MetaADEDB 2.0 @ LMMD
fexofenadine
(RWTNPBWLLIMQHL-UHFFFAOYSA-N)
Structure
SMILES
OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C
Type(s)
Approved; Investigational
ATC code(s)
R06AX26
Molecular Formula:
C32H39NO4
Molecular Weight:
501.656
Log P:
5.4484
Hydrogen Bond Acceptor:
5
Hydrogen Bond Donor:
3
TPSA:
81
CAS Number(s):
83799-24-0; 138452-21-8; 139965-10-9
Synonym(s)
1.
fexofenadine
2.
Allegra
3.
MDL 16,455A
4.
MDL 16.455
5.
MDL 16455
6.
MDL-16455
7.
Telfast
8.
alpha-(4-(1-carboxy-1-methylethyl)phenyl)-4-hydroxydiphenylmethyl-1-piperidinebutanol
9.
fexofenadine hydrochloride
External Link(s)
MeSHC093230
PubChem Compound3348
BindingDB22874
ChEBI5050
CHEMBLCHEMBL914
DrugBankDB00950
DrugCentral1170
IUPHAR/BPS Guide to PHARMACOLOGY4819
KEGGcpd:C06999
dr:D07958
Therapeutic Target DatabaseD01KPV
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Drug ineffectiveFAERS: 200OFFSIDES
US FAERS
2Drug administered to patient of inappropriate ageFAERS: 71US FAERS
3SomnolenceFAERS: 31SIDER
US FAERS
4DizzinessFAERS: 26OFFSIDES
SIDER
US FAERS
5Expired product administeredFAERS: 23US FAERS
6HeadacheFAERS: 20SIDER
US FAERS
7Incorrect dose administeredFAERS: 19OFFSIDES
US FAERS
8NauseaFAERS: 19OFFSIDES
SIDER
US FAERS
9Product substitution issueFAERS: 17US FAERS
10PalpitationsFAERS: 16SIDER
US FAERS
11Wrong technique in product usage processFAERS: 15US FAERS
12Pharmaceutical product complaintFAERS: 14OFFSIDES
US FAERS
13Therapeutic response unexpected with drug substitutionFAERS: 14US FAERS
14Drug ineffective for unapproved indicationFAERS: 13US FAERS
15Extra dose administeredFAERS: 13US FAERS
16HypersensitivityFAERS: 1217910814CTD
SIDER
US FAERS
17PruritusFAERS: 1110831005
17133778
19652466
CTD
SIDER
US FAERS
18FatigueFAERS: 10OFFSIDES
SIDER
US FAERS
19UrticariaFAERS: 1010831005CTD
SIDER
US FAERS
20AnxietyFAERS: 9OFFSIDES
US FAERS
21Product quality issueFAERS: 9US FAERS
22Product use issueFAERS: 9US FAERS
23NervousnessFAERS: 8SIDER
US FAERS
24PainFAERS: 8OFFSIDES
SIDER
US FAERS
25Product administered to patient of inappropriate ageFAERS: 8US FAERS
26Therapeutic response unexpectedFAERS: 8OFFSIDES
US FAERS
27VomitingFAERS: 8SIDER
US FAERS
28Abdominal discomfortFAERS: 7OFFSIDES
SIDER
US FAERS
29Drug effect incompleteFAERS: 7US FAERS
30Oropharyngeal painFAERS: 7OFFSIDES
US FAERS
31TachycardiaFAERS: 7SIDER
US FAERS
32Accidental overdoseFAERS: 6OFFSIDES
US FAERS
33EpistaxisFAERS: 6SIDER
US FAERS
34Inappropriate schedule of drug administrationFAERS: 6US FAERS
35MalaiseFAERS: 6US FAERS
36Throat irritationFAERS: 6SIDER
US FAERS
37Accidental exposure to product by childFAERS: 5US FAERS
38AstheniaFAERS: 5OFFSIDES
SIDER
US FAERS
39Back PainFAERS: 5SIDER
US FAERS
40Chest discomfortFAERS: 5SIDER
US FAERS
41DysgeusiaFAERS: 5US FAERS
42Feeling abnormalFAERS: 5OFFSIDES
US FAERS
43Feeling jitteryFAERS: 5US FAERS
44Lip swellingFAERS: 5US FAERS
