Procarbazine
(DERJYEZSLHIUKF-UHFFFAOYSA-N)
Structure
- SMILES
- CNNCc1ccc(cc1)C(=O)NC(C)C.Cl
- Molecular Formula:
- C12H20ClN3O
- Molecular Weight:
- 257.760
- Log P:
- 3.0235
- Hydrogen Bond Acceptor:
- 4
- Hydrogen Bond Donor:
- 4
- TPSA:
- 53.16
- CAS Number(s):
- 366-70-1
Synonym(s)
1.
Procarbazine
2.
Matulane
3.
Natulan
4.
Procarbazine Hydrochloride
5.
Procarbazine Monohydrobromide
6.
Procarbazine Monohydrochloride
7.
Hydrochloride, Procarbazine
8.
Monohydrobromide, Procarbazine
9.
Monohydrochloride, Procarbazine
External Link(s)
| MeSH | D011344 |
| PubChem Compound | 441273 9703 74764326 |
| BindingDB | 50247906 |
| ChEBI | 71428 |
| CHEMBL | CHEMBL1200410 |
| KEGG | cpd:C07376 dr:D00478 |
Adverse Drug Event(s)
| Name | Number of Reports | Reference(s) | Data Source | |
|---|---|---|---|---|
| 1 | Nausea | FAERS: 146 | US FAERS | |
| 2 | Fatigue | FAERS: 100 | US FAERS | |
| 3 | Disease Progression | FAERS: 54 | US FAERS | |
| 4 | Blood count abnormal | FAERS: 46 | US FAERS | |
| 5 | Vomiting | FAERS: 43 | US FAERS | |
| 6 | Constipation | FAERS: 40 | US FAERS | |
| 7 | White blood cell count decreased | FAERS: 33 | US FAERS | |
| 8 | Drug ineffective | FAERS: 21 | US FAERS | |
| 9 | Urticaria | FAERS: 21 | US FAERS | |
| 10 | Dizziness | FAERS: 18 | US FAERS | |
| 11 | Headache | FAERS: 18 | US FAERS | |
| 12 | Pneumonia | FAERS: 15 | US FAERS | |
| 13 | Asthenia | FAERS: 14 | US FAERS | |
| 14 | Dehydration | FAERS: 14 | US FAERS | |
| 15 | Neutropenia | FAERS: 13 | US FAERS | |
| 16 | Nonspecific reaction | FAERS: 13 | US FAERS | |
| 17 | Malaise | FAERS: 12 | US FAERS | |
| 18 | Malignant neoplasm progression | FAERS: 12 | US FAERS | |
| 19 | Pain | FAERS: 12 | US FAERS | |
| 20 | Abdominal Pain | FAERS: 10 | US FAERS | |
| 21 | Febrile Neutropenia | FAERS: 8 | US FAERS | |
| 22 | Infection | FAERS: 8 | US FAERS | |
| 23 | Cerebrovascular accident | FAERS: 7 | US FAERS | |
| 24 | Myalgia | FAERS: 7 | US FAERS | |
| 25 | Stomatitis | FAERS: 7 | US FAERS | |
| 26 | Weight decreased | FAERS: 7 | US FAERS | |
| 27 | Hypersensitivity | FAERS: 6 | US FAERS | |
| 28 | Adverse event | FAERS: 5 | US FAERS | |
| 29 | Alopecia | FAERS: 5 | US FAERS | |
| 30 | Arthralgia | FAERS: 5 | US FAERS | |
| 31 | Pancytopenia | FAERS: 5 | US FAERS | |
| 32 | Peripheral swelling | FAERS: 5 | US FAERS | |
| 33 | Sepsis | FAERS: 5 | US FAERS | |
| 34 | Hypotension | FAERS: 4 | US FAERS | |
| 35 | Influenza | FAERS: 4 | US FAERS | |
| 36 | Lymphoma | FAERS: 4 | US FAERS | |
| 37 | Pruritus | FAERS: 4 | US FAERS | |
| 38 | Pulmonary Embolism | FAERS: 4 | US FAERS | |
