MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Rocky Mountain Spotted Fever

(UMLS:C0035793)

Definition:: An acute febrile illness caused by RICKETTSIA RICKETTSII. It is transmitted to humans by bites of infected ticks and occurs only in North and South America. Characteristics include a sudden onset with headache and chills and fever lasting about two to three weeks. A cutaneous rash commonly appears on the extremities and trunk about the fourth day of illness.
UMLS ID:: C0035793
MeSH ID:: D012373

Classification:

Name:

Bacterial Infections and Mycoses
MeSH Tree Number(s):: C01.252.400.780.790.750.500|C01.252.400.825.887.500

Synonym(s)

Rocky Mountain Spotted Fever

Brazilian spotted fever

FIEBRE MACULOSA

FIEBRE MANCHADA

FIEBRE PETEQUIAL

Fiebre macuculosa

Fiebre manchada

Fiebre petequial

RMSF - Rocky Mountain spotted fever

10.

ROCKY MOUNTAIN SPOTTED FEVER

11.

Rickettsia; rickettsii, spotted fever

12.

Rocky Mountain fever

13.

Rocky Mountain spotted fever

14.

Rocky Mountain tick fever

15.

Rocky Mountain; spotted fever

16.

Rocky mountain spotted fever

Associated Drug(s)

	Name	Number of Reports	Data Source
1	4-Aminopyridine	FAERS: 2	US FAERS
2	Amlodipine	FAERS: 2	US FAERS
3	Dimethyl Fumarate	FAERS: 2	US FAERS
4	Ibuprofen	FAERS: 2	US FAERS
5	apremilast	FAERS: 2	US FAERS
6	4-hydroxybutyric acid	FAERS: 1	US FAERS
7	Azathioprine	FAERS: 1	US FAERS
8	Bosentan	FAERS: 1	US FAERS
9	Carbamazepine	FAERS: 1	US FAERS
10	Dasatinib	FAERS: 1	US FAERS
11	Desvenlafaxine Succinate	FAERS: 1	US FAERS
12	Isotretinoin	FAERS: 1	US FAERS
13	Lamotrigine	FAERS: 1	OFFSIDES US FAERS
14	Lenalidomide	FAERS: 1	US FAERS
15	Sulfamethoxazole	FAERS: 1	US FAERS
16	Teriparatide	FAERS: 1	US FAERS
17	Venlafaxine Hydrochloride	FAERS: 1	US FAERS
18	empagliflozin	FAERS: 1	US FAERS
19	ledipasvir, sofosbuvir drug combination	FAERS: 1	US FAERS
20	tofacitinib	FAERS: 1	US FAERS
21	Baclofen		OFFSIDES
22	Etodolac		OFFSIDES
23	Modafinil		OFFSIDES
24	Probenecid		OFFSIDES
25	tizanidine		OFFSIDES
26	zolmitriptan		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Human Ehrlichiosis	40.3%
2	Borrelia Infections	38.5%
3	Leptospirosis	38.5%
4	Lyme Disease	37.6%
5	Relapsing Fever	37.6%
6	Bordetella Infections	35.7%
7	Brucellosis	35.7%
8	Campylobacter infection	35.7%
9	Enterobacteriaceae Infections	35.7%
10	Pseudomonas Infections	35.7%
11	Q Fever	35.7%
12	Vibrio Infections	35.7%
13	Helicobacter Infections	35.7%
14	Neisseriaceae Infections	35.7%
15	Burkholderia Infections	35.7%
16	Flavobacteriaceae Infections	35.7%
17	Moraxellaceae Infections	35.7%
18	Burkholderia cepacia Infection	35.7%
19	Human anaplasmosis	33.8%
20	TYPHUS	31.9%
21	Scrub Typhus	31%
22	Gram-Positive Bacterial Infections	28.8%
23	Lyme Neuroborreliosis	23.8%
24	Central Nervous System Bacterial Infections	23.5%
25	Bacterial Vaginosis	21.4%
26	Skin Diseases, Bacterial	20.5%
27	Acinetobacter Infections	20.4%
28	Bacteroides Infections	20.4%
