MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Sotalol

(ZBMZVLHSJCTVON-UHFFFAOYSA-N)

Structure

SMILES: CC(NCC(c1ccc(cc1)NS(=O)(=O)C)O)C
Type(s): Approved
ATC code(s): C07AA07; C07BA07; C07FX02
Molecular Formula:: C12H20N2O3S
Molecular Weight:: 272.364
Log P:: 2.6342
Hydrogen Bond Acceptor:: 5
Hydrogen Bond Donor:: 3
TPSA:: 86.81
CAS Number(s):: 3930-20-9

Synonym(s)

Sotalol

Darob

MJ-1999

Sotalol Hydrochloride

Sotalol Monohydrochloride

MJ 1999

MJ1999

External Link(s)

MeSH	D013015
PubChem Compound	5253
BindingDB	25762
ChEBI	63622
CHEMBL	CHEMBL471
DrugBank	DB00489
DrugCentral	2464
IUPHAR/BPS Guide to PHARMACOLOGY	7297
KEGG	cpd:C07309 dr:D08525
Therapeutic Target Database	D04VMT

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Drug ineffective	FAERS: 18 Canada Vigilance: 1		Canada Vigilance OFFSIDES US FAERS
2	Atrial Fibrillation	FAERS: 15	View details 1409197 7653451 8122604 8187370 8671988 8744614 8904547 9448217 9474467 9681093 9844513 9875096 10496434 12854385 15851230 15985302 17383295 19563362	CTD US FAERS
3	Cardiac Arrest	FAERS: 10		US FAERS
4	Fatigue	FAERS: 10		OFFSIDES SIDER US FAERS
5	Bradycardia	FAERS: 9	View details 1279608 2417188 2565743 6963090 7653451 7787496 9669266 9733356 11157286 11798623 22744888	CTD OFFSIDES SIDER US FAERS
6	Ventricular Fibrillation	FAERS: 8	View details 2909562 4017207 6117468 7817931 8187370 8346726 8346732 9125676 9247523 11798623 19317712	CTD OFFSIDES SIDER US FAERS
7	Chest Pain	FAERS: 7		SIDER US FAERS
8	Toxicity to various agents	FAERS: 7		US FAERS
9	Asthenia	FAERS: 6 Canada Vigilance: 1		Canada Vigilance OFFSIDES SIDER US FAERS
10	Malaise	FAERS: 6		US FAERS
11	Product substitution issue	FAERS: 6 Canada Vigilance: 1		Canada Vigilance US FAERS
12	Tachycardia	FAERS: 6 Canada Vigilance: 2	View details 501565 3630895 4392540 7398733 9607136 15175557	CTD Canada Vigilance US FAERS
13	Feeling abnormal	FAERS: 5		US FAERS
14	Dizziness	FAERS: 4 Canada Vigilance: 3		Canada Vigilance OFFSIDES SIDER US FAERS
15	Nausea	FAERS: 4 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
16	Sinus bradycardia	FAERS: 4		OFFSIDES US FAERS
17	Disease recurrence	FAERS: 3		OFFSIDES US FAERS
18	Dysgeusia	FAERS: 3		SIDER US FAERS
19	Headache	FAERS: 3 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
20	Overdose	FAERS: 3		OFFSIDES US FAERS
21	Palpitations	FAERS: 3 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
22	Poisoning	FAERS: 3		US FAERS
23	Product quality issue	FAERS: 3		US FAERS
24	Syncope	FAERS: 3	6197982 6500767	CTD SIDER US FAERS
25	Atrial Flutter	FAERS: 2	8957602 9132656 10496434	CTD OFFSIDES US FAERS
26	Cerebral Infarction	FAERS: 2		US FAERS
27	Chest discomfort	FAERS: 2		US FAERS
28	Hypotension	FAERS: 2	View details 1975861 6963090 7653451 7900626 9594410 11157286	CTD SIDER US FAERS
29	Low birth weight baby	FAERS: 2		US FAERS
30	Musculoskeletal Pain	FAERS: 2		US FAERS
31	Neurological examination abnormal	FAERS: 2		US FAERS
