MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Mitoxantrone

(KKZJGLLVHKMTCM-UHFFFAOYSA-N)

Structure

SMILES: OCCNCCNc1ccc(c2c1C(=O)c1c(C2=O)c(O)ccc1O)NCCNCCO
Type(s): Approved; Investigational
ATC code(s): L01DB07
Molecular Formula:: C22H28N4O6
Molecular Weight:: 444.481
Log P:: 0.7886
Hydrogen Bond Acceptor:: 10
Hydrogen Bond Donor:: 8
TPSA:: 163.18
CAS Number(s):: 65271-80-9; 70476-82-3

Synonym(s)

Mitoxantrone

Mitozantrone

CL-232325

DHAQ

Mitoxantrone Acetate

Mitoxantrone Hydrochloride

Mitroxone

NSC-279836

NSC-287836

10.

NSC-299195

11.

NSC-301739

12.

NSC-301739D

13.

Novantron

14.

Novantrone

15.

Onkotrone

16.

Pralifan

17.

Ralenova

18.

Acetate, Mitoxantrone

19.

CL 232325

20.

CL232325

21.

Hydrochloride, Mitoxantrone

22.

NSC 279836

23.

NSC 287836

24.

NSC 299195

25.

NSC 301739

26.

NSC 301739D

27.

NSC279836

28.

NSC287836

29.

NSC299195

30.

NSC301739

31.

NSC301739D

External Link(s)

MeSH	D008942
PubChem Compound	4212
BindingDB	67690 50003674
ChEBI	50729
CHEMBL	CHEMBL58
DrugBank	DB01204
DrugCentral	1821
IUPHAR/BPS Guide to PHARMACOLOGY	7242
KEGG	cpd:C11195 dr:D08224
Therapeutic Target Database	D0R3JB
ZINC	3794794

