MetaADEDB 2.0 @ LMMD
Clofarabine
(WDDPHFBMKLOVOX-AYQXTPAHSA-N)
Structure
SMILES
OC[C@H]1O[C@H]([C@H]([C@@H]1O)F)n1cnc2c1nc(Cl)nc2N
Type(s)
Approved; Investigational
ATC code(s)
L01BB06
Molecular Formula:
C10H11ClFN5O3
Molecular Weight:
303.677
Log P:
0.2318
Hydrogen Bond Acceptor:
8
Hydrogen Bond Donor:
3
TPSA:
119.31
CAS Number(s):
123318-82-1
Synonym(s)
1.
Clofarabine
2.
2-Chloro-2'-arabino-fluoro-2'-deoxyadenosine
3.
2-Chloro-2'-fluoroarabino-2'-deoxyadenosine
4.
2-Chloro-9-(2-deoxy-2-fluoro-beta-D-arbinofuranosyl)adenine
5.
2-Chloro-9-(2-deoxy-2-fluoroarabinofuranosyl)adenine
6.
Cl-F-ara-A
7.
Clofarex
8.
Clolar
9.
Evoltra
10.
2 Chloro 2' arabino fluoro 2' deoxyadenosine
11.
2 Chloro 2' fluoroarabino 2' deoxyadenosine
External Link(s)
MeSHD000077866
PubChem Compound119182
BindingDB50247921
ChEBI681569
CHEMBLCHEMBL1750
DrugBankDB00631
DrugCentral691
IUPHAR/BPS Guide to PHARMACOLOGY6802
KEGGdr:D03546
Therapeutic Target DatabaseD0R5RR
ZINC3798247
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1NeutropeniaFAERS: 51
Canada Vigilance: 2
Canada Vigilance
SIDER
US FAERS
2Febrile NeutropeniaFAERS: 44OFFSIDES
SIDER
US FAERS
3SepsisFAERS: 32
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
4ThrombocytopeniaFAERS: 30SIDER
US FAERS
5Neutropenic sepsisFAERS: 26OFFSIDES
US FAERS
6PancytopeniaFAERS: 22SIDER
US FAERS
7HypotensionFAERS: 19SIDER
US FAERS
8White blood cell count decreasedFAERS: 19US FAERS
9Respiratory FailureFAERS: 16OFFSIDES
SIDER
US FAERS
10NauseaFAERS: 13OFFSIDES
SIDER
US FAERS
11ChillsFAERS: 12SIDER
US FAERS
12TachycardiaFAERS: 12SIDER
US FAERS
13Cardiac ArrestFAERS: 11US FAERS
14InfectionFAERS: 11OFFSIDES
SIDER
US FAERS
15Neutrophil count decreasedFAERS: 11US FAERS
16Atrial FibrillationFAERS: 10US FAERS
17Alanine Aminotransferase IncreasedFAERS: 9OFFSIDES
SIDER
US FAERS
18Blood creatinine increasedFAERS: 9OFFSIDES
SIDER
US FAERS
19Capillary Leak SyndromeFAERS: 920057324CTD
OFFSIDES
SIDER
US FAERS
20PneumoniaFAERS: 9SIDER
US FAERS
21Bronchopulmonary AspergillosisFAERS: 8US FAERS
22Chest PainFAERS: 8OFFSIDES
US FAERS
23General physical health deteriorationFAERS: 8OFFSIDES
US FAERS
24Lower respiratory tract infectionFAERS: 8US FAERS
25Malignant neoplasm progressionFAERS: 8US FAERS
26Disease ProgressionFAERS: 7OFFSIDES
US FAERS
27HeadacheFAERS: 7SIDER
US FAERS
28HepatotoxicityFAERS: 7OFFSIDES
SIDER
US FAERS
29Septic ShockFAERS: 7OFFSIDES
SIDER
US FAERS
30Therapy non-responderFAERS: 7OFFSIDES
US FAERS
31VomitingFAERS: 7SIDER
US FAERS
32AgitationFAERS: 6SIDER
US FAERS
33Aspartate Aminotransferase IncreasedFAERS: 6SIDER
US FAERS
