MetaADEDB 2.0 @ LMMD
ceritinib
(VERWOWGGCGHDQE-UHFFFAOYSA-N)
Structure
SMILES
CC(Oc1cc(C2CCNCC2)c(cc1Nc1ncc(c(n1)Nc1ccccc1S(=O)(=O)C(C)C)Cl)C)C
Type(s)
Approved
ATC code(s)
L01XE28
Molecular Formula:
C28H36ClN5O3S
Molecular Weight:
558.135
Log P:
7.9175
Hydrogen Bond Acceptor:
6
Hydrogen Bond Donor:
3
TPSA:
113.62
CAS Number(s):
1032900-25-6; 1190399-48-4
Synonym(s)
1.
ceritinib
2.
5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine
3.
LDK378
4.
Zykadia
External Link(s)
MeSHC586847
PubChem Compound57379345
BindingDB50436850
ChEBI78432
CHEMBLCHEMBL2403108
DrugBankDB09063
DrugCentral4866
IUPHAR/BPS Guide to PHARMACOLOGY7397
KEGGdr:D10551
Therapeutic Target DatabaseD04LVK
D0KJ9P
ZINC96272772
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Malignant neoplasm progressionFAERS: 275
Canada Vigilance: 5
Canada Vigilance
US FAERS
2NauseaFAERS: 191
Canada Vigilance: 7
Canada Vigilance
US FAERS
3VomitingFAERS: 124
Canada Vigilance: 3
Canada Vigilance
US FAERS
4Disease ProgressionFAERS: 78
Canada Vigilance: 1
Canada Vigilance
US FAERS
5Abdominal PainFAERS: 59
Canada Vigilance: 1
Canada Vigilance
US FAERS
6FatigueFAERS: 54
Canada Vigilance: 7
Canada Vigilance
US FAERS
7MalaiseFAERS: 36
Canada Vigilance: 4
Canada Vigilance
US FAERS
8Chest PainFAERS: 35US FAERS
9General physical health deteriorationFAERS: 34
Canada Vigilance: 1
Canada Vigilance
US FAERS
10Alanine Aminotransferase IncreasedFAERS: 33
Canada Vigilance: 1
Canada Vigilance
US FAERS
11Aspartate Aminotransferase IncreasedFAERS: 30
Canada Vigilance: 1
Canada Vigilance
US FAERS
12Blood creatinine increasedFAERS: 30
Canada Vigilance: 1
Canada Vigilance
US FAERS
13PneumoniaFAERS: 29US FAERS
14Drug ineffectiveFAERS: 28
Canada Vigilance: 2
Canada Vigilance
US FAERS
15Pericardial effusionFAERS: 27US FAERS
16Blood alkaline phosphatase increasedFAERS: 26US FAERS
17PericarditisFAERS: 26
Canada Vigilance: 1
Canada Vigilance
US FAERS
18Weight decreasedFAERS: 25US FAERS
19AstheniaFAERS: 22
Canada Vigilance: 1
Canada Vigilance
US FAERS
20ConstipationFAERS: 20
Canada Vigilance: 1
Canada Vigilance
US FAERS
21Gamma-Glutamyltransferase IncreasedFAERS: 19US FAERS
22Abdominal discomfortFAERS: 18
Canada Vigilance: 2
Canada Vigilance
US FAERS
23PneumonitisFAERS: 18US FAERS
24DehydrationFAERS: 16
Canada Vigilance: 1
Canada Vigilance
US FAERS
25HeadacheFAERS: 16US FAERS
26DizzinessFAERS: 13
Canada Vigilance: 2
Canada Vigilance
US FAERS
27Pulmonary EmbolismFAERS: 13US FAERS
28Blood glucose increasedFAERS: 12
Canada Vigilance: 2
Canada Vigilance
US FAERS
29PainFAERS: 12US FAERS
30Feeling abnormalFAERS: 11
Canada Vigilance: 1
Canada Vigilance
US FAERS
31Gastrointestinal toxicityFAERS: 10US FAERS
32InfectionFAERS: 10US FAERS
33ArthralgiaFAERS: 9
Canada Vigilance: 1
Canada Vigilance
US FAERS
34Drug resistanceFAERS: 9US FAERS
35NasopharyngitisFAERS: 9US FAERS
36Product use issueFAERS: 9US FAERS
37Transaminases increasedFAERS: 9US FAERS
38Central nervous system lesionFAERS: 8US FAERS
39MyalgiaFAERS: 8US FAERS
40Pleuritic painFAERS: 8US FAERS
41Urinary tract infectionFAERS: 8US FAERS
42Altered state of consciousnessFAERS: 7US FAERS
43NeutropeniaFAERS: 7US FAERS
44ThrombosisFAERS: 7
