MetaADEDB 2.0 @ LMMD
Megestrol Acetate
(RQZAXGRLVPAYTJ-GQFGMJRRSA-N)
Structure
SMILES
O=C1CC[C@]2(C(=C1)C(=C[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@]2(OC(=O)C)C(=O)C)C)C)C
Type(s)
Approved; Investigational; Vet_approved
ATC code(s)
G03AA04; G03AB01; G03AC05; G03DB02; G03FA08; G03FB04; L02AB01
Molecular Formula:
C24H32O4
Molecular Weight:
384.508
Log P:
4.5753
Hydrogen Bond Acceptor:
4
Hydrogen Bond Donor:
0
TPSA:
60.44
CAS Number(s):
595-33-5
Synonym(s)
1.
Megestrol Acetate
2.
Apo-Megestrol
3.
Borea
4.
Lin-Megestrol
5.
Maygace
6.
Megace
7.
Megefren
8.
Megestat
9.
Megostat
10.
Mestrel
11.
Nu-Megestrol
12.
Acetate, Megestrol
13.
Apo Megestrol
14.
ApoMegestrol
15.
Lin Megestrol
16.
LinMegestrol
17.
Nu Megestrol
18.
NuMegestrol
External Link(s)
MeSHD019290
PubChem Compound11683
ChEBI6723
CHEMBLCHEMBL1201139
DrugBankDB00351
DrugCentral1667
KEGGcpd:C08151
dr:D00952
ZINC4097467
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Deep Vein ThrombosisFAERS: 120US FAERS
2Malignant neoplasm progressionFAERS: 53OFFSIDES
US FAERS
3Pulmonary EmbolismFAERS: 34
Canada Vigilance: 1		Canada Vigilance
US FAERS
4ThrombosisFAERS: 22US FAERS
5AstheniaFAERS: 19OFFSIDES
US FAERS
6MeningiomaFAERS: 1919731987CTD
US FAERS
7Drug ineffectiveFAERS: 17US FAERS
8Weight decreasedFAERS: 17US FAERS
9Cerebrovascular accidentFAERS: 11US FAERS
10VomitingFAERS: 11
Canada Vigilance: 1		Canada Vigilance
US FAERS
11HypotensionFAERS: 10US FAERS
12NauseaFAERS: 10OFFSIDES
US FAERS
13Product taste abnormalFAERS: 9US FAERS
14DizzinessFAERS: 7OFFSIDES
US FAERS
15Blood glucose increasedFAERS: 6US FAERS
16DehydrationFAERS: 6
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
US FAERS
17FatigueFAERS: 6OFFSIDES
US FAERS
18HypogonadismFAERS: 6US FAERS
19Product use in unapproved indicationFAERS: 6US FAERS
20Pulmonary FibrosisFAERS: 6US FAERS
21CachexiaFAERS: 5US FAERS
22Diabetes MellitusFAERS: 5US FAERS
23DysgeusiaFAERS: 5US FAERS
24Feeling abnormalFAERS: 5US FAERS
25PneumoniaFAERS: 5US FAERS
26Adverse eventFAERS: 4US FAERS
27Blood cortisol decreasedFAERS: 4US FAERS
28Burning sensationFAERS: 4US FAERS
29DeliriumFAERS: 4US FAERS
30HeadacheFAERS: 4US FAERS
31ImpatienceFAERS: 4US FAERS
32Medication ErrorFAERS: 4US FAERS
33Memory impairmentFAERS: 4US FAERS
34Mental status changesFAERS: 4OFFSIDES
US FAERS
35Myocardial InfarctionFAERS: 4US FAERS
36OverdoseFAERS: 4US FAERS
37PregnancyFAERS: 4US FAERS
38Product quality issueFAERS: 4US FAERS
39Sinus TachycardiaFAERS: 4US FAERS
40Urinary tract infectionFAERS: 4US FAERS
41AgitationFAERS: 3US FAERS
42AnxietyFAERS: 3OFFSIDES
US FAERS
43ArthralgiaFAERS: 3US FAERS
44Chest PainFAERS: 3
Canada Vigilance: 2		Canada Vigilance
US FAERS
45Disease complicationFAERS: 3US FAERS
46Erectile dysfunctionFAERS: 3US FAERS
