Itraconazole
(VHVPQPYKVGDNFY-ZPGVKDDISA-N)
Structure
- SMILES
- CCC(n1ncn(c1=O)c1ccc(cc1)N1CCN(CC1)c1ccc(cc1)OC[C@H]1CO[C@](O1)(Cn1cncn1)c1ccc(cc1Cl)Cl)C
- Type(s)
- Approved; Investigational
- ATC code(s)
- J02AC02
- Molecular Formula:
- C35H38Cl2N8O4
- Molecular Weight:
- 705.633
- Log P:
- 5.7073
- Hydrogen Bond Acceptor:
- 12
- Hydrogen Bond Donor:
- 0
- TPSA:
- 104.7
- CAS Number(s):
- 84604-65-9; 84625-61-6; 252964-65-1; 873066-43-4
Synonym(s)
1.
Itraconazole
2.
Orungal
3.
R-51211
4.
Sporanox
5.
R 51211
6.
R51211
External Link(s)
Adverse Drug Event(s)
| Name | Number of Reports | Reference(s) | Data Source | |
|---|---|---|---|---|
| 1 | Fatigue | FAERS: 24 | US FAERS | |
| 2 | Chest discomfort | FAERS: 22 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 3 | Nausea | FAERS: 20 | US FAERS | |
| 4 | Dizziness | FAERS: 19 | US FAERS | |
| 5 | Drug dose omission | FAERS: 19 | US FAERS | |
| 6 | Drug ineffective | FAERS: 17 Canada Vigilance: 6 | Canada Vigilance US FAERS | |
| 7 | Palpitations | FAERS: 15 | US FAERS | |
| 8 | Malaise | FAERS: 14 | US FAERS | |
| 9 | Vomiting | FAERS: 14 | US FAERS | |
| 10 | Chest Pain | FAERS: 13 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 11 | Drug exposure during pregnancy | FAERS: 13 | US FAERS | |
| 12 | Headache | FAERS: 13 | US FAERS | |
| 13 | Abdominal Pain | FAERS: 12 | US FAERS | |
| 14 | Pruritus | FAERS: 12 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 15 | Asthenia | FAERS: 10 | US FAERS | |
| 16 | Hypersensitivity | FAERS: 10 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 17 | Pneumonia | FAERS: 10 | US FAERS | |
| 18 | Abdominal discomfort | FAERS: 9 | US FAERS | |
| 19 | Pain | FAERS: 9 | US FAERS | |
| 20 | Weight decreased | FAERS: 9 | US FAERS | |
| 21 | Aspartate Aminotransferase Increased | FAERS: 6 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 22 | Blood creatine phosphokinase increased | FAERS: 6 | US FAERS | |
| 23 | Erectile dysfunction | FAERS: 6 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 24 | Erythema | FAERS: 6 | US FAERS | |
| 25 | Myalgia | FAERS: 6 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 26 | Adverse event | FAERS: 5 | US FAERS | |
| 27 | Alanine Aminotransferase Increased | FAERS: 5 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 28 | Burning sensation | FAERS: 5 | US FAERS | |
| 29 | Drug prescribing error | FAERS: 5 | US FAERS | |
| 30 | Epilepsy | FAERS: 5 | US FAERS | |
| 31 | Incorrect dose administered | FAERS: 5 | US FAERS | |
| 32 | Lip swelling | FAERS: 5 | US FAERS | |
| 33 | Lymphadenopathy | FAERS: 5 | US FAERS | |
| 34 | Myocardial Infarction | FAERS: 5 | US FAERS | |
| 35 | Nasopharyngitis | FAERS: 5 | US FAERS | |
| 36 | Respiratory Failure | FAERS: 5 | US FAERS | |
| 37 | Wrong technique in drug usage process | FAERS: 5 | US FAERS | |