Canada Vigilance: 1
Canada Vigilance
US FAERS
45Wrong technique in product usage processFAERS: 7US FAERS
46Acute kidney injuryFAERS: 6US FAERS
47AppendicitisFAERS: 6US FAERS
48Back PainFAERS: 6US FAERS
49CholestasisFAERS: 6US FAERS
50DysgeusiaFAERS: 6US FAERS
51HepatotoxicityFAERS: 6US FAERS
52Intestinal PerforationFAERS: 6US FAERS
53Myocardial InfarctionFAERS: 6
Canada Vigilance: 1
Canada Vigilance
US FAERS
54Product use in unapproved indicationFAERS: 6
Canada Vigilance: 1
Canada Vigilance
US FAERS
55Respiratory FailureFAERS: 6US FAERS
56White blood cell count decreasedFAERS: 6US FAERS
57Atrial FibrillationFAERS: 5US FAERS
58BronchitisFAERS: 5US FAERS
59Cardiac TamponadeFAERS: 5US FAERS
60Cerebral InfarctionFAERS: 5US FAERS
61Cerebrovascular accidentFAERS: 5US FAERS
62CholangitisFAERS: 5US FAERS
63FlatulenceFAERS: 5
Canada Vigilance: 1
Canada Vigilance
US FAERS
64HepatitisFAERS: 5US FAERS
65IleusFAERS: 5US FAERS
66InfluenzaFAERS: 5US FAERS
67MetastasisFAERS: 5
Canada Vigilance: 1
Canada Vigilance
US FAERS
68Musculoskeletal PainFAERS: 5
Canada Vigilance: 1
Canada Vigilance
US FAERS
69PancreatitisFAERS: 5US FAERS
70Peripheral swellingFAERS: 5
Canada Vigilance: 1
Canada Vigilance
US FAERS
71SepsisFAERS: 5US FAERS
72ThrombocytopeniaFAERS: 5US FAERS
73Toxicity to various agentsFAERS: 5US FAERS
74Visual ImpairmentFAERS: 5US FAERS
75AlopeciaFAERS: 4US FAERS
76Amylase increasedFAERS: 4US FAERS
77CholecystitisFAERS: 4US FAERS
78Concomitant disease aggravatedFAERS: 4US FAERS
79Diabetes MellitusFAERS: 4
Canada Vigilance: 1
Canada Vigilance
US FAERS
80DyspepsiaFAERS: 4US FAERS
81EnterocolitisFAERS: 4US FAERS
82ErythemaFAERS: 4US FAERS
83GastritisFAERS: 4
Canada Vigilance: 1
Canada Vigilance
US FAERS
84Lower respiratory tract infectionFAERS: 4US FAERS
85MeningitisFAERS: 4US FAERS
86Oral painFAERS: 4
Canada Vigilance: 1
Canada Vigilance
US FAERS
87Performance status decreasedFAERS: 4US FAERS
88PleurisyFAERS: 4US FAERS
89Respiratory distressFAERS: 4US FAERS
90SomnolenceFAERS: 4US FAERS
91ThirstFAERS: 4US FAERS
92ThrombocytosisFAERS: 4US FAERS
93AnxietyFAERS: 3US FAERS
94AscitesFAERS: 3US FAERS
95Blood lactate dehydrogenase increasedFAERS: 3US FAERS
96Blood potassium decreasedFAERS: 3US FAERS
97Bone painFAERS: 3US FAERS
98BradycardiaFAERS: 3US FAERS
99CachexiaFAERS: 3US FAERS
100Cell DeathFAERS: 3US FAERS
101Chest discomfortFAERS: 3US FAERS
102Concomitant disease progressionFAERS: 3US FAERS
103Depressed Level of ConsciousnessFAERS: 3US FAERS
104Diabetic KetoacidosisFAERS: 3US FAERS
105Drug effect incompleteFAERS: 3US FAERS
106DysarthriaFAERS: 3US FAERS
107Ejection Fraction DecreasedFAERS: 3US FAERS
108EpilepsyFAERS: 3US FAERS
109Gastrointestinal obstructionFAERS: 3US FAERS
110Incorrect dose administeredFAERS: 3US FAERS
111IntussusceptionFAERS: 3US FAERS
112LeukocytosisFAERS: 3US FAERS
113LymphadenopathyFAERS: 3
Canada Vigilance: 1
Canada Vigilance
US FAERS
114Metastases to adrenalsFAERS: 3US FAERS
115Neck PainFAERS: 3US FAERS
116No adverse eventFAERS: 3US FAERS
117Non-small cell lung cancer stage IIIBFAERS: 3US FAERS
118PalpitationsFAERS: 3US FAERS
119PeritonitisFAERS: 3US FAERS
120Product physical issueFAERS: 3US FAERS
