MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Leprosy

(UMLS:C0023343)

Definition:: A chronic granulomatous infection caused by MYCOBACTERIUM LEPRAE. The granulomatous lesions are manifested in the skin, the mucous membranes, and the peripheral nerves. Two polar or principal types are lepromatous and tuberculoid.
UMLS ID:: C0023343
MeSH ID:: D007918

Classification:

Name:

Bacterial Infections and Mycoses
MeSH Tree Number(s):: C01.252.410.040.552.386

Synonym(s)

Leprosy

Disease;Hansens (Leprosy)

HANSEN DISEASE

Hansen

Hansen Disease

Hansen's Disease

Hansen's disease

Infection due to Mycobacterium leprae

Leprosy, NOS

10.

Leprosy, unspecified

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Thalidomide	FAERS: 3	2948676 12483964 28745489	CTD US FAERS
2	Varenicline	FAERS: 2		US FAERS
3	4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide	FAERS: 1		US FAERS
4	Alendronate	FAERS: 1		US FAERS
5	Clozapine	FAERS: 1		US FAERS
6	Goserelin	FAERS: 1		US FAERS
7	Haloperidol	FAERS: 1		US FAERS
8	Hydroxyurea	FAERS: 1		US FAERS
9	LCZ 696	FAERS: 1		US FAERS
10	Lamotrigine	FAERS: 1		US FAERS
11	Nevirapine	FAERS: 1		US FAERS
12	Pregabalin	FAERS: 1		US FAERS
13	apremilast	FAERS: 1		US FAERS
14	Chloroquine		9715604	CTD
15	Clofazimine		6260900 16015260	CTD
16	Dapsone		View details 1184260 5128221 6260900 9251603 12030789 16015260 18602405 21765237	CTD OFFSIDES
17	Enalapril			OFFSIDES
18	Leflunomide			OFFSIDES
19	Prednisolone		6260900	CTD
20	Ribavirin			OFFSIDES
21	Rifampin		View details 3249905 3746041 6260900 16015260	CTD
22	Varenicline			OFFSIDES
23	Zidovudine			OFFSIDES
24	efavirenz			OFFSIDES
25	triptolide		23639586	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Mycobacterium Infections, Nontuberculous	49.2%
2	Tuberculosis	49.2%
3	Mycobacterium abscessus Infection	49.2%
4	Mycobacterium avium-intracellulare Infection	36.8%
5	Lymph Node Tuberculosis	36.8%
6	Tuberculosis, Miliary	36.8%
7	Tuberculosis, Multidrug-Resistant	36.8%
8	Latent Tuberculosis	36.8%
9	Actinomycosis	36%
10	Corynebacterium Infections	36%
11	Nocardia Infections	36%
12	Pulmonary Nocardiosis	36%
13	Extensively Drug-Resistant Tuberculosis	30.6%
14	Clostridium Infections	28.5%
15	Listeriosis	28.5%
16	Staphylococcal Infections	28.5%
17	Streptococcal Infections	28.5%
18	Bacillaceae Infections	28.5%
19	Clostridium difficile infection	28.5%
20	Tuberculosis, Gastrointestinal	25.5%
21	Tuberculosis, Central Nervous System	24.7%
22	Diphtheria	23.8%
23	Gram-Negative Bacterial Infections	22.7%
24	Joint Tuberculosis	20.9%
25	Tuberculosis, Osteoarticular	20.9%
26	Bone Tuberculosis	20.9%
27	Erysipelothrix infection	20.5%
28	Tuberculosis, Pulmonary	19.5%
29	Gas Gangrene	16.8%
30	Pneumococcal Infections	16.8%