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Pancytopenia	FAERS: 7		SIDER US FAERS
2	Neutropenia	FAERS: 5	View details 10597740 10813714 11290867 12592360 15333686 20427751 20521909	CTD SIDER US FAERS
3	Leukopenia	FAERS: 4	View details 1650529 1802019 2468745 3383949 3894277 7101322 11290867 15493352 15623667	CTD SIDER US FAERS
4	Ejection Fraction Decreased	FAERS: 3		OFFSIDES SIDER US FAERS
5	Febrile Neutropenia	FAERS: 3		OFFSIDES SIDER US FAERS
6	Myocardial Infarction	FAERS: 3		SIDER US FAERS
7	Cardiotoxicity	FAERS: 2	25582955	CTD OFFSIDES SIDER US FAERS
8	General physical health deterioration	FAERS: 2		US FAERS
9	Hypotension	FAERS: 2		SIDER US FAERS
10	Pneumonia	FAERS: 2		SIDER US FAERS
11	Sinus Tachycardia	FAERS: 2		US FAERS
12	Ventricular Dysfunction	FAERS: 2		US FAERS
13	Vomiting	FAERS: 2	10597740 11851027 15333686	CTD SIDER US FAERS
14	Abdominal discomfort	FAERS: 1		OFFSIDES US FAERS
15	Accidental exposure to product	FAERS: 1		US FAERS
16	Alopecia	FAERS: 1	View details 2468745 10597740 11290867 11851027 12592360 15623667	CTD OFFSIDES SIDER US FAERS
17	Amniotic fluid volume decreased	FAERS: 1		US FAERS
18	Anoxic Encephalopathy	FAERS: 1		US FAERS
19	Aortic Valve Stenosis	FAERS: 1		US FAERS
20	Aphasia	FAERS: 1		US FAERS
21	Asthenia	FAERS: 1		OFFSIDES SIDER US FAERS
22	Atelectasis	FAERS: 1		OFFSIDES US FAERS
23	Atrial Fibrillation	FAERS: 1	16088176	CTD US FAERS
24	Autoimmune hepatitis	FAERS: 1		US FAERS
25	Bedridden	FAERS: 1		US FAERS
26	Bladder dysfunction	FAERS: 1		US FAERS
27	Cellulitis	FAERS: 1		OFFSIDES US FAERS
28	Chest Pain	FAERS: 1		OFFSIDES SIDER US FAERS
29	Chromaturia	FAERS: 1		SIDER US FAERS
30	Disseminated Intravascular Coagulation	FAERS: 1		OFFSIDES US FAERS
31	Drug dose omission	FAERS: 1		US FAERS
32	Drug toxicity	FAERS: 1		OFFSIDES US FAERS
33	Dysplasia	FAERS: 1		US FAERS
34	Endocarditis	FAERS: 1		US FAERS
35	Endometrial disorder	FAERS: 1		US FAERS
36	Endometriosis	FAERS: 1		US FAERS
37	Fatigue	FAERS: 1		OFFSIDES SIDER US FAERS
38	Gastrointestinal carcinoma	FAERS: 1		US FAERS
39	Haematotoxicity	FAERS: 1		OFFSIDES US FAERS
40	Headache	FAERS: 1		SIDER US FAERS
41	Hepatic Encephalopathy	FAERS: 1		US FAERS
42	Incorrect dose administered	FAERS: 1		US FAERS
43	Low birth weight baby	FAERS: 1		US FAERS
44	Lower respiratory tract infection bacterial	FAERS: 1		OFFSIDES US FAERS
45	Medication Error	FAERS: 1		US FAERS
46	Monocytosis	FAERS: 1		US FAERS
47	Nausea	FAERS: 1	1802019 10597740 11851027	CTD OFFSIDES SIDER US FAERS
48	Oropharyngeal pain	FAERS: 1		US FAERS
49	Palpitations	FAERS: 1		US FAERS
50	Pancreatic carcinoma	FAERS: 1		US FAERS
51	Paraparesis	FAERS: 1	2564552	CTD OFFSIDES US FAERS
52	Pericardial effusion	FAERS: 1		OFFSIDES US FAERS
53	Pericarditis	FAERS: 1		OFFSIDES US FAERS
54	Product physical issue	FAERS: 1		US FAERS
55	Product quality issue	FAERS: 1		US FAERS
56	Psoriasis	FAERS: 1		US FAERS
57	Pulmonary Embolism	FAERS: 1		US FAERS
58	Pulmonary Hypertension	FAERS: 1		OFFSIDES US FAERS
59	Respiratory Failure	FAERS: 1		OFFSIDES US FAERS
60	Respiratory distress	FAERS: 1		US FAERS
61	Sepsis	FAERS: 1		SIDER US FAERS
62	Septic Shock	FAERS: 1		OFFSIDES US FAERS
