MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Antiphospholipid Syndrome

(UMLS:C0085278)

Definition:: The presence of antibodies directed against phospholipids (ANTIBODIES, ANTIPHOSPHOLIPID). The condition is associated with a variety of diseases, notably systemic lupus erythematosus and other connective tissue diseases, thrombopenia, and arterial or venous thromboses. In pregnancy it can cause abortion. Of the phospholipids, the cardiolipins show markedly elevated levels of anticardiolipin antibodies (ANTIBODIES, ANTICARDIOLIPIN). Present also are high levels of lupus anticoagulant (LUPUS COAGULATION INHIBITOR).
UMLS ID:: C0085278
MeSH ID:: D016736

Classification:

Name:

Immune System Diseases
MeSH Tree Number(s):: C20.111.197

Synonym(s)

Antiphospholipid Syndrome

APL - Antiphospholipid syndrome

APS - Antiphospholipid syndrome

Anticardiolipin syndrome

Antiphospholipid Antibody Syndrome

Antiphospholipid syndrome

anti phospholipid syndrome

anti phospholipids syndrome

anti-phospholipid syndrome

10.

anticardiolipin syndrome

11.

anticardiolipin; syndrome

12.

antiphospholipid syndrome

13.

antiphospholipid; syndrome

14.

antiphospholipids syndrome

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	NuvaRing	FAERS: 43		OFFSIDES US FAERS
2	Rivaroxaban	FAERS: 28 Canada Vigilance: 1		Canada Vigilance US FAERS
3	apixaban	FAERS: 16		US FAERS
4	Norgestrel	FAERS: 7		US FAERS
5	Warfarin	FAERS: 6	11776303 20597268	CTD US FAERS
6	rofecoxib	FAERS: 6		OFFSIDES US FAERS
7	Minocycline	FAERS: 5		US FAERS
8	Warfarin	FAERS: 5		US FAERS
9	reviparin	FAERS: 5 Canada Vigilance: 1	11776303	CTD Canada Vigilance US FAERS
10	Aripiprazole	FAERS: 4		US FAERS
11	Dabigatran	FAERS: 4		US FAERS
12	Olanzapine	FAERS: 4		US FAERS
13	Simvastatin	FAERS: 4		US FAERS
14	Tamoxifen	FAERS: 4		US FAERS
15	eltrombopag	FAERS: 4		US FAERS
16	4-hydroxybutyric acid	FAERS: 3		US FAERS
17	Anastrozole	FAERS: 3		US FAERS
18	Glatiramer Acetate	FAERS: 3		US FAERS
19	Sulfasalazine	FAERS: 3		US FAERS
20	Tacrolimus	FAERS: 3		US FAERS
21	Aspirin	FAERS: 2	11776303 15219202	CTD US FAERS
22	Chlorpromazine	FAERS: 2		US FAERS
23	Clomipramine	FAERS: 2		US FAERS
24	Danazol	FAERS: 2		OFFSIDES US FAERS
25	Finasteride	FAERS: 2		US FAERS
26	Mycophenolic Acid	FAERS: 2 Canada Vigilance: 1		Canada Vigilance US FAERS
27	Ortho Evra	FAERS: 2		US FAERS
28	Pregabalin	FAERS: 2		US FAERS
29	Sertraline	FAERS: 2		US FAERS
30	Tamoxifen	FAERS: 2		US FAERS
31	eltrombopag	FAERS: 2		US FAERS
32	2-(Tert-butylamino)-1-(3-chlorophenyl)propan-1-one;hydron;chloride	FAERS: 1		US FAERS
33	Alendronate	FAERS: 1		US FAERS
34	Calcitriol	FAERS: 1		US FAERS
35	Celecoxib	FAERS: 1		US FAERS
36	Cysteamine	FAERS: 1		US FAERS
37	Daptomycin	FAERS: 1		US FAERS
38	Diclofenac	FAERS: 1		US FAERS
39	Fenofibrate	FAERS: 1		US FAERS
40	Fingolimod Hydrochloride	FAERS: 1		US FAERS
41	Flecainide	FAERS: 1		US FAERS
42	Fondaparinux	FAERS: 1		US FAERS
43	Fondaparinux	FAERS: 1		OFFSIDES US FAERS
44	Goserelin	FAERS: 1		US FAERS
45	Hydroxychloroquine	FAERS: 1		US FAERS
46	Imatinib Mesylate	FAERS: 1		US FAERS
47	Isotretinoin	FAERS: 1		US FAERS
48	Lamotrigine	FAERS: 1		US FAERS
49	Minocycline	FAERS: 1		US FAERS
50	Omeprazole	FAERS: 1		US FAERS
51	Propylthiouracil	FAERS: 1	15822032 15879050 18044264	CTD US FAERS