47Failure to ThriveFAERS: 3OFFSIDES
US FAERS
48FlatulenceFAERS: 3US FAERS
49InfectionFAERS: 3OFFSIDES
US FAERS
50Joint swellingFAERS: 3US FAERS
51Maternal exposure during pregnancyFAERS: 3US FAERS
52Night sweatsFAERS: 3US FAERS
53Pancreatic carcinomaFAERS: 3US FAERS
54PhlebitisFAERS: 3US FAERS
55Product use issueFAERS: 3US FAERS
56TremorFAERS: 3US FAERS
57kyphosisFAERS: 3US FAERS
58Abdominal discomfortFAERS: 2US FAERS
59AlopeciaFAERS: 2US FAERS
60AngerFAERS: 2US FAERS
61AnorexiaFAERS: 2OFFSIDES
US FAERS
62Back PainFAERS: 2
Canada Vigilance: 1		Canada Vigilance
US FAERS
63BronchitisFAERS: 2OFFSIDES
US FAERS
64ChokingFAERS: 2US FAERS
65Cor pulmonaleFAERS: 2US FAERS
66Coronary Artery DiseaseFAERS: 2US FAERS
67DementiaFAERS: 2US FAERS
68Disease recurrenceFAERS: 2US FAERS
69Drug dispensing errorFAERS: 2US FAERS
70General physical health deteriorationFAERS: 2OFFSIDES
US FAERS
71Impaired work abilityFAERS: 2OFFSIDES
US FAERS
72Incorrect dose administeredFAERS: 2US FAERS
73LethargyFAERS: 2OFFSIDES
US FAERS
74MalaiseFAERS: 2US FAERS
75Metastatic Renal Cell CarcinomaFAERS: 2US FAERS
76OsteoporosisFAERS: 2US FAERS
77Portal Vein ThrombosisFAERS: 2US FAERS
78Pulmonary thrombosisFAERS: 2US FAERS
79Renal painFAERS: 2US FAERS
80Respiratory arrestFAERS: 2US FAERS
81Restrictive pulmonary diseaseFAERS: 2US FAERS
82Retinal DetachmentFAERS: 2US FAERS
83SepsisFAERS: 2US FAERS
84SomnolenceFAERS: 2US FAERS
85Steroid withdrawal syndromeFAERS: 2US FAERS
86Stevens-Johnson SyndromeFAERS: 2US FAERS
87SwellingFAERS: 2US FAERS
88TachycardiaFAERS: 2US FAERS
89Therapy cessationFAERS: 2US FAERS
90Unevaluable eventFAERS: 2US FAERS
91Vaginal DischargeFAERS: 2US FAERS
92Wheelchair userFAERS: 2US FAERS
93AbasiaFAERS: 1OFFSIDES
US FAERS
94Abdominal PainFAERS: 1OFFSIDES
US FAERS
95Accidental exposureFAERS: 1US FAERS
96AcidosisFAERS: 1OFFSIDES
US FAERS
97AcneFAERS: 1OFFSIDES
US FAERS
98Activities of daily living impairedFAERS: 1OFFSIDES
US FAERS
99AgeusiaFAERS: 1US FAERS
100AkathisiaFAERS: 1US FAERS
101Alanine Aminotransferase IncreasedFAERS: 1US FAERS
102Altered state of consciousnessFAERS: 1US FAERS
103Anaphylactic shockFAERS: 1US FAERS
104AngioedemaFAERS: 1US FAERS
105AnhedoniaFAERS: 1OFFSIDES
US FAERS
106Anticonvulsant drug level increasedFAERS: 1US FAERS
107AscitesFAERS: 1OFFSIDES
US FAERS
108Aspartate Aminotransferase IncreasedFAERS: 1US FAERS
109AsphyxiaFAERS: 1US FAERS
110AsthmaFAERS: 1OFFSIDES
US FAERS
111Atrial FibrillationFAERS: 1US FAERS
112Bacterial test positiveFAERS: 1US FAERS
113Blood Corticotrophin DecreasedFAERS: 1US FAERS
114Blood chloride decreasedFAERS: 1US FAERS
115Blood cortisol abnormalFAERS: 1US FAERS
116Blood creatinine increasedFAERS: 1OFFSIDES
US FAERS
117Blood potassium decreasedFAERS: 1OFFSIDES
US FAERS
118Blood testosterone increasedFAERS: 1US FAERS