63	Skin necrosis	FAERS: 1		OFFSIDES US FAERS
64	Stem cell transplant	FAERS: 1		OFFSIDES US FAERS
65	Stridor	FAERS: 1		US FAERS
66	Synovial sarcoma metastatic	FAERS: 1		US FAERS
67	Tachycardia	FAERS: 1		SIDER US FAERS
68	Thrombocytopenia	FAERS: 1	View details 1650529 10597740 10813714 12592360 15493352 20521909	CTD SIDER US FAERS
69	Treatment related secondary malignancy	FAERS: 1		OFFSIDES US FAERS
70	Ulcer	FAERS: 1		OFFSIDES SIDER US FAERS
71	Urinary tract infection	FAERS: 1		SIDER US FAERS
72	Vertigo	FAERS: 1		US FAERS
73	Weight decreased	FAERS: 1		SIDER US FAERS
74	White blood cell count decreased	FAERS: 1		SIDER US FAERS
75	Abdominal Pain			OFFSIDES SIDER
76	Abdominal mass			OFFSIDES
77	Abnormal cervical smear			OFFSIDES
78	Accidental exposure			OFFSIDES
79	Actinomycosis			OFFSIDES
80	Activities of daily living impaired			OFFSIDES
81	Acute Coronary Syndrome			SIDER
82	Acute kidney injury		8832525 12180108	CTD
83	Acute myocardial infarction			OFFSIDES
84	Adenitis			OFFSIDES
85	Adenocarcinoma			OFFSIDES
86	Ageusia			OFFSIDES
87	Agranulocytosis			SIDER
88	Alanine Aminotransferase Increased			SIDER
89	Alcohol poisoning			OFFSIDES
90	Allogenic bone marrow transplantation therapy			OFFSIDES
91	Amenorrhea		15623667	CTD OFFSIDES
92	Amino acid level increased			OFFSIDES
93	Amphetamines			OFFSIDES
94	Anaphylactic shock			SIDER
95	Anaphylactoid Reaction			SIDER
96	Anemia		View details 2283895 10597740 12592360 15333686 15493352 20427751	CTD
97	Anhedonia			OFFSIDES
98	Anisocoria			OFFSIDES
99	Anorexia			OFFSIDES SIDER
100	Anticholinergic Syndrome			OFFSIDES
101	Anxiety			OFFSIDES SIDER
102	Apathy			OFFSIDES
103	Aphonia			OFFSIDES
104	Apparent life threatening event			OFFSIDES
105	Arteriosclerosis			OFFSIDES
106	Arthralgia			SIDER
107	Arthritis			OFFSIDES
108	Arthroscopy			OFFSIDES
109	Ascites			OFFSIDES
110	Aspartate Aminotransferase Increased			SIDER
111	Aspergillosis			OFFSIDES
112	Aspiration Pneumonia			OFFSIDES
113	Asterixis			OFFSIDES
114	Asthma			OFFSIDES
115	Ataxia			OFFSIDES
116	Atrial pressure increased			OFFSIDES
117	Atrial tachycardia			OFFSIDES
118	Atrioventricular Block			OFFSIDES
119	Autologous bone marrow transplantation therapy			OFFSIDES
120	Automatism			OFFSIDES
121	Azoospermia			OFFSIDES
122	B-cell lymphoma stage IV			OFFSIDES
123	Back Pain			SIDER
124	Back disorder			OFFSIDES
125	Bacteria stool identified			OFFSIDES
126	Bacterial Infections		12180108	CTD
127	Bacterial sepsis			OFFSIDES
128	Bartholinitis			OFFSIDES
129	Bifascicular block			OFFSIDES
130	Bilirubin conjugated increased			OFFSIDES
131	Blepharospasm			OFFSIDES
132	Blood albumin decreased			OFFSIDES
133	Blood alkaline phosphatase increased			OFFSIDES
134	Blood chloride decreased			OFFSIDES
135	Blood creatinine abnormal			SIDER
136	Blood creatinine decreased			OFFSIDES
137	Blood creatinine increased			SIDER
138	Blood fibrinogen increased			OFFSIDES
139	Blood glucose increased			SIDER
140	Blood immunoglobulin G decreased			OFFSIDES
141	Blood lactate dehydrogenase increased			OFFSIDES
142	Blood pH decreased			OFFSIDES
143	Blood pH increased			OFFSIDES
144	Blood potassium decreased			SIDER
145	Blood sodium increased			OFFSIDES
146	Blood urea abnormal			SIDER
