MetaADEDB 2.0 @ LMMD
Quinapril
(JSDRRTOADPPCHY-HSQYWUDLSA-N)
Structure
SMILES
CCOC(=O)[C@@H](N[C@H](C(=O)N1Cc2ccccc2C[C@H]1C(=O)O)C)CCc1ccccc1
Type(s)
Approved; Investigational
ATC code(s)
C09AA06; C09BA06
Molecular Formula:
C25H30N2O5
Molecular Weight:
438.516
Log P:
2.8959
Hydrogen Bond Acceptor:
7
Hydrogen Bond Donor:
2
TPSA:
95.94
CAS Number(s):
85441-61-8
Synonym(s)
1.
Quinapril
2.
2-(2-((1-(Ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid
3.
Accupril
4.
CI 906
5.
CI-906
6.
PD 109452-2
7.
PD-109,452-2
8.
Quinapril Hydrochloride
9.
PD 109,452 2
10.
PD 109452 2
11.
PD 1094522
External Link(s)
MeSHD000077583
PubChem Compound40466957
54892
BindingDB50368166
ChEBI8713
CHEMBLCHEMBL1592
DrugBankDB00881
DrugCentral2340
IUPHAR/BPS Guide to PHARMACOLOGY6350
KEGGcpd:C07398
dr:D03752
Therapeutic Target DatabaseD0I7SZ
ZINC3801163
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Drug ineffectiveFAERS: 43
Canada Vigilance: 3		Canada Vigilance
US FAERS
2Product substitution issueFAERS: 22
Canada Vigilance: 8		Canada Vigilance
US FAERS
3AngioedemaFAERS: 14
Canada Vigilance: 1		1581715
20689124		CTD
SIDER
Canada Vigilance
US FAERS
4DizzinessFAERS: 11
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
SIDER
US FAERS
5MalaiseFAERS: 11SIDER
US FAERS
6Pharmaceutical product complaintFAERS: 11US FAERS
7HeadacheFAERS: 10
Canada Vigilance: 2		Canada Vigilance
SIDER
US FAERS
8NauseaFAERS: 7OFFSIDES
SIDER
US FAERS
9AstheniaFAERS: 5OFFSIDES
SIDER
US FAERS
10Blood pressure inadequately controlledFAERS: 5
Canada Vigilance: 1		Canada Vigilance
US FAERS
11Therapeutic response unexpected with drug substitutionFAERS: 5US FAERS
12UrticariaFAERS: 5
Canada Vigilance: 1		Canada Vigilance
US FAERS
13Abdominal discomfortFAERS: 4OFFSIDES
US FAERS
14Chest PainFAERS: 4OFFSIDES
SIDER
US FAERS
15DysgeusiaFAERS: 4US FAERS
16Feeling abnormalFAERS: 4SIDER
US FAERS
17Upper airway obstructionFAERS: 4US FAERS
18AlopeciaFAERS: 3SIDER
US FAERS
19FatigueFAERS: 3OFFSIDES
SIDER
US FAERS
20HypotensionFAERS: 3
Canada Vigilance: 1		Canada Vigilance
US FAERS
21Intentional product use issueFAERS: 3US FAERS
22Product quality issueFAERS: 3US FAERS
23SwellingFAERS: 3US FAERS
24Adverse eventFAERS: 2US FAERS
25Anaphylactic shockFAERS: 2SIDER
US FAERS
26Drug effect incompleteFAERS: 2US FAERS
27Drug prescribing errorFAERS: 2US FAERS
28ErythemaFAERS: 2US FAERS
29LethargyFAERS: 2US FAERS
30PalpitationsFAERS: 2SIDER
US FAERS
31Peripheral swellingFAERS: 2US FAERS
32Product solubility abnormalFAERS: 2US FAERS
33VomitingFAERS: 2SIDER
US FAERS
34Abdominal PainFAERS: 1OFFSIDES
SIDER
US FAERS
35AcidosisFAERS: 1US FAERS
36Acute psychosisFAERS: 1US FAERS
37AgeusiaFAERS: 1OFFSIDES
US FAERS