31	Scarlet Fever	16.8%
32	Tetanus	16.8%
33	Borrelia Infections	16.4%
34	Leptospirosis	16.4%
35	Erythrasma	15.5%
36	Central Nervous System Bacterial Infections	15.3%
37	Mycoses	15.3%
38	Infection	15.3%
39	Bacterial Vaginosis	14.8%
40	Skin Diseases, Bacterial	13.4%
41	Tuberculosis, Spinal	13.3%
42	Bacteremia	13.2%
43	Tuberculosis, Meningeal	12.7%
44	Erysipelas	12.6%
45	Staphylococcal Skin Infections	12.6%
46	Impetigo	12.2%
47	Bordetella Infections	12.2%
48	Brucellosis	12.2%
49	Campylobacter infection	12.2%
50	Enterobacteriaceae Infections	12.2%
51	Pseudomonas Infections	12.2%
52	Q Fever	12.2%
53	Vibrio Infections	12.2%
54	Helicobacter Infections	12.2%
55	Neisseriaceae Infections	12.2%
56	Burkholderia Infections	12.2%
57	Flavobacteriaceae Infections	12.2%
58	Moraxellaceae Infections	12.2%
59	Burkholderia cepacia Infection	12.2%
60	Mycetoma	11.3%
61	Pneumonia, Bacterial	11.3%
62	Bacterial Endocarditis	10.8%
63	Lyme Disease	10.8%
64	Relapsing Fever	10.8%
65	Tuberculosis, Renal	10.6%
66	Ecthyma	10.6%
67	Subacute Bacterial Endocarditis	10.6%
68	Central Nervous System Infection	10.2%
69	Erythema Induratum	10.1%
70	Human Ehrlichiosis	9.6%
71	Meningitis, Listeria	9.6%
72	Lyme Neuroborreliosis	8.8%
73	Rheumatic Fever	8.7%
74	Neurosyphilis	8.7%
75	Enterocolitis, Pseudomembranous	8.4%
76	pseudomembranous colitis	8.4%
77	Syphilis	8.3%
78	Japanese Spotted Fever	8%
79	Staphylococcal Scalded Skin Syndrome	8%
80	Rheumatic Heart Disease	7.7%
81	Human anaplasmosis	7.7%
82	Aspergillosis	7.6%
83	Candidiasis	7.6%
84	Coccidioidomycosis	7.6%
85	Histoplasmosis	7.6%
86	Paracoccidioidomycosis	7.6%
87	Pelvic Infection	7.6%
88	Wound Infection	7.6%
89	Zygomycosis	7.6%
90	Soft Tissue Infection	7.6%
91	Community-Acquired Infections	7.6%
92	Phaeohyphomycosis	7.6%
93	Pneumocystis Infections	7.6%
94	Meningitis, Pneumococcal	7.3%
95	Chlamydia Infections	7.3%
96	Erythema Chronicum Migrans	7.3%
97	Gonorrhea	7.3%
98	Acinetobacter Infections	7.2%
99	Bacteroides Infections	7.2%
100	Cholera	7.2%
101	Escherichia coli Infections	7.2%
102	Haemophilus Infections	7.2%
103	Klebsiella Infections	7.2%
104	Meningococcal Infections	7.2%
105	Mycoplasma Infections	7.2%
106	Pasteurella Infections	7.2%
107	Proteus Infections	7.2%
108	Rickettsia Infections	7.2%
109	Salmonella infections	7.2%
110	Scrub Typhus	7.2%
111	Serratia Infections	7.2%
112	Ureaplasma Infections	7.2%
113	Botulism	7%
114	Furunculosis	6.8%
115	furuncle	6.8%
116	Hidradenitis Suppurativa	6.2%
117	Ulcerative stomatitis	6.1%
118	Meningitis, Bacterial	6.1%
119	Hordeolum	6%
120	Bacterial conjunctivitis	5.9%
121	Dermatomycoses	5.9%
122	Pertussis	5.8%
123	carbuncle	5.7%
124	Rocky Mountain Spotted Fever	5.5%
125	Eye Infection	5.4%
126	Respiratory Tract Infections	5.4%
