MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Acquired Immunodeficiency Syndrome

(UMLS:C0001175)

Definition:: An acquired defect of cellular immunity associated with infection by the human immunodeficiency virus (HIV), a CD4-positive T-lymphocyte count under 200 cells/microliter or less than 14% of total lymphocytes, and increased susceptibility to opportunistic infections and malignant neoplasms. Clinical manifestations also include emaciation (wasting) and dementia. These elements reflect criteria for AIDS as defined by the CDC in 1993.
UMLS ID:: C0001175
MeSH ID:: D000163

Classification 1:

Name:

Virus Diseases
MeSH Tree Number(s):: C02.782.815.616.400.040|C02.800.801.400.040|C02.839.040

Classification 2:

Name:

Immune System Diseases
MeSH Tree Number(s):: C20.673.480.040

Synonym(s)

Acquired Immunodeficiency Syndrome

ACQUIRED IMMUNE DEFICIENCY SYNDROME

AIDS

AIDS - Acquired immunodeficiency syndrome

AIDS HIV infection

AIDS HIV infections

AIDS disorders

AIDS, Acquired Immunodeficiency Syndrome

AIDS, NOS

10.

Acquired Immun-Deficiency Synd

11.

Acquired Immune Deficiency

12.

Acquired Immune Deficiency Syndrome

13.