32	Pharmaceutical product complaint	FAERS: 2		US FAERS
33	Poor peripheral circulation	FAERS: 2		US FAERS
34	Pre-Eclampsia	FAERS: 2		US FAERS
35	Presyncope	FAERS: 2		SIDER US FAERS
36	Pruritus	FAERS: 2		SIDER US FAERS
37	Throat irritation	FAERS: 2		US FAERS
38	Tinnitus	FAERS: 2		OFFSIDES US FAERS
39	Unevaluable event	FAERS: 2		OFFSIDES US FAERS
40	Visual Impairment	FAERS: 2		SIDER US FAERS
41	Abdominal discomfort	FAERS: 1		OFFSIDES US FAERS
42	Acute Coronary Syndrome	FAERS: 1		SIDER US FAERS
43	Acute left ventricular failure	FAERS: 1		US FAERS
44	Alopecia	FAERS: 1		OFFSIDES SIDER US FAERS
45	Anxiety	FAERS: 1		OFFSIDES SIDER US FAERS
46	Atrioventricular Block	FAERS: 1	7162978 9669266	CTD OFFSIDES SIDER US FAERS
47	Blood magnesium decreased	FAERS: 1		US FAERS
48	Blood potassium decreased	FAERS: 1		OFFSIDES US FAERS
49	Blood sodium decreased	FAERS: 1		US FAERS
50	Bronchiectasis	FAERS: 1		US FAERS
51	Bronchospasm	FAERS: 1		SIDER US FAERS
52	Burning sensation	FAERS: 1		US FAERS
53	Chronotropic incompetence	FAERS: 1		US FAERS
54	Crying	FAERS: 1		US FAERS
55	Dehydration	FAERS: 1		US FAERS
56	Depressed Level of Consciousness	FAERS: 1		OFFSIDES US FAERS
57	Diplopia	FAERS: 1		OFFSIDES US FAERS
58	Discomfort	FAERS: 1		US FAERS
59	Drug effect incomplete	FAERS: 1		US FAERS
60	Drug prescribing error	FAERS: 1		US FAERS
61	Dysphonia	FAERS: 1		OFFSIDES US FAERS
62	Electrolyte imbalance	FAERS: 1		US FAERS
63	Flatulence	FAERS: 1		OFFSIDES SIDER US FAERS
64	Fluid overload	FAERS: 1		OFFSIDES US FAERS
65	Flushing	FAERS: 1 Canada Vigilance: 2		Canada Vigilance US FAERS
66	Hyperacusis	FAERS: 1		US FAERS
67	Hypertensive crisis	FAERS: 1		US FAERS
68	Hypoperfusion	FAERS: 1		US FAERS
69	Hypoxia	FAERS: 1		US FAERS
70	Incorrect dose administered	FAERS: 1		OFFSIDES US FAERS
71	Inflammation	FAERS: 1		US FAERS
72	Joint swelling	FAERS: 1		US FAERS
73	Lung consolidation	FAERS: 1		US FAERS
74	Medication Error	FAERS: 1		US FAERS
75	Middle insomnia	FAERS: 1		US FAERS
76	Musculoskeletal chest pain	FAERS: 1		US FAERS
77	Myalgia	FAERS: 1		SIDER US FAERS
78	Osteoporosis	FAERS: 1		US FAERS
79	Pain	FAERS: 1		OFFSIDES SIDER US FAERS
80	Perineal disorder	FAERS: 1		US FAERS
81	Peripheral swelling	FAERS: 1 Canada Vigilance: 2		Canada Vigilance US FAERS
82	Photophobia	FAERS: 1		SIDER US FAERS
83	Product physical issue	FAERS: 1		US FAERS
84	Product use issue	FAERS: 1		US FAERS
85	Pulmonary Fibrosis	FAERS: 1		US FAERS
86	Respiratory Depression	FAERS: 1		US FAERS
87	Respiratory Failure	FAERS: 1		US FAERS
88	Retroperitoneal fibrosis	FAERS: 1		OFFSIDES SIDER US FAERS
89	Sick Sinus Syndrome	FAERS: 1	14593970	CTD OFFSIDES US FAERS
90	Suicide attempt	FAERS: 1		US FAERS
91	Therapeutic response unexpected with drug substitution	FAERS: 1		US FAERS
92	Therapy cessation	FAERS: 1		US FAERS
93	Thrombosis	FAERS: 1	9594410	CTD US FAERS
94	Tremor	FAERS: 1	6115732	CTD US FAERS
95	Urticaria	FAERS: 1		US FAERS
