MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Immune Reconstitution Inflammatory Syndrome

(UMLS:C1619738)

Definition:: Exuberant inflammatory response towards a previously acquired or undiagnosed opportunistic infection. It is frequently seen in AIDS patients following antiretroviral treatment.
UMLS ID:: C1619738
MeSH ID:: D054019

Classification:

Name:

Immune System Diseases
MeSH Tree Number(s):: C20.608

Synonym(s)

Immune Reconstitution Inflammatory Syndrome

Immune reconstitution inflammatory syndrome

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Fingolimod Hydrochloride	FAERS: 47 Canada Vigilance: 2	Canada Vigilance US FAERS
2	Triumeq	FAERS: 11	US FAERS
3	dolutegravir	FAERS: 9	US FAERS
4	Dimethyl Fumarate	FAERS: 7	US FAERS
5	Elvitegravir, Cobicistat, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination	FAERS: 6	US FAERS
6	Methotrexate	FAERS: 6	US FAERS
7	Tacrolimus	FAERS: 5	US FAERS
8	Ceftriaxone	FAERS: 2	US FAERS
9	Decitabine	FAERS: 2	US FAERS
10	abacavir, lamivudine drug combination	FAERS: 2	US FAERS
11	ledipasvir, sofosbuvir drug combination	FAERS: 2	US FAERS
12	Azathioprine	FAERS: 1	US FAERS
13	Caspofungin	FAERS: 1	US FAERS
14	Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination	FAERS: 1	US FAERS
15	Emtricitabine, Rilpivirine, Tenofovir Drug Combination	FAERS: 1	US FAERS
16	Glatiramer Acetate	FAERS: 1	US FAERS
17	Lenalidomide	FAERS: 1	US FAERS
18	Methylprednisolone	FAERS: 1	US FAERS
19	Mycophenolic Acid	FAERS: 1	US FAERS
20	Nevirapine	FAERS: 1	US FAERS
21	PCI 32765	FAERS: 1	US FAERS
22	Prednisolone	FAERS: 1	US FAERS
23	Prezcobix	FAERS: 1	US FAERS
24	Viekira Pak	FAERS: 1	US FAERS
25	Zoledronic Acid	FAERS: 1	US FAERS
26	atovaquone, proguanil drug combination	FAERS: 1	US FAERS
27	lamivudine, zidovudine drug combination	FAERS: 1	US FAERS
28	liposomal amphotericin B	FAERS: 1	US FAERS
29	sofosbuvir-velpatasvir drug combination	FAERS: 1	US FAERS
30	teriflunomide	FAERS: 1	US FAERS

Similar ADE(s)