147	Blood urea increased			OFFSIDES SIDER
148	Blood uric acid decreased			OFFSIDES
149	Bone Marrow Neoplasms		2214347	CTD
150	Bone density decreased			OFFSIDES
151	Bone lesion			OFFSIDES
152	Bone marrow depression			OFFSIDES SIDER
153	Bone pain			SIDER
154	Bone scan abnormal			OFFSIDES
155	Bradycardia		View details 8701956 9054290 10798520 10870375	CTD SIDER
156	Brain natriuretic peptide increased			OFFSIDES
157	Brain stem syndrome			OFFSIDES
158	Bronchitis			OFFSIDES
159	Bronchoalveolar Lavage			OFFSIDES
160	Bronchopneumonia			OFFSIDES
161	Bursitis			OFFSIDES
162	Calcific deposits removal			OFFSIDES
163	Calcinosis			OFFSIDES
164	Carcinoma, Transitional Cell		8260250 18510180	CTD
165	Carcinoma		9404925	CTD
166	Cardiac function test abnormal			OFFSIDES
167	Cardiac ventricular disorder			OFFSIDES
168	Cardiomyopathies		View details 1602607 3690154 8443051 8745224 15135385 15623667 17285358	CTD
169	Carotid artery aneurysm			OFFSIDES
170	Carotid bruit			OFFSIDES
171	Cataract operation			OFFSIDES
172	Catheter related infection			OFFSIDES
173	Catheter sepsis			OFFSIDES
174	Central Nervous System Neoplasms		2878247	CTD
175	Central line infection			OFFSIDES
176	Cerebral Hemorrhage		9404925	CTD
177	Cerebral artery occlusion			OFFSIDES
178	Cerebral disorder			OFFSIDES
179	Chemical and Drug Induced Liver Injury		30413070	CTD
180	Chills			SIDER
181	Choking sensation			OFFSIDES
182	Cholecystitis			OFFSIDES
183	Cholestasis		19393848	CTD
184	Chronic left ventricular failure			OFFSIDES
185	Chronic sinusitis			OFFSIDES
186	Cirrhosis			OFFSIDES
187	Citrobacter infection			OFFSIDES
188	Clostridium colitis			OFFSIDES
189	Clostridium difficile colitis			OFFSIDES
190	Colitis			OFFSIDES
191	Colorectal Neoplasms		17187072	CTD
192	Compression fracture			OFFSIDES
193	Concomitant disease aggravated			OFFSIDES
194	Confabulation			OFFSIDES
195	Congenital pyelocaliectasis			OFFSIDES
196	Congenital tricuspid valve incompetence			OFFSIDES
197	Conjunctivitis			SIDER
198	Constipation			SIDER
199	Contracture		18510180	CTD
200	Coronary artery dilatation			OFFSIDES
201	Creatinine abnormal NOS			SIDER
202	Cross resistance			SIDER
203	Cyanosis			OFFSIDES
204	Cyst aspiration			OFFSIDES
205	Cystitis escherichia			OFFSIDES
206	Cystitis		8260250	CTD
207	Cyst			OFFSIDES
208	Cytogenetic analysis abnormal			OFFSIDES
209	Cytomegalovirus gastrointestinal infection			OFFSIDES
210	Dacryostenosis acquired			OFFSIDES
211	Deafness Neurosensory			OFFSIDES
212	Debridement			OFFSIDES
213	Decreased Libido			OFFSIDES
214	Dehydration			OFFSIDES SIDER
215	Delayed Puberty			OFFSIDES
216	Demyelinating Diseases		2564552	CTD
217	Demyelination			OFFSIDES
218	Dental abscess			OFFSIDES
219	Dental caries			OFFSIDES
220	Depressed Level of Consciousness			OFFSIDES
221	Dermatitis			SIDER
222	Diabetic foot infection			OFFSIDES
223	Diarrhea		1802019	CTD OFFSIDES
224	Diastolic dysfunction			OFFSIDES
225	Discomfort			SIDER
226	Disease Progression		10597740	CTD OFFSIDES
227	Diverticular hernia			OFFSIDES
228	Diverticulitis			OFFSIDES
229	Diverticulosis			OFFSIDES
230	Diverticulum			OFFSIDES
231	Drowsiness			SIDER
232	Drug Eruptions		19393848	CTD