38Altered state of consciousnessFAERS: 1US FAERS
39AmnesiaFAERS: 1US FAERS
40AphasiaFAERS: 1US FAERS
41ArthropathyFAERS: 1OFFSIDES
US FAERS
42Blood blisterFAERS: 1US FAERS
43Blood glucose increasedFAERS: 1US FAERS
44BradycardiaFAERS: 1US FAERS
45BronchitisFAERS: 1OFFSIDES
US FAERS
46Burning sensationFAERS: 1US FAERS
47Cardiac ArrestFAERS: 1US FAERS
48Cardiac FlutterFAERS: 1US FAERS
49Cerebrovascular accidentFAERS: 1SIDER
US FAERS
50ChillsFAERS: 1US FAERS
51Clostridium difficile infectionFAERS: 1US FAERS
52DisorientationFAERS: 1US FAERS
53Drug dispensing errorFAERS: 1US FAERS
54Drug dose omissionFAERS: 1US FAERS
55Facial PainFAERS: 1US FAERS
56FlushingFAERS: 1US FAERS
57Food PoisoningFAERS: 1US FAERS
58Gluten sensitivityFAERS: 1US FAERS
59HypersensitivityFAERS: 1US FAERS
60HypersomniaFAERS: 1US FAERS
61HyperthyroidismFAERS: 1US FAERS
62Inappropriate schedule of drug administrationFAERS: 1US FAERS
63InfectionFAERS: 1SIDER
US FAERS
64Intercepted drug dispensing errorFAERS: 1US FAERS
65Joint swellingFAERS: 1US FAERS
66Lip swellingFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
67Lupus-like syndromeFAERS: 1US FAERS
68Medication residueFAERS: 1US FAERS
69Medication residue presentFAERS: 1US FAERS
70Myocardial InfarctionFAERS: 1SIDER
US FAERS
71NervousnessFAERS: 1SIDER
US FAERS
72NoduleFAERS: 1US FAERS
73PancreatitisFAERS: 1OFFSIDES
SIDER
US FAERS
74Product coating issueFAERS: 1US FAERS
75Product package associated injuryFAERS: 1US FAERS
76Product packaging issueFAERS: 1US FAERS
77Product residue presentFAERS: 1US FAERS
78Product use in unapproved indicationFAERS: 1US FAERS
79Productive CoughFAERS: 1US FAERS
80PruritusFAERS: 1
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
81Reaction to drug excipientsFAERS: 1US FAERS
82Respiratory distressFAERS: 1US FAERS
83Skin lesionFAERS: 1OFFSIDES
US FAERS
84SomnolenceFAERS: 1SIDER
US FAERS
85StomatitisFAERS: 1US FAERS
86SyncopeFAERS: 1SIDER
US FAERS
87Throat cancerFAERS: 1US FAERS
88TinnitusFAERS: 1US FAERS
89Tongue discomfortFAERS: 1US FAERS
90Toxicity to various agentsFAERS: 1US FAERS
91TremorFAERS: 1US FAERS
92Urine flow decreasedFAERS: 1OFFSIDES
US FAERS
93Visual ImpairmentFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
94Weight decreasedFAERS: 1US FAERS
95Abdominal InfectionOFFSIDES
96Acid refluxOFFSIDES
97Actinic keratosisOFFSIDES
98Acute Coronary SyndromeOFFSIDES
SIDER
99Acute bronchitisOFFSIDES
100Acute myocardial infarctionOFFSIDES
101Acute sinusitisOFFSIDES
102Administration site reactionOFFSIDES
103AgranulocytosisSIDER
104Allergy to arthropod stingOFFSIDES
105AmblyopiaSIDER
106Anaphylactoid ReactionSIDER
107Angina PectorisSIDER
108AnisocoriaOFFSIDES
109ArthralgiaSIDER
110ArthritisOFFSIDES
111AtaxiaOFFSIDES