45MyalgiaFAERS: 5SIDER
US FAERS
46SneezingFAERS: 5US FAERS
47Therapeutic product effect incompleteFAERS: 5US FAERS
48VertigoFAERS: 5US FAERS
49Abnormal weight gainFAERS: 4US FAERS
50AgitationFAERS: 4SIDER
US FAERS
51AngioedemaFAERS: 4SIDER
US FAERS
52AsthmaFAERS: 4OFFSIDES
US FAERS
53ChokingFAERS: 4US FAERS
54FlushingFAERS: 4SIDER
US FAERS
55ThirstFAERS: 4SIDER
US FAERS
56Accidental exposure to productFAERS: 3US FAERS
57AcneFAERS: 3OFFSIDES
US FAERS
58Atrial FibrillationFAERS: 3SIDER
US FAERS
59DiscomfortFAERS: 3US FAERS
60DyspepsiaFAERS: 3OFFSIDES
SIDER
US FAERS
61DysuriaFAERS: 3OFFSIDES
US FAERS
62OverdoseFAERS: 3US FAERS
63Product counterfeitFAERS: 3US FAERS
64Product use in unapproved indicationFAERS: 3US FAERS
65Productive CoughFAERS: 3OFFSIDES
US FAERS
66TinnitusFAERS: 3US FAERS
67TremorFAERS: 3US FAERS
68Wrong drug administeredFAERS: 3US FAERS
69AmnesiaFAERS: 2OFFSIDES
US FAERS
70AsphyxiaFAERS: 2US FAERS
71Cerebrovascular accidentFAERS: 2US FAERS
72CryingFAERS: 2OFFSIDES
US FAERS
73Drug DependenceFAERS: 2US FAERS
74Drug dose omissionFAERS: 2US FAERS
75Drug effect variableFAERS: 2US FAERS
76Ear discomfortFAERS: 2US FAERS
77ErythemaFAERS: 2US FAERS
78Failure of child resistant mechanism for pharmaceutical productFAERS: 2US FAERS
79FlatulenceFAERS: 2SIDER
US FAERS
80Incorrect drug administration durationFAERS: 2US FAERS
81InfluenzaFAERS: 2US FAERS
82Intentional self-injuryFAERS: 2US FAERS
83Oropharyngeal blisteringFAERS: 2US FAERS
84Paranasal sinus discomfortFAERS: 2US FAERS
85Peripheral swellingFAERS: 2US FAERS
86RetchingFAERS: 2US FAERS
87SinusitisFAERS: 2OFFSIDES
SIDER
US FAERS
88SwellingFAERS: 2US FAERS
89Urinary tract infectionFAERS: 2US FAERS
90WheezingFAERS: 2US FAERS
91Abdominal PainFAERS: 1OFFSIDES
SIDER
US FAERS
92AgeusiaFAERS: 1US FAERS
93AlopeciaFAERS: 1US FAERS
94AngerFAERS: 1US FAERS
95Angina PectorisFAERS: 1US FAERS
96AnosmiaFAERS: 1US FAERS
97Apparent deathFAERS: 1US FAERS
98ArthralgiaFAERS: 1US FAERS
99Blood glucose decreasedFAERS: 1US FAERS
100Blood glucose increasedFAERS: 1US FAERS
101Blood urine presentFAERS: 1US FAERS
102BronchospasmFAERS: 1US FAERS
103Burning Mouth SyndromeFAERS: 1US FAERS
104Chest PainFAERS: 1OFFSIDES
US FAERS
105Choking sensationFAERS: 1OFFSIDES
US FAERS
106DehydrationFAERS: 1US FAERS
107Depressed Level of ConsciousnessFAERS: 1US FAERS
108Disease recurrenceFAERS: 1US FAERS
109Drug abuseFAERS: 1US FAERS
110Drug administration errorFAERS: 1US FAERS
111Drug prescribing errorFAERS: 1US FAERS
112Drug screen false positiveFAERS: 1US FAERS
113Drug screen positiveFAERS: 1US FAERS
114DysphoniaFAERS: 1OFFSIDES
US FAERS
115DystoniaFAERS: 1US FAERS
116EczemaFAERS: 1US FAERS
117Exposure to unspecified agentFAERS: 1US FAERS
118Exposure via breast milkFAERS: 1US FAERS
119Eye inflammationFAERS: 1US FAERS
120Gastrointestinal motility disorderFAERS: 1OFFSIDES
US FAERS
121Gastrointestinal sounds abnormalFAERS: 1US FAERS
