MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Gas Gangrene

(UMLS:C0017105)

Definition:: A severe condition resulting from bacteria invading healthy muscle from adjacent traumatized muscle or soft tissue. The infection originates in a wound contaminated with bacteria of the genus CLOSTRIDIUM. C. perfringens accounts for the majority of cases (over eighty percent), while C. noyvi, C. septicum, and C. histolyticum cause most of the other cases.
UMLS ID:: C0017105
MeSH ID:: D005738

Classification:

Name:

Bacterial Infections and Mycoses
MeSH Tree Number(s):: C01.252.410.222.440

Synonym(s)

Gas Gangrene

CLOSTRIDIAL MYONECROSIS

CLOSTRIDIAL MYONECROSIS GAS GANGRENE

Clostridial myonecrosis

Clostridial myositis

Clostridium; gas-forming

GANGRENE GAS

Gangrene, gas

Gas bacillus infection

10.

Gas gangrene

11.

Gas gangrene due to Clostridia

12.

Gas gangrene due to Clostridia, NOS

13.

Gas gangrene, NOS

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Canagliflozin	FAERS: 77	US FAERS
2	Alendronate	FAERS: 6	US FAERS
3	Invokamet	FAERS: 6	US FAERS
4	Clindamycin	FAERS: 5	US FAERS
5	Alendronate	FAERS: 4	US FAERS
6	Zoledronic Acid	FAERS: 4	US FAERS
7	Epinephrine	FAERS: 3	SIDER US FAERS
8	Gefitinib	FAERS: 2	OFFSIDES US FAERS
9	Rivaroxaban	FAERS: 2	US FAERS
10	4-hydroxybutyric acid	FAERS: 1	US FAERS
11	Arthrotec	FAERS: 1	US FAERS
12	Azacitidine	FAERS: 1	US FAERS
13	Ciprofloxacin	FAERS: 1	US FAERS
14	Clindamycin	FAERS: 1	US FAERS
15	Clozapine	FAERS: 1	US FAERS
16	Cytarabine	FAERS: 1	OFFSIDES US FAERS
17	Deferasirox	FAERS: 1	OFFSIDES US FAERS
18	Diclofenac	FAERS: 1	US FAERS
19	Ruxolitinib phosphate	FAERS: 1	US FAERS
20	Sorafenib	FAERS: 1	US FAERS
21	Sulfasalazine	FAERS: 1	US FAERS
22	Tigecycline	FAERS: 1	US FAERS
23	liposomal doxorubicin	FAERS: 1	US FAERS
24	1-methylcyclopropene		OFFSIDES
25	Acetylcysteine		OFFSIDES
26	Dactinomycin		OFFSIDES
27	Etomidate		OFFSIDES
28	Etoposide		OFFSIDES
29	Imatinib Mesylate		OFFSIDES
30	Loperamide		OFFSIDES
31	Prochlorperazine		OFFSIDES
32	Ropivacaine		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Tetanus	48.4%
2	Actinomycetales Infections	34.4%
3	Listeriosis	34.4%
4	Staphylococcal Infections	34.4%
5	Streptococcal Infections	34.4%
6	Bacillaceae Infections	34.4%
7	Gram-Negative Bacterial Infections	25.4%
8	Erysipelothrix infection	24.7%
9	Enterocolitis, Pseudomembranous	24.2%
10	pseudomembranous colitis	24.2%
11	Actinomycosis	22.6%
12	Corynebacterium Infections	22.6%
13	Mycobacterium Infections	22.6%
14	Nocardia Infections	22.6%
15	Pneumococcal Infections	22.6%
16	Scarlet Fever	22.6%
17	Pulmonary Nocardiosis	22.6%
18	Botulism	20%
19	Borrelia Infections	19.8%
20	Leptospirosis	19.8%
21	Central Nervous System Bacterial Infections	17.1%
22	Impetigo	17.1%
23	Diphtheria	16.8%
24	Leprosy	16.8%
25	Mycobacterium Infections, Nontuberculous	16.8%
26	Tuberculosis	16.8%
27	Mycobacterium abscessus Infection	16.8%
