MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Histoplasmosis

(UMLS:C0019655)

Definition:: Infection resulting from exposure to the fungus HISTOPLASMA. It is worldwide in distribution and particularly common in the central and eastern states, especially areas around the Ohio and Mississippi River valleys.
UMLS ID:: C0019655
MeSH ID:: D006660

Classification:

Name:

Bacterial Infections and Mycoses
MeSH Tree Number(s):: C01.703.450

Synonym(s)

Histoplasmosis

Darling

Darling; histoplasmosis

HISTOPLASMOSIS

Histoplasma; infection

Histoplasmosis, NOS

Histoplasmosis, unspecified

histoplasmoses

histoplasmosis

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Itraconazole	FAERS: 9	11972151 14616112	CTD OFFSIDES US FAERS
2	tofacitinib	FAERS: 5 Canada Vigilance: 1		Canada Vigilance US FAERS
3	Lenalidomide	FAERS: 4		US FAERS
4	Prednisone	FAERS: 4		US FAERS
5	Fingolimod Hydrochloride	FAERS: 3		US FAERS
6	Methotrexate	FAERS: 3		US FAERS
7	Temozolomide	FAERS: 3		US FAERS
8	Itraconazole	FAERS: 2		US FAERS
9	Ketoconazole	FAERS: 2	3487266	CTD US FAERS
10	Lopinavir	FAERS: 2		OFFSIDES US FAERS
11	Methotrexate	FAERS: 2		SIDER US FAERS
12	Mycophenolic Acid	FAERS: 2		US FAERS
13	NuvaRing	FAERS: 2		OFFSIDES US FAERS
14	rofecoxib	FAERS: 2		US FAERS
15	Daptomycin	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
16	Dexlansoprazole	FAERS: 1		US FAERS
17	Dimethyl Fumarate	FAERS: 1		US FAERS
18	Droxidopa	FAERS: 1		US FAERS
19	Gabapentin	FAERS: 1		OFFSIDES US FAERS
20	INCB018424	FAERS: 1		US FAERS
21	Medroxyprogesterone Acetate	FAERS: 1		US FAERS
22	Methylprednisolone Acetate	FAERS: 1		OFFSIDES US FAERS
23	Methylprednisolone	FAERS: 1		US FAERS
24	Pregabalin	FAERS: 1		OFFSIDES US FAERS
25	Raltegravir Potassium	FAERS: 1		US FAERS
26	Rivaroxaban	FAERS: 1		US FAERS
27	Tacrolimus	FAERS: 1		US FAERS
28	Testosterone	FAERS: 1		US FAERS
29	Triumeq	FAERS: 1		US FAERS
30	Valganciclovir	FAERS: 1		US FAERS
31	ambrisentan	FAERS: 1		US FAERS
32	montelukast	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
33	Allopurinol			OFFSIDES
34	Beclomethasone			OFFSIDES
35	Biotin			OFFSIDES
36	Budesonide			OFFSIDES
37	Buspirone			OFFSIDES
38	Cimetidine			OFFSIDES
39	Citalopram			OFFSIDES
40	Clotrimazole			OFFSIDES
41	Codeine			OFFSIDES
42	Dacarbazine			OFFSIDES
43	Dehydroepiandrosterone			OFFSIDES
44	Dimethindene			OFFSIDES
45	Diphenoxylate			OFFSIDES
46	Doxepin			OFFSIDES
47	Estrogens, Conjugated (USP)			OFFSIDES
48	Etodolac			OFFSIDES
49	Fenofibrate			OFFSIDES
50	Fluconazole			OFFSIDES
51	Fluocinolone Acetonide		15767049	CTD
52	Furosemide			OFFSIDES
53	Ganciclovir			OFFSIDES
54	Gatifloxacin			OFFSIDES