Acquired Immunodeficiency Disease

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Isotretinoin	FAERS: 12		US FAERS
2	Lopinavir	FAERS: 5		US FAERS
3	Aspirin-oxycodone hydrochloride-oxycodone terephthalate combination	FAERS: 4		US FAERS
4	Enfuvirtide	FAERS: 4		US FAERS
5	Sildenafil Citrate	FAERS: 4		US FAERS
6	Clozapine	FAERS: 3 Canada Vigilance: 1		Canada Vigilance US FAERS
7	Thalidomide	FAERS: 3		SIDER US FAERS
8	Acetaminophen	FAERS: 2		US FAERS
9	Aripiprazole	FAERS: 2		US FAERS
10	Omeprazole	FAERS: 2		US FAERS
11	Rosuvastatin Calcium	FAERS: 2		US FAERS
12	Tiotropium Bromide	FAERS: 2		US FAERS
13	Valganciclovir	FAERS: 2		US FAERS
14	Varenicline	FAERS: 2		US FAERS
15	Voriconazole	FAERS: 2		US FAERS
16	4-Aminopyridine	FAERS: 1		US FAERS
17	Acetazolamide	FAERS: 1		US FAERS
18	Deferoxamine	FAERS: 1		US FAERS
19	Diphenhydramine	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
20	Erlotinib Hydrochloride	FAERS: 1		US FAERS
21	Erlotinib Hydrochloride	FAERS: 1		US FAERS
22	Finasteride	FAERS: 1		US FAERS
23	Fluoxetine	FAERS: 1		US FAERS
24	Imatinib Mesylate	FAERS: 1		US FAERS
25	Insulin Glargine	FAERS: 1		US FAERS
26	Lenalidomide	FAERS: 1		US FAERS
27	Maraviroc	FAERS: 1		SIDER US FAERS
28	Mesalamine	FAERS: 1		US FAERS
29	Methotrexate	FAERS: 1		US FAERS
30	Nicotine	FAERS: 1		US FAERS
31	Phenytoin	FAERS: 1		US FAERS
32	Pregabalin	FAERS: 1		US FAERS
33	Raltegravir Potassium	FAERS: 1		SIDER US FAERS
34	Ritonavir	FAERS: 1	8782789 10452668	CTD US FAERS
35	Rivastigmine	FAERS: 1		US FAERS
36	Tenofovir	FAERS: 1		US FAERS
37	Testosterone	FAERS: 1		US FAERS
38	Triumeq	FAERS: 1		US FAERS
39	Valsartan	FAERS: 1		US FAERS
40	Zoledronic Acid	FAERS: 1		US FAERS
41	apremilast	FAERS: 1		US FAERS
42	dolutegravir	FAERS: 1		US FAERS
43	emtricitabine tenofovir alafenamide	FAERS: 1		US FAERS
44	fexofenadine	FAERS: 1		US FAERS
45	rofecoxib	FAERS: 1		US FAERS
46	tipranavir	FAERS: 1		US FAERS
47	Acyclovir		2964805	CTD
48	Azithromycin			SIDER
49	Caspofungin			SIDER
50	Clarithromycin			SIDER
51	Cystamine		9207937	CTD
52	Cysteamine		9207937	CTD
53	D-Telaprevir			SIDER
54	Delavirdine			SIDER
55	Didanosine		View details 1659189 1974724 1974725 1974727 2166965 8093846	CTD SIDER
56	Disulfiram		9207937	CTD
57	Indinavir		View details 8992346 9338723 9716639 9776425 10452668 10737512 15384277 17180736	CTD SIDER
58	Leflunomide			SIDER
59	Micafungin			SIDER
60	Pentamidine		1972225	CTD
61	Rifabutin		9101573	CTD
62	Stavudine		7861015 7861017	CTD
63	Zalcitabine		2558314 8094279 8382349	CTD
64	Zidovudine		View details 1336487 1972225 1979744 2378412 2521663 2677429 2729341 2964805 3299090 8094279 8263554 9612607 9810533 9861562	CTD SIDER
65	posaconazole			SIDER
66	thiamine disulfide		9207937	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	AIDS related complex	56%
2	HIV Seropositivity	47.7%
3	HIV Wasting Syndrome	37.2%
4	AIDS Dementia Complex	37%
5	AIDS-Associated Nephropathy	37%
6	HIV-Associated Lipodystrophy Syndrome	33.2%
7	AIDS-Related Opportunistic Infections	30.8%
8	Simian Acquired Immunodeficiency Syndrome	30.1%
9	Rift Valley Fever	22.8%
10	Condylomata Acuminata	22.3%
11	Dengue Fever	21.7%
12	Yellow Fever	21.7%
13	Murine Acquired Immunodeficiency Syndrome	21.3%
14	Hepatitis E	21.2%
15	Hemorrhagic Fever, Crimean	21.1%
16	Subacute Sclerosing Panencephalitis	21.1%
17	Arbovirus Infections	20.4%
18	Warts	19.6%
19	Phlebotomus Fever	19%