| 38 | Asthma | FAERS: 4 | US FAERS | |
| 39 | Cholecystitis | FAERS: 4 | US FAERS | |
| 40 | Dyspepsia | FAERS: 4 | US FAERS | |
| 41 | Incorrect route of drug administration | FAERS: 4 | US FAERS | |
| 42 | Infection | FAERS: 4 | US FAERS | |
| 43 | Intentional drug misuse | FAERS: 4 | US FAERS | |
| 44 | Leukopenia | FAERS: 4 | US FAERS | |
| 45 | Renal pain | FAERS: 4 | US FAERS | |
| 46 | Sepsis | FAERS: 4 | US FAERS | |
| 47 | Shock | FAERS: 4 | US FAERS | |
| 48 | Somnolence | FAERS: 4 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 49 | Therapeutic response unexpected | FAERS: 4 | US FAERS | |
| 50 | VIIth nerve paralysis | FAERS: 4 | US FAERS | |
| 51 | jaundice | FAERS: 4 | US FAERS | |
| 52 | Adactyly | FAERS: 3 | US FAERS | |
| 53 | Anorexia | FAERS: 3 | US FAERS | |
| 54 | Application site swelling | FAERS: 3 | US FAERS | |
| 55 | Back Pain | FAERS: 3 | US FAERS | |
| 56 | Blood alkaline phosphatase increased | FAERS: 3 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 57 | Blood cholesterol increased | FAERS: 3 | US FAERS | |
| 58 | Diabetes Mellitus | FAERS: 3 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 59 | Extravasation | FAERS: 3 | US FAERS | |
| 60 | General physical health deterioration | FAERS: 3 | US FAERS | |
| 61 | Hypotension | FAERS: 3 | US FAERS | |
| 62 | Inappropriate schedule of drug administration | FAERS: 3 | US FAERS | |
| 63 | Infertility | FAERS: 3 | US FAERS | |
| 64 | Malignant neoplasm progression | FAERS: 3 | US FAERS | |
| 65 | Nephrolithiasis | FAERS: 3 | US FAERS | |
| 66 | Pancreatitis | FAERS: 3 | US FAERS | |
| 67 | Pericardial effusion | FAERS: 3 | US FAERS | |
| 68 | Priapism | FAERS: 3 | US FAERS | |
| 69 | Product packaging issue | FAERS: 3 | US FAERS | |
| 70 | Product quality issue | FAERS: 3 | US FAERS | |
| 71 | Product use issue | FAERS: 3 | US FAERS | |
| 72 | Rhabdomyolysis | FAERS: 3 | US FAERS | |
| 73 | Syncope | FAERS: 3 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 74 | Syndactyly | FAERS: 3 | US FAERS | |
| 75 | Transaminases increased | FAERS: 3 | US FAERS | |
| 76 | Acne | FAERS: 2 | US FAERS | |
| 77 | Anaphylactoid Reaction | FAERS: 2 | US FAERS | |
| 78 | Anencephaly | FAERS: 2 | US FAERS | |
| 79 | Angina Pectoris | FAERS: 2 | US FAERS | |
| 80 | Arthralgia | FAERS: 2 | US FAERS | |
| 81 | Atrial Fibrillation | FAERS: 2 | US FAERS | |
| 82 | Blood creatinine increased | FAERS: 2 | US FAERS | |
| 83 | Blood glucose increased | FAERS: 2 | US FAERS | |
| 84 | Bronchopulmonary Aspergillosis | FAERS: 2 | US FAERS | |
| 85 | Bursitis | FAERS: 2 | US FAERS | |
| 86 | Cardiomegaly | FAERS: 2 | US FAERS | |
| 87 | Chromaturia | FAERS: 2 | US FAERS | |
| 88 | Constipation | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 89 | Cyanosis | FAERS: 2 | US FAERS | |
| 90 | Deafness | FAERS: 2 | US FAERS | |
