MetaADEDB 2.0 @ LMMD
Epoprostenol
(KAQKFAOMNZTLHT-OZUDYXHBSA-N)
Structure
SMILES
CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/O2)O
Type(s)
Approved
ATC code(s)
B01AC09
Molecular Formula:
C20H32O5
Molecular Weight:
352.465
Log P:
3.4085
Hydrogen Bond Acceptor:
5
Hydrogen Bond Donor:
3
TPSA:
86.99
CAS Number(s):
35121-78-9; 63859-31-4
Synonym(s)
1.
Epoprostenol
2.
Prostacyclin
3.
Prostaglandin I2
4.
Epoprostanol
5.
Epoprostenol Sodium
6.
Epoprostenol Sodium Salt, (5Z,9alpha,11alpha,13E,15S)-Isomer
7.
Flolan
8.
Prostaglandin I(2)
9.
Veletri
External Link(s)
MeSHD011464
PubChem Compound5282411
5280427
ChEBI15552
CHEMBLCHEMBL1139
DrugBankDB01240
DrugCentral1034
IUPHAR/BPS Guide to PHARMACOLOGY1915
KEGGcpd:C01312
dr:D00106
Therapeutic Target DatabaseD0V0IX
ZINC3813078
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Right ventricular failureFAERS: 6SIDER
US FAERS
2HeadacheFAERS: 5

View details

CTD
SIDER
US FAERS
3HyperthyroidismFAERS: 4SIDER
US FAERS
4AscitesFAERS: 33552006CTD
OFFSIDES
SIDER
US FAERS
5HypopituitarismFAERS: 3OFFSIDES
US FAERS
6Silent thyroiditisFAERS: 3US FAERS
7Autoimmune thyroiditisFAERS: 2OFFSIDES
US FAERS
8HypophysitisFAERS: 2US FAERS
9HypotensionFAERS: 2

View details

CTD
SIDER
US FAERS
10MalaiseFAERS: 2US FAERS
11Mental status changesFAERS: 2US FAERS
12NauseaFAERS: 2

View details

CTD
OFFSIDES
SIDER
US FAERS
13ThrombocytopeniaFAERS: 2SIDER
US FAERS
14Activities of daily living impairedFAERS: 1US FAERS
15Acute right ventricular failureFAERS: 1US FAERS
16AstheniaFAERS: 1SIDER
US FAERS
17Atrial FibrillationFAERS: 1US FAERS
18Blood creatinine increasedFAERS: 1US FAERS
19Blood thyroid stimulating hormone decreasedFAERS: 1US FAERS
20Catheter site inflammationFAERS: 1US FAERS
21Catheter site vesiclesFAERS: 1US FAERS
22Complication associated with deviceFAERS: 1US FAERS
23ConstipationFAERS: 1SIDER
US FAERS
24Device dislocationFAERS: 1US FAERS
25Drug ineffectiveFAERS: 1US FAERS
26Drug withdrawal syndromeFAERS: 1US FAERS
27ErythemaFAERS: 17049212CTD
OFFSIDES
US FAERS
28Eye painFAERS: 1US FAERS
29FatigueFAERS: 1OFFSIDES
SIDER
US FAERS
30FlushingFAERS: 1