127	Bone Diseases, Infectious	5.1%
128	Otomycosis	5.1%
129	Pregnancy Complications, Infectious	5.1%
130	Skin Diseases, Infectious	5.1%
131	Arthritis, Infectious	5%
132	Piedra	5%
133	Central Nervous System Fungal Infections	5%
134	Suppuration	5%
135	Rhinoscleroma	5%
136	Cross Infection	5%
137	Septicemia	5%
138	Sepsis	5%
139	Syphilis, Congenital	4.9%
140	Meningitis, Haemophilus	4.8%
141	Psittacosis	4.8%
142	Paratyphoid Fever	4.8%
143	Plague	4.8%
144	Typhoid Fever	4.8%
145	TYPHUS	4.8%
146	Yersinia pseudotuberculosis Infections	4.8%
147	Bubonic Plague	4.8%
148	Lymphogranuloma Venereum	4.5%
149	Candidiasis, Chronic Mucocutaneous	4.2%
150	Cutaneous Candidiasis	4.2%
151	Opportunistic Infections	4.2%
152	Neuroaspergillosis	4.1%
153	Mucormycosis	4.1%
154	Fungemia	4.1%
155	Brain Abscess	4%
156	Ophthalmia Neonatorum	3.9%
157	Trachoma	3.9%
158	Lung Diseases, Fungal	3.9%
159	Urinary tract infection	3.8%
160	Dysentery, Bacillary	3.6%
161	Salmonella Infections, Animal	3.4%
162	Cellulitis	3.3%
163	Chromoblastomycosis	3.2%
164	Dermatophytosis	3.2%
165	Sporotrichosis	3.2%
166	Tinea	3.2%
167	Tinea Versicolor	3.2%
168	Trichophytosis	3.2%
169	Invasive Pulmonary Aspergillosis	3.2%
170	Hyalohyphomycosis	3.2%
171	Salmonella food poisoning	3.2%
172	Endotoxemia	3.2%
173	Panophthalmitis	3.2%
174	Candidemia	3.2%
175	Sexually Transmitted Diseases	3.2%
176	Blastomycosis	3%
177	Oral candidiasis	2.8%
178	Endophthalmitis	2.8%
179	Peritonitis	2.8%
180	Osteomyelitis	2.7%
181	Periostitis	2.7%
182	Surgical Wound Infection	2.7%
183	Pulmonary Aspergillosis	2.7%
184	Bronchopulmonary Aspergillosis	2.7%
185	Abscess	2.7%
186	Adnexitis	2.7%
187	Empyema	2.7%
188	Pelvic Inflammatory Disease	2.7%
189	Meningitis, Cryptococcal	2.6%
190	Psoas Abscess	2.4%
191	Abdominal Abscess	2.4%
192	Superinfection	2.1%
193	Corneal Ulcer	2.1%
194	Puerperal Infection	2.1%
195	Spondylitis	2.1%
196	Appendicitis	2%
197	Bacteriuria	2%
198	Pyuria	2%
199	Meningitis, Fungal	2%
200	Pyomyositis	2%
201	Endotoxic shock	2%
202	Septic Shock	2%
203	Toxic Shock Syndrome	2%
204	Candidiasis, Vulvovaginal	2%
205	Fusariosis	2%
206	Waterhouse-Friderichsen Syndrome	1.7%
207	Tinea Capitis	1.6%
208	Onychomycosis	1.6%
209	Arthritis, Reactive	1.6%
210	Diverticulitis	1.6%
211	Toxoplasmosis, Cerebral	1.4%
212	Lemierre Syndrome	1.4%
213	AIDS-Related Opportunistic Infections	1.4%
214	Tinea Pedis	1.3%
215	Lung Abscess	1.3%
216	Diverticulum	1.2%
217	Diverticulosis	1.2%
218	Discitis	1.2%
219	Mastoiditis	1.2%
220	Petrositis	1.2%
221	Liver Abscess	1.1%
222	Retropharyngeal Abscess	1%
223	Epidural Abscess	1%
224	Peritonsillar Abscess	1%
225	Aspergillosis, Allergic Bronchopulmonary	0.8%
226	Liver Abscess, Amebic	0.4%

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