MetaADEDB: Drug

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Labetalol

(SGUAFYQXFOLMHL-UHFFFAOYSA-N)

Structure

SMILES: CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=O)N)O)O
Type(s): Approved
ATC code(s): C07AG01; C07BG01; C07CG01
Molecular Formula:: C19H24N2O3
Molecular Weight:: 328.405
Log P:: 3.2266
Hydrogen Bond Acceptor:: 5
Hydrogen Bond Donor:: 4
TPSA:: 95.58
CAS Number(s):: 36894-69-6; 83167-24-2

Synonym(s)

Labetalol

AH-5158

Albetol

Apo-Labetalol

Dilevalol

Labetalol Hydrochloride

Labetalol, (R,R)-Isomer

Labetolol

Normodyne

10.

Presolol

11.

R,R-Labetalol

12.

SCH-19927

13.

Trandate

14.

AH 5158

15.

AH5158

16.

Apo Labetalol

17.

ApoLabetalol

18.

Hydrochloride, Labetalol

19.

R,R Labetalol

20.

SCH 19927

21.

SCH19927

External Link(s)

MeSH	D007741
PubChem Compound	3869
BindingDB	25758
ChEBI	6343
CHEMBL	CHEMBL429
DrugBank	DB00598
DrugCentral	1531
IUPHAR/BPS Guide to PHARMACOLOGY	7207
KEGG	cpd:C07063 dr:D08106
Therapeutic Target Database	D0A8XN