233	Drug ineffective			OFFSIDES
234	Drug withdrawal headache			OFFSIDES
235	Dysgeusia			SIDER
236	Dyspepsia			SIDER
237	Dysphasia			OFFSIDES
238	Dysphonia			OFFSIDES
239	Ear discharge			OFFSIDES
240	Ecchymosis			SIDER
241	Echocardiogram abnormal			OFFSIDES
242	Ejection fraction abnormal			OFFSIDES
243	Electrocardiogram abnormal			SIDER
244	Electrocardiogram poor R-wave progression			OFFSIDES
245	Empty Sella Syndrome			OFFSIDES
246	Endodontic procedure			OFFSIDES
247	Endometritis			SIDER
248	Endomyocardial Fibrosis		25582955	CTD
249	Engraft failure			OFFSIDES
250	Enteritis		9815949	CTD SIDER
251	Enterococcal infection			OFFSIDES
252	Enterocolitis			OFFSIDES
253	Eosinophilia		19393848	CTD
254	Epicondylitis			OFFSIDES
255	Epigastric pain			SIDER
256	Epilepsy			OFFSIDES
257	Epstein-Barr virus serology positive			OFFSIDES
258	Erectile dysfunction			SIDER
259	Erythema			SIDER
260	Escherichia infection			OFFSIDES
261	Escherichia sepsis			OFFSIDES
262	Escherichia urinary tract infection			OFFSIDES
263	Esophageal Stenosis		9404925	CTD
264	Eustachian tube disorder			OFFSIDES
265	Extravasation			SIDER
266	Fatty Liver			OFFSIDES
267	Feeling abnormal			SIDER
268	Fever		2636248 3481363	CTD
269	Fluid overload			OFFSIDES
270	Folliculitis			OFFSIDES
271	Formication			OFFSIDES
272	Full blood count decreased			OFFSIDES
273	Gallbladder necrosis			OFFSIDES
274	Gallop rhythm present			OFFSIDES
275	Gamma-Glutamyltransferase Increased			SIDER
276	Gastrointestinal Pain			SIDER
277	Gingival Hypertrophy			OFFSIDES
278	Gingival erythema			OFFSIDES
279	Glaucoma			OFFSIDES
280	Glossitis			OFFSIDES
281	Glucose increased			SIDER
282	Granuloma Annulare			OFFSIDES
283	Granuloma			OFFSIDES
284	Hay fever			OFFSIDES
285	Head titubation			OFFSIDES
286	Heart Diseases		View details 3169098 8425187 15517007 16019553 16374818 18004637	CTD
287	Heart failure		View details 2923813 3383949 3618544 3725288 6684503 7595745 9378456 11038041 12297576 14978418 15623667 15834643 16503747 20231672	CTD
288	Hematemesis		9404925	CTD
289	Hemiparesis			OFFSIDES
290	Hemiplegia			OFFSIDES
291	Hepatic congestion			OFFSIDES
292	Hepatic vein occlusion			OFFSIDES
293	Hepatitis B positive			OFFSIDES
294	Hepatitis B			OFFSIDES
295	Hepatitis			SIDER
296	Hip surgery			OFFSIDES
297	Histamine level increased			OFFSIDES
298	Histiocytic Disorders, Malignant		2466511	CTD
299	Hodgkin Disease		8260898	CTD
300	Hormone level abnormal			OFFSIDES
301	Hyperbilirubinemia		9815949 21239698	CTD
302	Hyperkeratosis			OFFSIDES
303	Hypersensitivity			SIDER
304	Hypokinesia			OFFSIDES
305	Idiopathic pneumonia syndrome			OFFSIDES
306	Idiosyncratic drug reaction			OFFSIDES
307	Immunosuppression			OFFSIDES
308	Implantable defibrillator insertion			OFFSIDES
309	Incoherent			OFFSIDES
310	Incontinence			OFFSIDES
311	Infection			OFFSIDES SIDER
312	Infertility			SIDER
313	Infusion Site Extravasation			OFFSIDES
314	Infusion site mobility decreased			OFFSIDES
315	Infusion site pain			OFFSIDES
316	Injection site discomfort			OFFSIDES
317	Injection site thrombosis			OFFSIDES
318	Intentional self-injury			OFFSIDES
319	Intermittent Claudication			OFFSIDES
320	Kidney Diseases		9815949	CTD
321	Labile blood pressure			OFFSIDES
