MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Schnitzler Syndrome

(UMLS:C0524988)

Definition:: An extremely rare condition manifested as monoclonal IMMUNOGLOBULIN M dysproteinemia without features of lymphoproliferative disease, but with chronic urticaria, fever of unknown origin, disabling bone pain, hyperostosis, and increased erythrocyte sedimentation rate.
UMLS ID:: C0524988
MeSH ID:: D019873

Classification:

Name:

Immune System Diseases
MeSH Tree Number(s):: C20.683.780.640.700

Synonym(s)

Schnitzler Syndrome

Schnitzler syndrome

Schnitzler's syndrome

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Thalidomide		16096327	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Primary amyloidosis	19.7%
2	Lymphoproliferative Disorders	17.2%
3	Heavy Chain Disease	17.2%
4	Autoimmune Diseases	16.4%
5	Hypersensitivity	16.4%
6	Immunologic Deficiency Syndromes	16.4%
7	Immune reconstitution syndrome	16.4%
8	Immune Reconstitution Inflammatory Syndrome	16.4%
9	Multiple Myeloma	14.1%
10	Cryoglobulinemia	13.7%
11	POEMS Syndrome	13.7%
12	Hypergammaglobulinemia	12.8%
13	Transfusion Reaction	10.8%
14	Hypotensive Transfusion Reaction	10.8%
15	Plasmacytoma	9.9%
16	Tumor Lysis Syndrome	9.9%
17	Waldenstrom Macroglobulinemia	9.9%
18	Autoimmune Lymphoproliferative Syndrome	9.5%
19	Immune Complex Diseases	8.5%
20	Antiphospholipid Syndrome	8.5%
21	Latex allergy	8.5%
22	Glomerulonephritis, Membranoproliferative	7.6%
23	Lymphoma	7.6%
24	Sezary Syndrome	6.6%
25	Environmental Illness	6%
26	Infectious Mononucleosis	5.9%
27	Monoclonal Gammopathy of Undetermined Significance	5.9%
28	Lupus Erythematosus, Systemic	5.7%
29	Overlap syndrome	5.7%
30	Addison Disease	5.6%
31	Pemphigus	5.6%
32	Autoimmune thyroiditis	5.6%
33	Primary Adrenal Insufficiency	5.6%
34	Lymphopenia	5.6%
35	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	5.6%
36	Autoimmune hepatitis	5.6%
37	Thrombocytopenic purpura	5%
38	anaphylaxis	4.9%
39	Food Allergy	4.9%
40	Anaphylactic shock	4.9%
41	Hodgkin Disease	4.9%
42	Leukemia, Plasma Cell	4.9%
43	Lymphoma, Non-Hodgkin	4.9%
44	Leukemia, T-Cell	4.8%
45	Leukemia, B-Cell	4.8%
46	Latent Autoimmune Diabetes in Adults	4.2%
47	Agammaglobulinemia	4.2%
48	Dermatitis Herpetiformis	4.2%
49	Kounis Syndrome	4.2%
50	HIV Infections	4.2%
51	Transfusion-Related Acute Lung Injury	4.2%
52	Autoimmune thrombocytopenia	4.1%
53	Immune thrombocytopenic purpura	4.1%
54	Composite Lymphoma	3.9%
55	Lymphangioleiomyomatosis	3.9%
56	Lymphoma, Follicular	3.6%
57	T-Cell Lymphoma	3.6%
58	Mantle cell lymphoma	3.6%
59	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	3.6%
60	Leukemia, Large Granular Lymphocytic	3.6%
61	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	3.6%
62	Respiratory Hypersensitivity	3.5%
63	Rheumatoid Arthritis	3.4%
64	Juvenile arthritis	3.4%
65	Sick Building Syndrome	3.4%
