MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Relapsing Fever

(UMLS:C0035021)

Definition:: An acute infection characterized by recurrent episodes of PYREXIA alternating with asymptomatic intervals of apparent recovery. This condition is caused by SPIROCHETES of the genus BORRELIA. It is transmitted by the BITES of either the body louse (PEDICULUS humanus corporis), for which humans are the reservoir, or by soft ticks of the genus ORNITHODOROS, for which rodents and other animals are the principal reservoirs.
UMLS ID:: C0035021
MeSH ID:: D012061

Classification:

Name:

Bacterial Infections and Mycoses
MeSH Tree Number(s):: C01.252.400.155.644|C01.252.400.825.750|C01.252.847.193.644

Synonym(s)

Relapsing Fever

FEVER, FAMINE

Fever;relapsing

Recurrent fever

Recurrent fever due to Borrelia

Recurrent fever, NOS

Relapsing fever

Relapsing fever due to Borrelia

Relapsing fever, NOS

10.

Relapsing fever, unspecified

11.

fever recurrent

12.

fever relapsing

13.

fever; relapsing

14.

fevers recurrent

15.

recurrent fever

16.

relapsing fever

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Zoledronic Acid	FAERS: 2	US FAERS
2	empagliflozin	FAERS: 2	US FAERS
3	posaconazole	FAERS: 2	US FAERS
4	Abiraterone Acetate	FAERS: 1	US FAERS
5	Itraconazole	FAERS: 1	US FAERS
6	Ivermectin	FAERS: 1	US FAERS
7	Levofloxacin	FAERS: 1	US FAERS
8	Methotrexate	FAERS: 1	US FAERS
9	Methylprednisolone Hemisuccinate	FAERS: 1	US FAERS
10	Moxifloxacin	FAERS: 1	US FAERS
11	Norgestrel	FAERS: 1	US FAERS
12	Sertraline	FAERS: 1	US FAERS
13	Sorafenib	FAERS: 1	US FAERS
14	Temozolomide	FAERS: 1	US FAERS
15	Vemurafenib	FAERS: 1	US FAERS
16	Venlafaxine Hydrochloride	FAERS: 1	US FAERS
17	montelukast	FAERS: 1	US FAERS
18	rofecoxib	FAERS: 1	US FAERS
19	Chlorambucil		OFFSIDES
20	Clarithromycin		OFFSIDES
21	Clozapine		OFFSIDES
22	Estradiol		OFFSIDES
23	Fluconazole		OFFSIDES
24	Goserelin		OFFSIDES
25	Irbesartan		OFFSIDES
26	Ivermectin		OFFSIDES
27	Oseltamivir		OFFSIDES
28	Penicillins		SIDER
29	Vinblastine		OFFSIDES
30	cefditoren pivoxil		OFFSIDES
31	fludarabine phosphate		OFFSIDES
32	fludarabine		OFFSIDES
33	propiomazine		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Lyme Disease	76.3%
2	Leptospirosis	58.8%
3	Human Ehrlichiosis	54.2%
4	Lyme Neuroborreliosis	53.7%
5	Japanese Spotted Fever	48.6%
6	Human anaplasmosis	46.9%
7	Erythema Chronicum Migrans	45.1%
8	Bordetella Infections	41.5%
9	Brucellosis	41.5%
10	Campylobacter infection	41.5%
11	Enterobacteriaceae Infections	41.5%
12	Pseudomonas Infections	41.5%
13	Q Fever	41.5%
14	Vibrio Infections	41.5%
15	Helicobacter Infections	41.5%
16	Neisseriaceae Infections	41.5%
17	Burkholderia Infections	41.5%
18	Flavobacteriaceae Infections	41.5%
19	Moraxellaceae Infections	41.5%
20	Burkholderia cepacia Infection	41.5%
21	Rocky Mountain Spotted Fever	37.6%
22	Gram-Positive Bacterial Infections	37.2%
23	Central Nervous System Bacterial Infections	33.5%
24	Syphilis	33.4%
25	Neurosyphilis	33.2%
26	Borrelia Infections	31.4%