322	Left Ventricular Hypertrophy			OFFSIDES
323	Left atrial dilatation			OFFSIDES
324	Left ventricular ejection fraction decreased			SIDER
325	Leukaemic infiltration brain			OFFSIDES
326	Leukopenia neonatal			OFFSIDES
327	Ligament rupture			OFFSIDES
328	Liver diseases		20427751	CTD
329	Local reaction			SIDER
330	Long QT Syndrome		24052561	CTD
331	Loose tooth			OFFSIDES
332	Lung Diseases, Interstitial		9404925	CTD
333	Lung Injury			OFFSIDES
334	Lung infection pseudomonal			OFFSIDES
335	Lymphedema			OFFSIDES
336	Lymphocyte count abnormal			SIDER
337	Lymphocyte count decreased			OFFSIDES
338	Lymphoma transformation			OFFSIDES
339	Lymphoma, Follicular		11571709	CTD
340	Lymphoma, Non-Hodgkin		View details 1617662 2259917 3690531 8780746	CTD
341	Lymphoma		12180108	CTD
342	Lymphoproliferative Disorders		2624510	CTD
343	MYELODYSPLASTIC SYNDROME			SIDER
344	Malaise			SIDER
345	Malignant neoplasm progression			OFFSIDES
346	Mass excision			OFFSIDES
347	Mastectomy			OFFSIDES
348	Maxillofacial operation			OFFSIDES
349	Mediastinal mass			OFFSIDES
350	Megacolon			OFFSIDES
351	Meniscus removal			OFFSIDES
352	Menorrhagia			SIDER
353	Metastasis			SIDER
354	Mitochondrial Diseases		7101322	CTD
355	Mononeuritis			OFFSIDES
356	Monoplegia			OFFSIDES
357	Morganella infection			OFFSIDES
358	Multiple Sclerosis, Chronic Progressive		View details 11851027 15834643 16088176 16100967 16503747 17548442 19393848	CTD
359	Multiple Sclerosis, Relapsing-Remitting		View details 15834643 16088176 16100967 16503747 17230484 17548442	CTD
360	Multiple Sclerosis		View details 12297576 12617270 14978418 15135385 15606626 15623667 16374818 17101825 18004637 19017314 20223599 20427751 20727669	CTD OFFSIDES
361	Multiple gated acquisition scan abnormal			OFFSIDES
362	Multiple sclerosis relapse			OFFSIDES
363	Musculoskeletal Diseases		22878004	CTD
364	Musculoskeletal discomfort			SIDER
365	Musculoskeletal stiffness			OFFSIDES
366	Myalgia			SIDER
367	Myelitis			OFFSIDES
368	Myelodysplasia			OFFSIDES
369	Myelosuppression			SIDER
370	Nail Diseases		2283895	CTD
371	Nail pigmentation			SIDER
372	Necrosis		2299913	CTD SIDER
373	Neoplasms, Experimental		8425187	CTD
374	Neoplasms, Second Primary		19884644	CTD
375	Neoplasms		1982927 3326667 16640825	CTD
376	Nephrolithiasis			OFFSIDES
377	Nephrostomy tube placement			OFFSIDES
378	Neuromyelitis Optica			OFFSIDES
379	Neurotoxicity Syndromes		10597740 30413070	CTD
380	Neutropenic sepsis			OFFSIDES
381	Neutrophil count decreased			OFFSIDES
382	Non-cardiac chest pain			OFFSIDES
383	Nonspecific reaction			OFFSIDES
384	Nystagmus			OFFSIDES
385	Obstruction			OFFSIDES
386	Onychalgia			OFFSIDES
387	Onycholysis			SIDER
388	Open wound			OFFSIDES
389	Oral discharge			OFFSIDES
390	Oral fungal infection			OFFSIDES
391	Orthopnea			OFFSIDES
392	Osteolysis			OFFSIDES
393	Osteomyelitis			OFFSIDES
394	Osteopenia			OFFSIDES
395	Osteoporosis			OFFSIDES
396	Osteosclerosis			OFFSIDES
397	Ovarian Rupture			OFFSIDES
398	Oxygen supplementation			OFFSIDES
399	Pain			SIDER
400	Palmar erythema			OFFSIDES
401	Pancreatic Cyst			OFFSIDES
402	Paracentesis			OFFSIDES
403	Paraplegia		2878247	CTD
404	Pathogen resistance			OFFSIDES SIDER