28	Bacterial Vaginosis	16.6%
29	Mycoses	16.4%
30	Infection	16.4%
31	Erysipelas	16.2%
32	Staphylococcal Skin Infections	16.2%
33	Skin Diseases, Bacterial	15.1%
34	Bacteremia	14.9%
35	Bordetella Infections	14.8%
36	Brucellosis	14.8%
37	Campylobacter infection	14.8%
38	Enterobacteriaceae Infections	14.8%
39	Pseudomonas Infections	14.8%
40	Q Fever	14.8%
41	Vibrio Infections	14.8%
42	Helicobacter Infections	14.8%
43	Neisseriaceae Infections	14.8%
44	Burkholderia Infections	14.8%
45	Flavobacteriaceae Infections	14.8%
46	Moraxellaceae Infections	14.8%
47	Burkholderia cepacia Infection	14.8%
48	Lyme Disease	14.5%
49	Relapsing Fever	14.5%
50	Mycobacterium avium-intracellulare Infection	13.9%
51	Lymph Node Tuberculosis	13.9%
52	Tuberculosis, Miliary	13.9%
53	Tuberculosis, Multidrug-Resistant	13.9%
54	Leprosy, Multibacillary	13.9%
55	Latent Tuberculosis	13.9%
56	Erythrasma	13.9%
57	Ecthyma	13.6%
58	Subacute Bacterial Endocarditis	13.6%
59	Human Ehrlichiosis	12.9%
60	Meningitis, Listeria	12.9%
61	Pneumonia, Bacterial	12.6%
62	Borderline leprosy	12.5%
63	Leprosy, Lepromatous	12.5%
64	Tuberculoid leprosy	12.5%
65	Extensively Drug-Resistant Tuberculosis	12.5%
66	Bacterial Endocarditis	12.2%
67	Lyme Neuroborreliosis	12.1%
68	Rheumatic Fever	11.7%
69	Neurosyphilis	11.6%
70	Rheumatic Heart Disease	11.6%
71	Staphylococcal Scalded Skin Syndrome	11.5%
72	Japanese Spotted Fever	11.2%
73	Central Nervous System Infection	10.8%
74	Mycetoma	10.8%
75	Syphilis	10.6%
76	Meningitis, Pneumococcal	10.6%
77	Human anaplasmosis	10.3%
78	Erythema Chronicum Migrans	9.9%
79	Furunculosis	9.8%
80	furuncle	9.8%
81	Acinetobacter Infections	9.7%
82	Bacteroides Infections	9.7%
83	Cholera	9.7%
84	Escherichia coli Infections	9.7%
85	Haemophilus Infections	9.7%
86	Klebsiella Infections	9.7%
87	Meningococcal Infections	9.7%
88	Mycoplasma Infections	9.7%
89	Pasteurella Infections	9.7%
90	Proteus Infections	9.7%
91	Rickettsia Infections	9.7%
92	Salmonella infections	9.7%
93	Scrub Typhus	9.7%
94	Serratia Infections	9.7%
95	Ureaplasma Infections	9.7%
96	Tuberculosis, Gastrointestinal	9.6%
97	Joint Tuberculosis	9.6%
98	Tuberculosis, Osteoarticular	9.6%
99	Bone Tuberculosis	9.6%
100	Tuberculosis, Central Nervous System	9.3%
101	carbuncle	9.2%
102	Chlamydia Infections	9.2%
103	Gonorrhea	9.2%
104	Rocky Mountain Spotted Fever	8.8%
105	Aspergillosis	8.5%
106	Candidiasis	8.5%
107	Coccidioidomycosis	8.5%
108	Histoplasmosis	8.5%
109	Paracoccidioidomycosis	8.5%
110	Pelvic Infection	8.5%
111	Wound Infection	8.5%
112	Zygomycosis	8.5%
113	Soft Tissue Infection	8.5%
114	Community-Acquired Infections	8.5%
115	Phaeohyphomycosis	8.5%
116	Pneumocystis Infections	8.5%
117	Ulcerative stomatitis	7.8%
118	Hidradenitis Suppurativa	7.6%
119	Pertussis	7.5%
120	Tuberculosis, Meningeal	7.4%
121	Syphilis, Congenital	7.4%
122	Meningitis, Bacterial	7.4%
123	Tuberculosis, Pulmonary	7.4%
124	Hordeolum	7.3%
125	Bacterial conjunctivitis	7.2%