View details

CTD
SIDER
US FAERS
31General physical health deteriorationFAERS: 1US FAERS
32HypersplenismFAERS: 1SIDER
US FAERS
33HypothyroidismFAERS: 1US FAERS
34InfluenzaFAERS: 1US FAERS
35Injection site erythemaFAERS: 1US FAERS
36LymphadenopathyFAERS: 1US FAERS
37Medical device complicationFAERS: 1OFFSIDES
US FAERS
38Musculoskeletal PainFAERS: 1SIDER
US FAERS
39Musculoskeletal stiffnessFAERS: 1US FAERS
40MyalgiaFAERS: 1SIDER
US FAERS
41Pituitary enlargementFAERS: 1US FAERS
42Pulmonary HypertensionFAERS: 1OFFSIDES
US FAERS
43Pulmonary arterial pressure increasedFAERS: 1OFFSIDES
US FAERS
44Respiratory distressFAERS: 1US FAERS
45RetchingFAERS: 1US FAERS
46Sinus TachycardiaFAERS: 1US FAERS
47SinusitisFAERS: 1SIDER
US FAERS
48Slow speechFAERS: 1US FAERS
49SomnolenceFAERS: 1SIDER
US FAERS
50SplenomegalyFAERS: 1SIDER
US FAERS
51TachycardiaFAERS: 11655886
3537354
7049212
CTD
SIDER
US FAERS
52Thyroglobulin increasedFAERS: 1US FAERS
53ThyroidectomyFAERS: 1US FAERS
54VomitingFAERS: 1SIDER
US FAERS
55Weight decreasedFAERS: 1SIDER
US FAERS
56treatment failureFAERS: 1US FAERS
57Abdominal PainSIDER
58Abdominal colicSIDER
59Abdominal discomfortOFFSIDES
SIDER
60Acute Coronary SyndromeSIDER
61Acute confusional stateSIDER
62Adverse eventOFFSIDES
63AgitationSIDER
64Alanine Aminotransferase IncreasedOFFSIDES
65AlopeciaOFFSIDES
66Anaphylactic shockSIDER
67Angina Pectoris2433921CTD
68Anorexia10733441CTD
OFFSIDES
SIDER
69Anti-neutrophil cytoplasmic antibody positive vasculitisOFFSIDES
70Anti-platelet antibodyOFFSIDES
71AnxietySIDER
72ApathyOFFSIDES
73Aphthous StomatitisOFFSIDES
74Application site painSIDER
75ArthralgiaSIDER
76ArthritisSIDER
77AsthmaOFFSIDES
78Back PainSIDER
79Biliary dilatationOFFSIDES
80Blood Platelet Disorders1576049CTD
81Blood albumin decreasedOFFSIDES
82Blood alkaline phosphatase increasedOFFSIDES
83Blood and lymphatic system disordersSIDER
84Blood blisterOFFSIDES
85Blood corticotrophinOFFSIDES
86Blood cortisol decreasedOFFSIDES
87Blood thyroid stimulating hormoneOFFSIDES
88Bradycardia6762901
7049212
CTD
SIDER
89Brain natriuretic peptide increasedOFFSIDES
90Cardiovascular Diseases17518513CTD
91Catalepsy6679984
6752913
7036117
CTD
92Catheter placementOFFSIDES
93Catheter related complicationOFFSIDES
94Catheter related infectionOFFSIDES
SIDER
95Catheter sepsisOFFSIDES
96Catheter site erythemaOFFSIDES
97Catheter site infectionOFFSIDES
98Catheter site painOFFSIDES
99Catheter site related reactionOFFSIDES
100CellulitisSIDER
101Central line infectionOFFSIDES
102Chest Pain2408809
7049212
CTD
SIDER
103Chest discomfortSIDER
104Chest tightnessSIDER
105ChillsSIDER
106Choking sensationOFFSIDES
107Coagulation test abnormalOFFSIDES
108ColitisOFFSIDES
109Congenital HydrocephalusOFFSIDES
110Contact DermatitisOFFSIDES
111Coronary Thrombosis6363581CTD
112Cramps of lower extremitiesSIDER
113CryingOFFSIDES
114CyanosisOFFSIDES
SIDER
115Depressive disorder2875251CTD
116DermatitisSIDER
117Device FailureOFFSIDES
118Device connection issueOFFSIDES
119Device related infectionOFFSIDES
SIDER
120DiarrheaOFFSIDES
121Disease ProgressionOFFSIDES
122DizzinessSIDER
123Drug administration errorOFFSIDES
124Drug exposure during pregnancyOFFSIDES
125Drug withdrawal headacheOFFSIDES
126Duodenal perforationOFFSIDES
127DysmorphismOFFSIDES
128Dyspepsia18936500CTD
SIDER
129EczemaSIDER
130Emotional disorderOFFSIDES
131Endometrial HyperplasiaOFFSIDES
132Endotracheal intubation complicationOFFSIDES
133Enlargement abdomenSIDER
134Enterobacter pneumoniaOFFSIDES
135Eosinophilic PneumoniaOFFSIDES
136EpistaxisOFFSIDES
SIDER
137Familial Mediterranean FeverOFFSIDES
138FlatulenceOFFSIDES
SIDER
139Food PoisoningOFFSIDES
140Foreign body aspirationOFFSIDES
141Gastric ulcerOFFSIDES
142GastritisSIDER
143Gastrointestinal PainSIDER
144GoiterOFFSIDES
145Heart-lung transplant rejectionOFFSIDES
146Hepatic congestionOFFSIDES
147HepatotoxicityOFFSIDES
148Hyperalgesia

