MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Multiple Chemical Sensitivity

(UMLS:C0242992)

Definition:: An acquired disorder characterized by recurrent symptoms, referable to multiple organ systems, occurring in response to demonstrable exposure to many chemically unrelated compounds at doses below those established in the general population to cause harmful effects. (Cullen MR. The worker with multiple chemical sensitivities: an overview. Occup Med 1987;2(4):655-61)
UMLS ID:: C0242992
MeSH ID:: D018777

Classification 1:

Name:

Immune System Diseases
MeSH Tree Number(s):: C20.543.312.500

Classification 2:

Name:

Disorders of Environmental Origin
MeSH Tree Number(s):: C21.223.500

Synonym(s)

Multiple Chemical Sensitivity

Idiopathic environmental intolerance

Multiple chemical sensitivity

chemical multiple sensitivity

chemicals multiple sensitivity

multiple chemical sensitivities

multiple chemical sensitivity

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Levofloxacin	FAERS: 8		US FAERS
2	Ciprofloxacin	FAERS: 6 Canada Vigilance: 1		Canada Vigilance US FAERS
3	Sertraline	FAERS: 2		US FAERS
4	Thyroxine	FAERS: 2		US FAERS
5	Albuterol	FAERS: 1		US FAERS
6	Alprazolam	FAERS: 1		US FAERS
7	Ciprofloxacin	FAERS: 1		US FAERS
8	Clonidine	FAERS: 1		US FAERS
9	Dexlansoprazole	FAERS: 1		US FAERS
10	Diazepam	FAERS: 1		US FAERS
11	Dicyclomine	FAERS: 1		US FAERS
12	Gadolinium	FAERS: 1		US FAERS
13	Imiquimod	FAERS: 1		US FAERS
14	Methylprednisolone Acetate	FAERS: 1		US FAERS
15	Moxifloxacin	FAERS: 1		US FAERS
16	Moxifloxacin	FAERS: 1		US FAERS
17	Norgestrel	FAERS: 1		US FAERS
18	Restasis	FAERS: 1		US FAERS
19	Teriparatide	FAERS: 1		US FAERS
20	Venlafaxine Hydrochloride	FAERS: 1		US FAERS
21	gadobenic acid	FAERS: 1		US FAERS
22	valdecoxib	FAERS: 1		US FAERS
23	Acetaminophen		17075259	CTD
24	Alcohols			OFFSIDES
25	Aspirin		17075259	CTD
26	Pentachlorophenol		8766847	CTD
27	Tartrazine		17075259	CTD
28	Tretinoin			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Sick Building Syndrome	44.8%
2	Immune Complex Diseases	20.9%
3	Latex allergy	20.9%
4	anaphylaxis	13.6%
5	Food Allergy	13.6%
6	Anaphylactic shock	13.6%
7	Kounis Syndrome	12.3%
8	Autoimmune Diseases	12.2%
9	Immunologic Deficiency Syndromes	12.2%
10	Immunoproliferative Disorders	12.2%
11	Immune reconstitution syndrome	12.2%
12	Immune Reconstitution Inflammatory Syndrome	12.2%
13	Serum Sickness	11.6%
14	Asthma, Aspirin-Induced	11.5%
15	Respiratory Hypersensitivity	10.7%
16	Urticaria	10.2%
17	Vasculitis, Leukocytoclastic, Cutaneous	10.2%
18	Milk Allergy	10.1%
19	Wheat Hypersensitivity	10.1%
20	Transfusion Reaction	9.1%
21	Hypotensive Transfusion Reaction	9.1%
22	Mastocytosis	8.2%
23	Drug Eruptions	8.1%
24	Dermatitis, Allergic Contact	8%
25	Mastocytosis, Systemic	7.5%
26	Antiphospholipid Syndrome	7%
27	Glomerulonephritis, Membranoproliferative	6.9%
28	Angioedema	6.1%
29	Acute Generalized Exanthematous Pustulosis	6%
30	Dermatitis, Atopic	5.8%
31	Autoimmune Lymphoproliferative Syndrome	5.7%
32	Lupus Erythematosus, Systemic	5.3%
33	Lymphoproliferative Disorders	5.3%
34	Overlap syndrome	5.3%
35	Addison Disease	5.2%
36	Paraproteinemias	5.2%
37	Pemphigus	5.2%
38	Autoimmune thyroiditis	5.2%
39	Primary Adrenal Insufficiency	5.2%
40	Asthma	5.1%
41	Lymphopenia	5.1%
42	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	5.1%
43	Autoimmune hepatitis	5.1%
44	Asthma, Exercise-Induced	5%
45	Status Asthmaticus	5%
46	Erythema Nodosum	5%
47	Dermatitis, Photoallergic	4.9%