119Blood triglycerides increasedFAERS: 1US FAERS
120Blood urine presentFAERS: 1US FAERS
121Bone density increasedFAERS: 1US FAERS
122BronchiectasisFAERS: 1US FAERS
123Budd-Chiari SyndromeFAERS: 1US FAERS
124Carpal Tunnel SyndromeFAERS: 1US FAERS
125Cerebral InfarctionFAERS: 1US FAERS
126Cerebral atrophyFAERS: 1OFFSIDES
US FAERS
127Chest discomfortFAERS: 1US FAERS
128ConstipationFAERS: 1US FAERS
129Cortisol decreasedFAERS: 1US FAERS
130Cortisol free urine abnormalFAERS: 1US FAERS
131Creatine urine increasedFAERS: 1US FAERS
132Creatinine renal clearance decreasedFAERS: 1US FAERS
133CyanosisFAERS: 1US FAERS
134Cystitis escherichiaFAERS: 1US FAERS
135Depressed Level of ConsciousnessFAERS: 1US FAERS
136Disease ProgressionFAERS: 1OFFSIDES
US FAERS
137DisorientationFAERS: 1US FAERS
138Drug ineffective for unapproved indicationFAERS: 1US FAERS
139Drug toxicityFAERS: 1US FAERS
140DysarthriaFAERS: 1US FAERS
141DyspepsiaFAERS: 1US FAERS
142EcchymosisFAERS: 1US FAERS
143Ejection Fraction DecreasedFAERS: 1OFFSIDES
US FAERS
144Enterocutaneous FistulaFAERS: 1US FAERS
145EructationFAERS: 1US FAERS
146Escherichia sepsisFAERS: 1OFFSIDES
US FAERS
147Feeding tube complicationFAERS: 1US FAERS
148FlushingFAERS: 1US FAERS
149Food cravingFAERS: 1US FAERS
150GlossitisFAERS: 1US FAERS
151Glucocorticoids abnormalFAERS: 1US FAERS
152Hepatitis CFAERS: 1US FAERS
153HyperthyroidismFAERS: 1US FAERS
154HypophagiaFAERS: 1US FAERS
155Hypothalamo-pituitary disorderFAERS: 1US FAERS
156Incorrect product storageFAERS: 1US FAERS
157Intentional drug misuseFAERS: 1US FAERS
158Intercepted medication errorFAERS: 1US FAERS
159Intracranial HypotensionFAERS: 1US FAERS
160Joint stiffnessFAERS: 1US FAERS
161LeukopeniaFAERS: 1US FAERS
162Libido disorderFAERS: 1US FAERS
163Liquid product physical issueFAERS: 1US FAERS
164Lower respiratory tract infectionFAERS: 1US FAERS
165MenorrhagiaFAERS: 1US FAERS
166Mental impairmentFAERS: 1US FAERS
167Metabolic acidosisFAERS: 1OFFSIDES
US FAERS
168MetrorrhagiaFAERS: 1US FAERS
169Mood swingsFAERS: 1US FAERS
170Musculoskeletal chest painFAERS: 1OFFSIDES
US FAERS
171Musculoskeletal stiffnessFAERS: 1US FAERS
172NasopharyngitisFAERS: 1US FAERS
173Neck PainFAERS: 1US FAERS
174No adverse eventFAERS: 1US FAERS
175PalpitationsFAERS: 1US FAERS
176Pericardial effusionFAERS: 1US FAERS
177Personality ChangeFAERS: 1US FAERS
178Pharmaceutical product complaintFAERS: 1US FAERS
179Pharyngolaryngeal PainFAERS: 1US FAERS
180Physical assaultFAERS: 1US FAERS
181Procedural complicationFAERS: 1US FAERS
182Protein total decreasedFAERS: 1OFFSIDES
US FAERS
183PruritusFAERS: 1US FAERS
184Pulmonary granulomaFAERS: 1US FAERS
185Respiratory FailureFAERS: 1OFFSIDES
US FAERS
186Respiratory distressFAERS: 1US FAERS
187Respiratory tract congestionFAERS: 1US FAERS