20	Leukoencephalopathy, Progressive Multifocal	19%
21	Hemorrhagic Fever, American	18.3%
22	Lassa Fever	18.3%
23	Orthomyxoviridae Infections	17.8%
24	Picornaviridae Infections	17.8%
25	Reoviridae Infections	17.8%
26	Hepatitis, Viral, Human	16.9%
27	Viremia	16.8%
28	HTLV-I Infections	16.3%
29	Epstein-Barr Virus Infections	16.2%
30	Hepatitis C	16.2%
31	West Nile Fever	16.2%
32	Zika Virus Infection	16.2%
33	Genital Herpes	15.9%
34	Hemorrhagic Fever with Renal Syndrome	15.4%
35	Opportunistic Infections	15%
36	Hepatitis, Viral, Animal	14.5%
37	Pneumonia, Viral	14.4%
38	Hepatitis B	13.8%
39	Molluscum Contagiosum	13.8%
40	Hepatitis A	13.8%
41	Epidermodysplasia Verruciformis	13%
42	Chronic Fatigue Syndrome	12.8%
43	Pseudorabies	12.4%
44	Erythema Infectiosum	12.1%
45	Herpesviridae Infections	11.8%
46	Polyomavirus Infections	11.8%
47	Herpes Zoster Ophthalmicus	11.7%
48	Enterovirus Infections	11%
49	Flavivirus Infections	11%
50	Paramyxoviridae Infections	11%
51	Cardiovirus Infections	11%
52	Rhabdoviridae Infections	11%
53	Keratitis, Herpetic	10.9%
54	Cytomegalovirus Retinitis	10.9%
55	Exanthema Subitum	10.8%
56	Lymphopenia	10%
57	Herpangina	9.8%
58	Foot-and-Mouth Disease	9.5%
59	Hepatitis C, Chronic	9.4%
60	Eczema Herpeticum	9.4%
61	Common Cold	9.2%
62	Influenza	9.2%
63	Catarrh	9.2%
64	Acquired Immunodeficiency Syndrome	9.1%
65	Sexually Transmitted Diseases	8.9%
66	Retroviridae Infections	8.8%
67	Agammaglobulinemia	8.6%
68	Superinfection	8.5%
69	Herpes Labialis	8.2%
70	Hepatitis B, Chronic	8.2%
71	Burkitt Lymphoma	8%
72	Cytomegalovirus Infections	7.6%
73	Smallpox	7.6%
74	Varicella Zoster Virus Infection	7.6%
75	Coxsackievirus Infections	7.6%
76	Rubella	7.6%
77	Coronavirus Infections	7.6%
78	Nipah Virus Infection	7.6%
79	Hydrophobia	7.6%
80	HIV Infections	7.4%
81	Autoimmune Diseases	6.9%
82	Hypersensitivity	6.9%
83	Immunoproliferative Disorders	6.9%
84	Immune reconstitution syndrome	6.9%
85	Immune Reconstitution Inflammatory Syndrome	6.9%
86	Job Syndrome	6.6%
87	Porcine Reproductive and Respiratory Syndrome	6.4%
88	Measles	5.9%
89	Pleurodynia, Epidemic	5.9%
90	Respiratory Syncytial Virus Infections	5.9%
91	Transfusion Reaction	5.8%
92	Hypotensive Transfusion Reaction	5.8%
93	Chronic granulomatous disease	5.7%
94	Chickenpox	5.6%
95	Vesicular Stomatitis	5.6%
96	Ataxia Telangiectasia	5.5%
97	Infectious Mononucleosis	5.2%
98	Gastroenteritis, Transmissible, of Swine	5%
99	Severe Acute Respiratory Syndrome	5%
100	Mumps	4.9%
101	Bell Palsy	4.8%
102	Glomerulonephritis, Membranoproliferative	4.8%
103	Poliomyelitis	4.8%
104	Autoimmune Lymphoproliferative Syndrome	4.2%
105	Immune Complex Diseases	4%
106	Antiphospholipid Syndrome	4%
107	Latex allergy	4%
108	Wiskott-Aldrich Syndrome	4%
109	Thrombocytopenic purpura	3.7%
110	Autoimmune thrombocytopenia	3.6%
111	Immune thrombocytopenic purpura	3.6%
112	Environmental Illness	3.5%
113	Lupus Erythematosus, Systemic	3.4%
114	Lymphoproliferative Disorders	3.4%
115	Overlap syndrome	3.4%
116	Addison Disease	3.4%
117	Paraproteinemias	3.4%
118	Pemphigus	3.4%
119	Autoimmune thyroiditis	3.4%
120	Primary Adrenal Insufficiency	3.4%
121	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	3.3%
122	Autoimmune hepatitis	3.3%
123	Primary amyloidosis	3.3%
124	Monoclonal Gammopathy of Undetermined Significance	3.3%
125	Asthma, Aspirin-Induced	3%
126	Herpes Zoster Oticus	2.9%
127	Hypergammaglobulinemia	2.9%
128	Latent Autoimmune Diabetes in Adults	2.9%