View details

CTD
149HyperkinesiaSIDER
150HypersensitivitySIDER
151HypogeusiaOFFSIDES
152HypoxiaOFFSIDES
SIDER
153Implant site infectionOFFSIDES
154InfectionSIDER
155InfestationSIDER
156Influenza-like symptomsSIDER
157Infusion Site ExtravasationOFFSIDES
158Injection Site ReactionSIDER
159Injection site painSIDER
160Injury asphyxiationOFFSIDES
161Instillation site painSIDER
162IntussusceptionOFFSIDES
163Ischemia2433921CTD
164LassitudeSIDER
165Live BirthOFFSIDES
166Liver Failure, Acute15633222CTD
167Lung consolidationOFFSIDES
168Micrococcal sepsisOFFSIDES
169Micrococcus infectionOFFSIDES
170MorpheaOFFSIDES
171Multiple SclerosisOFFSIDES
172Muscle tightnessOFFSIDES
173Musculoskeletal discomfortSIDER
174Myocardial Infarction15905461CTD
SIDER
175Myocardial Ischemia2329180
2408809
7856280
CTD
176Neck PainSIDER
177Necrosis3281885CTD
178Neoplasms17264769CTD
179Nephrotic SyndromeOFFSIDES
180NervousnessSIDER
181Nonspecific reactionOFFSIDES
182OliguriaOFFSIDES
183Oropharyngeal blisteringOFFSIDES
184Oxygen saturation increasedOFFSIDES
185Oxygen supplementationOFFSIDES
186PROTHROMBIN TIMEOFFSIDES
187Pain10733441
18936500
CTD
SIDER
188Pallor7049212CTD
OFFSIDES
SIDER
189Palpable purpuraOFFSIDES
190PalpitationsSIDER
191PancytopeniaSIDER
192Pharmaceutical product complaintOFFSIDES
193PharyngitisSIDER
194PlasmapheresisOFFSIDES
195PneumoniaSIDER
196PneumothoraxOFFSIDES
SIDER
197Portal HypertensionOFFSIDES
198Procedural complicationSIDER
199Productive CoughOFFSIDES
200Protein total decreasedOFFSIDES
201PruritusSIDER
202PsoriasisOFFSIDES
203Psychomotor Agitation7049212CTD
204Pulmonary Embolism1723582CTD
SIDER
205Pulmonary EosinophiliaOFFSIDES
206Pulmonary arterial hypertensionOFFSIDES
207Pulmonary artery aneurysmOFFSIDES
208Pulmonary congestionOFFSIDES
209Pulmonary vein occlusionOFFSIDES
210Raynaud Disease2875251CTD
211Respiratory syncytial virus bronchiolitisOFFSIDES
212Retinal exudatesOFFSIDES
213Retinopathy of PrematurityOFFSIDES
214RhinitisSIDER
215RhinorrheaOFFSIDES
216Right Ventricular HypertrophyOFFSIDES
217Right ventricular systolic pressure increasedOFFSIDES
218Sepsis3552006CTD
SIDER
219Septic embolusOFFSIDES
220SepticemiaSIDER
221ShockSIDER
222Skin UlcerSIDER
223Skin lesionOFFSIDES
224Stereotypic Movement Disorder6752913CTD
225StressOFFSIDES
226SubileusOFFSIDES
227Sudden deathOFFSIDES
228SweatingSIDER
229SyncopeSIDER
230Tachycardia, Ventricular3899655CTD
231Temperature regulation disorderOFFSIDES
232TensionSIDER
233Therapy cessationOFFSIDES
234Therapy non-responderOFFSIDES
235ThirstSIDER
236Thromboembolism8682124CTD
237Thrombosis19691487
25339356
CTD
238ThyroiditisOFFSIDES
239TremorSIDER
240Urinary tract infectionSIDER
241UrticariaSIDER
242Vagus Nerve DisorderOFFSIDES
243Vasculitic rashOFFSIDES
244Vasodilation procedureSIDER
245VasodilationSIDER
246Vasospasm, Intracranial19350202CTD
247Ventricular Dysfunction, Left2675122CTD
248Weight GainOFFSIDES
249furuncleOFFSIDES
250nervous system disorderSIDER
Powered by :

Page last updated at 2020-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 120269

Copyright © 2019-2020 Laboratory of Molecular Modeling and Design, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology. All rights reserved.