34Blood alkaline phosphatase increasedFAERS: 6US FAERS
35BradycardiaFAERS: 6OFFSIDES
US FAERS
36Disseminated Intravascular CoagulationFAERS: 6US FAERS
37Drug ineffectiveFAERS: 6
Canada Vigilance: 2
Canada Vigilance
US FAERS
38LeukopeniaFAERS: 6SIDER
US FAERS
39PainFAERS: 6OFFSIDES
SIDER
US FAERS
40Respiratory distressFAERS: 6SIDER
US FAERS
41Transaminases increasedFAERS: 6OFFSIDES
US FAERS
42AstheniaFAERS: 5SIDER
US FAERS
43Blood potassium increasedFAERS: 5OFFSIDES
US FAERS
44DehydrationFAERS: 5OFFSIDES
SIDER
US FAERS
45Ejection Fraction DecreasedFAERS: 5US FAERS
46Enterococcal infectionFAERS: 5OFFSIDES
US FAERS
47Myocardial InfarctionFAERS: 5US FAERS
48TremorFAERS: 5SIDER
US FAERS
49Abdominal PainFAERS: 4SIDER
US FAERS
50ArthralgiaFAERS: 4SIDER
US FAERS
51Blood urea increasedFAERS: 4US FAERS
52Cerebrovascular accidentFAERS: 4US FAERS
53Device related infectionFAERS: 4OFFSIDES
SIDER
US FAERS
54EpistaxisFAERS: 4OFFSIDES
SIDER
US FAERS
55ErythemaFAERS: 4OFFSIDES
SIDER
US FAERS
56FatigueFAERS: 4SIDER
US FAERS
57HypersensitivityFAERS: 4SIDER
US FAERS
58IleusFAERS: 4US FAERS
59MalaiseFAERS: 4US FAERS
60Mental status changesFAERS: 4OFFSIDES
US FAERS
61PancreatitisFAERS: 4OFFSIDES
SIDER
US FAERS
62SyncopeFAERS: 4US FAERS
63Systemic Inflammatory Response SyndromeFAERS: 4SIDER
US FAERS
64VasculitisFAERS: 4US FAERS
65Acute kidney injuryFAERS: 3US FAERS
66AspergillosisFAERS: 3OFFSIDES
US FAERS
67Burning sensationFAERS: 3OFFSIDES
US FAERS
68CardiomegalyFAERS: 3US FAERS
69CellulitisFAERS: 3OFFSIDES
SIDER
US FAERS
70Disease recurrenceFAERS: 3US FAERS
71DisorientationFAERS: 3US FAERS
72Drug toxicityFAERS: 3US FAERS
73HaematotoxicityFAERS: 3OFFSIDES
US FAERS
74HydrocephalusFAERS: 3US FAERS
75HypoxiaFAERS: 3OFFSIDES
US FAERS
76Pericardial effusionFAERS: 3OFFSIDES
SIDER
US FAERS
77PneumonitisFAERS: 3US FAERS
78PruritusFAERS: 3SIDER
US FAERS
79Skin lesionFAERS: 3OFFSIDES
US FAERS
80Soft tissue necrosisFAERS: 3OFFSIDES
US FAERS
81StomatitisFAERS: 3SIDER
US FAERS
82UrticariaFAERS: 3US FAERS
83Vaginal lesionFAERS: 3OFFSIDES
US FAERS
84Acute graft versus host disease in liverFAERS: 2OFFSIDES
US FAERS
85Acute respiratory failureFAERS: 2OFFSIDES
US FAERS
86Anal UlcerFAERS: 2US FAERS
87Back PainFAERS: 2SIDER
US FAERS
88Bacterial sepsisFAERS: 2OFFSIDES
US FAERS
89Blood count abnormalFAERS: 2US FAERS
90CandidiasisFAERS: 2US FAERS
91Cardiac TamponadeFAERS: 2US FAERS
92Cerebral InfarctionFAERS: 2US FAERS
93Cerebral artery occlusionFAERS: 2US FAERS
94ChorioretinitisFAERS: 2US FAERS
95Clostridium test positiveFAERS: 2US FAERS
96Cytokine stormFAERS: 2OFFSIDES
US FAERS
97Deep Vein ThrombosisFAERS: 2US FAERS