96	Vaginal mucosal blistering	FAERS: 1		US FAERS
97	Vomiting	FAERS: 1		SIDER US FAERS
98	Weight decreased	FAERS: 1		US FAERS
99	Wrong technique in product usage process	FAERS: 1		US FAERS
100	nervous system disorder	FAERS: 1		US FAERS
101	Abasia			OFFSIDES
102	Abdominal Compartment Syndrome			OFFSIDES
103	Abdominal Pain			OFFSIDES SIDER
104	Abdominal strangulated hernia			OFFSIDES
105	Abdominal tenderness			OFFSIDES
106	Abnormal vision			OFFSIDES
107	Abnormalities, Drug-Induced		2417188	CTD
108	Abscess			OFFSIDES
109	Accidental exposure			OFFSIDES
110	Ache			SIDER
111	Acidosis			OFFSIDES
112	Acoustic Neuroma			OFFSIDES
113	Acquired diaphragmatic eventration			OFFSIDES
114	Activities of daily living impaired			OFFSIDES
115	Adenitis			OFFSIDES
116	Adverse event			OFFSIDES
117	Ageusia			OFFSIDES
118	Agranulocytosis			SIDER
119	Alcohol consumption			OFFSIDES
120	Allergic sinusitis			OFFSIDES
121	Alopecia reversible			SIDER
122	Altered state of consciousness			SIDER
123	Amaurosis Fugax			OFFSIDES
124	Amnesia			OFFSIDES SIDER
125	Angina Pectoris		1360557 7171401	CTD SIDER
126	Anhedonia			OFFSIDES
127	Animal scratch			OFFSIDES
128	Ankle Fracture			OFFSIDES
129	Anorexia			OFFSIDES
130	Anoxic Encephalopathy			OFFSIDES
131	Anticholinergic Syndrome			OFFSIDES
132	Anuria			OFFSIDES
133	Aortic Aneurysm			OFFSIDES
134	Apathy			OFFSIDES
135	Arterial thrombosis			SIDER
136	Arthritis			OFFSIDES
137	Ascites			OFFSIDES
138	Asthma			SIDER
139	Astigmatism			OFFSIDES
140	Atrial tachycardia			OFFSIDES
141	Autoimmune thrombocytopenia			OFFSIDES
142	Back Pain			SIDER
143	Benign Prostatic Hyperplasia			OFFSIDES
144	Blast cell count decreased			OFFSIDES
145	Blast cell count increased			OFFSIDES
146	Blood Glucose			OFFSIDES
147	Blood alkaline phosphatase increased			OFFSIDES
148	Blood chloride decreased			OFFSIDES
149	Blood creatine phosphokinase decreased			OFFSIDES
150	Blood electrolytes abnormal			OFFSIDES
151	Blood glucose decreased			OFFSIDES
152	Blood glucose fluctuation			OFFSIDES
153	Blood immunoglobulin G increased			OFFSIDES
154	Blood magnesium increased			OFFSIDES
155	Blood phosphorus increased			OFFSIDES
156	Blood pressure fluctuation			OFFSIDES
157	Blood sodium			OFFSIDES
158	Blood thyroid stimulating hormone			OFFSIDES
159	Blood urea increased			OFFSIDES
160	Blurred vision			OFFSIDES
161	Bone pain			OFFSIDES
162	Bone swelling			OFFSIDES
163	Brain Hypoxia			OFFSIDES
164	Brain natriuretic peptide abnormal			OFFSIDES
165	Brain natriuretic peptide increased			OFFSIDES
166	Bronchial Obstruction			OFFSIDES
167	Bronchopleural Fistula			OFFSIDES
168	Bronchopneumopathy			OFFSIDES
169	Carcinoma			OFFSIDES
170	Cardiac Flutter			OFFSIDES
171	Cardiac ablation			OFFSIDES
172	Cardiac asthma			OFFSIDES
173	Cardiac discomfort			OFFSIDES
174	Cardiac pain			SIDER
175	Cardiac stress test abnormal			OFFSIDES
176	Cardioactive drug level			OFFSIDES
177	Cardioactive drug level above therapeutic			OFFSIDES