188Septic ShockFAERS: 1OFFSIDES
US FAERS
189SerositisFAERS: 1US FAERS
190Sexual DysfunctionFAERS: 1US FAERS
191ShockFAERS: 1US FAERS
192Skin UlcerFAERS: 1US FAERS
193Sperm count decreasedFAERS: 1US FAERS
194SyncopeFAERS: 1US FAERS
195Therapeutic response unexpectedFAERS: 1US FAERS
196ThirstFAERS: 1US FAERS
197Throat irritationFAERS: 1US FAERS
198Treatment related secondary malignancyFAERS: 1US FAERS
199Unresponsive to stimuliFAERS: 1OFFSIDES
US FAERS
200Urine leukocyte esterase positiveFAERS: 1US FAERS
201UrticariaFAERS: 1US FAERS
202Venous thrombosis limbFAERS: 1US FAERS
203Visual ImpairmentFAERS: 1US FAERS
204Vitamin D DeficiencyFAERS: 1US FAERS
205WheezingFAERS: 1US FAERS
206Wiskott-Aldrich SyndromeFAERS: 1US FAERS
207jaundiceFAERS: 1US FAERS
208treatment failureFAERS: 1US FAERS
209Abnormal visionOFFSIDES
210AbscessOFFSIDES
211Acid refluxOFFSIDES
212Acute kidney injuryCanada Vigilance: 1Canada Vigilance
213Acute respiratory failureOFFSIDES
214AdenocarcinomaOFFSIDES
215AphagiaOFFSIDES
216ArteriosclerosisOFFSIDES
217ArthropathyOFFSIDES
218Aspiration PneumoniaOFFSIDES
219AtelectasisOFFSIDES
220Atrial tachycardiaOFFSIDES
221BK virus infectionOFFSIDES
222Bacteria urine identifiedOFFSIDES
223Biopsy bladder abnormalOFFSIDES
224Blood GlucoseOFFSIDES
225Blood albumin decreasedOFFSIDES
226Blood glucose abnormalOFFSIDES
227Blood glucose decreasedOFFSIDES
228Blood osmolarity decreasedOFFSIDES
229Blood potassium increasedOFFSIDES
230Blood sodiumOFFSIDES
231Blood uric acid decreasedOFFSIDES
232Bone density decreasedOFFSIDES
233Bone erosionOFFSIDES
234Bone lesionOFFSIDES
235Bone scan abnormalOFFSIDES
236Bone swellingOFFSIDES
237BursitisOFFSIDES
238Candida sepsisOFFSIDES
239Carcinoembryonic antigen increasedOFFSIDES
240Cardiovascular Diseases3284149CTD
241Cataract operationOFFSIDES
242CataractOFFSIDES
243CatatoniaOFFSIDES
244Catheter related complicationOFFSIDES
245Catheter related infectionOFFSIDES
246Catheter site infectionOFFSIDES
247CellulitisOFFSIDES
248Choking sensationOFFSIDES
249Chronic Obstructive Airway DiseaseOFFSIDES
250Clostridium difficile colitisOFFSIDES
251ConfabulationOFFSIDES
252Congenital tricuspid valve incompetenceOFFSIDES
253Cushing Syndrome8522428CTD
254DeafnessOFFSIDES
255DebridementOFFSIDES
256DemyelinationOFFSIDES
257Device related infectionOFFSIDES
258DiarrheaOFFSIDES
259DiplopiaOFFSIDES
260DrowsinessOFFSIDES
261DuodenitisOFFSIDES
262Economic problemOFFSIDES
263Electromechanical dissociationOFFSIDES
264EmbolismOFFSIDES
265EndocarditisOFFSIDES
266Endodontic procedureOFFSIDES
267Endometrial Neoplasms11559956CTD
268Endotracheal intubation complicationOFFSIDES
269Enterococcal sepsisOFFSIDES
270EpistaxisOFFSIDES
271Epstein-Barr virus associated lymphoproliferative disorderOFFSIDES
272EscharOFFSIDES
273Extremity contractureOFFSIDES