121PyelonephritisFAERS: 3US FAERS
122RhabdomyolysisFAERS: 3US FAERS
123TachycardiaFAERS: 3US FAERS
124Therapy partial responderFAERS: 3US FAERS
125UrticariaFAERS: 3
Canada Vigilance: 1
Canada Vigilance
US FAERS
126WheezingFAERS: 3US FAERS
127AdenocarcinomaFAERS: 2US FAERS
128AgeusiaFAERS: 2
Canada Vigilance: 1
Canada Vigilance
US FAERS
129Blood bilirubin unconjugated increasedFAERS: 2US FAERS
130Blood creatine increasedFAERS: 2US FAERS
131Blood creatine phosphokinase increasedFAERS: 2US FAERS
132Blood sodium decreasedFAERS: 2
Canada Vigilance: 2
Canada Vigilance
US FAERS
133Bone lesionFAERS: 2US FAERS
134Carcinoembryonic antigen increasedFAERS: 2US FAERS
135Cardiac ArrestFAERS: 2US FAERS
136CardiomegalyFAERS: 2US FAERS
137CellulitisFAERS: 2US FAERS
138Cerebral disorderFAERS: 2US FAERS
139CholelithiasisFAERS: 2US FAERS
140Chronic gastritisFAERS: 2US FAERS
141Cold sweatFAERS: 2US FAERS
142CystitisFAERS: 2US FAERS
143Disseminated Intravascular CoagulationFAERS: 2US FAERS
144Dry skinFAERS: 2US FAERS
145EczemaFAERS: 2US FAERS
146EpididymitisFAERS: 2US FAERS
147Failure to ThriveFAERS: 2US FAERS
148FibrosisFAERS: 2
Canada Vigilance: 1
Canada Vigilance
US FAERS
149Fluid overloadFAERS: 2US FAERS
150Food PoisoningFAERS: 2US FAERS
151Gait inabilityFAERS: 2
Canada Vigilance: 1
Canada Vigilance
US FAERS
152Gastrointestinal PainFAERS: 2US FAERS
153Gastrointestinal infectionFAERS: 2US FAERS
154General physical condition abnormalFAERS: 2US FAERS
155HemiplegiaFAERS: 2US FAERS
156Hepatic necrosisFAERS: 2US FAERS
157Inappropriate schedule of drug administrationFAERS: 2US FAERS
158Incorrect route of drug administrationFAERS: 2US FAERS
159InflammationFAERS: 2US FAERS
160Intestinal ObstructionFAERS: 2US FAERS
161LethargyFAERS: 2US FAERS
162Limb discomfortFAERS: 2
Canada Vigilance: 1
Canada Vigilance
US FAERS
163Lipase increasedFAERS: 2US FAERS
164Metastatic NeoplasmFAERS: 2US FAERS
165Musculoskeletal stiffnessFAERS: 2
Canada Vigilance: 1
Canada Vigilance
US FAERS
166Neutrophil count decreasedFAERS: 2US FAERS
167Night sweatsFAERS: 2US FAERS
168Oral candidiasisFAERS: 2US FAERS
169OsteoporosisFAERS: 2US FAERS
170Palpable purpuraFAERS: 2US FAERS
171Pancreatic carcinomaFAERS: 2US FAERS
172Pancreatic enzymes increasedFAERS: 2US FAERS
173PancytopeniaFAERS: 2US FAERS
174ParaplegiaFAERS: 2US FAERS
175Pericarditis malignantFAERS: 2US FAERS
176Productive CoughFAERS: 2
Canada Vigilance: 1
Canada Vigilance
US FAERS
177ProteinuriaFAERS: 2US FAERS
178Pulmonary toxicityFAERS: 2US FAERS
179Sinus TachycardiaFAERS: 2US FAERS
180StomatitisFAERS: 2US FAERS
181Sudden deathFAERS: 2US FAERS
182Supraventricular tachycardiaFAERS: 2US FAERS
183SwellingFAERS: 2
Canada Vigilance: 1
Canada Vigilance
US FAERS
184SyncopeFAERS: 2US FAERS
185TachyarrhythmiaFAERS: 2US FAERS
186Therapy cessationFAERS: 2US FAERS
187Therapy non-responderFAERS: 2
Canada Vigilance: 3
Canada Vigilance
US FAERS
188Urinary RetentionFAERS: 2US FAERS
189Uterine CancerFAERS: 2US FAERS
190Viral pericarditisFAERS: 2US FAERS
191AbasiaFAERS: 1US FAERS
192Abdominal massFAERS: 1US FAERS
193Abdominal rigidityFAERS: 1US FAERS
194AcneFAERS: 1US FAERS
195Activities of daily living impairedFAERS: 1US FAERS
