MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Betaxolol

(NWIUTZDMDHAVTP-UHFFFAOYSA-N)

Structure

SMILES: OC(COc1ccc(cc1)CCOCC1CC1)CNC(C)C
Type(s): Approved; Investigational
ATC code(s): C07AB05; S01ED02; S01ED52
Molecular Formula:: C18H29NO3
Molecular Weight:: 307.428
Log P:: 2.7843
Hydrogen Bond Acceptor:: 4
Hydrogen Bond Donor:: 2
TPSA:: 50.72
CAS Number(s):: 63659-18-7

Synonym(s)

Betaxolol

ALO-1401-02

Betaxolol Alcon

Betaxolol Hydrochloride

Betoptic

Betoptima

Kerlon

Kerlone

Oxodal

10.

SL-75212

11.

ALO 1401 02

12.

ALO140102

13.

Alcon, Betaxolol

14.

Hydrochloride, Betaxolol

15.

SL 75212

16.

SL75212

External Link(s)

MeSH	D015784
PubChem Compound	2369
BindingDB	50405521
ChEBI	3082
CHEMBL	CHEMBL423
DrugBank	DB00195
DrugCentral	356
IUPHAR/BPS Guide to PHARMACOLOGY	549
KEGG	cpd:C06849 dr:D07526
Therapeutic Target Database	D03ROX