52	Risperidone	FAERS: 1		US FAERS
53	Rivastigmine	FAERS: 1		US FAERS
54	Ruxolitinib phosphate	FAERS: 1		US FAERS
55	Sulfamethoxazole	FAERS: 1		US FAERS
56	Thalidomide	FAERS: 1	15303578	CTD US FAERS
57	Thyroxine	FAERS: 1		US FAERS
58	Trimethoprim, Sulfamethoxazole Drug Combination	FAERS: 1		US FAERS
59	ambrisentan	FAERS: 1		US FAERS
60	anagrelide	FAERS: 1		US FAERS
61	argatroban	FAERS: 1		US FAERS
62	beyaz	FAERS: 1		US FAERS
63	edoxaban	FAERS: 1		US FAERS
64	macitentan	FAERS: 1		US FAERS
65	norethindrone acetate, ethinyl estradiol, ferrous fumarate drug combination	FAERS: 1		US FAERS
66	pasireotide	FAERS: 1		US FAERS
67	Acetazolamide			OFFSIDES
68	Beclomethasone			OFFSIDES
69	Beclomethasone			OFFSIDES
70	Calcium Chloride			OFFSIDES
71	Cephalexin			OFFSIDES
72	Chlordiazepoxide			OFFSIDES
73	Ciprofloxacin		9485080	CTD
74	Clomipramine			OFFSIDES
75	Cyclophosphamide		15658543	CTD
76	Cyproheptadine			OFFSIDES
77	Desogestrel			OFFSIDES
78	Ephedrine			OFFSIDES
79	Gadolinium			OFFSIDES
80	Lamivudine			OFFSIDES
81	Mesalamine			OFFSIDES
82	Mycophenolic Acid			OFFSIDES
83	Phenprocoumon			OFFSIDES
84	Phentermine			OFFSIDES
85	Quinidine			OFFSIDES
86	Terbutaline			OFFSIDES
87	Trazodone			OFFSIDES
88	Tropicamide			OFFSIDES
89	Valacyclovir			OFFSIDES
90	Vardenafil Dihydrochloride			OFFSIDES
91	Zonisamide			OFFSIDES
92	alfacalcidol			OFFSIDES
93	balsalazide			OFFSIDES
94	defibrotide		12233899	CTD
95	mizoribine			OFFSIDES
96	ropinirole			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Lupus Erythematosus, Systemic	28.6%
2	Overlap syndrome	28.6%
3	Addison Disease	27.9%
4	Pemphigus	27.9%
5	Autoimmune thyroiditis	27.9%
6	Primary Adrenal Insufficiency	27.9%
7	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	27.6%
8	Autoimmune hepatitis	27.6%
9	Hypersensitivity	23.1%
10	Immunologic Deficiency Syndromes	23.1%
11	Immunoproliferative Disorders	23.1%
12	Immune reconstitution syndrome	23.1%
13	Immune Reconstitution Inflammatory Syndrome	23.1%
14	Latent Autoimmune Diabetes in Adults	20.9%
15	Autoimmune Lymphoproliferative Syndrome	20.8%
16	Dermatitis Herpetiformis	20.7%
17	Rheumatoid Arthritis	16.7%
18	Juvenile arthritis	16.7%
19	Graves Disease	16.4%
20	Anti-Glomerular Basement Membrane Disease	16.1%
21	Myasthenia Gravis	15.5%
22	Uveomeningoencephalitic Syndrome	15.5%
23	Granulomatosis with polyangiitis	15.1%
24	Transfusion Reaction	15%
25	Hypotensive Transfusion Reaction	15%
26	Immune Complex Diseases	14.3%
27	Latex allergy	14.3%
28	Myasthenia Gravis, Autoimmune, Experimental	14.2%
29	Autoimmune thrombocytopenia	13.3%
30	Immune thrombocytopenic purpura	13.3%
31	Multiple Sclerosis	12.6%
32	Stiff-Person Syndrome	12.5%
33	Polyradiculoneuropathy	12.4%
34	Polyradiculoneuritis	12.4%
35	Felty Syndrome	12%
36	Lupus Nephritis	11.9%
37	Multiple Sclerosis, Chronic Progressive	11.1%
38	Multiple Sclerosis, Relapsing-Remitting	11.1%
39	Neuromyelitis Optica	10.4%
40	Glomerulonephritis, Membranoproliferative	10.4%
41	anaphylaxis	10.3%
42	Food Allergy	10.3%
43	Anaphylactic shock	10.3%
44	Leukoencephalitis, Acute Hemorrhagic	10.3%
45	Vasculitis, Central Nervous System	10.2%
46	Environmental Illness	10%
47	Encephalomyelitis, Acute Disseminated	10%
48	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	10%