196Acute respiratory failureFAERS: 1US FAERS
197Adverse eventFAERS: 1US FAERS
198AngioedemaFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
199AnosmiaFAERS: 1US FAERS
200AnuriaFAERS: 1US FAERS
201AphasiaFAERS: 1US FAERS
202ArthritisFAERS: 1US FAERS
203AtelectasisFAERS: 1US FAERS
204Back disorderFAERS: 1US FAERS
205Bacterial sepsisFAERS: 1US FAERS
206Biliary dilatationFAERS: 1US FAERS
207Blighted ovumFAERS: 1US FAERS
208BlindnessFAERS: 1US FAERS
209Blood albumin increasedFAERS: 1US FAERS
210Blood beta-D-glucan increasedFAERS: 1US FAERS
211Blood count abnormalFAERS: 1US FAERS
212Bone marrow infiltrationFAERS: 1US FAERS
213Bone swellingFAERS: 1US FAERS
214Bowel movement irregularityFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
215Brain HypoxiaFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
216Bronchial secretion retentionFAERS: 1US FAERS
217BronchiectasisFAERS: 1US FAERS
218Bronchopulmonary AspergillosisFAERS: 1US FAERS
219Cancer PainFAERS: 1US FAERS
220Cauda Equina SyndromeFAERS: 1US FAERS
221Cerebral calcificationFAERS: 1US FAERS
222ChromaturiaFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
223DeafnessFAERS: 1US FAERS
224Deep Vein ThrombosisFAERS: 1US FAERS
225DementiaFAERS: 1US FAERS
226Desmoplastic melanomaFAERS: 1US FAERS
227Device related infectionFAERS: 1US FAERS
228Dilatation intrahepatic duct acquiredFAERS: 1US FAERS
229DisorientationFAERS: 1US FAERS
230DiverticulitisFAERS: 1US FAERS
231Drug administration errorFAERS: 1US FAERS
232Drug dose omissionFAERS: 1US FAERS
233DysuriaFAERS: 1US FAERS
234Electrolyte imbalanceFAERS: 1US FAERS
235Emotional disorderFAERS: 1US FAERS
236EncephalomalaciaFAERS: 1US FAERS
237Epigastric discomfortFAERS: 1US FAERS
238Eye painFAERS: 1US FAERS
239Fibrin D dimer decreasedFAERS: 1US FAERS
240FlushingFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
241Food cravingFAERS: 1US FAERS
242FractureFAERS: 1US FAERS
243GastroenteritisFAERS: 1US FAERS
244Gastrointestinal inflammationFAERS: 1US FAERS
245Gastrointestinal sounds abnormalFAERS: 1US FAERS
246Glucose tolerance increasedFAERS: 1US FAERS
247Grip strength decreasedFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
248HemiparesisFAERS: 1US FAERS
249Hepatic EncephalopathyFAERS: 1US FAERS
250Hepatic congestionFAERS: 1US FAERS
251HepatosplenomegalyFAERS: 1US FAERS
252Histiocytosis haematophagicFAERS: 1US FAERS
253HypersensitivityFAERS: 1US FAERS
254HyperthyroidismFAERS: 1US FAERS
255HypokinesiaFAERS: 1US FAERS
256HypophagiaFAERS: 1US FAERS
257HypotensionFAERS: 1US FAERS
258HypoxiaFAERS: 1US FAERS
259Impaired gastric emptyingFAERS: 1US FAERS
260Impaired work abilityFAERS: 1US FAERS
261Inappropriate schedule of product administrationFAERS: 1US FAERS
262Infectious pleural effusionFAERS: 1US FAERS
263Intra-abdominal fluid collectionFAERS: 1US FAERS
264Janus kinase 2 mutationFAERS: 1US FAERS
265KeratitisFAERS: 1US FAERS
266Large intestine perforationFAERS: 1US FAERS
267LeukopeniaFAERS: 1US FAERS
268Liver AbscessFAERS: 1US FAERS
269Loss of personal independence in daily activitiesFAERS: 1US FAERS
270Lung adenocarcinoma recurrentFAERS: 1US FAERS
271Lymphangiosis carcinomatosaFAERS: 1US FAERS