29	Cholera	20.4%
30	Escherichia coli Infections	20.4%
31	Haemophilus Infections	20.4%
32	Klebsiella Infections	20.4%
33	Meningococcal Infections	20.4%
34	Mycoplasma Infections	20.4%
35	Pasteurella Infections	20.4%
36	Proteus Infections	20.4%
37	Salmonella infections	20.4%
38	Serratia Infections	20.4%
39	Ureaplasma Infections	20.4%
40	Bacteremia	20.3%
41	Erythema Chronicum Migrans	19.6%
42	Mycoses	19.2%
43	Infection	19.2%
44	Syphilis	17.9%
45	Pneumonia, Bacterial	17.4%
46	Bacterial Endocarditis	17.3%
47	Neurosyphilis	17%
48	Chlamydia Infections	16.6%
49	Gonorrhea	16.6%
50	Pertussis	15.8%
51	Actinomycetales Infections	15.3%
52	Clostridium Infections	15.3%
53	Listeriosis	15.3%
54	Staphylococcal Infections	15.3%
55	Streptococcal Infections	15.3%
56	Bacillaceae Infections	15.3%
57	Clostridium difficile infection	15.3%
58	Central Nervous System Infection	14.5%
59	Ulcerative stomatitis	13.6%
60	Erysipelas	13.6%
61	Staphylococcal Skin Infections	13.6%
62	Psittacosis	12.9%
63	Paratyphoid Fever	12.9%
64	Plague	12.9%
65	Typhoid Fever	12.9%
66	Yersinia pseudotuberculosis Infections	12.9%
67	Bubonic Plague	12.9%
68	Japanese Spotted Fever	12.5%
69	Dysentery, Bacillary	12.3%
70	Erysipelothrix infection	12.2%
71	Erythrasma	11.9%
72	Ecthyma	11.7%
73	Subacute Bacterial Endocarditis	11.7%
74	Syphilis, Congenital	11.3%
75	Rickettsia Infections	11.1%
76	Meningitis, Haemophilus	10.9%
77	Rhinoscleroma	10.8%
78	Impetigo	10.7%
79	Mycetoma	10.7%
80	Salmonella Infections, Animal	10.3%
81	Lymphogranuloma Venereum	10.1%
82	Hidradenitis Suppurativa	10.1%
83	Salmonella food poisoning	9.8%
84	Aspergillosis	9.6%
85	Candidiasis	9.6%
86	Coccidioidomycosis	9.6%
87	Histoplasmosis	9.6%
88	Paracoccidioidomycosis	9.6%
89	Pelvic Infection	9.6%
90	Wound Infection	9.6%
91	Zygomycosis	9.6%
92	Soft Tissue Infection	9.6%
93	Community-Acquired Infections	9.6%
94	Phaeohyphomycosis	9.6%
95	Pneumocystis Infections	9.6%
96	Hordeolum	9.3%
97	Meningitis, Bacterial	9.2%
98	Bacterial conjunctivitis	9.2%
99	Ophthalmia Neonatorum	9%
100	Trachoma	9%
101	Dermatomycoses	8.9%
102	Meningitis, Listeria	8.8%
103	Actinomycosis	8.8%
104	Corynebacterium Infections	8.8%
105	Gas Gangrene	8.8%
106	Mycobacterium Infections	8.8%
107	Nocardia Infections	8.8%
108	Pneumococcal Infections	8.8%
109	Scarlet Fever	8.8%
110	Tetanus	8.8%
111	Pulmonary Nocardiosis	8.8%
112	Rocky Mountain Spotted Fever	8.3%
113	Staphylococcal Scalded Skin Syndrome	8.1%
114	Eye Infection	7.6%
115	Respiratory Tract Infections	7.6%
116	Bone Diseases, Infectious	7.3%
117	Otomycosis	7.3%
118	Pregnancy Complications, Infectious	7.3%
119	Skin Diseases, Infectious	7.3%
120	Arthritis, Infectious	7.2%
121	Piedra	7.2%
122	Central Nervous System Fungal Infections	7.2%
123	Suppuration	7.2%
124	Meningitis, Pneumococcal	7.2%
125	Cross Infection	7.2%
126	Septicemia	7.2%
127	Sepsis	7.2%
128	Furunculosis	7%
129	furuncle	7%
130	Candidiasis, Chronic Mucocutaneous	6.6%
131	Cutaneous Candidiasis	6.6%