49	Rheumatoid Vasculitis	9.9%
50	Neuritis, Autoimmune, Experimental	9.9%
51	Lymphoproliferative Disorders	9.5%
52	Paraproteinemias	9.3%
53	Lymphopenia	9.2%
54	Lupus Vasculitis, Central Nervous System	9%
55	Lambert-Eaton Myasthenic Syndrome	8.7%
56	Sicca Syndrome	8.5%
57	Sjogren's Syndrome	8.5%
58	Milk Allergy	8.5%
59	Schnitzler Syndrome	8.5%
60	Wheat Hypersensitivity	8.5%
61	Guillain-Barre Syndrome	8.3%
62	Primary amyloidosis	8.1%
63	Monoclonal Gammopathy of Undetermined Significance	8%
64	Respiratory Hypersensitivity	7.3%
65	Serum Sickness	7.3%
66	Hypergammaglobulinemia	7%
67	Sick Building Syndrome	7%
68	Multiple Chemical Sensitivity	7%
69	Agammaglobulinemia	6.9%
70	Kounis Syndrome	6.9%
71	HIV Infections	6.8%
72	Transfusion-Related Acute Lung Injury	6.8%
73	Plasmacytoma	6.8%
74	Tumor Lysis Syndrome	6.8%
75	Urticaria	6.8%
76	Vasculitis, Leukocytoclastic, Cutaneous	6.8%
77	Thrombocytopenic purpura	6.8%
78	HTLV-I Infections	6.7%
79	Asthma, Aspirin-Induced	6.7%
80	Job Syndrome	6.7%
81	Giant Cell Arteritis	6.2%
82	Temporal Arteritis	6.2%
83	Multiple Myeloma	5.7%
84	Mastocytosis, Systemic	5.5%
85	Sezary Syndrome	5.5%
86	Myelitis, Transverse	5.5%
87	Lymphoma	5.2%
88	Mastocytosis	5.1%
89	Drug Eruptions	5.1%
90	Chronic granulomatous disease	5%
91	Heavy Chain Disease	5%
92	Dermatitis, Allergic Contact	5%
93	HIV Seropositivity	5%
94	Miller Fisher Syndrome	4.9%
95	Angioedema	4.2%
96	Hodgkin Disease	4.2%
97	Leukemia, Plasma Cell	4.2%
98	Lymphoma, Non-Hodgkin	4.2%
99	Leukemia, T-Cell	4.1%
100	Acute Generalized Exanthematous Pustulosis	4.1%
101	Leukemia, B-Cell	4.1%
102	Acquired Immunodeficiency Syndrome	4%
103	AIDS related complex	4%
104	Infectious Mononucleosis	4%
105	Cryoglobulinemia	4%
106	POEMS Syndrome	4%
107	Kernicterus	3.9%
108	Asthma, Exercise-Induced	3.8%
109	Status Asthmaticus	3.8%
110	Lymphoma, Follicular	3.7%
111	T-Cell Lymphoma	3.7%
112	Mantle cell lymphoma	3.7%
113	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	3.7%
114	Leukemia, Large Granular Lymphocytic	3.7%
115	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	3.7%
116	Hereditary Angioedema Type III	3.5%
117	Hereditary Angioedema Types I and II	3.5%
118	Lymphoma, T-Cell, Cutaneous	3.5%
119	Lymphoma, AIDS-Related	3.5%
120	Enteropathy-Associated T-Cell Lymphoma	3.5%
121	Primary Effusion Lymphoma	3.5%
122	Asthma	3.4%
123	AIDS-Related Opportunistic Infections	3.4%
124	Ataxia Telangiectasia	3.4%
125	Dermatitis, Atopic	3.4%
126	Mycosis Fungoides	3.3%
127	Lymphomatoid Papulosis	3.3%
128	Plasmablastic lymphoma	3.3%
129	Hydrops Fetalis	3.3%
130	Composite Lymphoma	3.3%
131	HIV Wasting Syndrome	3.3%
132	Erythema Nodosum	3.3%
133	AIDS Dementia Complex	3.3%
134	AIDS-Associated Nephropathy	3.3%
135	Dermatitis, Photoallergic	3.3%
136	Lymphangioleiomyomatosis	3.3%
137	Asthma, Occupational	3.1%
138	Farmer's Lung	3%
139	Angioedemas, Hereditary	3%
140	Hay fever	3%
141	Rhinitis, Allergic, Perennial	3%
142	Waldenstrom Macroglobulinemia	2.9%
143	Wiskott-Aldrich Syndrome	2.9%
144	Lymphomatoid Granulomatosis	2.8%
145	HIV-Associated Lipodystrophy Syndrome	2.8%
146	Aspergillosis, Allergic Bronchopulmonary	2.8%
147	Toxic Epidermal Necrolysis	2.3%
148	Stevens-Johnson Syndrome	2.3%
149	Burkitt Lymphoma	2.3%

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