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Drug ineffective	FAERS: 12 Canada Vigilance: 2		Canada Vigilance US FAERS
2	Dizziness	FAERS: 11 Canada Vigilance: 3	2464109 2472530	CTD OFFSIDES SIDER Canada Vigilance US FAERS
3	Hypotension	FAERS: 7 Canada Vigilance: 1	View details 42517 1316047 1539484 1721975 1874198 1897344 2082945 2168244 2603701 2696505 2718706 3136985 3281701 3802704 6130003 6151891 6476508 7248122 8198664 8310785 8424298 9783506 16803915	CTD SIDER Canada Vigilance US FAERS
4	Fatigue	FAERS: 6	2867049	CTD OFFSIDES SIDER US FAERS
5	Headache	FAERS: 5	2867049	CTD SIDER US FAERS
6	Peripheral swelling	FAERS: 5		US FAERS
7	Maternal exposure during pregnancy	FAERS: 4 Canada Vigilance: 1		Canada Vigilance US FAERS
8	Asthenia	FAERS: 3		OFFSIDES SIDER US FAERS
9	Dyspepsia	FAERS: 3		OFFSIDES SIDER US FAERS
10	Eosinophilic Pneumonia	FAERS: 3 Canada Vigilance: 1		Canada Vigilance US FAERS
11	Feeling abnormal	FAERS: 3		SIDER US FAERS
12	Nausea	FAERS: 3 Canada Vigilance: 1	2472530	CTD OFFSIDES SIDER Canada Vigilance US FAERS
13	Nipple pain	FAERS: 3		US FAERS
14	Product quality issue	FAERS: 3		US FAERS
15	Product substitution issue	FAERS: 3 Canada Vigilance: 1		Canada Vigilance US FAERS
16	Pruritus	FAERS: 3 Canada Vigilance: 2		Canada Vigilance SIDER US FAERS
17	Syncope	FAERS: 3	6844370	CTD SIDER US FAERS
18	Abdominal Pain	FAERS: 2 Canada Vigilance: 1		Canada Vigilance OFFSIDES SIDER US FAERS
19	Bradycardia	FAERS: 2	View details 42517 6844370 8198664 8302145 11004045 16803915	CTD SIDER US FAERS
20	Cardiac Arrest	FAERS: 2		US FAERS
21	Chest Pain	FAERS: 2 Canada Vigilance: 2	8506886	CTD OFFSIDES Canada Vigilance US FAERS
22	Chills	FAERS: 2		US FAERS
23	Constipation	FAERS: 2		SIDER US FAERS
24	Disorientation	FAERS: 2		SIDER US FAERS
25	Drug exposure during pregnancy	FAERS: 2		OFFSIDES US FAERS
26	Drug screen false positive	FAERS: 2		US FAERS
27	Dysgeusia	FAERS: 2		US FAERS
28	Erythema	FAERS: 2		SIDER US FAERS
29	Exposure via breast milk	FAERS: 2		US FAERS
30	Malaise	FAERS: 2		SIDER US FAERS
31	Therapy change	FAERS: 2		US FAERS
32	Wrong technique in product usage process	FAERS: 2		US FAERS
33	Abasia	FAERS: 1		US FAERS
34	Abdominal discomfort	FAERS: 1		US FAERS
35	Acute kidney injury	FAERS: 1	3094808	CTD US FAERS
36	Agitation	FAERS: 1		US FAERS
37	Alopecia	FAERS: 1		SIDER US FAERS
38	Aphasia	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
39	Asthma	FAERS: 1		US FAERS
40	Atrial Fibrillation	FAERS: 1	9698967	CTD US FAERS
41	Atrioventricular Block	FAERS: 1	6476508	CTD OFFSIDES SIDER US FAERS
42	Blood pressure fluctuation	FAERS: 1		US FAERS
43	Blood pressure inadequately controlled	FAERS: 1 Canada Vigilance: 2		Canada Vigilance OFFSIDES US FAERS
44	Bone pain	FAERS: 1		US FAERS
45	Bronchospasm	FAERS: 1		SIDER US FAERS
46	Cold sweat	FAERS: 1		US FAERS
47	Contraindicated product administered	FAERS: 1		US FAERS
48	Depressed Level of Consciousness	FAERS: 1		OFFSIDES US FAERS
49	Diabetic Ketoacidosis	FAERS: 1		US FAERS
50	Drug dispensing error	FAERS: 1		US FAERS
51	Drug exposure via breast milk	FAERS: 1		OFFSIDES US FAERS
52	Drug prescribing error	FAERS: 1		US FAERS
53	Embolism	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
54	Epistaxis	FAERS: 1		SIDER US FAERS
55	Exposure during breast feeding	FAERS: 1		US FAERS
56	Gastrointestinal sounds abnormal	FAERS: 1		US FAERS
57	Head discomfort	FAERS: 1		US FAERS
