MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Extensively Drug-Resistant Tuberculosis

(UMLS:C1827301)

Definition:: Tuberculosis resistant to ISONIAZID and RIFAMPIN and at least three of the six main classes of second-line drugs (AMINOGLYCOSIDES; polypeptide agents; FLUOROQUINOLONES; THIOAMIDES; CYCLOSERINE; and PARA-AMINOSALICYLIC ACID) as defined by the CDC.
UMLS ID:: C1827301
MeSH ID:: D054908

Classification:

Name:

Bacterial Infections and Mycoses
MeSH Tree Number(s):: C01.252.410.040.552.846.775.500

Synonym(s)

Extensively Drug-Resistant Tuberculosis

Extensively Drug-Resistant TB

Extensively drug resistant tuberculosis

Extreme drug resistant tuberculosis

Extremely drug resistant tuberculosis

XDR-TB

extremely drug-resistant tuberculosis

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Ethambutol	24088636	CTD
2	Linezolid	16857689 24088636	CTD
3	Tolcapone	19578428	CTD
4	entacapone	19578428	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Lymph Node Tuberculosis	37.1%
2	Tuberculosis, Miliary	37.1%
3	Latent Tuberculosis	37.1%
4	Leprosy	30.6%
5	Mycobacterium Infections, Nontuberculous	30.6%
6	Mycobacterium abscessus Infection	30.6%
7	Actinomycosis	26.8%
8	Corynebacterium Infections	26.8%
9	Nocardia Infections	26.8%
10	Pulmonary Nocardiosis	26.8%
11	Tuberculosis, Gastrointestinal	25.8%
12	Tuberculosis, Central Nervous System	25%
13	Clostridium Infections	24%
14	Listeriosis	24%
15	Staphylococcal Infections	24%
16	Streptococcal Infections	24%
17	Bacillaceae Infections	24%
18	Clostridium difficile infection	24%
19	Joint Tuberculosis	20.8%
20	Tuberculosis, Osteoarticular	20.8%
21	Bone Tuberculosis	20.8%
22	Gram-Negative Bacterial Infections	20.7%
23	Tuberculosis, Pulmonary	19.7%
24	Mycobacterium avium-intracellulare Infection	18.3%
25	Leprosy, Multibacillary	18.3%
26	Erysipelothrix infection	17.3%
27	Diphtheria	14.8%
28	Mycoses	14.5%
29	Infection	14.5%
30	Central Nervous System Bacterial Infections	14%
31	Borrelia Infections	13.9%
32	Leptospirosis	13.9%
33	Bacterial Vaginosis	13.5%
34	Gas Gangrene	12.5%
35	Pneumococcal Infections	12.5%
36	Scarlet Fever	12.5%
37	Tetanus	12.5%
38	Borderline leprosy	12.2%
39	Leprosy, Lepromatous	12.2%
40	Tuberculoid leprosy	12.2%
41	Skin Diseases, Bacterial	12.1%
42	Bacteremia	11.9%
43	Erythrasma	10.9%
44	Tuberculosis, Spinal	10.8%
45	Pneumonia, Bacterial	10.3%
46	Bordetella Infections	10.3%
47	Brucellosis	10.3%
48	Campylobacter infection	10.3%
49	Enterobacteriaceae Infections	10.3%
50	Pseudomonas Infections	10.3%
51	Q Fever	10.3%
52	Vibrio Infections	10.3%
53	Helicobacter Infections	10.3%
54	Neisseriaceae Infections	10.3%
55	Burkholderia Infections	10.3%
56	Flavobacteriaceae Infections	10.3%
57	Moraxellaceae Infections	10.3%
58	Burkholderia cepacia Infection	10.3%
59	Tuberculosis, Meningeal	10.1%
60	Erysipelas	9.9%
61	Staphylococcal Skin Infections	9.9%
62	Bacterial Endocarditis	9.8%
63	Central Nervous System Infection	9.7%
64	Impetigo	8.6%
65	Tuberculosis, Renal	8.6%
66	Ecthyma	8.3%
67	Subacute Bacterial Endocarditis	8.3%
68	Mycetoma	8.1%
69	Lyme Disease	8.1%
70	Relapsing Fever	8.1%
71	Erythema Induratum	8%
72	Meningitis, Listeria	7.2%
73	Human Ehrlichiosis	7.2%
74	Aspergillosis	6.9%
75	Candidiasis	6.9%
76	Coccidioidomycosis	6.9%
77	Histoplasmosis	6.9%
78	Paracoccidioidomycosis	6.9%
79	Pelvic Infection	6.9%
80	Wound Infection	6.9%
81	Zygomycosis	6.9%
82	Soft Tissue Infection	6.9%
83	Community-Acquired Infections	6.9%
84	Phaeohyphomycosis	6.9%
85	Pneumocystis Infections	6.9%
86	Syphilis	6.6%
87	Rheumatic Fever	6.5%
88	Neurosyphilis	6.5%
89	Lyme Neuroborreliosis	6.4%
90	Enterocolitis, Pseudomembranous	6.3%
91	pseudomembranous colitis	6.3%
92	Chlamydia Infections	5.8%
93	Gonorrhea	5.8%
94	Human anaplasmosis	5.7%