55	Indomethacin			OFFSIDES
56	Lactic Acid			OFFSIDES
57	Mefenamic Acid			OFFSIDES
58	Meperidine			OFFSIDES
59	Mercaptopurine			OFFSIDES
60	Methyltestosterone			OFFSIDES
61	Mometasone Furoate			OFFSIDES
62	Norepinephrine			OFFSIDES
63	Oxandrolone			OFFSIDES
64	Pamidronate			OFFSIDES
65	Pantoprazole			OFFSIDES
66	Pentamidine			SIDER
67	Piperacillin, Tazobactam Drug Combination			OFFSIDES
68	Ranitidine			OFFSIDES
69	Risedronic Acid			OFFSIDES
70	Rosiglitazone			OFFSIDES
71	Sitagliptin Phosphate			OFFSIDES
72	Sulfamethoxazole			OFFSIDES
73	Tetracycline			OFFSIDES
74	Timolol			OFFSIDES
75	Vinblastine			OFFSIDES
76	Vitamin D			OFFSIDES
77	Zidovudine			OFFSIDES
78	Zoledronic Acid			OFFSIDES
79	azelastine			OFFSIDES
80	balsalazide			OFFSIDES
81	betamethasone-17,21-dipropionate			OFFSIDES
82	bucindolol			OFFSIDES
83	chlordiazepoxide, clidinium drug combination			OFFSIDES
84	cyclobenzaprine			OFFSIDES
85	desloratadine			OFFSIDES
86	dolasetron			OFFSIDES
87	eletriptan			OFFSIDES
88	etravirine			OFFSIDES
89	liposomal amphotericin B		3487266 6113376 7178410	CTD OFFSIDES
90	valdecoxib			OFFSIDES
91	zolmitriptan			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Aspergillosis	42.9%
2	Candidiasis	42.9%
3	Coccidioidomycosis	42.9%
4	Paracoccidioidomycosis	42.9%
5	Zygomycosis	42.9%
6	Phaeohyphomycosis	42.9%
7	Pneumocystis Infections	42.9%
8	Mucormycosis	31%
9	Neuroaspergillosis	30.3%
10	Otomycosis	28.6%
11	Piedra	27.9%
12	Central Nervous System Fungal Infections	27.9%
13	Invasive Pulmonary Aspergillosis	27.5%
14	Candidiasis, Chronic Mucocutaneous	27.3%
15	Cutaneous Candidiasis	27.3%
16	Candidemia	27.2%
17	Dermatomycoses	25.9%
18	Bacterial Infections	23.1%
19	Infection	23.1%
20	Meningitis, Cryptococcal	21.8%
21	Lung Diseases, Fungal	21.4%
22	Oral candidiasis	20.9%
23	Pulmonary Aspergillosis	20.5%
24	Bronchopulmonary Aspergillosis	20.5%
25	Fungemia	20.1%
26	Blastomycosis	19.5%
27	Chromoblastomycosis	19.2%
28	Dermatophytosis	19.2%
29	Sporotrichosis	19.2%
30	Tinea	19.2%
31	Tinea Versicolor	19.2%
32	Trichophytosis	19.2%
33	Hyalohyphomycosis	19.2%
34	Fusariosis	16%
35	Mycetoma	15.8%
36	Meningitis, Fungal	15.1%
37	Central Nervous System Infection	15%
38	Candidiasis, Vulvovaginal	14.8%
39	Pelvic Infection	14.3%
40	Wound Infection	14.3%
41	Gram-Negative Bacterial Infections	14.3%
42	Gram-Positive Bacterial Infections	14.3%
43	Soft Tissue Infection	14.3%
44	Community-Acquired Infections	14.3%
45	Central Nervous System Bacterial Infections	14%
46	Borrelia Infections	13.6%
47	Leptospirosis	13.6%
48	Tinea Capitis	12.8%
49	Onychomycosis	12.8%
50	Lyme Disease	12.4%
51	Relapsing Fever	12.4%
52	Skin Diseases, Bacterial	12.1%