58	Hepatic Encephalopathy	FAERS: 1		US FAERS
59	Hepatic necrosis	FAERS: 1		SIDER US FAERS
60	Hepatorenal Syndrome	FAERS: 1		US FAERS
61	Hypersensitivity	FAERS: 1		SIDER US FAERS
62	Hypertensive crisis	FAERS: 1		US FAERS
63	Hypertrophic Cardiomyopathy	FAERS: 1		US FAERS
64	Inappropriate schedule of drug administration	FAERS: 1		US FAERS
65	Intentional misuse	FAERS: 1		US FAERS
66	Intercepted product selection error	FAERS: 1		US FAERS
67	Maternal exposure during delivery	FAERS: 1		US FAERS
68	Medication residue present	FAERS: 1		US FAERS
69	Mental status changes	FAERS: 1		OFFSIDES US FAERS
70	Nasopharyngitis	FAERS: 1		US FAERS
71	Neonatal disorder	FAERS: 1		US FAERS
72	Night sweats	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
73	Pain	FAERS: 1		OFFSIDES SIDER US FAERS
74	Palpitations	FAERS: 1		SIDER US FAERS
75	Pre-Eclampsia	FAERS: 1	1316047 7608802 20006421	CTD OFFSIDES US FAERS
76	Product label confusion	FAERS: 1		US FAERS
77	Product label issue	FAERS: 1		US FAERS
78	Product packaging quantity issue	FAERS: 1		US FAERS
79	Product substitution	FAERS: 1		US FAERS
80	Reaction to azo-dyes	FAERS: 1		US FAERS
81	Respiratory arrest	FAERS: 1		US FAERS
82	Restlessness	FAERS: 1		US FAERS
83	Semen analysis abnormal	FAERS: 1		US FAERS
84	Sinus bradycardia	FAERS: 1		OFFSIDES US FAERS
85	Somnolence	FAERS: 1 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
86	Stevens-Johnson Syndrome	FAERS: 1		US FAERS
87	Suicide attempt	FAERS: 1		US FAERS
88	Tachycardia	FAERS: 1 Canada Vigilance: 1	View details 10949 12778 42517 75487 1316047 2370642 3802704 3938237 6845955 11425575	CTD Canada Vigilance US FAERS
89	Tinnitus	FAERS: 1		US FAERS
90	Unresponsive to stimuli	FAERS: 1		OFFSIDES US FAERS
91	Urticaria	FAERS: 1 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
92	Visual Impairment	FAERS: 1		SIDER US FAERS
93	Vomiting	FAERS: 1		SIDER US FAERS
94	Abdominal Abscess			OFFSIDES
95	Abdominal Compartment Syndrome			OFFSIDES
96	Abuse			OFFSIDES
97	Ache			SIDER
98	Actinic keratosis			OFFSIDES
99	Acute Coronary Syndrome		20133495	CTD
100	Acute retention of urine			SIDER
101	Adenocarcinoma			OFFSIDES
102	Adnexitis			OFFSIDES
103	Agranulocytosis			SIDER
104	Alcoholic Intoxication			OFFSIDES
105	Alopecia reversible			SIDER
106	Amnesia			OFFSIDES SIDER
107	Amphetamines			OFFSIDES
108	Anaphylactic shock			SIDER
109	Anaphylactoid Reaction			SIDER
110	Angina Pectoris		View details 2908732 3154919 6849167 6876536	CTD SIDER
111	Angioedema			SIDER
112	Anhedonia			OFFSIDES
113	Anoxic Encephalopathy			OFFSIDES
114	Anuria			OFFSIDES
115	Anxiety	Canada Vigilance: 1		Canada Vigilance OFFSIDES
116	Aortic Aneurysm		2060359	CTD
117	Aortic valve calcification			OFFSIDES
118	Arteriovenous fistula thrombosis			OFFSIDES
119	Arteriovenous graft thrombosis			OFFSIDES
120	Arthritis			OFFSIDES
121	Ascites			OFFSIDES
122	Ataxia			OFFSIDES
123	Autonomic neuropathy			OFFSIDES
124	Axillary vein thrombosis			OFFSIDES
125	Bacteria urine identified			OFFSIDES
126	Bladder neck obstruction			OFFSIDES
127	Blood Glucose			OFFSIDES
128	Blood cholesterol			OFFSIDES
129	Blood fibrinogen increased			OFFSIDES
130	Blood glucose decreased			OFFSIDES
131	Blood osmolarity increased			OFFSIDES
132	Blood potassium decreased			OFFSIDES
133	Blood potassium increased			OFFSIDES
134	Blood sodium increased			OFFSIDES
135	Blood urea increased			SIDER
136	Blurred vision			OFFSIDES