| 91 | Denervation atrophy | FAERS: 2 | US FAERS | |
| 92 | Discomfort | FAERS: 2 | US FAERS | |
| 93 | Drug dispensing error | FAERS: 2 | US FAERS | |
| 94 | Drug ineffective for unapproved indication | FAERS: 2 | US FAERS | |
| 95 | Drug level decreased | FAERS: 2 | US FAERS | |
| 96 | Drug toxicity | FAERS: 2 | US FAERS | |
| 97 | Exposure via father | FAERS: 2 | US FAERS | |
| 98 | Hepatomegaly | FAERS: 2 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 99 | Hepatotoxicity | FAERS: 2 | US FAERS | |
| 100 | Histoplasmosis | FAERS: 2 | US FAERS | |
| 101 | Hydrothorax | FAERS: 2 | US FAERS | |
| 102 | Impaired work ability | FAERS: 2 | US FAERS | |
| 103 | Incorrect product storage | FAERS: 2 | US FAERS | |
| 104 | Liquid product physical issue | FAERS: 2 | US FAERS | |
| 105 | Medication Error | FAERS: 2 | US FAERS | |
| 106 | Mental status changes | FAERS: 2 | US FAERS | |
| 107 | Musculoskeletal chest pain | FAERS: 2 | US FAERS | |
| 108 | Nephritis | FAERS: 2 | US FAERS | |
| 109 | Onychomycosis | FAERS: 2 | US FAERS | |
| 110 | Osteoporosis | FAERS: 2 | US FAERS | |
| 111 | Pallor | FAERS: 2 | US FAERS | |
| 112 | Pancytopenia | FAERS: 2 | US FAERS | |
| 113 | Peripheral swelling | FAERS: 2 | US FAERS | |
| 114 | Phlebitis | FAERS: 2 | US FAERS | |
| 115 | Pleuritic pain | FAERS: 2 | US FAERS | |
| 116 | Polyneuropathy | FAERS: 2 | US FAERS | |
| 117 | Product availability issue | FAERS: 2 | US FAERS | |
| 118 | Product container issue | FAERS: 2 | US FAERS | |
| 119 | Product difficult to swallow | FAERS: 2 | US FAERS | |
| 120 | Product dose omission | FAERS: 2 | US FAERS | |
| 121 | Proteinuria | FAERS: 2 | US FAERS | |
| 122 | Pulmonary Embolism | FAERS: 2 | US FAERS | |
| 123 | Rash erythematous | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 124 | Septic Shock | FAERS: 2 | US FAERS | |
| 125 | Sinus bradycardia | FAERS: 2 | US FAERS | |
| 126 | Sudden death | FAERS: 2 | US FAERS | |
| 127 | Swelling | FAERS: 2 | US FAERS | |
| 128 | Thrombocytopenia | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 129 | Urticaria | FAERS: 2 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 130 | Vasculitis | FAERS: 2 | US FAERS | |
| 131 | Vertigo | FAERS: 2 | US FAERS | |
| 132 | Visual Impairment | FAERS: 2 | US FAERS | |
| 133 | White blood cell count decreased | FAERS: 2 | US FAERS | |
| 134 | Acute post asthmatic amyotrophy | FAERS: 1 | US FAERS | |
| 135 | Acute psychosis | FAERS: 1 | US FAERS | |
| 136 | Ageusia | FAERS: 1 | US FAERS | |
| 137 | Alopecia | FAERS: 1 | US FAERS | |
| 138 | Amaurosis | FAERS: 1 | US FAERS | |
| 139 | Anaphylactic shock | FAERS: 1 | US FAERS | |
| 140 | Anuria | FAERS: 1 | US FAERS | |
| 141 | Anxiety | FAERS: 1 | US FAERS | |
| 142 | Aphthous Stomatitis | FAERS: 1 | US FAERS | |
| 143 | Apparent life threatening event | FAERS: 1 | US FAERS | |