132	Brain Abscess	6.3%
133	Opportunistic Infections	6.3%
134	Neuroaspergillosis	6.2%
135	Fungemia	6.1%
136	Lung Diseases, Fungal	5.9%
137	Urinary tract infection	5.9%
138	Diphtheria	5.5%
139	Leprosy	5.5%
140	Mycobacterium Infections, Nontuberculous	5.5%
141	Tuberculosis	5.5%
142	Mycobacterium abscessus Infection	5.5%
143	Joint Tuberculosis	5.5%
144	Tuberculosis, Osteoarticular	5.5%
145	Bone Tuberculosis	5.5%
146	Rheumatic Fever	5.4%
147	carbuncle	5.4%
148	Enterocolitis, Pseudomembranous	5.3%
149	pseudomembranous colitis	5.3%
150	Cellulitis	5.2%
151	Panophthalmitis	5.2%
152	Tuberculosis, Meningeal	5.1%
153	Mucormycosis	5.1%
154	Sexually Transmitted Diseases	5.1%
155	Candidemia	5%
156	Blastomycosis	5%
157	Lemierre Syndrome	5%
158	Chromoblastomycosis	4.8%
159	Dermatophytosis	4.8%
160	Sporotrichosis	4.8%
161	Tinea	4.8%
162	Tinea Versicolor	4.8%
163	Trichophytosis	4.8%
164	Invasive Pulmonary Aspergillosis	4.8%
165	Hyalohyphomycosis	4.8%
166	Endotoxemia	4.8%
167	Erythema Induratum	4.7%
168	Botulism	4.5%
169	Rheumatic Heart Disease	4.3%
170	Waterhouse-Friderichsen Syndrome	4.1%
171	Meningitis, Cryptococcal	4%
172	Mycobacterium avium-intracellulare Infection	3.9%
173	Lymph Node Tuberculosis	3.9%
174	Tuberculosis, Miliary	3.9%
175	Tuberculosis, Multidrug-Resistant	3.9%
176	Leprosy, Multibacillary	3.9%
177	Latent Tuberculosis	3.9%
178	Oral candidiasis	3.9%
179	Endophthalmitis	3.9%
180	Peritonitis	3.9%
181	Osteomyelitis	3.9%
182	Periostitis	3.9%
183	Surgical Wound Infection	3.9%
184	Pulmonary Aspergillosis	3.9%
185	Bronchopulmonary Aspergillosis	3.9%
186	Abscess	3.8%
187	Adnexitis	3.8%
188	Empyema	3.8%
189	Pelvic Inflammatory Disease	3.8%
190	Superinfection	3.2%
191	Borderline leprosy	3.2%
192	Leprosy, Lepromatous	3.2%
193	Tuberculoid leprosy	3.2%
194	Extensively Drug-Resistant Tuberculosis	3.2%
195	Corneal Ulcer	3.1%
196	Puerperal Infection	3.1%
197	Spondylitis	3.1%
198	Appendicitis	3.1%
199	Bacteriuria	3.1%
200	Pyuria	3.1%
201	Meningitis, Fungal	3.1%
202	Pyomyositis	3.1%
203	Tuberculosis, Spinal	3.1%
204	Endotoxic shock	3%
205	Septic Shock	3%
206	Toxic Shock Syndrome	3%
207	Tuberculosis, Gastrointestinal	3%
208	Candidiasis, Vulvovaginal	3%
209	Tuberculosis, Central Nervous System	3%
210	Psoas Abscess	2.9%
211	Abdominal Abscess	2.9%
212	Fusariosis	2.9%
213	Arthritis, Reactive	2.5%
214	Tuberculosis, Pulmonary	2.5%
215	Tinea Capitis	2.4%
216	Onychomycosis	2.4%
217	Toxoplasmosis, Cerebral	2.3%
218	AIDS-Related Opportunistic Infections	2.3%
219	Diverticulitis	2.2%
220	Tinea Pedis	2.1%
221	Lung Abscess	1.8%
222	Diverticulum	1.8%
223	Diverticulosis	1.8%
224	Discitis	1.8%
225	Mastoiditis	1.8%
226	Petrositis	1.8%
227	Retropharyngeal Abscess	1.5%
228	Epidural Abscess	1.5%
229	Peritonsillar Abscess	1.5%
230	Liver Abscess	1.4%
231	Tuberculosis, Renal	1.4%
232	Aspergillosis, Allergic Bronchopulmonary	1.3%
233	Liver Abscess, Amebic	0.6%

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