178	Cardioactive drug level increased			OFFSIDES
179	Cataract operation			OFFSIDES
180	Catatonia			SIDER
181	Cellulitis			OFFSIDES
182	Cerebral atrophy			OFFSIDES
183	Cerebral disorder			OFFSIDES
184	Cerebrovascular accident			SIDER
185	Choking sensation			OFFSIDES
186	Chromatopsia			OFFSIDES
187	Chronic Obstructive Airway Disease			OFFSIDES
188	Circumstance or information capable of leading to medication error			OFFSIDES
189	Cirrhosis			OFFSIDES
190	Clostridium colitis			OFFSIDES
191	Colitis			OFFSIDES
192	Completed Suicide			OFFSIDES
193	Compression stockings application			OFFSIDES
194	Confabulation			OFFSIDES
195	Congenital heart disease			OFFSIDES
196	Congenital tricuspid valve incompetence			OFFSIDES
197	Constipation		20350559	CTD
198	Coronary angioplasty			OFFSIDES
199	Creatinine renal clearance decreased			OFFSIDES
200	Culture positive			OFFSIDES
201	Cyanosis			OFFSIDES
202	Cystocele			OFFSIDES
203	Cytolytic hepatitis			OFFSIDES
204	Demyelination			OFFSIDES
205	Dependent Personality Disorder			OFFSIDES
206	Dermatitis			SIDER
207	Dermo-hypodermitis			OFFSIDES
208	Diabetic Nephropathy			OFFSIDES
209	Diarrhea			OFFSIDES
210	Diastolic dysfunction			OFFSIDES
211	Disorientation			SIDER
212	Distention			SIDER
213	Drowsiness			SIDER
214	Drug Eruptions		17659030	CTD
215	Drug administration error			OFFSIDES
216	Drug dispensing error			OFFSIDES
217	Drug toxicity			OFFSIDES
218	Duodenitis			OFFSIDES
219	Dysmorphism			OFFSIDES
220	Dyspepsia			SIDER
221	Dyspnea		7900626 12078937	CTD
222	Ear discomfort			OFFSIDES
223	Economic problem			OFFSIDES
224	Eczema			OFFSIDES
225	Ejection Fraction Decreased			OFFSIDES
226	Electrocardiogram ST segment abnormal			OFFSIDES
227	Electrocardiogram ST-T change			OFFSIDES
228	Electrocardiogram ST-T segment abnormal			OFFSIDES
229	Electrocardiogram abnormal			SIDER
230	Embolic stroke			OFFSIDES
231	Embolism			OFFSIDES
232	Enterobacter sepsis			OFFSIDES
233	Enterocele			OFFSIDES
234	Enterococcal infection			OFFSIDES
235	Eosinophilia			SIDER
236	Epilepsy			OFFSIDES
237	Epistaxis			OFFSIDES
238	Erythema			OFFSIDES
239	Escherichia infection			OFFSIDES
240	Euphoric mood			OFFSIDES
241	Eustachian tube disorder			OFFSIDES
242	Exophthalmos			OFFSIDES
243	Expired drug administered			OFFSIDES
244	Eye irritation			SIDER
245	Febrile bone marrow aplasia			OFFSIDES
246	Gangrene			OFFSIDES
247	Gastrointestinal Pain			SIDER
248	Gastrointestinal sounds abnormal			OFFSIDES
249	General physical health deterioration			OFFSIDES
250	Glasgow coma scale			OFFSIDES
251	Glaucoma			OFFSIDES
252	Glioblastoma			OFFSIDES
253	Head titubation			OFFSIDES
254	Heart failure		View details 2403737 9250567 11157286 11798623	CTD
255	Heartburn			SIDER
256	Hepatitis			OFFSIDES
257	Herpes Zoster Oticus			OFFSIDES
258	Hiccough			OFFSIDES
259	Hilar lymphadenopathy			OFFSIDES
260	Hypercreatininaemia			OFFSIDES
261	Hyperglycemia		1032269	CTD
262	Hyperinsulinism			SIDER