| 144 | Arthritis | FAERS: 1 | US FAERS | |
| 145 | Arthropathy | FAERS: 1 | US FAERS | |
| 146 | Ascites | FAERS: 1 | US FAERS | |
| 147 | Aspergillosis | FAERS: 1 | US FAERS | |
| 148 | Bedridden | FAERS: 1 | US FAERS | |
| 149 | Biliary dilatation | FAERS: 1 | US FAERS | |
| 150 | Blighted ovum | FAERS: 1 | US FAERS | |
| 151 | Blood creatine phosphokinase MB increased | FAERS: 1 | US FAERS | |
| 152 | Blood lactate dehydrogenase increased | FAERS: 1 | US FAERS | |
| 153 | Blood pressure fluctuation | FAERS: 1 | US FAERS | |
| 154 | Blood sodium decreased | FAERS: 1 | US FAERS | |
| 155 | Blood urea increased | FAERS: 1 | US FAERS | |
| 156 | Body Temperature | FAERS: 1 | US FAERS | |
| 157 | Bone density decreased | FAERS: 1 | US FAERS | |
| 158 | Bradycardia | FAERS: 1 | US FAERS | |
| 159 | Bradyphrenia | FAERS: 1 | US FAERS | |
| 160 | Carcinoma | FAERS: 1 | US FAERS | |
| 161 | Cardiac Flutter | FAERS: 1 | US FAERS | |
| 162 | Cardiac discomfort | FAERS: 1 | US FAERS | |
| 163 | Central Nervous System Infection | FAERS: 1 | US FAERS | |
| 164 | Cerebral atrophy | FAERS: 1 | US FAERS | |
| 165 | Cerebral disorder | FAERS: 1 | US FAERS | |
| 166 | Chills | FAERS: 1 | US FAERS | |
| 167 | Choking | FAERS: 1 | US FAERS | |
| 168 | Cholelithiasis | FAERS: 1 | US FAERS | |
| 169 | Chronic respiratory failure | FAERS: 1 | US FAERS | |
| 170 | Colonoscopy abnormal | FAERS: 1 | US FAERS | |
| 171 | Complications of maternal exposure to therapeutic drugs | FAERS: 1 | US FAERS | |
| 172 | Deep Vein Thrombosis | FAERS: 1 | US FAERS | |
| 173 | Delirium | FAERS: 1 | US FAERS | |
| 174 | Dental caries | FAERS: 1 | US FAERS | |
| 175 | Diabetes mellitus inadequate control | FAERS: 1 | US FAERS | |
| 176 | Disability | FAERS: 1 | US FAERS | |
| 177 | Disease Progression | FAERS: 1 | US FAERS | |
| 178 | Drug level increased | FAERS: 1 | US FAERS | |
| 179 | Dry skin | FAERS: 1 | US FAERS | |
| 180 | Duodenal Ulcer | FAERS: 1 | US FAERS | |
| 181 | Dysarthria | FAERS: 1 | US FAERS | |
| 182 | Dysgeusia | FAERS: 1 | US FAERS | |
| 183 | Dystonia | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 184 | Ear congestion | FAERS: 1 | US FAERS | |
| 185 | Electrolyte imbalance | FAERS: 1 | US FAERS | |
| 186 | Empyema | FAERS: 1 | US FAERS | |
| 187 | Enteral Nutrition | FAERS: 1 | US FAERS | |
| 188 | Eosinophilia | FAERS: 1 | US FAERS | |
| 189 | Eosinophilic Pneumonia | FAERS: 1 | US FAERS | |
| 190 | Epigastric discomfort | FAERS: 1 | US FAERS | |
| 191 | Erythema Multiforme | FAERS: 1 | US FAERS | |
| 192 | Eustachian tube disorder | FAERS: 1 | US FAERS | |
| 193 | Exfoliative rash | FAERS: 1 | US FAERS | |
| 194 | Expired product administered | FAERS: 1 | US FAERS | |
| 195 | External ear pain | FAERS: 1 | US FAERS | |
| 196 | Feeling Cold | FAERS: 1 | US FAERS | |