137	Bronchitis			OFFSIDES
138	Bulbar palsy			OFFSIDES
139	Bullous lichen planus			SIDER
140	Calcinosis			OFFSIDES
141	Cardiomegaly		9828745	CTD
142	Cardiovascular Diseases		10672977 20206876	CTD
143	Carotid bruit			OFFSIDES
144	Cataplexy			OFFSIDES
145	Catatonia			SIDER
146	Causalgia			OFFSIDES
147	Cellulitis			OFFSIDES
148	Cerebral disorder			OFFSIDES
149	Chemical and Drug Induced Liver Injury		View details 1504402 1603212 11927791 18524759 22258563 28437613	CTD
150	Choking sensation			OFFSIDES
151	Cluster Headache			OFFSIDES
152	Confabulation			OFFSIDES
153	Congenital tricuspid valve incompetence			OFFSIDES
154	Contracture			OFFSIDES
155	Corneal abscess			OFFSIDES
156	Crying			OFFSIDES
157	Culture wound positive			OFFSIDES
158	Cytokine storm			OFFSIDES
159	Dental caries			OFFSIDES
160	Depressed mood			SIDER
161	Dermatitis			SIDER
162	Device related infection			OFFSIDES
163	Diabetic Foot			OFFSIDES
164	Diarrhea		672730	CTD OFFSIDES
165	Diastolic dysfunction			OFFSIDES
166	Discomfort			SIDER
167	Disseminated Intravascular Coagulation			OFFSIDES
168	Diverticulitis			OFFSIDES
169	Drowsiness			SIDER
170	Drug Tolerance			OFFSIDES
171	Drug abuser			OFFSIDES
172	Drug addict			OFFSIDES
173	Drug withdrawal headache			OFFSIDES
174	Duodenal Ulcer			OFFSIDES
175	Duodenitis			OFFSIDES
176	Dysphonia			OFFSIDES
177	Dysthymic Disorder			OFFSIDES
178	Dysuria	Canada Vigilance: 2		Canada Vigilance OFFSIDES SIDER
179	Electrocardiogram ST segment abnormal			OFFSIDES
180	Electrocardiogram ST-T change			OFFSIDES
181	Emotional distress			OFFSIDES
182	Encephalomalacia			OFFSIDES
183	Endocarditis			OFFSIDES
184	Enterococcal infection			OFFSIDES
185	Epigastric pain			SIDER
186	Erectile dysfunction			SIDER
187	Euphoric mood			OFFSIDES
188	Exanthema		672730 2873208	CTD
189	Fatty Liver			OFFSIDES
190	Feeling Cold	Canada Vigilance: 1		Canada Vigilance
191	Flank Pain			OFFSIDES
192	Fluid overload			OFFSIDES
193	Flushing			SIDER
194	Formication			OFFSIDES
195	Gastroenteritis			OFFSIDES
196	Gastrointestinal Diseases		2867049	CTD
197	Gastrointestinal Pain			SIDER
198	General physical health deterioration			OFFSIDES
199	Globulinuria			OFFSIDES
200	Granulocytosis			OFFSIDES
201	Heart Diseases		378019	CTD
202	Heart failure		514938 6151891 7608802	CTD
203	Hemorrhage		9783506	CTD
204	Heparin-induced thrombocytopenia			OFFSIDES
205	Hepatitis			SIDER
206	Hernia			OFFSIDES
207	Hydronephrosis			OFFSIDES
208	Hyperkeratosis			OFFSIDES
209	Hyperpigmentation			OFFSIDES
210	Hyperprolactinemia		7105431	CTD
211	Hypertensive Encephalopathy		115540	CTD
212	Hypertensive emergency			OFFSIDES
213	Hypertensive heart disease			OFFSIDES
214	Hyperthyroidism			SIDER
215	Hypoglycemia		8198664	CTD
216	Hypotension orthostatic symptomatic			SIDER
217	Hypotension, Orthostatic		View details 14627 75487 672730 990154 2867049 4032646 6130864 6844370 6961758 8124849	CTD
218	Immunosuppression			OFFSIDES
219	Impaired driving ability			OFFSIDES
220	Incontinence			OFFSIDES
221	Increased bronchial secretion			OFFSIDES
222	Infusion site mobility decreased			OFFSIDES
223	Intercapillary glomerulosclerosis			OFFSIDES
224	Intermittent Claudication			SIDER
225	Intracranial Aneurysm			OFFSIDES
226	Intracranial Hemorrhage, Hypertensive		11927791	CTD
227	Ischemia		2764457	CTD
228	Joint Range of Motion Decreased			OFFSIDES
229	Joint stiffness			OFFSIDES
230	Joint swelling			SIDER
231	Kidney Failure			OFFSIDES