263	Hyperthyroidism		83509	CTD
264	Hypokalemia		1032269 9733356	CTD
265	Hypothermia neonatal			OFFSIDES
266	Impaired gastric emptying			OFFSIDES
267	Impaired self-care			OFFSIDES
268	Implant site pain			OFFSIDES
269	Implantable defibrillator insertion			OFFSIDES
270	Incoherent			OFFSIDES
271	Incontinence			OFFSIDES
272	Incorrect route of drug administration			OFFSIDES
273	Increased upper airway secretion			OFFSIDES
274	Induration			OFFSIDES
275	Infection			SIDER
276	Infertility			OFFSIDES
277	Influenza			SIDER
278	Injection site mass			OFFSIDES
279	Injection site stinging			OFFSIDES
280	Injection site ulcer			OFFSIDES
281	Insulin Resistance			OFFSIDES
282	Intentional drug misuse			OFFSIDES
283	Intentional misuse			OFFSIDES
284	Intervertebral Disc Degeneration			OFFSIDES
285	Iron Overload			OFFSIDES
286	Joint sprain			OFFSIDES
287	Kidney Failure			OFFSIDES
288	Laboratory test interference			OFFSIDES
289	Laceration			OFFSIDES
290	Laryngospasm			SIDER
291	Left Ventricular Hypertrophy			OFFSIDES
292	Left atrial dilatation			OFFSIDES
293	Lethargy	Canada Vigilance: 1		Canada Vigilance OFFSIDES SIDER
294	Leukopenia			SIDER
295	Lightheadedness			SIDER
296	Livedo Reticularis			OFFSIDES
297	Long QT Syndrome		View details 6117468 6500767 6744407 7846927 9148161 9669266 11401944 11989578 15350150 16178046 16757186 17916157 19367688 20128168 20636881 24052561 25822712	CTD OFFSIDES
298	Lupus-like syndrome			OFFSIDES
299	Lymphoma			OFFSIDES
300	Markedly reduced dietary intake			OFFSIDES
301	Mediastinal mass			OFFSIDES
302	Medication residue			OFFSIDES
303	Megakaryocytes			OFFSIDES
304	Metabolic acidosis			OFFSIDES
305	Microalbuminuria			OFFSIDES
306	Microcephaly		2417188	CTD
307	Monocytosis			OFFSIDES
308	Mood swings			SIDER
309	Muscle Weakness		519436	CTD
310	Muscle hypertrophy			OFFSIDES
311	Muscle necrosis			OFFSIDES
312	Muscle tightness	Canada Vigilance: 1		Canada Vigilance
313	Musculoskeletal discomfort			SIDER
314	Myelodysplasia			OFFSIDES
315	Myelodysplastic syndrome transformation			OFFSIDES
316	Myocardial Infarction		2040324	CTD SIDER
317	Myocardial Ischemia		7171401	CTD
318	Neuralgia			OFFSIDES
319	Neurological decompensation			OFFSIDES
320	Non-sustained ventricular tachycardia			SIDER
321	Ocular Hypertension			OFFSIDES
322	Orchitis			OFFSIDES
323	Oropharyngeal discomfort			SIDER
324	Oropharyngeal pain			SIDER
325	Orthopnea			OFFSIDES
326	Osteopenia			OFFSIDES
327	PCO2 increased			OFFSIDES
328	Pacemaker complication			OFFSIDES
329	Pallor			OFFSIDES
330	Paresis		1699270	CTD
331	Paroxysmal arrhythmia			OFFSIDES
332	Partner stress			OFFSIDES
333	Pelvic prolapse			OFFSIDES
334	Pericarditis			OFFSIDES
335	Peridiverticular abscess			OFFSIDES
336	Phlebitis			OFFSIDES
337	Physical disability			OFFSIDES
338	Polyuria			OFFSIDES
339	Portal Vein Thrombosis			OFFSIDES
340	Post procedural complication			OFFSIDES
341	Proarrhythmia			SIDER
342	Procedural complication			OFFSIDES
343	Prothrombin time abnormal			OFFSIDES