| 39 | Thrombosis | FAERS: 4 | US FAERS | |
| 40 | Tremor | FAERS: 4 | US FAERS | |
| 41 | Abdominal discomfort | FAERS: 3 | US FAERS | |
| 42 | Bone pain | FAERS: 3 | US FAERS | |
| 43 | Intestinal Obstruction | FAERS: 3 | US FAERS | |
| 44 | Lethargy | FAERS: 3 | US FAERS | |
| 45 | Leukopenia | FAERS: 3 | US FAERS | |
| 46 | Syncope | FAERS: 3 | US FAERS | |
| 47 | Thrombocytopenia | FAERS: 3 | US FAERS | |
| 48 | Agitation | FAERS: 2 | US FAERS | |
| 49 | Back Pain | FAERS: 2 | US FAERS | |
| 50 | Blood creatinine increased | FAERS: 2 | US FAERS | |
| 51 | Blood glucose increased | FAERS: 2 | US FAERS | |
| 52 | Blood potassium decreased | FAERS: 2 | US FAERS | |
| 53 | Blood sodium decreased | FAERS: 2 | US FAERS | |
| 54 | Burning sensation | FAERS: 2 | US FAERS | |
| 55 | Chest Pain | FAERS: 2 | US FAERS | |
| 56 | Chills | FAERS: 2 | US FAERS | |
| 57 | Clostridium difficile colitis | FAERS: 2 | US FAERS | |
| 58 | Clostridium difficile infection | FAERS: 2 | US FAERS | |
| 59 | Deep Vein Thrombosis | FAERS: 2 | US FAERS | |
| 60 | Device related infection | FAERS: 2 | US FAERS | |
| 61 | Drug dose omission | FAERS: 2 | US FAERS | |
| 62 | Dysgeusia | FAERS: 2 | US FAERS | |
| 63 | Dyspepsia | FAERS: 2 | US FAERS | |
| 64 | Full blood count decreased | FAERS: 2 | US FAERS | |
| 65 | Hyperthyroidism | FAERS: 2 | US FAERS | |
| 66 | Memory impairment | FAERS: 2 | US FAERS | |
| 67 | Nasopharyngitis | FAERS: 2 | US FAERS | |
| 68 | Nerve injury | FAERS: 2 | US FAERS | |
| 69 | Neurological infection | FAERS: 2 | US FAERS | |
| 70 | Pain of skin | FAERS: 2 | US FAERS | |
| 71 | Respiratory Failure | FAERS: 2 | US FAERS | |
| 72 | Septic Shock | FAERS: 2 | US FAERS | |
| 73 | Unevaluable event | FAERS: 2 | US FAERS | |
| 74 | Visual Impairment | FAERS: 2 | US FAERS | |
| 75 | Abasia | FAERS: 1 | US FAERS | |
| 76 | Acne | FAERS: 1 | US FAERS | |
| 77 | Allergy to arthropod bite | FAERS: 1 | US FAERS | |
| 78 | Ammonia increased | FAERS: 1 | US FAERS | |
| 79 | Amnesia | FAERS: 1 | US FAERS | |
| 80 | Anger | FAERS: 1 | US FAERS | |
| 81 | Angina Pectoris | FAERS: 1 | US FAERS | |
| 82 | Anxiety | FAERS: 1 | US FAERS | |
| 83 | Atrial Fibrillation | FAERS: 1 | US FAERS | |
| 84 | Blood count normal | FAERS: 1 | US FAERS | |
| 85 | Cardiac Arrest | FAERS: 1 | US FAERS | |
| 86 | Cardiotoxicity | FAERS: 1 | US FAERS | |
| 87 | Cholecystitis | FAERS: 1 | US FAERS | |
| 88 | Colitis | FAERS: 1 | US FAERS | |
| 89 | Completed Suicide | FAERS: 1 | US FAERS | |
| 90 | Diffuse Large B-Cell Lymphoma | FAERS: 1 | US FAERS | |
| 91 | Disorientation | FAERS: 1 | US FAERS | |