66	Multiple Chemical Sensitivity	3.4%
67	Graves Disease	3.4%
68	Asthma, Aspirin-Induced	3.3%
69	Urticaria	3.3%
70	Vasculitis, Leukocytoclastic, Cutaneous	3.3%
71	Anti-Glomerular Basement Membrane Disease	3.3%
72	HTLV-I Infections	3.3%
73	Job Syndrome	3.3%
74	Serum Sickness	3.2%
75	Milk Allergy	3.2%
76	Wheat Hypersensitivity	3.2%
77	Lymphoma, T-Cell, Cutaneous	3%
78	Lymphoma, AIDS-Related	3%
79	Enteropathy-Associated T-Cell Lymphoma	3%
80	Primary Effusion Lymphoma	3%
81	Mycosis Fungoides	2.7%
82	Lymphomatoid Papulosis	2.7%
83	Plasmablastic lymphoma	2.7%
84	Myasthenia Gravis	2.5%
85	Uveomeningoencephalitic Syndrome	2.5%
86	Mastocytosis	2.5%
87	Drug Eruptions	2.5%
88	Chronic granulomatous disease	2.5%
89	Granulomatosis with polyangiitis	2.4%
90	Dermatitis, Allergic Contact	2.4%
91	Lymphomatoid Granulomatosis	2.4%
92	HIV Seropositivity	2.4%
93	Kernicterus	2.4%
94	Mastocytosis, Systemic	2.1%
95	Ataxia Telangiectasia	2.1%
96	Hydrops Fetalis	2.1%
97	Stiff-Person Syndrome	2%
98	Polyradiculoneuropathy	2%
99	Polyradiculoneuritis	2%
100	Burkitt Lymphoma	2%
101	Acquired Immunodeficiency Syndrome	2%
102	AIDS related complex	2%
103	Felty Syndrome	2%
104	Lupus Nephritis	1.9%
105	Myasthenia Gravis, Autoimmune, Experimental	1.9%
106	AIDS-Related Opportunistic Infections	1.7%
107	Vasculitis, Central Nervous System	1.7%
108	Dermatitis, Atopic	1.7%
109	Angioedema	1.7%
110	Multiple Sclerosis	1.6%
111	HIV Wasting Syndrome	1.6%
112	Rheumatoid Vasculitis	1.6%
113	AIDS Dementia Complex	1.6%
114	AIDS-Associated Nephropathy	1.6%
115	Acute Generalized Exanthematous Pustulosis	1.6%
116	Lambert-Eaton Myasthenic Syndrome	1.4%
117	Wiskott-Aldrich Syndrome	1.4%
118	Sicca Syndrome	1.4%
119	Sjogren's Syndrome	1.4%
120	HIV-Associated Lipodystrophy Syndrome	1.4%
121	Asthma	1.4%
122	Lupus Vasculitis, Central Nervous System	1.3%
123	Encephalomyelitis, Acute Disseminated	1.3%
124	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	1.3%
125	Erythema Nodosum	1.3%
126	Neuritis, Autoimmune, Experimental	1.3%
127	Dermatitis, Photoallergic	1.3%
128	Neuromyelitis Optica	1.3%
129	Leukoencephalitis, Acute Hemorrhagic	1.3%
130	Asthma, Exercise-Induced	1.2%
131	Status Asthmaticus	1.2%
132	Multiple Sclerosis, Chronic Progressive	1.2%
133	Multiple Sclerosis, Relapsing-Remitting	1.2%
134	Aspergillosis, Allergic Bronchopulmonary	1.1%
135	Guillain-Barre Syndrome	1.1%
136	Asthma, Occupational	1%
137	Hereditary Angioedema Type III	1%
138	Hereditary Angioedema Types I and II	1%
139	Farmer's Lung	1%
140	Angioedemas, Hereditary	1%
141	Hay fever	1%
142	Rhinitis, Allergic, Perennial	1%
143	Toxic Epidermal Necrolysis	0.9%
144	Stevens-Johnson Syndrome	0.9%
145	Giant Cell Arteritis	0.8%
146	Temporal Arteritis	0.8%
147	Myelitis, Transverse	0.7%
148	Miller Fisher Syndrome	0.5%

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