344	Psoriasis			OFFSIDES
345	Pulmonary Hypertension			OFFSIDES
346	Pulmonary vascular disorder			OFFSIDES
347	Purpura			SIDER
348	Pyelonephritis			OFFSIDES
349	Pyuria			OFFSIDES
350	Rectal Prolapse			OFFSIDES
351	Rectocele			OFFSIDES
352	Renal cyst			OFFSIDES
353	Renal tubular necrosis			OFFSIDES
354	Respiratory distress			SIDER
355	Right atrial dilatation			OFFSIDES
356	Scab			OFFSIDES
357	Scleroderma			OFFSIDES
358	Septic embolus			OFFSIDES
359	Seroma			OFFSIDES
360	Sexual Dysfunction			SIDER
361	Shock			SIDER
362	Sinusitis			OFFSIDES
363	Skin laceration			OFFSIDES
364	Somnolence			SIDER
365	Spinal vascular disorder			OFFSIDES
366	Spondylolisthesis			OFFSIDES
367	Stent occlusion			OFFSIDES
368	Stress			OFFSIDES
369	Sudden Cardiac Death			OFFSIDES
370	Sudden death			SIDER
371	Supraventricular tachycardia			OFFSIDES
372	Sustained ventricular tachycardia			SIDER
373	Synovial Cyst			OFFSIDES
374	Tachyarrhythmia			SIDER
375	Tachycardia, Ventricular		View details 1279608 1281807 1975861 2487531 2909562 3213144 4017207 6197982 7509121 7789381 7817931 7948800 8346725 8346726 8346732 8744614 9125676 9247523 9300303 9659206 10690307 11798623 15609701 19317712	CTD
376	Thoracotomy			OFFSIDES
377	Thrombocytopenia			SIDER
378	Thrombophlebitis			OFFSIDES
379	Tobacco user			OFFSIDES
380	Tongue biting			OFFSIDES
381	Tongue blistering			OFFSIDES
382	Tooth Extraction			OFFSIDES
383	Torsades de Pointes		View details 1409197 1699270 1990770 2403737 2487531 3143334 3383886 3436333 3687770 3924255 4049179 6197982 6691231 6744407 6963090 7162978 7301675 7502575 7817931 7846927 8187370 8230644 8346726 8671988 8701528 8744073 8744614 8904547 8921798 9039065 9125676 9132656 9141970 9159848 9247523 9250567 9474467 9604253 9669266 9733356 9844513 9990619 10321848 11157286 11334843 11401944 11989578 12854385 15477402 15586745 15985302 16178046 17126428 17467628 17969573 18344633 18449951 18957528 20128168	CTD
384	Tracheal Stenosis		2417188	CTD
385	Tracheobronchitis			SIDER
386	Troponin increased			OFFSIDES
387	Umbilical hernia			OFFSIDES
388	Unresponsive to stimuli			OFFSIDES
389	Urinary tract infection staphylococcal			OFFSIDES
390	Urine ketone body present			OFFSIDES
391	Urine output increased			OFFSIDES
392	Uterine Cancer			OFFSIDES
393	Vaginal Prolapse			OFFSIDES
394	Vagus Nerve Disorder			OFFSIDES
395	Vascular purpura			SIDER
396	Vasculitis, Leukocytoclastic, Cutaneous		9448217 17659030	CTD
397	Vasodilation procedure			SIDER
398	Vasodilation			SIDER
399	Venous Insufficiency			OFFSIDES
400	Vertigo			SIDER
401	Visual brightness			OFFSIDES
402	Visual disturbance			OFFSIDES SIDER
403	Walking aid user			OFFSIDES
404	Wheelchair user			OFFSIDES
405	White blood cell count abnormal			OFFSIDES
406	Wound Complication			OFFSIDES
407	Wound infection staphylococcal			OFFSIDES
408	effusion			OFFSIDES
409	prostatitis			OFFSIDES

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