274Eye painOFFSIDES
275Facial NeuralgiaOFFSIDES
276Febrile NeutropeniaOFFSIDES
277Feeling of body temperature changeOFFSIDES
278Feminization3284149CTD
279Flank PainOFFSIDES
280Fluid overloadOFFSIDES
281Fluid replacementOFFSIDES
282FolliculitisOFFSIDES
283GastroenteritisOFFSIDES
284GlaucomaOFFSIDES
285GoutOFFSIDES
286Granulocyte count increasedOFFSIDES
287GranulocytosisOFFSIDES
288HiccoughOFFSIDES
289High frequency ablationOFFSIDES
290HordeolumOFFSIDES
291HydronephrosisOFFSIDES
292HypercreatininaemiaOFFSIDES
293Hypoaesthesia facialOFFSIDES
294Hypocoagulable stateOFFSIDES
295HyporeflexiaOFFSIDES
296ImmunosuppressionOFFSIDES
297Impaired gastric emptyingOFFSIDES
298Implant site reactionOFFSIDES
299IncontinenceOFFSIDES
300Infusion site mobility decreasedOFFSIDES
301Injection site cellulitisOFFSIDES
302Injection site phlebitisOFFSIDES
303Intermittent ClaudicationOFFSIDES
304Intervertebral Disc DegenerationOFFSIDES
305Joint Range of Motion DecreasedOFFSIDES
306Kidney FailureOFFSIDES
307Limb injuryOFFSIDES
308Loose toothOFFSIDES
309Lumbar radiculopathyOFFSIDES
310Lung consolidationOFFSIDES
311Mass excisionOFFSIDES
312Mastication disorderOFFSIDES
313Metastatic NeoplasmOFFSIDES
314Multiple MyelomaOFFSIDES
315Muscle WeaknessOFFSIDES
316Muscle strainOFFSIDES
317Musculoskeletal discomfortOFFSIDES
318MyelodysplasiaOFFSIDES
319Neoplasms, Hormone-Dependent12058236CTD
320Nephrogenic Fibrosing DermopathyOFFSIDES
321NeuralgiaOFFSIDES
322Neutropenic sepsisOFFSIDES
323Neutrophil count decreasedOFFSIDES
324OliguriaOFFSIDES
325Optic NeuropathyOFFSIDES
326Osteitis DeformansOFFSIDES
327OsteomyelitisOFFSIDES
328OsteopeniaOFFSIDES
329OsteosclerosisOFFSIDES
330PO2 decreasedOFFSIDES
331PainOFFSIDES
332PallorOFFSIDES
333PancreatitisOFFSIDES
334PeriodontitisOFFSIDES
335Physical disabilityOFFSIDES
336Polymyalgia RheumaticaOFFSIDES
337Poor personal hygieneOFFSIDES
338Portal hypertensive gastropathyOFFSIDES
339Recall phenomenonOFFSIDES
340Renal cystOFFSIDES
341Retinal Vein OcclusionOFFSIDES
342Retinoic acid syndromeOFFSIDES
343Risus sardonicusOFFSIDES
344SequestrectomyOFFSIDES
345SinusitisOFFSIDES
346Skin IndurationOFFSIDES
347Skin hypertrophyOFFSIDES
348Skin lesionOFFSIDES
349Spinal column stenosisOFFSIDES
350SpondylitisOFFSIDES
351Supraventricular tachycardiaOFFSIDES
352Synovial CystOFFSIDES
353ThrombophlebitisOFFSIDES
354Thrombosis in deviceOFFSIDES
355Tooth ExtractionOFFSIDES
356Urethral StenosisOFFSIDES
357Urine ketone body presentOFFSIDES
358Venous Thrombosis11559956CTD
359Ventricular FibrillationOFFSIDES
360Ventricular hypokinesiaOFFSIDES
361Vitamin B 12 DeficiencyOFFSIDES
362Vitreous DetachmentOFFSIDES
363Walking aid userOFFSIDES
364White blood cell count abnormalOFFSIDES
365Wound dehiscenceOFFSIDES
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