| 197 | Feeling abnormal | FAERS: 1 | US FAERS | |
| 198 | Flatulence | FAERS: 1 | US FAERS | |
| 199 | Focal Nodular Hyperplasia | FAERS: 1 | US FAERS | |
| 200 | Fungal peritonitis | FAERS: 1 | US FAERS | |
| 201 | Gallbladder pain | FAERS: 1 | US FAERS | |
| 202 | Gamma-Glutamyltransferase Increased | FAERS: 1 | US FAERS | |
| 203 | Gastric Dilatation | FAERS: 1 | US FAERS | |
| 204 | Gastritis | FAERS: 1 | US FAERS | |
| 205 | General physical condition abnormal | FAERS: 1 | US FAERS | |
| 206 | Gout | FAERS: 1 | US FAERS | |
| 207 | Helicobacter pylori identification test positive | FAERS: 1 | US FAERS | |
| 208 | Hyperpyrexia | FAERS: 1 | US FAERS | |
| 209 | Hypokinesia | FAERS: 1 | US FAERS | |
| 210 | Hypophagia | FAERS: 1 | US FAERS | |
| 211 | Hypothyroidism | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 212 | Inappropriate schedule of product administration | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 213 | Incorrect drug administration duration | FAERS: 1 | US FAERS | |
| 214 | Incorrect drug dosage form administered | FAERS: 1 | US FAERS | |
| 215 | Increased upper airway secretion | FAERS: 1 | US FAERS | |
| 216 | Inflammation | FAERS: 1 | US FAERS | |
| 217 | Intentional product misuse | FAERS: 1 | US FAERS | |
| 218 | Intestinal resection | FAERS: 1 | US FAERS | |
| 219 | Intubation | FAERS: 1 | US FAERS | |
| 220 | Joint swelling | FAERS: 1 | US FAERS | |
| 221 | Keratopathy | FAERS: 1 | US FAERS | |
| 222 | Lesion of ulnar nerve | FAERS: 1 | US FAERS | |
| 223 | Lethargy | FAERS: 1 | US FAERS | |
| 224 | Limb crushing injury | FAERS: 1 | US FAERS | |
| 225 | Limb discomfort | FAERS: 1 | US FAERS | |
| 226 | Lobar Pneumonia | FAERS: 1 | US FAERS | |
| 227 | Lower respiratory tract infection | FAERS: 1 | US FAERS | |
| 228 | Lung transplant rejection | FAERS: 1 | US FAERS | |
| 229 | Lymphoma | FAERS: 1 | US FAERS | |
| 230 | Maternal exposure during pregnancy | FAERS: 1 | US FAERS | |
| 231 | Meniscus injury | FAERS: 1 | US FAERS | |
| 232 | Multiple Myeloma | FAERS: 1 | US FAERS | |
| 233 | Muscle Cramp | FAERS: 1 | US FAERS | |
| 234 | Muscle Rigidity | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 235 | Musculoskeletal Pain | FAERS: 1 | US FAERS | |
| 236 | Negative cardiac inotropic effect | FAERS: 1 | US FAERS | |
| 237 | Nerve injury | FAERS: 1 | US FAERS | |
| 238 | Nervousness | FAERS: 1 | US FAERS | |
| 239 | Neurogenic Bowel | FAERS: 1 | US FAERS | |
| 240 | Nocturia | FAERS: 1 | US FAERS | |
| 241 | Obstruction | FAERS: 1 | US FAERS | |
| 242 | Optic Neuritis | FAERS: 1 | US FAERS | |
| 243 | Oropharyngeal blistering | FAERS: 1 | US FAERS | |
| 244 | Oropharyngeal pain | FAERS: 1 | US FAERS | |
| 245 | Osteomyelitis | FAERS: 1 | US FAERS | |
| 246 | Ototoxicity | FAERS: 1 | US FAERS | |
| 247 | Overdose | FAERS: 1 | US FAERS | |