27	Skin Diseases, Bacterial	29.8%
28	Bacteremia	29.6%
29	Bacterial Vaginosis	29.5%
30	Relapsing Fever	28%
31	Acinetobacter Infections	27.4%
32	Bacteroides Infections	27.4%
33	Cholera	27.4%
34	Escherichia coli Infections	27.4%
35	Haemophilus Infections	27.4%
36	Klebsiella Infections	27.4%
37	Meningococcal Infections	27.4%
38	Mycoplasma Infections	27.4%
39	Pasteurella Infections	27.4%
40	Proteus Infections	27.4%
41	Rickettsia Infections	27.4%
42	Salmonella infections	27.4%
43	Scrub Typhus	27.4%
44	Serratia Infections	27.4%
45	Ureaplasma Infections	27.4%
46	Chlamydia Infections	27.1%
47	Gonorrhea	27.1%
48	Bacterial Endocarditis	25.8%
49	Pneumonia, Bacterial	24.9%
50	Syphilis, Congenital	24.5%
51	Pertussis	23.6%
52	Erysipelas	23.6%
53	Staphylococcal Skin Infections	23.6%
54	Mycoses	23.1%
55	Infection	23.1%
56	Ulcerative stomatitis	22%
57	Actinomycetales Infections	22%
58	Clostridium Infections	22%
59	Listeriosis	22%
60	Staphylococcal Infections	22%
61	Streptococcal Infections	22%
62	Bacillaceae Infections	22%
63	Clostridium difficile infection	22%
64	Impetigo	21.6%
65	Erythrasma	21.5%
66	Ecthyma	20.7%
67	Subacute Bacterial Endocarditis	20.7%
68	Psittacosis	20.5%
69	Paratyphoid Fever	20.5%
70	Plague	20.5%
71	Typhoid Fever	20.5%
72	TYPHUS	20.5%
73	Yersinia pseudotuberculosis Infections	20.5%
74	Bubonic Plague	20.5%
75	Meningitis, Haemophilus	20%
76	Mycetoma	19.9%
77	Rhinoscleroma	19.5%
78	Lymphogranuloma Venereum	19.2%
79	Central Nervous System Infection	18.6%
80	Erysipelothrix infection	18.4%
81	Dysentery, Bacillary	18.3%
82	Ophthalmia Neonatorum	17.3%
83	Trachoma	17.3%
84	Salmonella Infections, Animal	17.2%
85	Hidradenitis Suppurativa	17.1%
86	Meningitis, Listeria	16.6%
87	Salmonella food poisoning	16.5%
88	Staphylococcal Scalded Skin Syndrome	16.5%
89	Hordeolum	15.6%
90	Bacterial conjunctivitis	15.4%
91	Meningitis, Bacterial	14.7%
92	Furunculosis	14.6%
93	furuncle	14.6%
94	Actinomycosis	14.5%
95	Corynebacterium Infections	14.5%
96	Gas Gangrene	14.5%
97	Mycobacterium Infections	14.5%
98	Nocardia Infections	14.5%
99	Pneumococcal Infections	14.5%
100	Scarlet Fever	14.5%
101	Tetanus	14.5%
102	Pulmonary Nocardiosis	14.5%
103	Meningitis, Pneumococcal	14.4%
104	Dermatomycoses	13.3%
105	carbuncle	13%
106	Aspergillosis	12.4%
107	Candidiasis	12.4%
108	Coccidioidomycosis	12.4%
109	Histoplasmosis	12.4%
110	Paracoccidioidomycosis	12.4%
111	Pelvic Infection	12.4%
112	Wound Infection	12.4%
113	Zygomycosis	12.4%
114	Gram-Negative Bacterial Infections	12.4%
115	Soft Tissue Infection	12.4%
116	Community-Acquired Infections	12.4%
117	Phaeohyphomycosis	12.4%
118	Pneumocystis Infections	12.4%
119	Tuberculosis, Meningeal	11.3%
120	Candidiasis, Chronic Mucocutaneous	11.2%
121	Cutaneous Candidiasis	11.2%
122	Joint Tuberculosis	11%
123	Tuberculosis, Osteoarticular	11%
124	Bone Tuberculosis	11%
125	Diphtheria	10.8%
126	Leprosy	10.8%
127	Mycobacterium Infections, Nontuberculous	10.8%
128	Tuberculosis	10.8%
129	Mycobacterium abscessus Infection	10.8%