112Atrial tachycardiaOFFSIDES
113Back PainSIDER
114Back disorderOFFSIDES
115Band neutrophil percentage increasedOFFSIDES
116Basal cell carcinomaOFFSIDES
117Benign NeoplasmOFFSIDES
118BereavementOFFSIDES
119Bipolar I disorderOFFSIDES
120Bladder discomfortOFFSIDES
121Blood GlucoseOFFSIDES
122Blood and lymphatic system disordersSIDER
123Blood calcium abnormalOFFSIDES
124Blood chloride decreasedOFFSIDES
125Blood cholesterolOFFSIDES
126Blood creatinine increasedOFFSIDES
127Blood glucose decreasedOFFSIDES
128Blood phosphorus increasedOFFSIDES
129Blood potassium decreasedOFFSIDES
130Blood sodiumOFFSIDES
131Blood thyroid stimulating hormone increasedOFFSIDES
132Blood triglycerides increasedOFFSIDES
133Blood urea increasedSIDER
134Bone painOFFSIDES
135BruxismOFFSIDES
136Cardiac stress test abnormalOFFSIDES
137Cardioactive drug levelOFFSIDES
138Cardiomegaly9869009CTD
139Catheter sepsisOFFSIDES
140Central line infectionOFFSIDES
141Cerebrovascular Disorders8305170CTD
142Choking sensationOFFSIDES
143ChromaturiaOFFSIDES
144Chronic Obstructive Airway DiseaseOFFSIDES
145Chronic left ventricular failureOFFSIDES
146Colonic StenosisOFFSIDES
147Concomitant disease progressionOFFSIDES
148Congenital heart diseaseOFFSIDES
149Congenital heart valve disorderOFFSIDES
150Congenital tracheomalaciaOFFSIDES
151ConstipationSIDER
152Coronary Artery Disease16907931CTD
153DehydrationOFFSIDES
154Dental cariesOFFSIDES
155DermatitisSIDER
156DermatomyositisSIDER
157Device FailureOFFSIDES
158DiabetesOFFSIDES
159Diabetes mellitus inadequate controlOFFSIDES
160Diabetic FootOFFSIDES
161Diabetic NephropathyOFFSIDES
162Diabetic gastropathyOFFSIDES
163Dialysis disequilibrium syndromeOFFSIDES
164DiarrheaOFFSIDES
165DiscomfortSIDER
166DiverticulitisOFFSIDES
167DiverticulumOFFSIDES
168DrowsinessOFFSIDES
169Drug toxicityOFFSIDES
170Drug withdrawal convulsionsOFFSIDES
171Drug withdrawal headacheOFFSIDES
172Duodenal ulcer perforationOFFSIDES
173DuodenitisOFFSIDES
174DyspepsiaOFFSIDES
SIDER
175DysuriaOFFSIDES
176Electrocardiogram ST segment abnormalOFFSIDES
177Emotional distressOFFSIDES
178Epidural AbscessOFFSIDES
179Erectile dysfunctionSIDER
180Esophageal StenosisOFFSIDES
181ExcoriationOFFSIDES
182Flank PainOFFSIDES
183FlatulenceSIDER
184Fluid overloadOFFSIDES
185FormicationOFFSIDES
186GamblingOFFSIDES
187Gastrointestinal PainSIDER
188Gastrointestinal ulcerOFFSIDES
189GlaucomaOFFSIDES
190GoutOFFSIDES
191GranulocytosisOFFSIDES
192Heart failure

View details

1691407
1696671
7965279
8227822
9068523
15161998
 		CTD
193HepatitisSIDER
194HyperkeratosisOFFSIDES
195Hyperplasia8305170CTD
196Hypertensive crisisSIDER
197Hypertensive heart diseaseOFFSIDES
198Hypokalemia8006914CTD
199HyporeflexiaOFFSIDES