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Eye pain	FAERS: 6		OFFSIDES SIDER US FAERS
2	Headache	FAERS: 3	2895577	CTD SIDER US FAERS
3	Mydriasis	FAERS: 3		US FAERS
4	Anxiety	FAERS: 2		SIDER US FAERS
5	Dizziness	FAERS: 2		SIDER US FAERS
6	Drug exposure during pregnancy	FAERS: 2		US FAERS
7	Posterior capsule opacification	FAERS: 2		US FAERS
8	Pregnancy	FAERS: 2		US FAERS
9	Product friable	FAERS: 2		US FAERS
10	Product substitution issue	FAERS: 2		US FAERS
11	Reaction to drug excipients	FAERS: 2		US FAERS
12	Ageusia	FAERS: 1		SIDER US FAERS
13	Agitation	FAERS: 1		US FAERS
14	Anosmia	FAERS: 1		US FAERS
15	Asthenia	FAERS: 1		OFFSIDES SIDER US FAERS
16	Cardiac discomfort	FAERS: 1		US FAERS
17	Cerebrovascular accident	FAERS: 1		US FAERS
18	Complications of maternal exposure to therapeutic drugs	FAERS: 1		US FAERS
19	Eosinophilic Pneumonia	FAERS: 1		OFFSIDES US FAERS
20	Fatigue	FAERS: 1	2895577	CTD SIDER US FAERS
21	Hallucinations, mixed	FAERS: 1		OFFSIDES US FAERS
22	Hypophagia	FAERS: 1		OFFSIDES US FAERS
23	Malaise	FAERS: 1		SIDER US FAERS
24	Medication Error	FAERS: 1		US FAERS
25	Nausea	FAERS: 1		OFFSIDES SIDER US FAERS
26	Pharmaceutical product complaint	FAERS: 1		US FAERS
27	Product physical issue	FAERS: 1		US FAERS
28	Product quality issue	FAERS: 1		US FAERS
29	Respiratory arrest	FAERS: 1		US FAERS
30	Retinal Detachment	FAERS: 1		US FAERS
31	Scotoma	FAERS: 1		SIDER US FAERS
32	Thirst	FAERS: 1		SIDER US FAERS
33	Ventricular hypokinesia	FAERS: 1		OFFSIDES US FAERS
34	Vertigo	FAERS: 1		SIDER US FAERS
35	Visual disturbance	FAERS: 1		US FAERS
36	Wrong drug administered	FAERS: 1		US FAERS
37	jaundice	FAERS: 1		US FAERS
38	Abnormal vision			SIDER
39	Abscess			OFFSIDES
40	Ache			SIDER
41	Acidosis			OFFSIDES SIDER
42	Acute Coronary Syndrome			SIDER
43	Agranulocytosis			SIDER
44	Akinesia			OFFSIDES
45	Alanine Aminotransferase Increased			SIDER
46	Alopecia			SIDER
47	Alveolitis			OFFSIDES
48	Alveoloplasty			OFFSIDES
49	Amnesia			SIDER
50	Amniotic cavity disorder			OFFSIDES
51	Aneurysm			OFFSIDES
52	Angina Pectoris		8296748 14559135	CTD SIDER
53	Ankle Fracture			OFFSIDES
54	Anorexia			SIDER
55	Anticholinergic Syndrome			OFFSIDES
56	Anuria			OFFSIDES
57	Apathy			OFFSIDES
58	Appendicitis			OFFSIDES
59	Application site erosion			OFFSIDES
60	Application site erythema			OFFSIDES
61	Application site pruritus			OFFSIDES
62	Arterial thrombosis			SIDER
63	Arteriogram coronary abnormal			OFFSIDES
64	Arteriosclerosis Obliterans			OFFSIDES
65	Arteriosclerosis			OFFSIDES
66	Arthralgia			SIDER
67	Arthritis			OFFSIDES SIDER
68	Arthropathy			SIDER
69	Aspartate Aminotransferase Increased			SIDER
70	Aspiration Pneumonia			OFFSIDES
71	Asterixis			OFFSIDES
72	Asthenopia			SIDER
73	Asthma			SIDER
74	Ataxia			SIDER
75	Atrial Flutter			OFFSIDES
76	Atrioventricular Block			SIDER
77	Bizarre dreams			SIDER
78	Bladder pain			SIDER
79	Blepharitis			SIDER
80	Blepharoptosis			OFFSIDES
81	Blepharospasm			OFFSIDES SIDER
82	Blood albumin decreased			OFFSIDES
83	Blood chloride increased			OFFSIDES
84	Blood creatine phosphokinase increased			OFFSIDES
85	Blood creatinine increased			OFFSIDES
86	Blood glucose abnormal			OFFSIDES
87	Blood human chorionic gonadotropin decreased			OFFSIDES
88	Blood lactate dehydrogenase increased			SIDER
89	Blood magnesium increased			OFFSIDES
90	Blood phosphorus decreased			OFFSIDES
91	Blood potassium increased			OFFSIDES
92	Blood sodium			OFFSIDES
93	Blood urea increased			OFFSIDES
94	Blunted affect			OFFSIDES
95	Bradycardia		2895577	CTD OFFSIDES SIDER