| 248 | Oxygen supplementation | FAERS: 1 | US FAERS | |
| 249 | Pain of skin | FAERS: 1 | US FAERS | |
| 250 | Paraplegia | FAERS: 1 | US FAERS | |
| 251 | Pericarditis | FAERS: 1 | US FAERS | |
| 252 | Pharmaceutical product complaint | FAERS: 1 | US FAERS | |
| 253 | Poisoning | FAERS: 1 | US FAERS | |
| 254 | Post inflammatory pigmentation change | FAERS: 1 | US FAERS | |
| 255 | Post procedural complication | FAERS: 1 | US FAERS | |
| 256 | Pregnancy | FAERS: 1 | US FAERS | |
| 257 | Primary amyloidosis | FAERS: 1 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 258 | Product counterfeit | FAERS: 1 | US FAERS | |
| 259 | Product expiration date issue | FAERS: 1 | US FAERS | |
| 260 | Product size issue | FAERS: 1 | US FAERS | |
| 261 | Product solubility abnormal | FAERS: 1 | US FAERS | |
| 262 | Product taste abnormal | FAERS: 1 | US FAERS | |
| 263 | Product use complaint | FAERS: 1 | US FAERS | |
| 264 | Product use in unapproved indication | FAERS: 1 | US FAERS | |
| 265 | Prostatectomy | FAERS: 1 | US FAERS | |
| 266 | Pulmonary Fibrosis | FAERS: 1 | US FAERS | |
| 267 | Pulmonary malformation | FAERS: 1 | US FAERS | |
| 268 | Purpura | FAERS: 1 | US FAERS | |
| 269 | Respiratory distress | FAERS: 1 | US FAERS | |
| 270 | Retinal Vein Occlusion | FAERS: 1 | US FAERS | |
| 271 | Sciatica | FAERS: 1 | US FAERS | |
| 272 | Skin Induration | FAERS: 1 | US FAERS | |
| 273 | Slow response to stimuli | FAERS: 1 | US FAERS | |
| 274 | Spermatozoa progressive motility abnormal | FAERS: 1 | US FAERS | |
| 275 | Stenotrophomonas sepsis | FAERS: 1 | US FAERS | |
| 276 | Stridor | FAERS: 1 | US FAERS | |
| 277 | Suspected counterfeit product | FAERS: 1 | US FAERS | |
| 278 | Synovial Cyst | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 279 | Tachycardia | FAERS: 1 | US FAERS | |
| 280 | Therapeutic product ineffective | FAERS: 1 | US FAERS | |
| 281 | Thrombocytosis | FAERS: 1 | US FAERS | |
| 282 | Thrombosis | FAERS: 1 | US FAERS | |
| 283 | Tinea Pedis | FAERS: 1 | US FAERS | |
| 284 | Tinnitus | FAERS: 1 | US FAERS | |
| 285 | Toothache | FAERS: 1 | US FAERS | |
| 286 | Torticollis | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 287 | Tremor | FAERS: 1 | US FAERS | |
| 288 | Ulnar Nerve Palsy | FAERS: 1 | US FAERS | |
| 289 | Unexpected therapeutic drug effect | FAERS: 1 | US FAERS | |
| 290 | Unresponsive to stimuli | FAERS: 1 | US FAERS | |
| 291 | Urinary tract infection | FAERS: 1 | US FAERS | |
| 292 | effusion | FAERS: 1 | US FAERS | |
| 293 | Facial paralysis | Canada Vigilance: 3 | Canada Vigilance | |
| 294 | Hepatitis | Canada Vigilance: 2 | Canada Vigilance | |
| 295 | Neutropenia | Canada Vigilance: 1 | Canada Vigilance | |
| 296 | treatment failure | Canada Vigilance: 1 | Canada Vigilance |
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