422 | Therapeutic response unexpected | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 423 | Thermal burn | FAERS: 1 | US FAERS | |
| 424 | Thrombocytopenia | FAERS: 1 | US FAERS | |
| 425 | Tinnitus | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 426 | Toe operation | FAERS: 1 | US FAERS | |
| 427 | Tooth Extraction | FAERS: 1 | US FAERS | |
| 428 | Toxicity to various agents | FAERS: 1 | US FAERS | |
| 429 | Tracheostomy malfunction | FAERS: 1 | US FAERS | |
| 430 | Transaminases increased | FAERS: 1 | US FAERS | |
| 431 | Transfusion Reaction | FAERS: 1 | US FAERS | |
| 432 | Tuberculosis | FAERS: 1 | US FAERS | |
| 433 | Urinary Retention | FAERS: 1 | US FAERS | |
| 434 | Urinary hesitation | FAERS: 1 | US FAERS | |
| 435 | Venoocclusive disease | FAERS: 1 | US FAERS | |
| 436 | Ventilation perfusion mismatch | FAERS: 1 | US FAERS | |
| 437 | Vessel perforation | FAERS: 1 | US FAERS | |
| 438 | Vitreous Detachment | FAERS: 1 | US FAERS | |
| 439 | Vitreous floaters | FAERS: 1 | US FAERS | |
| 440 | Wound Complication | FAERS: 1 | US FAERS | |
| 441 | Wound Infection | FAERS: 1 | US FAERS | |
| 442 | Wrong drug administered | FAERS: 1 | US FAERS | |
| 443 | Wrong technique in drug usage process | FAERS: 1 | US FAERS | |
| 444 | nervous system disorder | FAERS: 1 | SIDER US FAERS | |
| 445 | Ageusia | Canada Vigilance: 1 | Canada Vigilance | |
| 446 | Anticoagulation drug level below therapeutic | Canada Vigilance: 1 | Canada Vigilance | |
| 447 | Appendicitis | Canada Vigilance: 1 | Canada Vigilance | |
| 448 | Bedridden | Canada Vigilance: 1 | Canada Vigilance | |
| 449 | Bladder neoplasm surgery | Canada Vigilance: 1 | Canada Vigilance | |
| 450 | Blood creatinine increased | Canada Vigilance: 1 | Canada Vigilance | |
| 451 | Breast cancer recurrent | Canada Vigilance: 1 | Canada Vigilance | |
| 452 | Cataract operation | Canada Vigilance: 4 | Canada Vigilance | |
| 453 | Chemotherapy | Canada Vigilance: 1 | Canada Vigilance | |
| 454 | Chronic sinusitis | Canada Vigilance: 1 | Canada Vigilance | |
| 455 | Depressed Level of Consciousness | Canada Vigilance: 1 | Canada Vigilance | |
| 456 | Diverticulum | Canada Vigilance: 1 | Canada Vigilance | |
| 457 | Dyschezia | Canada Vigilance: 1 | Canada Vigilance | |
| 458 | Ecchymosis | Canada Vigilance: 1 | Canada Vigilance | |
| 459 | Embolism | Canada Vigilance: 1 | Canada Vigilance | |
| 460 | Feeling of body temperature change | Canada Vigilance: 1 | Canada Vigilance | |
| 461 | Gait deviation | Canada Vigilance: 1 | Canada Vigilance | |
| 462 | Gastrointestinal viral infection | Canada Vigilance: 1 | Canada Vigilance | |
| 463 | Hepatitis | Canada Vigilance: 1 | Canada Vigilance | |
| 464 | Increased upper airway secretion | Canada Vigilance: 1 | Canada Vigilance | |
| 465 | Infestation | SIDER | ||
| 466 | Infrequent bowel movements | Canada Vigilance: 1 | Canada Vigilance | |
| 467 | Initial insomnia | Canada Vigilance: 1 | Canada Vigilance | |
| 468 | Iron deficiency | Canada Vigilance: 1 | Canada Vigilance | |
| 469 | Labile blood pressure | Canada Vigilance: 1 | Canada Vigilance | |
| 470 | Living in residential institution | Canada Vigilance: 1 | Canada Vigilance | |
| 471 | Lung cyst | Canada Vigilance: 1 | Canada Vigilance | |
| 472 | Macular degeneration | Canada Vigilance: 1 | Canada Vigilance | |
| 473 | Middle insomnia | Canada Vigilance: 1 | Canada Vigilance | |
| 474 | Musculoskeletal discomfort | Canada Vigilance: 2 | Canada Vigilance | |
| 475 | Nasal Polyps | Canada Vigilance: 1 | Canada Vigilance | |
| 476 | Nasal inflammation | Canada Vigilance: 1 | Canada Vigilance | |
| 477 | Nephritis | Canada Vigilance: 1 | Canada Vigilance | |
| 478 | Onychalgia | Canada Vigilance: 1 | Canada Vigilance | |
| 479 | Oxygen consumption decreased | Canada Vigilance: 1 | Canada Vigilance | |
| 480 | Pharyngitis | Canada Vigilance: 2 | Canada Vigilance | |
| 481 | Product administration error | Canada Vigilance: 1 | Canada Vigilance | |
| 482 | Pulmonary arterial pressure decreased | Canada Vigilance: 1 | Canada Vigilance | |
| 483 | Pulmonary artery therapeutic procedure | Canada Vigilance: 2 | Canada Vigilance | |
| 484 | Radiculopathy | Canada Vigilance: 1 | Canada Vigilance | |
| 485 | Regurgitation | Canada Vigilance: 1 | Canada Vigilance | |
| 486 | Renal pain | Canada Vigilance: 1 | Canada Vigilance | |
| 487 | Rotator cuff syndrome | Canada Vigilance: 1 | Canada Vigilance | |
| 488 | Splenomegaly | Canada Vigilance: 1 | Canada Vigilance | |
| 489 | Stomatitis | Canada Vigilance: 1 | Canada Vigilance | |
| 490 | Throat cancer | Canada Vigilance: 1 | Canada Vigilance | |
| 491 | Tonsillitis | Canada Vigilance: 1 | Canada Vigilance | |
| 492 | Transfusion-related circulatory overload | Canada Vigilance: 1 | Canada Vigilance | |
| 493 | Vascular device infection | Canada Vigilance: 1 | Canada Vigilance | |
| 494 | Walking aid user | Canada Vigilance: 1 | Canada Vigilance | |
| 495 | Wheelchair user | Canada Vigilance: 1 | Canada Vigilance | |
| 496 | White Coat Hypertension | Canada Vigilance: 1 | Canada Vigilance |
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