122HyperthyroidismFAERS: 1US FAERS
123HypokinesiaFAERS: 1US FAERS
124ImmobileFAERS: 1US FAERS
125Impaired driving abilityFAERS: 1OFFSIDES
US FAERS
126Inappropriate schedule of product administrationFAERS: 1US FAERS
127Initial insomniaFAERS: 1US FAERS
128Maternal exposure during pregnancyFAERS: 1US FAERS
129Memory impairmentFAERS: 1US FAERS
130Middle insomniaFAERS: 1US FAERS
131Mouth swellingFAERS: 1US FAERS
132Mucosal erosionFAERS: 1US FAERS
133Myasthenia GravisFAERS: 1US FAERS
134Nasal pruritusFAERS: 1US FAERS
135NasopharyngitisFAERS: 1SIDER
US FAERS
136No adverse eventFAERS: 1US FAERS
137Oral pruritusFAERS: 1US FAERS
138PapuleFAERS: 1US FAERS
139Pharyngolaryngeal PainFAERS: 1OFFSIDES
US FAERS
140PoisoningFAERS: 1US FAERS
141Product container issueFAERS: 1US FAERS
142Product taste abnormalFAERS: 1US FAERS
143Pulmonary congestionFAERS: 1US FAERS
144Rash erythematousFAERS: 1US FAERS
145Reaction to excipientFAERS: 1US FAERS
146Renal painFAERS: 1US FAERS
147Respiratory FailureFAERS: 1US FAERS
148Restless Legs SyndromeFAERS: 1US FAERS
149ScreamingFAERS: 1US FAERS
150Sinus operationFAERS: 1US FAERS
151Skin lesionFAERS: 1US FAERS
152SluggishnessFAERS: 1US FAERS
153SomnambulismFAERS: 1US FAERS
154Sputum decreasedFAERS: 1US FAERS
155Suicide attemptFAERS: 1US FAERS
156SyncopeFAERS: 110540625CTD
US FAERS
157Terminal dribblingFAERS: 1US FAERS
158Therapeutic product effect delayedFAERS: 1US FAERS
159Toxic Epidermal NecrolysisFAERS: 1US FAERS
160Upper-airway cough syndromeFAERS: 1US FAERS
161Urinary RetentionFAERS: 1US FAERS
162Urine flow decreasedFAERS: 1US FAERS
163AbasiaOFFSIDES
164Abdominal hernia obstructiveOFFSIDES
165Abdominal panniculectomyOFFSIDES
166Abdominal wound dehiscenceOFFSIDES
167Abnormal visionOFFSIDES
168Accidental exposureOFFSIDES
169Acid refluxOFFSIDES
170Activities of daily living impairedOFFSIDES
171Acute bronchitisOFFSIDES
172Acute myocardial infarctionOFFSIDES
173Acute sinusitisOFFSIDES
174Altered state of consciousnessOFFSIDES
175Amaurosis FugaxOFFSIDES
176AmyloidosisOFFSIDES
177Analgesic drug level increasedOFFSIDES
178Anaphylactic shockSIDER
179AnhedoniaOFFSIDES
180AnorexiaOFFSIDES
181Antinuclear antibody increasedOFFSIDES
182ApathyOFFSIDES
183Application site rashOFFSIDES
184ArteriosclerosisOFFSIDES
185ArthritisOFFSIDES
186ArthropathyOFFSIDES
187AscitesOFFSIDES
188Aspartate aminotransferase decreasedOFFSIDES
189AtelectasisOFFSIDES
190Atherosclerosis25020133CTD
191Bacterial conjunctivitisOFFSIDES
192Basal cell carcinomaOFFSIDES
193Bladder cancer recurrentOFFSIDES
194Bladder spasmOFFSIDES
195Blood 1,25-dihydroxycholecalciferol decreasedOFFSIDES
196Blood GlucoseOFFSIDES
197Blood alkaline phosphatase increasedOFFSIDES
198Blood cholesterolOFFSIDES
199Blood creatine phosphokinase increasedOFFSIDES
200Blood potassium increasedOFFSIDES
201Blood sodiumOFFSIDES
202Blood triglycerides increasedOFFSIDES