98DizzinessFAERS: 2SIDER
US FAERS
99Drug administration errorFAERS: 2US FAERS
100Electrolyte imbalanceFAERS: 2US FAERS
101Escherichia infectionFAERS: 2OFFSIDES
US FAERS
102Fluid overloadFAERS: 2OFFSIDES
US FAERS
103HydronephrosisFAERS: 2US FAERS
104Intracardiac massFAERS: 2US FAERS
105LeukocytosisFAERS: 2US FAERS
106Lung consolidationFAERS: 2OFFSIDES
US FAERS
107LymphadenopathyFAERS: 2US FAERS
108Lymphocyte count decreasedFAERS: 2US FAERS
109Medication ErrorFAERS: 2US FAERS
110Mouth swellingFAERS: 2US FAERS
111MyocarditisFAERS: 2US FAERS
112NoduleFAERS: 2US FAERS
113ObstructionFAERS: 2OFFSIDES
US FAERS
114Oral mucosal erythemaFAERS: 2US FAERS
115Perineal painFAERS: 2US FAERS
116Post procedural complicationFAERS: 2US FAERS
117Pseudomonal sepsisFAERS: 2OFFSIDES
US FAERS
118Pulmonary function test decreasedFAERS: 2OFFSIDES
US FAERS
119Radiation injuryFAERS: 2US FAERS
120Rash erythematousFAERS: 2SIDER
US FAERS
121Renal massFAERS: 2US FAERS
122Respiratory arrestFAERS: 2US FAERS
123Skin hypertrophyFAERS: 2US FAERS
124SplenomegalyFAERS: 2US FAERS
125Stem cell transplantFAERS: 2US FAERS
126Toxic Epidermal NecrolysisFAERS: 2SIDER
US FAERS
127ToxoplasmosisFAERS: 2US FAERS
128Unresponsive to stimuliFAERS: 2OFFSIDES
US FAERS
129Unresponsive to verbal stimuliFAERS: 2OFFSIDES
US FAERS
130Urinary IncontinenceFAERS: 2US FAERS
131Venoocclusive diseaseFAERS: 2OFFSIDES
SIDER
US FAERS
132Ventricular DysfunctionFAERS: 2US FAERS
133WheezingFAERS: 2US FAERS
134AcidosisFAERS: 1OFFSIDES
US FAERS
135Acute graft versus host disease in intestineFAERS: 1OFFSIDES
US FAERS
136Acute graft versus host disease in skinFAERS: 1US FAERS
137AmnesiaFAERS: 1US FAERS
138Anal inflammationFAERS: 1US FAERS
139AnorexiaFAERS: 1SIDER
US FAERS
140Antibiotic resistant Staphylococcus test positiveFAERS: 1US FAERS
141AnxietyFAERS: 1SIDER
US FAERS
142AphasiaFAERS: 1US FAERS
143AspergillomaFAERS: 1US FAERS
144AtelectasisFAERS: 1OFFSIDES
US FAERS
145Atrial FlutterFAERS: 1US FAERS
146Autoimmune thrombocytopeniaFAERS: 1US FAERS
147Bacterial test positiveFAERS: 1OFFSIDES
US FAERS
148Bilirubin conjugated increasedFAERS: 1OFFSIDES
US FAERS
149Blast cell count decreasedFAERS: 1OFFSIDES
US FAERS
150Blast cell count increasedFAERS: 1US FAERS
151Blood albumin decreasedFAERS: 1US FAERS
152Blood creatine abnormalFAERS: 1US FAERS
153Blood creatine increasedFAERS: 1US FAERS
154Blood creatinine decreasedFAERS: 1US FAERS
155Blood fibrinogen increasedFAERS: 1US FAERS
156Blood lactate dehydrogenase increasedFAERS: 1US FAERS
157Blood magnesium decreasedFAERS: 1US FAERS
158Blood phosphorus increasedFAERS: 1US FAERS