96	Brain Death			OFFSIDES
97	Breast Microcalcification			OFFSIDES
98	Breast cancer stage II			OFFSIDES
99	Breathing-related sleep disorder			OFFSIDES
100	Bronchitis			SIDER
101	Bronchospasm			SIDER
102	Cardiotoxicity			OFFSIDES
103	Cataract			OFFSIDES SIDER
104	Catatonia			SIDER
105	Causalgia			OFFSIDES
106	Cell marker increased			OFFSIDES
107	Cellulitis			OFFSIDES
108	Chemotherapeutic drug level increased			OFFSIDES
109	Chest Pain			SIDER
110	Chest wall pain			OFFSIDES
111	Chills			SIDER
112	Choking sensation			OFFSIDES
113	Chondrosis			OFFSIDES
114	Congenital tricuspid valve incompetence			OFFSIDES
115	Conjunctivitis			SIDER
116	Constipation			SIDER
117	Cor pulmonale			OFFSIDES
118	Corneal Ulcer			OFFSIDES
119	Corneal erosion			OFFSIDES
120	Cramps of lower extremities			SIDER
121	Creatine urine abnormal			OFFSIDES
122	Creatinine renal clearance decreased			OFFSIDES
123	Culture positive			OFFSIDES
124	Cystitis escherichia			OFFSIDES
125	Cystitis			SIDER
126	Cystocele			OFFSIDES
127	Cytolytic hepatitis			OFFSIDES
128	Deafness			SIDER
129	Decreased Libido			OFFSIDES
130	Dehydration			OFFSIDES
131	Depressed Level of Consciousness			OFFSIDES SIDER
132	Depressive disorder		11551270	CTD
133	Dermatitis			SIDER
134	Diabetes Mellitus			SIDER
135	Diabetes mellitus inadequate control			OFFSIDES
136	Diarrhea			OFFSIDES
137	Discomfort			SIDER
138	Disease Progression			OFFSIDES
139	Disorientation			SIDER
140	Disseminated Intravascular Coagulation			OFFSIDES
141	Distress			SIDER
142	Disturbance in sexual arousal			SIDER
143	Duodenal Ulcer			OFFSIDES
144	Dysgeusia			SIDER
145	Dyspepsia			SIDER
146	Dysthymic Disorder			OFFSIDES
147	Dystonia			OFFSIDES
148	Dysuria			SIDER
149	Eczema			SIDER
150	Embolism			OFFSIDES
151	Emotional distress			OFFSIDES SIDER
152	Endophthalmitis			SIDER
153	Eosinophil percentage increased			OFFSIDES
154	Epistaxis			SIDER
155	Erectile dysfunction			OFFSIDES SIDER
156	Erosive gastritis			OFFSIDES
157	Erythema Multiforme			OFFSIDES
158	Erythema			OFFSIDES SIDER
159	Escherichia infection			OFFSIDES
160	Eye Redness			OFFSIDES
161	Eye irritation			SIDER
162	Eyelid infection			OFFSIDES
163	Eyelid margin crusting			SIDER
164	Feeling abnormal			SIDER
165	Fibroadenoma of breast			SIDER
166	Fibroadenosis of breast			SIDER
167	Fibrosis		1977670	CTD
168	Flushing			SIDER
169	Foreign body sensation in eyes			SIDER
170	Gangrene			OFFSIDES
171	Gastrointestinal motility disorder			OFFSIDES
172	Glaucoma		11551270 15321024	CTD OFFSIDES
173	Glioblastoma Multiforme			OFFSIDES
174	Glioblastoma			OFFSIDES
175	Glossitis			SIDER
176	Gout			SIDER
177	Growth of eyelashes			OFFSIDES
178	Hemiplegia			OFFSIDES
179	Hemothorax			OFFSIDES
180	Hepatitis A			OFFSIDES
181	High density lipoprotein increased			OFFSIDES
182	Hypersensitivity			SIDER
183	Hyperthyroidism			SIDER
184	Hypertrichosis			SIDER
185	Hypervigilance			OFFSIDES
186	Hypokinesia			OFFSIDES
187	Hypopyon			OFFSIDES
188	Hypotension			SIDER
189	Hypothyroidism			SIDER
190	Infection in an immunocompromised host			OFFSIDES
191	Infection			OFFSIDES SIDER
192	Infestation			SIDER
193	Inflammation			SIDER
194	Influenza			SIDER
195	Injury asphyxiation			OFFSIDES
196	Intermittent Claudication			SIDER
197	Intraocular inflammation			OFFSIDES
198	Iritis			SIDER
199	Joint sprain			OFFSIDES
200	Keratitis			SIDER
201	Kidney Failure			OFFSIDES
202	Lacrimation abnormal NOS			SIDER
203	Lacrimation			SIDER
204	Lactic dehydrogenase activity increased			SIDER
205	Laryngospasm			SIDER
206	Left atrial dilatation			OFFSIDES
207	Lethargy			SIDER