| 92 | Dry skin | FAERS: 1 | US FAERS | |
| 93 | Epistaxis | FAERS: 1 | US FAERS | |
| 94 | Eructation | FAERS: 1 | US FAERS | |
| 95 | Erythema | FAERS: 1 | US FAERS | |
| 96 | Escherichia infection | FAERS: 1 | US FAERS | |
| 97 | Failure to Thrive | FAERS: 1 | US FAERS | |
| 98 | Feeling Cold | FAERS: 1 | US FAERS | |
| 99 | Gait inability | FAERS: 1 | US FAERS | |
| 100 | Glioblastoma | FAERS: 1 | US FAERS | |
| 101 | Glioma | FAERS: 1 | US FAERS | |
| 102 | Heart alternation | FAERS: 1 | US FAERS | |
| 103 | Heat Exhaustion | FAERS: 1 | US FAERS | |
| 104 | Hospice Care | FAERS: 1 | US FAERS | |
| 105 | Hyperchlorhydria | FAERS: 1 | US FAERS | |
| 106 | Hypoxia | FAERS: 1 | US FAERS | |
| 107 | Immunosuppression | FAERS: 1 | US FAERS | |
| 108 | Joint swelling | FAERS: 1 | US FAERS | |
| 109 | Lobar Pneumonia | FAERS: 1 | US FAERS | |
| 110 | Lymphadenopathy | FAERS: 1 | US FAERS | |
| 111 | MYELODYSPLASTIC SYNDROME | FAERS: 1 | US FAERS | |
| 112 | Medication Error | FAERS: 1 | US FAERS | |
| 113 | Mental status changes | FAERS: 1 | US FAERS | |
| 114 | Mood swings | FAERS: 1 | US FAERS | |
| 115 | Muscle tightness | FAERS: 1 | US FAERS | |
| 116 | Musculoskeletal stiffness | FAERS: 1 | US FAERS | |
| 117 | Myocardial Infarction | FAERS: 1 | US FAERS | |
| 118 | Nervousness | FAERS: 1 | US FAERS | |
| 119 | Neutrophil count decreased | FAERS: 1 | US FAERS | |
| 120 | Night sweats | FAERS: 1 | US FAERS | |
| 121 | No adverse event | FAERS: 1 | US FAERS | |
| 122 | Oral pain | FAERS: 1 | US FAERS | |
| 123 | Oropharyngeal pain | FAERS: 1 | US FAERS | |
| 124 | Pancreatitis | FAERS: 1 | US FAERS | |
| 125 | Pathogen resistance | FAERS: 1 | US FAERS | |
| 126 | Peripheral arterial occlusive disease | FAERS: 1 | US FAERS | |
| 127 | Peripheral paralysis | FAERS: 1 | US FAERS | |
| 128 | Pneumonitis | FAERS: 1 | US FAERS | |
| 129 | Rhinitis | FAERS: 1 | US FAERS | |
| 130 | Skin Ulcer | FAERS: 1 | US FAERS | |
| 131 | Skin irritation | FAERS: 1 | US FAERS | |
| 132 | Tachycardia | FAERS: 1 | US FAERS | |
| 133 | Thermal burn | FAERS: 1 | US FAERS | |
| 134 | Throat irritation | FAERS: 1 | US FAERS | |
| 135 | Toothache | FAERS: 1 | US FAERS | |
| 136 | Toxicity to various agents | FAERS: 1 | US FAERS | |
| 137 | Ulcer | FAERS: 1 | US FAERS | |
| 138 | Unresponsive to stimuli | FAERS: 1 | US FAERS | |
| 139 | Urinary Retention | FAERS: 1 | US FAERS | |
| 140 | Urinary tract infection | FAERS: 1 | US FAERS | |
| 141 | White blood cell count abnormal | FAERS: 1 | US FAERS | |
| 142 | effusion | FAERS: 1 | US FAERS |
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