53	Bacteremia	11.9%
54	Panophthalmitis	11.8%
55	Human Ehrlichiosis	11.1%
56	Lyme Neuroborreliosis	10.6%
57	Tinea Pedis	10.6%
58	Erysipelas	10.6%
59	Staphylococcal Skin Infections	10.6%
60	Ulcerative stomatitis	10.5%
61	Japanese Spotted Fever	10.5%
62	Actinomycetales Infections	10.3%
63	Bordetella Infections	10.3%
64	Brucellosis	10.3%
65	Campylobacter infection	10.3%
66	Clostridium Infections	10.3%
67	Enterobacteriaceae Infections	10.3%
68	Listeriosis	10.3%
69	Pseudomonas Infections	10.3%
70	Q Fever	10.3%
71	Staphylococcal Infections	10.3%
72	Streptococcal Infections	10.3%
73	Vibrio Infections	10.3%
74	Helicobacter Infections	10.3%
75	Bacillaceae Infections	10.3%
76	Neisseriaceae Infections	10.3%
77	Burkholderia Infections	10.3%
78	Clostridium difficile infection	10.3%
79	Flavobacteriaceae Infections	10.3%
80	Moraxellaceae Infections	10.3%
81	Burkholderia cepacia Infection	10.3%
82	Impetigo	10.3%
83	Erythrasma	10.2%
84	Erythema Chronicum Migrans	10%
85	Eye Infection	10%
86	Respiratory Tract Infections	10%
87	Neurosyphilis	9.9%
88	Syphilis	9.8%
89	Bacterial Endocarditis	9.7%
90	Rocky Mountain Spotted Fever	9.6%
91	Bone Diseases, Infectious	9.5%
92	Pregnancy Complications, Infectious	9.5%
93	Skin Diseases, Infectious	9.5%
94	Pertussis	9.4%
95	Hidradenitis Suppurativa	9.4%
96	Arthritis, Infectious	9.3%
97	Suppuration	9.3%
98	Cross Infection	9.2%
99	Septicemia	9.2%
100	Sepsis	9.2%
101	Bacterial Vaginosis	9.1%
102	Staphylococcal Scalded Skin Syndrome	9.1%
103	Endotoxemia	9.1%
104	Brain Abscess	8.8%
105	Ecthyma	8.8%
106	Subacute Bacterial Endocarditis	8.8%
107	Human anaplasmosis	8.8%
108	Chlamydia Infections	8.8%
109	Gonorrhea	8.8%
110	Joint Tuberculosis	8.6%
111	Tuberculosis, Osteoarticular	8.6%
112	Bone Tuberculosis	8.6%
113	Acinetobacter Infections	8.5%
114	Actinomycosis	8.5%
115	Bacteroides Infections	8.5%
116	Cholera	8.5%
117	Corynebacterium Infections	8.5%
118	Escherichia coli Infections	8.5%
119	Gas Gangrene	8.5%
120	Haemophilus Infections	8.5%
121	Klebsiella Infections	8.5%
122	Meningococcal Infections	8.5%
123	Mycobacterium Infections	8.5%
124	Mycoplasma Infections	8.5%
125	Nocardia Infections	8.5%
126	Pasteurella Infections	8.5%
127	Pneumococcal Infections	8.5%
128	Proteus Infections	8.5%
129	Rickettsia Infections	8.5%
130	Salmonella infections	8.5%
131	Scarlet Fever	8.5%
132	Scrub Typhus	8.5%
133	Tetanus	8.5%
134	Psoas Abscess	8.5%
135	Serratia Infections	8.5%
136	Ureaplasma Infections	8.5%
137	Abdominal Abscess	8.5%
138	Pulmonary Nocardiosis	8.5%
139	carbuncle	8.4%
140	Aspergillosis, Allergic Bronchopulmonary	8.4%
141	Cellulitis	8.2%
142	Furunculosis	7.7%
143	furuncle	7.7%