208	Leukocytosis			SIDER
209	Leukopenia neonatal			OFFSIDES
210	Life expectancy shortened			OFFSIDES
211	Limb operation			OFFSIDES
212	Lupus Erythematosus			SIDER
213	Lymphadenopathy			SIDER
214	Malnutrition			SIDER
215	Mood swings			SIDER
216	Multiple drug overdose			OFFSIDES
217	Musculoskeletal chest pain			SIDER
218	Musculoskeletal discomfort			SIDER
219	Myalgia			SIDER
220	Myasthenia Gravis			SIDER
221	Myocardial Infarction		15321024	CTD SIDER
222	Myofascial spasm			OFFSIDES
223	Nasopharyngitis			SIDER
224	Neck Pain			SIDER
225	Nervousness			SIDER
226	Neuralgia			SIDER
227	Neuropathy			SIDER
228	Neutrophil count decreased			OFFSIDES
229	Numbness			SIDER
230	Nystagmus			OFFSIDES
231	Ocular Hypertension			OFFSIDES
232	Ocular Hypotension		7619450 15321024	CTD
233	Ocular discomfort			SIDER
234	Oliguria			SIDER
235	Optic Neuritis			OFFSIDES
236	Oropharyngeal discomfort			SIDER
237	Oropharyngeal pain			SIDER
238	Otitis Media			SIDER
239	Pain			SIDER
240	Palmar erythema			OFFSIDES
241	Palpitations			SIDER
242	Pancreatitis			OFFSIDES
243	Panophthalmitis			SIDER
244	Paranasal sinus mucosal hypertrophy			OFFSIDES
245	Percutaneous Coronary Intervention			OFFSIDES
246	Performance status decreased			OFFSIDES
247	Peritoneal Dialysis			OFFSIDES
248	Pharyngitis			SIDER
249	Photophobia			SIDER
250	Physical disability			OFFSIDES
251	Pneumonia			SIDER
252	Postoperative wound complication			OFFSIDES
253	Prescribed overdose			OFFSIDES
254	Primary sequestrum			OFFSIDES
255	Product contamination			OFFSIDES
256	Protein urine present			SIDER
257	Proteinuria			SIDER
258	Pruritus			SIDER
259	Psoriasis			SIDER
260	Pulmonary Hypertension			OFFSIDES
261	Pulmonary arterial hypertension			OFFSIDES
262	Punctate keratitis			OFFSIDES SIDER
263	Purpura			SIDER
264	Purulent discharge			OFFSIDES
265	Rales			OFFSIDES
266	Rash erythematous			SIDER
267	Renal embolism			OFFSIDES
268	Renal pain			SIDER
269	Respiratory Failure			SIDER
270	Respiratory distress			SIDER
271	Retinal Vein Occlusion			OFFSIDES
272	Rhabdomyolysis			OFFSIDES
273	Rhinitis			SIDER
274	Rhinorrhea			OFFSIDES
275	Right atrial dilatation			OFFSIDES
276	Shock			SIDER
277	Sinus bradycardia			OFFSIDES
278	Sinusitis			SIDER
279	Skin Wrinkling			OFFSIDES
280	Sopor			OFFSIDES
281	Sputum culture positive			OFFSIDES
282	Squamous cell carcinoma of skin			OFFSIDES
283	Stevens-Johnson Syndrome			OFFSIDES
284	Stomatitis			SIDER
285	Stridor			OFFSIDES
286	Stupor			SIDER
287	Subcutaneous Abscess			OFFSIDES
288	Substance Withdrawal Syndrome		17513029 18596687	CTD
289	Sweat gland infection			OFFSIDES
290	Sweating			SIDER
291	Symblepharon			OFFSIDES
292	Syncope		8296748	CTD SIDER
293	Tachycardia			SIDER
294	Tension			SIDER
295	Therapy regimen changed			OFFSIDES
296	Thrombocytopenia			SIDER
297	Thrombocytopenic purpura			SIDER
298	Thrombophlebitis			SIDER
299	Thrombosis			SIDER
300	Thyrotoxicosis			SIDER
301	Tinnitus			OFFSIDES SIDER
302	Tooth Extraction			OFFSIDES
303	Toxic Epidermal Necrolysis			SIDER
304	Tremor			SIDER
305	Troponin increased			OFFSIDES
306	Unresponsive to stimuli			OFFSIDES
307	Urticaria			SIDER
308	Vascular anomaly			SIDER
309	Vascular calcification			OFFSIDES
310	Vascular purpura			SIDER
311	Vasculitis		1977670	CTD
312	Visual Impairment			SIDER
313	Vitamin A Deficiency			OFFSIDES
314	Vomiting			SIDER
315	Weight decreased			SIDER
316	Wound necrosis			OFFSIDES
317	diagnostic procedure			OFFSIDES
318	effusion			OFFSIDES
319	nervous system disorder			SIDER
320	prostatitis			SIDER

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