203Blurred visionOFFSIDES
204Bone density decreasedOFFSIDES
205Bone fragmentationOFFSIDES
206Bone marrow necrosisOFFSIDES
207Bone painOFFSIDES
208Brain natriuretic peptide increasedOFFSIDES
209Breast MicrocalcificationOFFSIDES
210Bronchial ObstructionOFFSIDES
211BronchiectasisOFFSIDES
212BruxismOFFSIDES
213Burning sensationOFFSIDES
214BursitisOFFSIDES
215Cardioactive drug levelOFFSIDES
216Cardioactive drug level increasedOFFSIDES
217CataractOFFSIDES
218Catheter related infectionOFFSIDES
219CellulitisOFFSIDES
220Cervical myelopathyOFFSIDES
221Cervical spine flatteningOFFSIDES
222Chest tightnessSIDER
223Chronic Obstructive Airway DiseaseOFFSIDES
224Chronic sinusitisOFFSIDES
225Compression fractureOFFSIDES
226ConfabulationOFFSIDES
227Congenital tricuspid valve incompetenceOFFSIDES
228Contact DermatitisOFFSIDES
229DeafnessOFFSIDES
230DebridementOFFSIDES
231DemyelinationOFFSIDES
232Dental abscessOFFSIDES
233Denture wearerOFFSIDES
234Depressed moodOFFSIDES
235Dermatitis, Atopic17133778CTD
236DermatitisSIDER
237Device FailureOFFSIDES
238Device dislocationOFFSIDES
239DiabetesOFFSIDES
240DiarrheaOFFSIDES
241Diastolic dysfunctionOFFSIDES
242Disease ProgressionOFFSIDES
243DrowsinessSIDER
244Drug toxicityOFFSIDES
245Drug withdrawal headacheOFFSIDES
246Dry skinOFFSIDES
247DyscalculiaOFFSIDES
248DysgraphiaOFFSIDES
249Economic problemOFFSIDES
250Emotional distressOFFSIDES
251EmpyemaOFFSIDES
252Endodontic procedureOFFSIDES
253Erythema MultiformeOFFSIDES
254Essential HypertensionOFFSIDES
255Eustachian tube disorderOFFSIDES
256Factor V Leiden mutationOFFSIDES
257Failure to ThriveOFFSIDES
258Fatty Liver24852568CTD
259FibromyalgiaOFFSIDES
260Food PoisoningOFFSIDES
261Foreign body sensation in eyesOFFSIDES
262FormicationOFFSIDES
263GamblingOFFSIDES
264Gastric hypomotilityOFFSIDES
265Gastrointestinal PainSIDER
266Gastrointestinal ulcerOFFSIDES
267Genital rashOFFSIDES
268Gingival HyperplasiaOFFSIDES
269GlobulinuriaOFFSIDES
270GlomerulonephritisOFFSIDES
271GoiterOFFSIDES
272GranulomaOFFSIDES
273Hay feverOFFSIDES
274HerniaOFFSIDES
275HyperventilationOFFSIDES
276HypoparathyroidismOFFSIDES
277HypophagiaOFFSIDES
278Impaired gastric emptyingOFFSIDES
279IncontinenceOFFSIDES
280Incorrect drug administration rateOFFSIDES
281InfectionSIDER
282Injection site dermatitisOFFSIDES
283Injection site discomfortOFFSIDES
284Injection site erythemaOFFSIDES
285Injection site irritationOFFSIDES
286Injection site pruritusOFFSIDES
287Insulin-requiring type 2 diabetes mellitusOFFSIDES
288Intention tremorOFFSIDES
289IntertrigoOFFSIDES
290Intervertebral Disc DegenerationOFFSIDES
291Intestinal ObstructionOFFSIDES
292Intrinsic factor antibody negativeOFFSIDES
293Joint injuryOFFSIDES
294Keratitis siccaOFFSIDES
295Kidney FailureOFFSIDES
296LeukoplakiaOFFSIDES
297Life expectancy shortenedOFFSIDES
298Ligament ruptureOFFSIDES
299Limb crushing injuryOFFSIDES
