MetaADEDB 2.0 @ LMMD
Tiotropium Bromide
(LERNTVKEWCAPOY-FPISHFTHSA-N)
Structure
SMILES
O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3
Type(s)
Approved
ATC code(s)
R03AL06; R03BB04; R03BB54
Molecular Formula:
C19H22NO4S2+
Molecular Weight:
392.512
Log P:
2.3045
Hydrogen Bond Acceptor:
6
Hydrogen Bond Donor:
1
TPSA:
115.54
CAS Number(s):
186691-13-4
Synonym(s)
1.
Tiotropium Bromide
2.
7-((hydroxybis(2-thienyl)acetyl)oxy)-9,9-dimethyl-3-oxa-9-azoniatricyclo(3.3.1.0(2,4))nonane bromide
3.
BA 679 BR
4.
BA-679 BR
5.
Spiriva
6.
Tiotropium
7.
679 BR, BA
8.
BA679 BR
9.
BR, BA 679
10.
Bromide, Tiotropium
External Link(s)
MeSHD000069447
PubChem Compound5487427
BindingDB50066861
ChEBI90960
CHEMBLCHEMBL1900528
CHEMBL3305968
DrugBankDB01409
DrugCentral2677
IUPHAR/BPS Guide to PHARMACOLOGY367
8592
Therapeutic Target DatabaseD0P1WA
D00VAD
ZINC145199092
13900863
100008319
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Urinary RetentionFAERS: 4SIDER
US FAERS
2Cardiac ArrestFAERS: 3US FAERS
3PneumoniaFAERS: 3US FAERS
4SyncopeFAERS: 3SIDER
US FAERS
5ArteriosclerosisFAERS: 2US FAERS
6FatigueFAERS: 2OFFSIDES
US FAERS
7Oropharyngeal painFAERS: 2OFFSIDES
US FAERS
8Unresponsive to stimuliFAERS: 2US FAERS
9Abdominal PainFAERS: 1SIDER
US FAERS
10Alanine Aminotransferase IncreasedFAERS: 1US FAERS
11Angina PectorisFAERS: 1SIDER
US FAERS
12AngioedemaFAERS: 1SIDER
US FAERS
13AstheniaFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
14Atrial FibrillationFAERS: 1US FAERS
15Atrial FlutterFAERS: 1US FAERS
16BronchopneumoniaFAERS: 1US FAERS
17BronchospasmFAERS: 1US FAERS
18Burning sensationFAERS: 1US FAERS
19Cardiac FlutterFAERS: 1US FAERS
20Chest discomfortFAERS: 1US FAERS
21Colonic Pseudo-ObstructionFAERS: 1US FAERS
22Diffuse panbronchiolitisFAERS: 1US FAERS
23DizzinessFAERS: 1SIDER
US FAERS
24Drug ineffectiveFAERS: 1
Canada Vigilance: 12		Canada Vigilance
OFFSIDES
US FAERS
25Eye painFAERS: 1OFFSIDES
US FAERS
26HeadacheFAERS: 1SIDER
US FAERS
27ImmobileFAERS: 1US FAERS
28LeukocytosisFAERS: 1US FAERS
29Lip swellingFAERS: 1US FAERS
30Lower respiratory tract infectionFAERS: 1US FAERS
31MyalgiaFAERS: 1SIDER
US FAERS
32Myocardial InfarctionFAERS: 1
Canada Vigilance: 2		Canada Vigilance
US FAERS
33PalpitationsFAERS: 1SIDER
US FAERS
34Product substitution issueFAERS: 1US FAERS
35PruritusFAERS: 1SIDER
US FAERS
36Pulmonary EmbolismFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
37Respiratory FailureFAERS: 1OFFSIDES
US FAERS
38StomatitisFAERS: 1SIDER
US FAERS
39Sudden Cardiac DeathFAERS: 1US FAERS
40Sudden deathFAERS: 1US FAERS
41Supraventricular tachycardiaFAERS: 1SIDER
US FAERS
42Ventricular arrhythmiaFAERS: 1US FAERS
43Visual ImpairmentFAERS: 1SIDER
US FAERS
44Abdominal InfectionOFFSIDES
45Abdominal discomfortOFFSIDES
46Abnormal visionOFFSIDES
47Acute glaucomaSIDER
48Acute respiratory failureOFFSIDES
49AneurysmOFFSIDES
SIDER
50Angina pectoris aggravatedSIDER
51Angle Closure GlaucomaSIDER
52AnosmiaOFFSIDES
53Anti-SS-A antibody positiveOFFSIDES
54Antimicrobial susceptibility test resistantOFFSIDES
55Aortic AneurysmOFFSIDES
56ApathyOFFSIDES
57AphoniaOFFSIDES
58Apparent deathCanada Vigilance: 1Canada Vigilance