95	Japanese Spotted Fever	5.6%
96	Acinetobacter Infections	5.4%
97	Bacteroides Infections	5.4%
98	Cholera	5.4%
99	Escherichia coli Infections	5.4%
100	Haemophilus Infections	5.4%
101	Klebsiella Infections	5.4%
102	Meningococcal Infections	5.4%
103	Mycoplasma Infections	5.4%
104	Pasteurella Infections	5.4%
105	Proteus Infections	5.4%
106	Rickettsia Infections	5.4%
107	Salmonella infections	5.4%
108	Scrub Typhus	5.4%
109	Serratia Infections	5.4%
110	Ureaplasma Infections	5.4%
111	Staphylococcal Scalded Skin Syndrome	5.3%
112	Erythema Chronicum Migrans	5.3%
113	Botulism	5.2%
114	Dermatomycoses	5.2%
115	Hidradenitis Suppurativa	5.2%
116	Meningitis, Bacterial	5.2%
117	Hordeolum	5%
118	Meningitis, Pneumococcal	4.9%
119	Eye Infection	4.9%
120	Respiratory Tract Infections	4.9%
121	Bacterial conjunctivitis	4.9%
122	Ulcerative stomatitis	4.9%
123	Rheumatic Heart Disease	4.8%
124	Bone Diseases, Infectious	4.7%
125	Otomycosis	4.7%
126	Pregnancy Complications, Infectious	4.7%
127	Skin Diseases, Infectious	4.7%
128	Arthritis, Infectious	4.6%
129	Piedra	4.6%
130	Central Nervous System Fungal Infections	4.6%
131	Suppuration	4.6%
132	Pertussis	4.6%
133	Cross Infection	4.5%
134	Septicemia	4.5%
135	Sepsis	4.5%
136	Furunculosis	4.5%
137	furuncle	4.5%
138	Rhinoscleroma	3.9%
139	Opportunistic Infections	3.8%
140	Lung Diseases, Fungal	3.6%
141	Urinary tract infection	3.5%
142	Candidiasis, Chronic Mucocutaneous	3.5%
143	Cutaneous Candidiasis	3.5%
144	Brain Abscess	3.5%
145	Neuroaspergillosis	3.5%
146	Fungemia	3.4%
147	Mucormycosis	3.4%
148	Meningitis, Haemophilus	3.3%
149	Rocky Mountain Spotted Fever	3.2%
150	Lymphogranuloma Venereum	3.1%
151	carbuncle	3.1%
152	Syphilis, Congenital	3.1%
153	Psittacosis	3%
154	Paratyphoid Fever	3%
155	Plague	3%
156	Typhoid Fever	3%
157	TYPHUS	3%
158	Yersinia pseudotuberculosis Infections	3%
159	Bubonic Plague	3%
160	Sexually Transmitted Diseases	2.9%
161	Cellulitis	2.8%
162	Ophthalmia Neonatorum	2.7%
163	Trachoma	2.7%
164	Dysentery, Bacillary	2.7%
165	Chromoblastomycosis	2.6%
166	Dermatophytosis	2.6%
167	Sporotrichosis	2.6%
168	Tinea	2.6%
169	Tinea Versicolor	2.6%
170	Trichophytosis	2.6%
171	Invasive Pulmonary Aspergillosis	2.6%
172	Hyalohyphomycosis	2.6%
173	Endotoxemia	2.6%
174	Blastomycosis	2.5%
175	Candidemia	2.4%
176	Oral candidiasis	2.4%
177	Endophthalmitis	2.4%
178	Peritonitis	2.4%
179	Osteomyelitis	2.3%
180	Periostitis	2.3%
181	Surgical Wound Infection	2.3%
182	Pulmonary Aspergillosis	2.3%
183	Bronchopulmonary Aspergillosis	2.3%
184	Panophthalmitis	2.3%
185	Abscess	2.3%
186	Adnexitis	2.3%
187	Empyema	2.3%
188	Pelvic Inflammatory Disease	2.3%
189	Salmonella Infections, Animal	2.1%
190	Meningitis, Cryptococcal	2.1%
191	Salmonella food poisoning	2%
192	Superinfection	1.8%
193	Psoas Abscess	1.8%
194	Abdominal Abscess	1.8%
195	Corneal Ulcer	1.8%
196	Puerperal Infection	1.7%
197	Spondylitis	1.7%
198	Appendicitis	1.7%
199	Bacteriuria	1.7%
200	Pyuria	1.7%
201	Meningitis, Fungal	1.7%
202	Pyomyositis	1.7%
203	Endotoxic shock	1.7%
204	Septic Shock	1.7%
205	Toxic Shock Syndrome	1.7%
206	Candidiasis, Vulvovaginal	1.7%
207	Fusariosis	1.4%
208	Arthritis, Reactive	1.4%
209	Diverticulitis	1.2%
210	AIDS-Related Opportunistic Infections	1.2%
211	Tinea Capitis	1.1%
212	Onychomycosis	1.1%
213	Toxoplasmosis, Cerebral	1.1%
214	Waterhouse-Friderichsen Syndrome	1%
215	Lung Abscess	0.9%
216	Tinea Pedis	0.9%
217	Diverticulum	0.9%
218	Diverticulosis	0.9%
219	Discitis	0.9%
220	Mastoiditis	0.9%
221	Petrositis	0.9%
222	Lemierre Syndrome	0.9%
223	Retropharyngeal Abscess	0.7%
224	Epidural Abscess	0.7%
225	Peritonsillar Abscess	0.7%
226	Liver Abscess	0.7%
227	Aspergillosis, Allergic Bronchopulmonary	0.6%
228	Liver Abscess, Amebic	0.2%

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