159Bone marrow transplant rejectionFAERS: 1US FAERS
160BronchopneumoniaFAERS: 1US FAERS
161BronchospasmFAERS: 1US FAERS
162Catheter related infectionFAERS: 1SIDER
US FAERS
163Catheter site infectionFAERS: 1OFFSIDES
US FAERS
164Catheter site phlebitisFAERS: 1US FAERS
165Central Nervous System InfectionFAERS: 1OFFSIDES
US FAERS
166Central line infectionFAERS: 1US FAERS
167Cholecystitis infectiveFAERS: 1US FAERS
168CholecystitisFAERS: 1OFFSIDES
US FAERS
169CholelithiasisFAERS: 1SIDER
US FAERS
170ColitisFAERS: 1OFFSIDES
SIDER
US FAERS
171Complications of transplant surgeryFAERS: 1US FAERS
172ConstipationFAERS: 1US FAERS
173Conversion disorderFAERS: 1US FAERS
174CryingFAERS: 1US FAERS
175Cytomegalovirus test positiveFAERS: 1US FAERS
176Delayed engraftmentFAERS: 1US FAERS
177DeliriumFAERS: 1US FAERS
178Dental cariesFAERS: 1US FAERS
179Depressed Level of ConsciousnessFAERS: 1OFFSIDES
US FAERS
180Diabetes MellitusFAERS: 1US FAERS
181Diffuse vasculitisFAERS: 1US FAERS
182Disease complicationFAERS: 1US FAERS
183DysarthriaFAERS: 1US FAERS
184EpilepsyFAERS: 1US FAERS
185Escherichia sepsisFAERS: 1SIDER
US FAERS
186Eye InfectionFAERS: 1US FAERS
187Febrile bone marrow aplasiaFAERS: 1US FAERS
188FlushingFAERS: 1SIDER
US FAERS
189Fungus culture positiveFAERS: 1US FAERS
190Gamma-Glutamyltransferase IncreasedFAERS: 1US FAERS
191Gastrointestinal obstructionFAERS: 1US FAERS
192GoutFAERS: 1US FAERS
193Graft versus host disease in intestineFAERS: 1US FAERS
194Gram stain positiveFAERS: 1US FAERS
195HemiplegiaFAERS: 1US FAERS
196HepatitisFAERS: 1US FAERS
197Histiocytosis haematophagicFAERS: 1US FAERS
198Hyperdynamic left ventricleFAERS: 1US FAERS
199Iatrogenic injuryFAERS: 1US FAERS
200ImmunosuppressionFAERS: 1US FAERS
201Infection in an immunocompromised hostFAERS: 1US FAERS
202InfluenzaFAERS: 1SIDER
US FAERS
203Intestinal mucosal hypertrophyFAERS: 1US FAERS
204Joint swellingFAERS: 1US FAERS
205Lung infection pseudomonalFAERS: 1US FAERS
206Medical device complicationFAERS: 1OFFSIDES
US FAERS
207Metabolic acidosisFAERS: 1OFFSIDES
US FAERS
208Micrococcus infectionFAERS: 1US FAERS
209Nasal FlaringFAERS: 1US FAERS
210Nephrotic SyndromeFAERS: 1OFFSIDES
US FAERS
211Neurological decompensationFAERS: 1US FAERS
212Neutropenic colitisFAERS: 1OFFSIDES
US FAERS
213No adverse eventFAERS: 1US FAERS
214Nonspecific reactionFAERS: 1US FAERS
215Nuchal RigidityFAERS: 1US FAERS
216Occult blood positiveFAERS: 1OFFSIDES
US FAERS
217Pain of skinFAERS: 1US FAERS
218Palmar erythemaFAERS: 1US FAERS
219Pathogen resistanceFAERS: 1OFFSIDES
US FAERS
220PericarditisFAERS: 1OFFSIDES
SIDER
US FAERS
221Platelet count abnormalFAERS: 1OFFSIDES