OFFSIDES
59Application site irritationSIDER
60Arteriosclerosis ObliteransOFFSIDES
61ArthralgiaSIDER
62ArthritisSIDER
63AsthmaOFFSIDES
64AtelectasisOFFSIDES
65AuraOFFSIDES
66Back PainSIDER
67Benign Prostatic HyperplasiaOFFSIDES
SIDER
68Biopsy bladder abnormalOFFSIDES
69Bladder neck obstructionSIDER
70BlepharoptosisOFFSIDES
71Blood amylase decreasedOFFSIDES
72Blood chloride decreasedOFFSIDES
73Blood cholesterolOFFSIDES
74Blood creatinine decreasedOFFSIDES
75Blood insulinOFFSIDES
76Blood magnesium decreasedOFFSIDES
77Blood phosphorus decreasedOFFSIDES
78Blood phosphorus increasedOFFSIDES
79Blood potassium decreasedOFFSIDES
80Blood pressure fluctuationOFFSIDES
81Blood sodiumOFFSIDES
82Blurred visionOFFSIDES
83Bone density decreasedOFFSIDES
84Bone erosionOFFSIDES
85Bone painSIDER
86Brain ConcussionOFFSIDES
87Brain natriuretic peptide increasedOFFSIDES
88BronchitisCanada Vigilance: 2Canada Vigilance
OFFSIDES
89BunionOFFSIDES
90Candida sepsisOFFSIDES
91Cardiac DeathSIDER
92Cardioactive drug levelOFFSIDES
93CataractOFFSIDES
SIDER
94Catheter placementOFFSIDES
95Central Nervous System InfectionOFFSIDES
96Cerebrovascular accidentCanada Vigilance: 2Canada Vigilance
97Cervical dysplasiaOFFSIDES
98Chest PainCanada Vigilance: 1Canada Vigilance
SIDER
99Choking sensationOFFSIDES
100Chronic Obstructive Airway DiseaseOFFSIDES
101Clostridium difficile colitisOFFSIDES
102ColitisOFFSIDES
103ConstipationSIDER
104Contact DermatitisOFFSIDES
105Continuous Positive Airway PressureOFFSIDES
106ContractureOFFSIDES
107CystOFFSIDES
108Deafness NeurosensoryOFFSIDES
109DehydrationSIDER
110Dental discomfortOFFSIDES
111DermatitisSIDER
112Device interactionOFFSIDES
113DiplopiaOFFSIDES
114DiscomfortCanada Vigilance: 1Canada Vigilance
115DiverticulumOFFSIDES
116Dry skinSIDER
117DysgeusiaOFFSIDES
118DyspepsiaSIDER
119DysphemiaOFFSIDES
120DysphoniaOFFSIDES
SIDER
121DystoniaOFFSIDES
122DysuriaOFFSIDES
SIDER
123Emotional distressOFFSIDES
124EmpyemaOFFSIDES
125End stage AIDSOFFSIDES
126Enzyme abnormalityOFFSIDES
127EpistaxisOFFSIDES
SIDER
128Erythema NodosumOFFSIDES
129Escherichia urinary tract infectionOFFSIDES
130FasciitisOFFSIDES
131Febrile NeutropeniaOFFSIDES
132Feelings of worthlessnessOFFSIDES
133Fluid overloadOFFSIDES
134Foaming at mouthOFFSIDES
135Gastrointestinal PainSIDER
136General physical health deteriorationCanada Vigilance: 1Canada Vigilance
OFFSIDES
137GiardiasisOFFSIDES
138GingivitisSIDER
139GlaucomaOFFSIDES
SIDER
140GlossitisSIDER
141GoutOFFSIDES
142GranulocytosisOFFSIDES
143GranulomaOFFSIDES
144Guillain-Barre SyndromeCanada Vigilance: 1Canada Vigilance
145HaematotoxicityOFFSIDES
146Hearing aid userOFFSIDES
147HemiplegiaOFFSIDES
148HoarsenessSIDER
149HordeolumOFFSIDES
150Human papilloma virus test positiveOFFSIDES
151HypersensitivityCanada Vigilance: 1Canada Vigilance
SIDER
152HypophagiaOFFSIDES
153HyporeflexiaOFFSIDES
154HypoxiaOFFSIDES
155Implant site infectionOFFSIDES
156Incorrect dose administered by deviceCanada Vigilance: 1Canada Vigilance
157Incorrect route of drug administrationOFFSIDES
158Increased upper airway secretionOFFSIDES
159InfectionOFFSIDES
SIDER
160Infective exacerbation of chronic obstructive airways diseaseOFFSIDES