300Limb discomfortOFFSIDES
301Lung consolidationOFFSIDES
302Lupus-like syndromeOFFSIDES
303LymphedemaOFFSIDES
304Lymphocyte percentage decreasedOFFSIDES
305Macrophage ActivationOFFSIDES
306Medical device removalOFFSIDES
307MeningiomaOFFSIDES
308Migraine with AuraOFFSIDES
309Mitral Valve StenosisOFFSIDES
310Monocyte percentage decreasedOFFSIDES
311MononeuritisOFFSIDES
312Muscle tightnessOFFSIDES
313Musculoskeletal PainOFFSIDES
314Musculoskeletal discomfortOFFSIDES
SIDER
315MyringitisOFFSIDES
316Nephrogenic Fibrosing DermopathyOFFSIDES
317NephrolithiasisOFFSIDES
318Nephrotic SyndromeOFFSIDES
319Nerve Root CompressionOFFSIDES
320NeuralgiaOFFSIDES
321Neurogenic Inflammation19672097CTD
322NoduleOFFSIDES
323Non-cardiac chest painOFFSIDES
324Oral Cavity FistulaOFFSIDES
325Oral mucosal exfoliationOFFSIDES
326Oral polypectomyOFFSIDES
327OrchitisOFFSIDES
328Oropharyngeal plaqueOFFSIDES
329OsteolysisOFFSIDES
330OsteomyelitisOFFSIDES
331OsteopeniaOFFSIDES
332OsteoporosisOFFSIDES
333OsteosclerosisOFFSIDES
334Otitis MediaSIDER
335PancreatitisOFFSIDES
336ParanoiaSIDER
337Partner stressOFFSIDES
338Patellofemoral Pain SyndromeOFFSIDES
339Pelvic fluid collectionOFFSIDES
340PeriodontitisOFFSIDES
341Physical disabilityOFFSIDES
342PleurisyOFFSIDES
343PleurodesisOFFSIDES
344PneumothoraxOFFSIDES
345PolyneuropathyOFFSIDES
346Post procedural complicationOFFSIDES
347Post procedural painOFFSIDES
348Prescribed overdoseOFFSIDES
349Primary sequestrumOFFSIDES
350Procedural hypertensionOFFSIDES
351Protein total increasedOFFSIDES
352Psychiatric symptomOFFSIDES
353Pulmonary EosinophiliaOFFSIDES
354Pulmonary InfarctionOFFSIDES
355Radiation PneumonitisOFFSIDES
356Retinal VasculitisOFFSIDES
357Rhinitis perennialSIDER
358Rhinitis19672097CTD
359SclerodermaOFFSIDES
360Seizures20012267CTD
361SequestrectomyOFFSIDES
362SeromaOFFSIDES
363Shoulder PainOFFSIDES
364Sinus polypOFFSIDES
365Sjogren's SyndromeOFFSIDES
366Skin tightnessOFFSIDES
367Small intestine carcinomaOFFSIDES
368SnoringOFFSIDES
369Spinal fusion surgeryOFFSIDES
370Stent occlusionOFFSIDES
371Stevens-Johnson SyndromeOFFSIDES
372StridorOFFSIDES
373SubileusOFFSIDES
374Synovial CystOFFSIDES
375Tachycardia, Ventricular10459910CTD
376Tardive DyskinesiaOFFSIDES
377Temperature intoleranceOFFSIDES
378TenosynovitisOFFSIDES
379TensionSIDER
380Thoracic Outlet SyndromeOFFSIDES
381Thoracic cavity drainageOFFSIDES
382Thoracic vertebral fractureOFFSIDES
383Tinea crurisOFFSIDES
384Tooth ExtractionOFFSIDES
385Torsades de Pointes10540625CTD
386Tympanic Membrane PerforationOFFSIDES
387Upset stomachSIDER
388UrethritisOFFSIDES
389Venous InsufficiencyOFFSIDES
390Ventricular Fibrillation10459910
10540625
11503802
CTD
391Vitamin A DeficiencyOFFSIDES
392Vitamin B 12 DeficiencyOFFSIDES
393Weight Gain24852568CTD
OFFSIDES
394XanthopsiaOFFSIDES
395carbuncleOFFSIDES
396effusionOFFSIDES
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