232	Labile hypertension			OFFSIDES
233	Laceration			OFFSIDES
234	Laryngospasm			SIDER
235	Latex allergy			OFFSIDES
236	Left Ventricular Hypertrophy			OFFSIDES
237	Lethargy			OFFSIDES SIDER
238	Lichen Planus			OFFSIDES SIDER
239	Lipase			OFFSIDES
240	Livedo Reticularis			OFFSIDES
241	Liver diseases		8124849	CTD
242	Lupus Erythematosus			SIDER
243	Lymphoid tissue hyperplasia			OFFSIDES
244	Malignant Hypertension			OFFSIDES
245	Mastoiditis			OFFSIDES
246	Mood swings			SIDER
247	Multiple sclerosis relapse			OFFSIDES
248	Muscle necrosis			OFFSIDES
249	Musculoskeletal stiffness			OFFSIDES
250	Myalgia	Canada Vigilance: 1		Canada Vigilance
251	Myocardial Ischemia		2908732	CTD
252	Necrosis		2764457	CTD
253	Neonatal respiratory acidosis			OFFSIDES
254	Nephrogenic Fibrosing Dermopathy			OFFSIDES
255	Nervousness	Canada Vigilance: 1		Canada Vigilance
256	Nicotine Dependence			OFFSIDES
257	Numbness			SIDER
258	Oligohydramnios			OFFSIDES
259	Oral infection			OFFSIDES
260	Oropharyngeal discomfort			SIDER
261	Oropharyngeal pain			SIDER
262	Orthopnea			OFFSIDES
263	Pancreatic Neoplasm			OFFSIDES
264	Pancreatic Pseudocyst			OFFSIDES
265	Paresis		115540	CTD
266	Paresthesia		View details 69898 71532 293566 630239	CTD
267	Pericardial effusion		9828745	CTD OFFSIDES
268	Pharyngolaryngeal Pain			OFFSIDES
269	Pheochromocytoma		View details 14627 990158 1268685 6151891	CTD
270	Pleurisy			OFFSIDES
271	Polyuria		293566	CTD
272	Poor quality sleep	Canada Vigilance: 1		Canada Vigilance
273	Post procedural complication			OFFSIDES
274	Product administration error	Canada Vigilance: 1		Canada Vigilance
275	Pulmonary Hypertension			OFFSIDES
276	Pulmonary Infarction			OFFSIDES
277	Reflex Sympathetic Dystrophy			OFFSIDES
278	Renal Artery Stenosis			OFFSIDES
279	Renal cyst			OFFSIDES
280	Renal mass			OFFSIDES
281	Respiratory Failure			OFFSIDES
282	Respiratory distress			SIDER
283	Reticulocyte count decreased			OFFSIDES
284	Retinopathy of Prematurity			OFFSIDES
285	Rhabdomyolysis		2206162	CTD OFFSIDES
286	Salpingitis			OFFSIDES
287	Septic Shock			OFFSIDES
288	Seroma			OFFSIDES
289	Shock			SIDER
290	Skin Induration			OFFSIDES
291	Skin hypertrophy			OFFSIDES
292	Skin lesion			OFFSIDES SIDER
293	Skin tightness			OFFSIDES
294	Stress			OFFSIDES
295	Subarachnoid Hemorrhage		16803915	CTD
296	Substance Withdrawal Syndrome		View details 14627 990158 1268685 3303314 6273179	CTD
297	Supraventricular tachycardia			OFFSIDES
298	Suture insertion			OFFSIDES
299	Sweating			SIDER
300	Tachycardia, Ventricular		2068045	CTD
301	Tension Headache			OFFSIDES
302	Tetanus		6151891	CTD
303	Thyrotoxicosis			SIDER
304	Tremor		2370642	CTD SIDER
305	Troponin increased			OFFSIDES
306	Unevaluable event			OFFSIDES
307	Urinary Retention	Canada Vigilance: 1	990154 2873208	CTD SIDER Canada Vigilance
308	Urinary tract infection staphylococcal			OFFSIDES
309	Urination Disorders		71532 3339748	CTD
310	Vascular calcification			OFFSIDES
311	Vasculitis	Canada Vigilance: 1		Canada Vigilance
312	Ventricular Fibrillation			OFFSIDES
313	Ventricular arrhythmia			SIDER
314	Vertigo			SIDER
315	Vulvovaginal discomfort			OFFSIDES
316	Wheezing			SIDER
317	White blood cell count abnormal			OFFSIDES
318	Wound Debridement			OFFSIDES
319	Wound Infection			OFFSIDES
320	Wound infection staphylococcal			OFFSIDES
321	Yawning			SIDER
322	jaundice			SIDER

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