200Hypotension, Orthostatic7564350CTD
201HypoxiaOFFSIDES
202Immune reconstitution syndromeOFFSIDES
203Impaired gastric emptyingOFFSIDES
204InfestationSIDER
205Infusion site painOFFSIDES
206Injection site irritationOFFSIDES
207Insulin-requiring type 2 diabetes mellitusOFFSIDES
208Intervertebral Disc DegenerationOFFSIDES
209Intervertebral disc disorderOFFSIDES
210Intestinal PerforationOFFSIDES
211Intestinal infarctionOFFSIDES
212Joint injuryOFFSIDES
213Joint sprainOFFSIDES
214Kidney Diseases15831368CTD
215Kidney FailureOFFSIDES
216LazinessOFFSIDES
217Limb injuryOFFSIDES
218Lung AbscessOFFSIDES
219Lymphocyte stimulation test negativeOFFSIDES
220Musculoskeletal chest painOFFSIDES
221Musculoskeletal discomfortOFFSIDES
SIDER
222MyalgiaSIDER
223Necrosis8305170CTD
224Nephritis, Interstitial8305170CTD
225Nephrogenic Fibrosing DermopathyOFFSIDES
226NephrolithiasisOFFSIDES
227Nerve Root CompressionOFFSIDES
228Non-cardiac chest painOFFSIDES
229Nonspecific reactionOFFSIDES
230OliguriaOFFSIDES
231Optic NeuropathyOFFSIDES
232OrthopneaOFFSIDES
233OsteomyelitisOFFSIDES
234OsteoporosisOFFSIDES
235PCO2 decreasedOFFSIDES
236Pancreatic InsufficiencyOFFSIDES
237Panic DisorderOFFSIDES
238ParanoiaOFFSIDES
239Patellofemoral Pain SyndromeOFFSIDES
240PemphigusSIDER
241PeriodontitisOFFSIDES
242PeritonitisOFFSIDES
243Pharyngeal swellingCanada Vigilance: 1Canada Vigilance
244PharyngitisSIDER
245Physical assaultOFFSIDES
246PneumobiliaOFFSIDES
247Polysubstance abuseOFFSIDES
248Polysubstance dependenceOFFSIDES
249Postoperative infectionOFFSIDES
250PregnancySIDER
251Protein total decreasedOFFSIDES
252Proteinuria8305170
15831368		CTD
253Pseudomonal sepsisOFFSIDES
254PsittacosisOFFSIDES
255Pulmonary EosinophiliaSIDER
256Pulmonary HypertensionOFFSIDES
257Pulmonary malformationOFFSIDES
258Reaction to excipientCanada Vigilance: 1Canada Vigilance
259Regurgitation of foodOFFSIDES
260Renal Insufficiency15728788CTD
261Renal cystOFFSIDES
262Respiratory tract congestionOFFSIDES
263SeromaOFFSIDES
264ShockSIDER
265Shoulder PainOFFSIDES
266Skin lacerationOFFSIDES
267Skin tightnessOFFSIDES
268Squamous cell carcinoma of skinOFFSIDES
269Stent occlusionOFFSIDES
270TachycardiaSIDER
271TendinitisOFFSIDES
272TensionSIDER
273ThrombocytopeniaSIDER
274Thrombosis14592556
15626595
16689755		CTD
275Tooth InfectionOFFSIDES
276Urinary tract infectionSIDER
277Vascular Diseases1724542CTD
278Vasodilation procedureSIDER
279VasodilationSIDER
280Ventricular Dysfunction, Left9068523CTD
281Ventricular FibrillationOFFSIDES
282VertigoSIDER
283Visual brightnessOFFSIDES
284Visual disturbanceOFFSIDES
285Weight GainOFFSIDES
286effusionOFFSIDES
287nervous system disorderSIDER
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