405	Periodontal infection			OFFSIDES
406	Periodontal operation			OFFSIDES
407	Peritoneal Dialysis			OFFSIDES
408	Peritonitis		10370195	CTD OFFSIDES
409	Petechiae			SIDER
410	Pharyngitis			SIDER
411	Phlebitis			OFFSIDES SIDER
412	Placental Insufficiency			OFFSIDES
413	Platelet count abnormal			SIDER
414	Poisoning		23261645	CTD
415	Polyneuropathy			OFFSIDES
416	Potassium low			SIDER
417	Primary sequestrum			OFFSIDES
418	Procedural hypotension			OFFSIDES
419	Progressive multiple sclerosis			OFFSIDES
420	Prostatic Neoplasms		15333686	CTD
421	Protein total decreased			OFFSIDES
422	Protein urine present			SIDER
423	Proteinuria			SIDER
424	Pulmonary radiation injury			OFFSIDES
425	Purulent discharge			OFFSIDES
426	Pyelonephritis			OFFSIDES
427	Radicular pain			OFFSIDES
428	Rales			OFFSIDES
429	Recall phenomenon			OFFSIDES
430	Recurrence		2214347	CTD
431	Reflux laryngitis			OFFSIDES
432	Renal Insufficiency		9404925	CTD
433	Renal aneurysm			OFFSIDES
434	Reticulocyte count increased			OFFSIDES
435	Rhabdomyolysis		8832525	CTD
436	Rhabdomyosarcoma		6684503	CTD
437	Rhinitis			OFFSIDES SIDER
438	Rhinorrhea			OFFSIDES
439	Ruptured ectopic pregnancy			OFFSIDES
440	Salpingo-oophorectomy			OFFSIDES
441	Septic embolus			OFFSIDES
442	Sequestrectomy			OFFSIDES
443	Shock			SIDER
444	Sinoatrial Block			OFFSIDES
445	Sinus bradycardia			OFFSIDES SIDER
446	Sinus operation			OFFSIDES
447	Sinusitis			OFFSIDES SIDER
448	Soft Tissue Infection			OFFSIDES
449	Soft tissue inflammation			OFFSIDES
450	Somnolence			SIDER
451	Spinal column stenosis			OFFSIDES
452	Status Epilepticus			OFFSIDES
453	Stenotrophomonas infection			OFFSIDES
454	Stenotrophomonas sepsis			OFFSIDES
455	Steroid withdrawal syndrome			OFFSIDES
456	Stomach ache			SIDER
457	Stomatitis		1802019 2468745	CTD SIDER
458	Stomatocytes present			OFFSIDES
459	Sudden death			SIDER
460	Sweating			SIDER
461	Swelling			SIDER
462	Swollen tear duct			OFFSIDES
463	Synovial Cyst			OFFSIDES
464	Synovitis			OFFSIDES
465	Systemic mycosis			OFFSIDES
466	T-Cell Lymphoma			OFFSIDES
467	Tendinitis			OFFSIDES
468	Tenosynovitis			OFFSIDES
469	Therapy non-responder			OFFSIDES
470	Tonsillitis			SIDER
471	Tooth Extraction			OFFSIDES
472	Tooth Infection			OFFSIDES
473	Tooth Loss			OFFSIDES
474	Torsades de Pointes		19358226	CTD
475	Tracheobronchitis			OFFSIDES
476	Tremor		2564552	CTD
477	Trichosporon infection			OFFSIDES
478	Trisomy 11			OFFSIDES
479	Troponin I increased			OFFSIDES
480	Troponin increased			OFFSIDES
481	Tubal rupture			OFFSIDES
482	Tumor Lysis Syndrome		21239698	CTD
483	Urinary Bladder Diseases		18510180	CTD
484	Urine leukocyte esterase			OFFSIDES
485	Urticaria			SIDER
486	Uterine Cancer			OFFSIDES
487	Ventricular Fibrillation			OFFSIDES
488	Ventricular Flutter			OFFSIDES
489	Ventricular hypokinesia			OFFSIDES
490	Vertebroplasty			OFFSIDES
491	Viral upper respiratory tract infection			OFFSIDES
492	Vitamin B 12 Deficiency			OFFSIDES
493	Vulvovaginal pruritus			OFFSIDES
494	Wound Debridement			OFFSIDES
495	jaundice			SIDER
496	leukemia		View details 3481363 8262731 15623667 16503747	CTD
497	muscle injury			OFFSIDES

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