126	Psittacosis	7.2%
127	Paratyphoid Fever	7.2%
128	Plague	7.2%
129	Typhoid Fever	7.2%
130	TYPHUS	7.2%
131	Yersinia pseudotuberculosis Infections	7.2%
132	Bubonic Plague	7.2%
133	Meningitis, Haemophilus	6.7%
134	Dermatomycoses	6.7%
135	Rhinoscleroma	6.5%
136	Lymphogranuloma Venereum	6.4%
137	Tuberculosis, Spinal	6.3%
138	Erythema Induratum	6.2%
139	Eye Infection	6%
140	Respiratory Tract Infections	6%
141	Bone Diseases, Infectious	5.7%
142	Otomycosis	5.7%
143	Pregnancy Complications, Infectious	5.7%
144	Skin Diseases, Infectious	5.7%
145	Arthritis, Infectious	5.6%
146	Piedra	5.6%
147	Central Nervous System Fungal Infections	5.6%
148	Suppuration	5.6%
149	Ophthalmia Neonatorum	5.6%
150	Trachoma	5.6%
151	Cross Infection	5.6%
152	Septicemia	5.6%
153	Sepsis	5.6%
154	Candidiasis, Chronic Mucocutaneous	5.2%
155	Cutaneous Candidiasis	5.2%
156	Salmonella Infections, Animal	5.2%
157	Mucormycosis	4.9%
158	Neuroaspergillosis	4.9%
159	Fungemia	4.9%
160	Salmonella food poisoning	4.9%
161	Dysentery, Bacillary	4.8%
162	Opportunistic Infections	4.7%
163	Brain Abscess	4.7%
164	Panophthalmitis	4.4%
165	Lung Diseases, Fungal	4.3%
166	Tuberculosis, Renal	4.3%
167	Candidemia	4.3%
168	Urinary tract infection	4.3%
169	Chromoblastomycosis	4.1%
170	Dermatophytosis	4.1%
171	Sporotrichosis	4.1%
172	Tinea	4.1%
173	Tinea Versicolor	4.1%
174	Trichophytosis	4.1%
175	Invasive Pulmonary Aspergillosis	4.1%
176	Hyalohyphomycosis	4.1%
177	Endotoxemia	4%
178	Cellulitis	4%
179	Blastomycosis	3.8%
180	Sexually Transmitted Diseases	3.5%
181	Oral candidiasis	3.4%
182	Endophthalmitis	3.4%
183	Peritonitis	3.4%
184	Osteomyelitis	3.3%
185	Periostitis	3.3%
186	Surgical Wound Infection	3.3%
187	Pulmonary Aspergillosis	3.3%
188	Bronchopulmonary Aspergillosis	3.3%
189	Abscess	3.3%
190	Adnexitis	3.3%
191	Empyema	3.3%
192	Pelvic Inflammatory Disease	3.3%
193	Meningitis, Cryptococcal	3.2%
194	Psoas Abscess	3.2%
195	Abdominal Abscess	3.2%
196	Fusariosis	2.8%
197	Waterhouse-Friderichsen Syndrome	2.7%
198	Superinfection	2.6%
199	Corneal Ulcer	2.5%
200	Puerperal Infection	2.5%
201	Spondylitis	2.5%
202	Appendicitis	2.5%
203	Bacteriuria	2.5%
204	Pyuria	2.5%
205	Meningitis, Fungal	2.5%
206	Pyomyositis	2.5%
207	Endotoxic shock	2.4%
208	Septic Shock	2.4%
209	Toxic Shock Syndrome	2.4%
210	Candidiasis, Vulvovaginal	2.4%
211	Tinea Capitis	2.3%
212	Onychomycosis	2.3%
213	Diverticulitis	2.2%
214	Lemierre Syndrome	2.1%
215	Arthritis, Reactive	1.9%
216	Tinea Pedis	1.9%
217	Toxoplasmosis, Cerebral	1.8%
218	Lung Abscess	1.7%
219	AIDS-Related Opportunistic Infections	1.7%
220	Liver Abscess	1.7%
221	Diverticulum	1.7%
222	Diverticulosis	1.7%
223	Discitis	1.6%
224	Mastoiditis	1.6%
225	Petrositis	1.6%
226	Retropharyngeal Abscess	1.3%
227	Epidural Abscess	1.3%
228	Peritonsillar Abscess	1.3%
229	Aspergillosis, Allergic Bronchopulmonary	1.1%
230	Liver Abscess, Amebic	0.7%

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