272LymphangitisFAERS: 1US FAERS
273LymphopeniaFAERS: 1US FAERS
274Malignant ascitesFAERS: 1US FAERS
275MalnutritionFAERS: 1US FAERS
276Maternal exposure during pregnancyFAERS: 1US FAERS
277MesotheliomaFAERS: 1US FAERS
278Metastases to abdominal cavityFAERS: 1US FAERS
279Metastases to pelvisFAERS: 1US FAERS
280Musculoskeletal discomfortFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
281Nasal discomfortFAERS: 1US FAERS
282NecrosisFAERS: 1US FAERS
283NephrolithiasisFAERS: 1US FAERS
284Nerve injuryFAERS: 1US FAERS
285NeuroblastomaFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
286NeurocysticercosisFAERS: 1US FAERS
287Neurological decompensationFAERS: 1US FAERS
288Neutrophil count abnormalFAERS: 1US FAERS
289NoduleFAERS: 1US FAERS
290Non-cardiac chest painFAERS: 1US FAERS
291Oesophagopleural fistulaFAERS: 1US FAERS
292OsteosclerosisFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
293Pancreatic duct dilatationFAERS: 1US FAERS
294ParaparesisFAERS: 1US FAERS
295ParesisFAERS: 1US FAERS
296Pelvic PainFAERS: 1US FAERS
297PhlebitisFAERS: 1US FAERS
298Pneumococcal sepsisFAERS: 1US FAERS
299PneumothoraxFAERS: 1US FAERS
300Positron emission tomogram abnormalFAERS: 1US FAERS
301Post procedural complicationFAERS: 1US FAERS
302Procedural complicationFAERS: 1US FAERS
303Product dispensing errorFAERS: 1US FAERS
304Product quality issueFAERS: 1US FAERS
305PruritusFAERS: 1US FAERS
306Psychiatric symptomFAERS: 1US FAERS
307Pulmonary HypertensionFAERS: 1US FAERS
308Pulmonary painFAERS: 1US FAERS
309Rash erythematousFAERS: 1US FAERS
310Refeeding SyndromeFAERS: 1US FAERS
311RegurgitationFAERS: 1US FAERS
312Renal Cell CarcinomaFAERS: 1US FAERS
313Renal massFAERS: 1US FAERS
314RestlessnessFAERS: 1US FAERS
315RetchingFAERS: 1US FAERS
316Retinal Vein OcclusionFAERS: 1US FAERS
317Retroperitoneal massFAERS: 1US FAERS
318Rheumatoid ArthritisFAERS: 1US FAERS
319Secretion dischargeFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
320Septic ShockFAERS: 1US FAERS
321Simple Partial SeizuresFAERS: 1US FAERS
322Sinus bradycardiaFAERS: 1US FAERS
323Skin UlcerFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
324Skin lesionFAERS: 1US FAERS
325Skin reactionFAERS: 1US FAERS
326Splenic RuptureFAERS: 1US FAERS
327Squamous cell carcinoma of lungFAERS: 1US FAERS
328Squamous cell carcinomaFAERS: 1US FAERS
329Suture related complicationFAERS: 1US FAERS
330Terminal stateFAERS: 1US FAERS
331Therapeutic response unexpectedFAERS: 1US FAERS
332Throat irritationFAERS: 1US FAERS
333ToothacheFAERS: 1US FAERS
334TremorFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
335TuberculosisFAERS: 1US FAERS
336UlcerFAERS: 1US FAERS
337Upper-airway cough syndromeFAERS: 1US FAERS
338VasculitisFAERS: 1US FAERS
339Vocal Cord ParalysisFAERS: 1US FAERS
340White matter lesionFAERS: 1US FAERS
341jaundiceFAERS: 1US FAERS
342nervous system disorderFAERS: 1US FAERS
343treatment failureFAERS: 1US FAERS
344Electrocardiogram abnormalCanada Vigilance: 1Canada Vigilance
345HypersomniaCanada Vigilance: 1Canada Vigilance
346Urine flow decreasedCanada Vigilance: 1Canada Vigilance
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