48	Thrombocytopenic purpura	4.8%
49	Primary amyloidosis	4.5%
50	Monoclonal Gammopathy of Undetermined Significance	4.4%
51	Autoimmune thrombocytopenia	4.4%
52	Immune thrombocytopenic purpura	4.4%
53	Hereditary Angioedema Type III	4.4%
54	Hereditary Angioedema Types I and II	4.4%
55	Asthma, Occupational	4.3%
56	Aspergillosis, Allergic Bronchopulmonary	4.3%
57	Farmer's Lung	4.2%
58	Angioedemas, Hereditary	4.2%
59	Hypergammaglobulinemia	4.2%
60	Latent Autoimmune Diabetes in Adults	4.1%
61	Hay fever	4.1%
62	Rhinitis, Allergic, Perennial	4.1%
63	Agammaglobulinemia	4.1%
64	Dermatitis Herpetiformis	4.1%
65	HIV Infections	4.1%
66	Transfusion-Related Acute Lung Injury	4.1%
67	Toxic Epidermal Necrolysis	3.7%
68	Stevens-Johnson Syndrome	3.7%
69	Rheumatoid Arthritis	3.4%
70	Juvenile arthritis	3.4%
71	Graves Disease	3.4%
72	Plasmacytoma	3.4%
73	Tumor Lysis Syndrome	3.4%
74	Schnitzler Syndrome	3.4%
75	HTLV-I Infections	3.4%
76	Job Syndrome	3.4%
77	Anti-Glomerular Basement Membrane Disease	3.3%
78	Multiple Myeloma	3.3%
79	Sezary Syndrome	2.9%
80	Lymphoma	2.7%
81	Myasthenia Gravis	2.7%
82	Uveomeningoencephalitic Syndrome	2.7%
83	Chronic granulomatous disease	2.7%
84	Heavy Chain Disease	2.7%
85	Granulomatosis with polyangiitis	2.7%
86	HIV Seropositivity	2.7%
87	Kernicterus	2.5%
88	Myasthenia Gravis, Autoimmune, Experimental	2.5%
89	Stiff-Person Syndrome	2.3%
90	Polyradiculoneuropathy	2.3%
91	Polyradiculoneuritis	2.3%
92	Ataxia Telangiectasia	2.3%
93	Acquired Immunodeficiency Syndrome	2.2%
94	AIDS related complex	2.2%
95	Infectious Mononucleosis	2.2%
96	Cryoglobulinemia	2.2%
97	Felty Syndrome	2.2%
98	Hydrops Fetalis	2.2%
99	POEMS Syndrome	2.2%
100	Lupus Nephritis	2.2%
101	Multiple Sclerosis	2%
102	Hodgkin Disease	2%
103	Leukemia, Plasma Cell	2%
104	Lymphoma, Non-Hodgkin	2%
105	Leukemia, T-Cell	2%
106	Leukemia, B-Cell	2%
107	AIDS-Related Opportunistic Infections	1.9%
108	Vasculitis, Central Nervous System	1.9%
109	HIV Wasting Syndrome	1.9%
110	Rheumatoid Vasculitis	1.9%
111	AIDS Dementia Complex	1.9%
112	AIDS-Associated Nephropathy	1.9%
113	Neuromyelitis Optica	1.8%
114	Leukoencephalitis, Acute Hemorrhagic	1.8%
115	Lupus Vasculitis, Central Nervous System	1.8%
116	Lambert-Eaton Myasthenic Syndrome	1.7%
117	Waldenstrom Macroglobulinemia	1.7%
118	Composite Lymphoma	1.7%
119	Wiskott-Aldrich Syndrome	1.7%
120	Encephalomyelitis, Acute Disseminated	1.7%
121	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	1.7%
122	Sicca Syndrome	1.7%
123	Sjogren's Syndrome	1.7%
124	Neuritis, Autoimmune, Experimental	1.7%
125	Multiple Sclerosis, Chronic Progressive	1.7%
126	Multiple Sclerosis, Relapsing-Remitting	1.7%
127	Lymphangioleiomyomatosis	1.6%
128	Lymphoma, Follicular	1.6%
129	T-Cell Lymphoma	1.6%
130	Mantle cell lymphoma	1.6%
131	HIV-Associated Lipodystrophy Syndrome	1.6%
132	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	1.6%
133	Leukemia, Large Granular Lymphocytic	1.6%
134	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	1.6%
135	Lymphoma, T-Cell, Cutaneous	1.5%
136	Lymphoma, AIDS-Related	1.5%
137	Enteropathy-Associated T-Cell Lymphoma	1.5%
138	Primary Effusion Lymphoma	1.5%
139	Guillain-Barre Syndrome	1.4%
140	Mycosis Fungoides	1.4%
141	Lymphomatoid Papulosis	1.4%
142	Plasmablastic lymphoma	1.4%
143	Lymphomatoid Granulomatosis	1.2%
144	Giant Cell Arteritis	1.1%
145	Temporal Arteritis	1.1%
146	Burkitt Lymphoma	1.1%
147	Myelitis, Transverse	1%
148	Miller Fisher Syndrome	0.8%

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