US FAERS
222PneumothoraxFAERS: 1US FAERS
223Precursor B-lymphoblastic lymphoma recurrentFAERS: 1US FAERS
224Procedural complicationFAERS: 1US FAERS
225Product preparation errorFAERS: 1US FAERS
226Product use issueFAERS: 1US FAERS
227ProteinuriaFAERS: 1US FAERS
228Pulmonary EmbolismFAERS: 1US FAERS
229Pulmonary congestionFAERS: 1OFFSIDES
US FAERS
230Pulmonary sepsisFAERS: 1US FAERS
231RalesFAERS: 1US FAERS
232Septic embolusFAERS: 1US FAERS
233Sinusitis aspergillusFAERS: 1US FAERS
234Skin irritationFAERS: 1US FAERS
235Skin reactionFAERS: 1US FAERS
236SomnolenceFAERS: 1SIDER
US FAERS
237Staphylococcal Scalded Skin SyndromeFAERS: 1US FAERS
238StridorFAERS: 1OFFSIDES
US FAERS
239Systemic mycosisFAERS: 1US FAERS
240Therapeutic response delayedFAERS: 1US FAERS
241ThrombocytosisFAERS: 1US FAERS
242Transfusion ReactionFAERS: 1OFFSIDES
US FAERS
243Transfusion-Related Acute Lung InjuryFAERS: 1US FAERS
244Trifascicular blockFAERS: 1US FAERS
245VIIth nerve paralysisFAERS: 1US FAERS
246Vaginal DischargeFAERS: 1US FAERS
247Ventricular FibrillationFAERS: 1US FAERS
248Weight decreasedFAERS: 1SIDER
US FAERS
249hypertensive nephropathyFAERS: 1US FAERS
250Abdominal Compartment SyndromeOFFSIDES
251Abdominal tendernessOFFSIDES
252Acid refluxOFFSIDES
253Activities of daily living impairedOFFSIDES
254AlopeciaOFFSIDES
SIDER
255Anal FistulaOFFSIDES
256Anal abscessOFFSIDES
257Anticonvulsant drug level decreasedOFFSIDES
258AnuriaOFFSIDES
259Aortic valve sclerosisOFFSIDES
260AscitesOFFSIDES
261Aspiration PneumoniaOFFSIDES
262Atrial tachycardiaOFFSIDES
263Atypical pneumoniaSIDER
264AuraOFFSIDES
265Axonal neuropathyOFFSIDES
266Bacteria sputum identifiedOFFSIDES
267Bacteria stool identifiedOFFSIDES
268Biliary dilatationOFFSIDES
269Blood amylase increasedOFFSIDES
270Blood and lymphatic system disordersSIDER
271Blood electrolytes decreasedOFFSIDES
272Blood phosphorus decreasedOFFSIDES
273Blood potassium decreasedOFFSIDES
274Blood uric acidOFFSIDES
275Bone marrow depressionOFFSIDES
276Bone painSIDER
277Brain scan abnormalOFFSIDES
278Bronchial wall thickeningOFFSIDES
279BronchiectasisOFFSIDES
280Cardioactive drug levelOFFSIDES
281Carotid artery occlusionOFFSIDES
282CatatoniaOFFSIDES
283Catheter site cellulitisOFFSIDES
284Catheter site dischargeOFFSIDES
285Catheter site erythemaOFFSIDES
286Catheter site necrosisOFFSIDES
287Central nervous system lesionOFFSIDES
288Chest wall painSIDER
289Choking sensationOFFSIDES
290CholangiolitisOFFSIDES
291Clostridium colitisSIDER
292Clostridium difficile colitisOFFSIDES
SIDER
293Clostridium difficile toxin test positiveOFFSIDES
294ConfabulationOFFSIDES