144	Opportunistic Infections	7.7%
145	Diphtheria	7.6%
146	Leprosy	7.6%
147	Mycobacterium Infections, Nontuberculous	7.6%
148	Psittacosis	7.6%
149	Paratyphoid Fever	7.6%
150	Plague	7.6%
151	Syphilis, Congenital	7.6%
152	Tuberculosis	7.6%
153	Typhoid Fever	7.6%
154	TYPHUS	7.6%
155	Yersinia pseudotuberculosis Infections	7.6%
156	Bubonic Plague	7.6%
157	Mycobacterium abscessus Infection	7.6%
158	Lymphogranuloma Venereum	7.6%
159	Hordeolum	7.5%
160	Bacterial conjunctivitis	7.4%
161	Erysipelothrix infection	7.3%
162	Mycobacterium avium-intracellulare Infection	7.1%
163	Lymph Node Tuberculosis	7.1%
164	Tuberculosis, Miliary	7.1%
165	Tuberculosis, Multidrug-Resistant	7.1%
166	Leprosy, Multibacillary	7.1%
167	Latent Tuberculosis	7.1%
168	Urinary tract infection	7%
169	Endophthalmitis	7%
170	Peritonitis	7%
171	Pneumonia, Bacterial	6.9%
172	Borderline leprosy	6.9%
173	Leprosy, Lepromatous	6.9%
174	Tuberculoid leprosy	6.9%
175	Extensively Drug-Resistant Tuberculosis	6.9%
176	Osteomyelitis	6.8%
177	Periostitis	6.8%
178	Surgical Wound Infection	6.8%
179	Abscess	6.7%
180	Adnexitis	6.7%
181	Empyema	6.7%
182	Pelvic Inflammatory Disease	6.7%
183	Ophthalmia Neonatorum	6.6%
184	Trachoma	6.6%
185	Rhinoscleroma	6.6%
186	Meningitis, Listeria	6.6%
187	Meningitis, Haemophilus	6.2%
188	Meningitis, Pneumococcal	6.2%
189	Tuberculosis, Spinal	6%
190	Sexually Transmitted Diseases	5.8%
191	Erythema Induratum	5.6%
192	Diverticulitis	5.6%
193	Salmonella Infections, Animal	5.4%
194	Superinfection	5.3%
195	Corneal Ulcer	5.2%
196	Liver Abscess	5.1%
197	Rheumatic Heart Disease	5.1%
198	Puerperal Infection	5.1%
199	Spondylitis	5.1%
200	Appendicitis	5%
201	Bacteriuria	5%
202	Pyuria	5%
203	Meningitis, Bacterial	5%
204	Pyomyositis	5%
205	Salmonella food poisoning	5%
206	Endotoxic shock	5%
207	Septic Shock	5%
208	Toxic Shock Syndrome	5%
209	Tuberculosis, Meningeal	4.9%
210	Tuberculosis, Gastrointestinal	4.8%
211	Tuberculosis, Central Nervous System	4.7%
212	Lung Abscess	4.3%
213	Toxoplasmosis, Cerebral	4.3%
214	Rheumatic Fever	4.3%
215	Diverticulum	4.2%
216	Diverticulosis	4.2%
217	Discitis	4.1%
218	Enterocolitis, Pseudomembranous	4.1%
219	Mastoiditis	4.1%
220	Petrositis	4.1%
221	pseudomembranous colitis	4.1%
222	Dysentery, Bacillary	4.1%
223	Arthritis, Reactive	3.9%
224	Tuberculosis, Pulmonary	3.7%
225	AIDS-Related Opportunistic Infections	3.4%
226	Botulism	3.4%
227	Retropharyngeal Abscess	3.4%
228	Epidural Abscess	3.3%
229	Peritonsillar Abscess	3.3%
230	Waterhouse-Friderichsen Syndrome	2.8%
231	Liver Abscess, Amebic	2.4%
232	Tuberculosis, Renal	2.3%
233	Lemierre Syndrome	2.1%

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