	Name	Semantic Similarity
1	Autoimmune Diseases	33.3%
2	Hypersensitivity	33.3%
3	Immunologic Deficiency Syndromes	33.3%
4	Immunoproliferative Disorders	33.3%
5	Immune Complex Diseases	23.1%
6	Antiphospholipid Syndrome	23.1%
7	Latex allergy	23.1%
8	Transfusion Reaction	21.1%
9	Hypotensive Transfusion Reaction	21.1%
10	anaphylaxis	18.5%
11	Food Allergy	18.5%
12	Anaphylactic shock	18.5%
13	Milk Allergy	16.4%
14	Schnitzler Syndrome	16.4%
15	Wheat Hypersensitivity	16.4%
16	Environmental Illness	15.8%
17	Autoimmune Lymphoproliferative Syndrome	15.7%
18	Lupus Erythematosus, Systemic	15%
19	Lymphoproliferative Disorders	15%
20	Overlap syndrome	15%
21	Addison Disease	14.6%
22	Paraproteinemias	14.6%
23	Pemphigus	14.6%
24	Autoimmune thyroiditis	14.6%
25	Primary Adrenal Insufficiency	14.6%
26	Lymphopenia	14.5%
27	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	14.5%
28	Autoimmune hepatitis	14.5%
29	Glomerulonephritis, Membranoproliferative	14.4%
30	Primary amyloidosis	13.8%
31	Monoclonal Gammopathy of Undetermined Significance	13.7%
32	Serum Sickness	12.9%
33	Respiratory Hypersensitivity	12.8%
34	Sick Building Syndrome	12.2%
35	Multiple Chemical Sensitivity	12.2%
36	Plasmacytoma	11.9%
37	Tumor Lysis Syndrome	11.9%
38	Urticaria	11.9%
39	Vasculitis, Leukocytoclastic, Cutaneous	11.9%
40	HTLV-I Infections	11.8%
41	Job Syndrome	11.8%
42	Asthma, Aspirin-Induced	11.5%
43	Hypergammaglobulinemia	10.9%
44	Latent Autoimmune Diabetes in Adults	10.8%
45	Agammaglobulinemia	10.7%
46	Dermatitis Herpetiformis	10.7%
47	Kounis Syndrome	10.7%
48	HIV Infections	10.6%
49	Transfusion-Related Acute Lung Injury	10.6%
50	Mastocytosis, Systemic	10.4%
51	Autoimmune thrombocytopenia	10.2%
52	Immune thrombocytopenic purpura	10.2%
53	Sezary Syndrome	10.1%
54	Multiple Myeloma	9.7%
55	Thrombocytopenic purpura	9.3%
56	Lymphoma	8.9%
57	Myasthenia Gravis	8.9%
58	Uveomeningoencephalitic Syndrome	8.9%
59	Mastocytosis	8.8%
60	Drug Eruptions	8.8%
61	Chronic granulomatous disease	8.7%
62	Heavy Chain Disease	8.7%
63	Granulomatosis with polyangiitis	8.7%
64	Myasthenia Gravis, Autoimmune, Experimental	8.7%
65	Dermatitis, Allergic Contact	8.6%
66	HIV Seropositivity	8.6%
67	Rheumatoid Arthritis	8.6%
68	Juvenile arthritis	8.6%
69	Graves Disease	8.5%
70	Anti-Glomerular Basement Membrane Disease	8.3%
71	Angioedema	7.9%
72	Multiple Sclerosis	7.8%
73	Hodgkin Disease	7.8%
74	Leukemia, Plasma Cell	7.8%
75	Lymphoma, Non-Hodgkin	7.8%
76	Leukemia, T-Cell	7.7%
77	Acute Generalized Exanthematous Pustulosis	7.7%
78	Leukemia, B-Cell	7.7%
79	Asthma, Exercise-Induced	7.4%
80	Status Asthmaticus	7.4%
81	Multiple Sclerosis, Chronic Progressive	7.2%
82	Multiple Sclerosis, Relapsing-Remitting	7.2%
83	Lymphoma, Follicular	7.2%
84	T-Cell Lymphoma	7.2%
85	Mantle cell lymphoma	7.2%
86	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	7.2%
87	Leukemia, Large Granular Lymphocytic	7.2%
88	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	7.2%
89	Stiff-Person Syndrome	7.1%
90	Polyradiculoneuropathy	7.1%
91	Polyradiculoneuritis	7.1%
92	Hereditary Angioedema Type III	7%
93	Hereditary Angioedema Types I and II	7%
94	Lymphoma, T-Cell, Cutaneous	6.9%
95	Lymphoma, AIDS-Related	6.9%
96	Enteropathy-Associated T-Cell Lymphoma	6.9%
97	Primary Effusion Lymphoma	6.9%
98	Acquired Immunodeficiency Syndrome	6.9%
99	AIDS related complex	6.9%
100	Infectious Mononucleosis	6.9%
101	Cryoglobulinemia	6.8%
102	Felty Syndrome	6.8%
103	POEMS Syndrome	6.8%
104	Mycosis Fungoides	6.8%
105	Lymphomatoid Papulosis	6.8%
106	Plasmablastic lymphoma	6.8%
107	Lupus Nephritis	6.8%
108	Neuromyelitis Optica	6.5%
109	Leukoencephalitis, Acute Hemorrhagic	6.4%
110	Asthma	6.4%
111	Composite Lymphoma	6.2%
112	Encephalomyelitis, Acute Disseminated	6.1%
113	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	6.1%
114	Erythema Nodosum	6.1%
115	Neuritis, Autoimmune, Experimental	6.1%
116	Asthma, Occupational	6.1%
117	Dermatitis, Photoallergic	6.1%
118	Lymphangioleiomyomatosis	6.1%
119	Kernicterus	5.9%
120	Farmer's Lung	5.9%
121	Angioedemas, Hereditary	5.9%
122	AIDS-Related Opportunistic Infections	5.8%
123	Vasculitis, Central Nervous System	5.8%
124	Hay fever	5.8%
125	Rhinitis, Allergic, Perennial	5.8%
126	Dermatitis, Atopic	5.7%
127	HIV Wasting Syndrome	5.7%
128	Rheumatoid Vasculitis	5.6%
129	AIDS Dementia Complex	5.6%
130	AIDS-Associated Nephropathy	5.6%
131	Lymphomatoid Granulomatosis	5.6%
132	Lupus Vasculitis, Central Nervous System	5.2%
133	Ataxia Telangiectasia	5.2%
134	Aspergillosis, Allergic Bronchopulmonary	5.1%
135	Guillain-Barre Syndrome	5.1%
136	Hydrops Fetalis	5.1%
137	Lambert-Eaton Myasthenic Syndrome	4.9%
138	Waldenstrom Macroglobulinemia	4.9%
139	Wiskott-Aldrich Syndrome	4.8%
140	Sicca Syndrome	4.8%
141	Sjogren's Syndrome	4.8%
142	HIV-Associated Lipodystrophy Syndrome	4.8%
143	Burkitt Lymphoma	4.6%
144	Toxic Epidermal Necrolysis	4.3%
145	Stevens-Johnson Syndrome	4.3%
146	Giant Cell Arteritis	3.8%
147	Temporal Arteritis	3.8%
148	Myelitis, Transverse	3.4%
149	Miller Fisher Syndrome	3.2%

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