295Congenital tracheomalaciaOFFSIDES
296Congenital tricuspid valve incompetenceOFFSIDES
297Conjunctival depositOFFSIDES
298Creatinine increasedSIDER
299Culture positiveOFFSIDES
300CystSIDER
301DeafnessSIDER
302DermatitisSIDER
303DiarrheaOFFSIDES
304Diverticular perforationOFFSIDES
305Drug withdrawal headacheOFFSIDES
306Dry skinSIDER
307Ear and labyrinth disordersSIDER
308Electromechanical dissociationOFFSIDES
309EncephalitisOFFSIDES
310Enterobacter sepsisOFFSIDES
311Enterococcal sepsisOFFSIDES
312EnterocolitisSIDER
313EpidermolysisOFFSIDES
314EpiglottitisOFFSIDES
315Epstein-Barr virus test positiveOFFSIDES
316Erythema MultiformeOFFSIDES
SIDER
317ExcoriationOFFSIDES
318Exfoliative conditionsSIDER
319Feeling abnormalSIDER
320Fluid imbalanceOFFSIDES
321Fungal rashOFFSIDES
322Fungus serology test positiveOFFSIDES
323Gastrointestinal PainSIDER
324Gastrointestinal ulcerOFFSIDES
325Hallucinations, mixedOFFSIDES
326Hepatic infection fungalOFFSIDES
327Hepatitis B core antigen positiveOFFSIDES
328Hepatitis B positiveOFFSIDES
329HepatosplenomegalyOFFSIDES
330HypercapniaOFFSIDES
331HypotensiveSIDER
332InfestationSIDER
333Kidney FailureOFFSIDES
334Klebsiella sepsisOFFSIDES
335LacerationOFFSIDES
336LethargyOFFSIDES
SIDER
337Leukopenia neonatalOFFSIDES
338LipaseOFFSIDES
339Liver scan abnormalOFFSIDES
340Lower respiratory tract infection fungalOFFSIDES
341LymphopeniaSIDER
342MalnutritionSIDER
343MenorrhagiaSIDER
344Musculoskeletal chest painSIDER
345Musculoskeletal discomfortSIDER
346MyalgiaSIDER
347Myelodysplastic syndrome transformationOFFSIDES
348Nasogastric output highOFFSIDES
349NecrosisSIDER
350Neutropenic infectionOFFSIDES
351Neutrophil count abnormalOFFSIDES
352Ocular ToxicityOFFSIDES
353Optic NeuritisOFFSIDES
354Oral candidiasisSIDER
355Oral mucosal petechiaeSIDER
356ParanoiaOFFSIDES
357ParaparesisOFFSIDES
358Pedal pulse decreasedOFFSIDES
359PetechiaeSIDER
360Portal HypertensionOFFSIDES
361Prolonged mensesSIDER
362PrurigoSIDER
363Pulmonary HypertensionOFFSIDES
364Rectal fissureOFFSIDES
365Refusal of treatment by relativeOFFSIDES
366Renal tubular necrosisOFFSIDES
367Retrograde portal vein flowOFFSIDES
368RhabdomyosarcomaOFFSIDES
369SinusitisSIDER
370Splenic InfectionOFFSIDES
371Stevens-Johnson Syndrome25811541CTD
SIDER
372Sudden deathOFFSIDES
373Supraventricular tachycardiaOFFSIDES
374T-Cell LymphomaOFFSIDES
375Tonic clonic movementsOFFSIDES
376Urinary tract infection pseudomonalOFFSIDES
377Vaginal cellulitisOFFSIDES
378Virus urine test positiveOFFSIDES
379effusionOFFSIDES
380jaundiceSIDER
381nervous system disorderSIDER
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