161Influenza-like symptomsSIDER
162Injection site calcificationOFFSIDES
163Intervertebral Disc DegenerationOFFSIDES
164Intervertebral disc disorderOFFSIDES
165Intestinal ObstructionSIDER
166Joint injuryOFFSIDES
167Joint swellingSIDER
168LaryngitisSIDER
169LaryngospasmOFFSIDES
170LethargyOFFSIDES
171Leukopenia neonatalOFFSIDES
172Life expectancy shortenedOFFSIDES
173LipaseOFFSIDES
174Lipids abnormalOFFSIDES
175Loop electrosurgical excision procedureOFFSIDES
176Loose toothOFFSIDES
177MalaiseCanada Vigilance: 2Canada Vigilance
178MalnutritionSIDER
179Mastication disorderOFFSIDES
180Mechanical ventilationOFFSIDES
181Medical device complicationOFFSIDES
182Medical device removalOFFSIDES
183Mesenteric vascular insufficiencyOFFSIDES
184Muscle WeaknessOFFSIDES
185Muscle hypertrophyOFFSIDES
186Musculoskeletal PainOFFSIDES
187Musculoskeletal discomfortSIDER
188Myelocyte count decreasedOFFSIDES
189NauseaSIDER
190NocturiaOFFSIDES
191NoduleOFFSIDES
192Oral candidiasisSIDER
193Oropharyngeal candidiasisSIDER
194Osteitis DeformansOFFSIDES
195OsteoporosisOFFSIDES
196OsteotomyOFFSIDES
197Oxygen consumption increasedOFFSIDES
198Pelvic fluid collectionOFFSIDES
199PharyngitisSIDER
200Pharyngo-oral irritationSIDER
201Pharyngolaryngeal PainSIDER
202Physical disabilityOFFSIDES
203PingueculaOFFSIDES
204PolyneuropathyOFFSIDES
205Postmenopausal bleedingOFFSIDES
206Postoperative wound complicationOFFSIDES
207Primary sequestrumOFFSIDES
208Product administration errorCanada Vigilance: 1Canada Vigilance
209Product quality issueCanada Vigilance: 4Canada Vigilance
210Product use in unapproved indicationCanada Vigilance: 1Canada Vigilance
211Prostate cancer recurrentOFFSIDES
212Prostatic HypertrophySIDER
213Prostatic ObstructionOFFSIDES
214Pseudomonas bronchitisOFFSIDES
215Pulmonary congestionOFFSIDES
216Pulmonary radiation injuryOFFSIDES
217Radiation associated painOFFSIDES
218Radical hysterectomyOFFSIDES
219RalesOFFSIDES
220Respiratory TherapyOFFSIDES
221Respiratory distressCanada Vigilance: 1Canada Vigilance
222RhinitisSIDER
223RhonchiOFFSIDES
224Risus sardonicusOFFSIDES
225Secretion dischargeOFFSIDES
226ShockSIDER
227SinusitisOFFSIDES
SIDER
228Skin UlcerSIDER
229Sleep disorder due to general medical condition, insomnia typeOFFSIDES
230Spinal column stenosisOFFSIDES
231StressCanada Vigilance: 2Canada Vigilance
232TachycardiaSIDER
233Therapeutic product effect decreasedCanada Vigilance: 1Canada Vigilance
234Therapeutic product effect incompleteCanada Vigilance: 1Canada Vigilance
235Throat irritationSIDER
236Tongue exfoliationOFFSIDES
237Tooth ExtractionOFFSIDES
238Tooth InfectionOFFSIDES
239Ulcerative stomatitisSIDER
240Urethral StenosisOFFSIDES
241Urinary tract infectionSIDER
242UrticariaSIDER
243VIIth nerve paralysisOFFSIDES
244Ventricular hypokinesiaOFFSIDES
245Violence-related symptomOFFSIDES
246VomitingSIDER
247Walking aid userOFFSIDES
248Weight GainOFFSIDES
249WheezingCanada Vigilance: 1Canada Vigilance
250Wrong technique in product usage processCanada Vigilance: 1Canada Vigilance
251effusionOFFSIDES
252nervous system disorderSIDER
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