130	Panophthalmitis	10.6%
131	Erythema Induratum	10.6%
132	Eye Infection	10.3%
133	Respiratory Tract Infections	10.3%
134	Bone Diseases, Infectious	10.1%
135	Otomycosis	10.1%
136	Pregnancy Complications, Infectious	10.1%
137	Skin Diseases, Infectious	10.1%
138	Arthritis, Infectious	9.9%
139	Piedra	9.9%
140	Central Nervous System Fungal Infections	9.9%
141	Suppuration	9.9%
142	Brain Abscess	9.9%
143	Rheumatic Fever	9.9%
144	Cross Infection	9.9%
145	Septicemia	9.9%
146	Sepsis	9.9%
147	Neuroaspergillosis	9.8%
148	Fungemia	9.8%
149	Enterocolitis, Pseudomembranous	9.7%
150	pseudomembranous colitis	9.7%
151	Candidemia	9.6%
152	Waterhouse-Friderichsen Syndrome	9.3%
153	Lemierre Syndrome	9.3%
154	Mycobacterium avium-intracellulare Infection	9%
155	Lymph Node Tuberculosis	9%
156	Tuberculosis, Miliary	9%
157	Tuberculosis, Multidrug-Resistant	9%
158	Leprosy, Multibacillary	9%
159	Latent Tuberculosis	9%
160	Opportunistic Infections	8.9%
161	Rheumatic Heart Disease	8.9%
162	Blastomycosis	8.7%
163	Botulism	8.5%
164	Cellulitis	8.5%
165	Lung Diseases, Fungal	8.5%
166	Urinary tract infection	8.4%
167	Chromoblastomycosis	8.1%
168	Dermatophytosis	8.1%
169	Borderline leprosy	8.1%
170	Leprosy, Lepromatous	8.1%
171	Tuberculoid leprosy	8.1%
172	Sporotrichosis	8.1%
173	Tinea	8.1%
174	Tinea Versicolor	8.1%
175	Trichophytosis	8.1%
176	Invasive Pulmonary Aspergillosis	8.1%
177	Hyalohyphomycosis	8.1%
178	Extensively Drug-Resistant Tuberculosis	8.1%
179	Endotoxemia	8.1%
180	Tuberculosis, Spinal	7.4%
181	Sexually Transmitted Diseases	7.4%
182	Tuberculosis, Gastrointestinal	7.4%
183	Mucormycosis	7.3%
184	Tuberculosis, Central Nervous System	7.2%
185	Meningitis, Cryptococcal	6.9%
186	Tuberculosis, Pulmonary	6.2%
187	Oral candidiasis	6%
188	Endophthalmitis	6%
189	Peritonitis	6%
190	Osteomyelitis	5.9%
191	Periostitis	5.9%
192	Surgical Wound Infection	5.9%
193	Pulmonary Aspergillosis	5.9%
194	Bronchopulmonary Aspergillosis	5.9%
195	Abscess	5.8%
196	Adnexitis	5.8%
197	Empyema	5.8%
198	Pelvic Inflammatory Disease	5.8%
199	Fusariosis	5.6%
200	Superinfection	5%
201	Corneal Ulcer	5%
202	Puerperal Infection	4.9%
203	Spondylitis	4.9%
204	Appendicitis	4.9%
205	Bacteriuria	4.9%
206	Pyuria	4.9%
207	Meningitis, Fungal	4.9%
208	Pyomyositis	4.9%
209	Endotoxic shock	4.9%
210	Septic Shock	4.9%
211	Toxic Shock Syndrome	4.9%
212	Tinea Capitis	4.8%
213	Onychomycosis	4.8%
214	Psoas Abscess	4.8%
215	Abdominal Abscess	4.8%
216	Candidiasis, Vulvovaginal	4.8%
217	Toxoplasmosis, Cerebral	4.4%
218	Tinea Pedis	4.2%
219	Tuberculosis, Renal	4.2%
220	Arthritis, Reactive	4.1%
221	Diverticulitis	3.9%
222	AIDS-Related Opportunistic Infections	3.7%
223	Lung Abscess	3.3%
224	Diverticulum	3.3%
225	Diverticulosis	3.3%
226	Discitis	3.2%
227	Mastoiditis	3.2%
228	Petrositis	3.2%
229	Liver Abscess	3%
230	Retropharyngeal Abscess	2.8%
231	Epidural Abscess	2.8%
232	Peritonsillar Abscess	2.8%
233	Aspergillosis, Allergic Bronchopulmonary	2.5%
234	Liver Abscess, Amebic	1.5%

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