129	Dermatitis Herpetiformis	2.9%
130	Kounis Syndrome	2.9%
131	Serum Sickness	2.9%
132	Transfusion-Related Acute Lung Injury	2.9%
133	anaphylaxis	2.7%
134	Food Allergy	2.7%
135	Anaphylactic shock	2.7%
136	Multiple Myeloma	2.6%
137	Rheumatoid Arthritis	2.5%
138	Juvenile arthritis	2.5%
139	Graves Disease	2.5%
140	Anti-Glomerular Basement Membrane Disease	2.5%
141	Respiratory Hypersensitivity	2.3%
142	Sick Building Syndrome	2.2%
143	Multiple Chemical Sensitivity	2.2%
144	Sezary Syndrome	2.2%
145	Plasmacytoma	2.2%
146	Tumor Lysis Syndrome	2.2%
147	Urticaria	2.2%
148	Vasculitis, Leukocytoclastic, Cutaneous	2.2%
149	Kernicterus	2%
150	Milk Allergy	2%
151	Schnitzler Syndrome	2%
152	Wheat Hypersensitivity	2%
153	Myasthenia Gravis, Autoimmune, Experimental	2%
154	Lymphoma	1.9%
155	Myasthenia Gravis	1.9%
156	Uveomeningoencephalitic Syndrome	1.9%
157	Mastocytosis	1.9%
158	Drug Eruptions	1.9%
159	Heavy Chain Disease	1.9%
160	Granulomatosis with polyangiitis	1.9%
161	Dermatitis, Allergic Contact	1.9%
162	Hydrops Fetalis	1.8%
163	Stiff-Person Syndrome	1.7%
164	Polyradiculoneuropathy	1.7%
165	Polyradiculoneuritis	1.7%
166	Cryoglobulinemia	1.6%
167	Felty Syndrome	1.6%
168	POEMS Syndrome	1.6%
169	Lupus Nephritis	1.6%
170	Mastocytosis, Systemic	1.6%
171	Lupus Vasculitis, Central Nervous System	1.5%
172	Neuromyelitis Optica	1.5%
173	Leukoencephalitis, Acute Hemorrhagic	1.5%
174	Vasculitis, Central Nervous System	1.5%
175	Dermatitis, Atopic	1.5%
176	Rheumatoid Vasculitis	1.5%
177	Angioedema	1.4%
178	Multiple Sclerosis	1.4%
179	Hodgkin Disease	1.4%
180	Leukemia, Plasma Cell	1.4%
181	Lymphoma, Non-Hodgkin	1.4%
182	Leukemia, T-Cell	1.4%
183	Acute Generalized Exanthematous Pustulosis	1.4%
184	Leukemia, B-Cell	1.4%
185	Lambert-Eaton Myasthenic Syndrome	1.3%
186	Waldenstrom Macroglobulinemia	1.3%
187	Sicca Syndrome	1.3%
188	Sjogren's Syndrome	1.3%
189	Asthma	1.3%
190	Composite Lymphoma	1.2%
191	Encephalomyelitis, Acute Disseminated	1.2%
192	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	1.2%
193	Erythema Nodosum	1.2%
194	Neuritis, Autoimmune, Experimental	1.2%
195	Dermatitis, Photoallergic	1.2%
196	Lymphangioleiomyomatosis	1.2%
197	Asthma, Exercise-Induced	1.2%
198	Status Asthmaticus	1.2%
199	Multiple Sclerosis, Chronic Progressive	1.2%
200	Multiple Sclerosis, Relapsing-Remitting	1.2%
201	Lymphoma, Follicular	1.2%
202	T-Cell Lymphoma	1.2%
203	Mantle cell lymphoma	1.2%
204	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	1.2%
205	Leukemia, Large Granular Lymphocytic	1.2%
206	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	1.2%
207	Aspergillosis, Allergic Bronchopulmonary	1.1%
208	Guillain-Barre Syndrome	1.1%
209	Asthma, Occupational	1.1%
210	Hereditary Angioedema Type III	1%
211	Hereditary Angioedema Types I and II	1%
212	Lymphoma, T-Cell, Cutaneous	1%
213	Lymphoma, AIDS-Related	1%
214	Enteropathy-Associated T-Cell Lymphoma	1%
215	Primary Effusion Lymphoma	1%
216	Farmer's Lung	1%
217	Angioedemas, Hereditary	1%
218	Hay fever	1%
219	Rhinitis, Allergic, Perennial	1%
220	Mycosis Fungoides	1%
221	Lymphomatoid Papulosis	1%
222	Plasmablastic lymphoma	1%
223	Toxic Epidermal Necrolysis	1%
224	Stevens-Johnson Syndrome	1%
225	Lymphomatoid Granulomatosis	0.9%
226	Giant Cell Arteritis	0.9%
227	Temporal Arteritis	0.9%
228	Myelitis, Transverse	0.8%
229	Miller Fisher Syndrome	0.7%

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