MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Soft Tissue Infection

(UMLS:C0149778)

Definition:: Infections of non-skeletal tissue, i.e., exclusive of bone, ligaments, cartilage, and fibrous tissue. The concept is usually referred to as skin and soft tissue infections and usually subcutaneous and muscle tissue are involved. The predisposing factors in anaerobic infections are trauma, ischemia, and surgery. The organisms often derive from the fecal or oral flora, particularly in wounds associated with intestinal surgery, decubitus ulcer, and human bites. (From Cecil Textbook of Medicine, 19th ed, p1688)
UMLS ID:: C0149778
MeSH ID:: D018461

Classification:

Name:

Bacterial Infections and Mycoses
MeSH Tree Number(s):: C01.539.820

Synonym(s)

Soft Tissue Infection

SOFT TISSUE INFECTION

Soft tissue infection

Soft tissue infection, NOS

infection soft tissue

infections soft tissue

infections soft tissues

soft tissue infection

soft tissue infections

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Zoledronic Acid	FAERS: 53	OFFSIDES US FAERS
2	Diclofenac	FAERS: 40	US FAERS
3	Pamidronate	FAERS: 13	US FAERS
4	Alendronate	FAERS: 11	US FAERS
5	Arthrotec	FAERS: 6	US FAERS
6	Insulin Glargine	FAERS: 6	US FAERS
7	paricalcitol	FAERS: 6	US FAERS
8	Canagliflozin	FAERS: 5	US FAERS
9	Azacitidine	FAERS: 4	OFFSIDES US FAERS
10	Teriparatide	FAERS: 4	US FAERS
11	tofacitinib	FAERS: 4	US FAERS
12	Docetaxel	FAERS: 3	OFFSIDES US FAERS
13	Methylprednisolone Acetate	FAERS: 3	US FAERS
14	Temozolomide	FAERS: 3	OFFSIDES US FAERS
15	Terbinafine	FAERS: 3	US FAERS
16	4-hydroxybutyric acid	FAERS: 2	US FAERS
17	4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide	FAERS: 2	US FAERS
18	Baclofen	FAERS: 2	US FAERS
19	Crizotinib	FAERS: 2	US FAERS
20	Erlotinib Hydrochloride	FAERS: 2	US FAERS
21	Nicotine	FAERS: 2	US FAERS
22	Ondansetron	FAERS: 2	US FAERS
23	Oxycodone and acetaminophen	FAERS: 2	US FAERS
24	Ruxolitinib phosphate	FAERS: 2	US FAERS
25	Tacrolimus	FAERS: 2	US FAERS
26	Thalidomide	FAERS: 2	OFFSIDES US FAERS
27	Triamcinolone Acetonide	FAERS: 2	US FAERS
28	dexamethasone 21-phosphate	FAERS: 2	US FAERS
29	Abiraterone Acetate	FAERS: 1	US FAERS
30	Adenosine	FAERS: 1	US FAERS
31	Anastrozole	FAERS: 1	US FAERS
32	Bortezomib	FAERS: 1	US FAERS
33	Bosentan	FAERS: 1	US FAERS
34	Bupivacaine	FAERS: 1	US FAERS
35	Cefazolin	FAERS: 1	US FAERS
36	Chlorambucil	FAERS: 1	US FAERS
37	Ciprofloxacin	FAERS: 1	OFFSIDES US FAERS
38	Cyclosporine	FAERS: 1	US FAERS
39	Deferasirox	FAERS: 1	US FAERS
40	Deferiprone	FAERS: 1	US FAERS
41	Dimethyl Fumarate	FAERS: 1	US FAERS
42	Doxorubicin	FAERS: 1	OFFSIDES US FAERS
43	Everolimus	FAERS: 1	OFFSIDES US FAERS
44	Fingolimod Hydrochloride	FAERS: 1	US FAERS
45	Gefitinib	FAERS: 1	US FAERS
46	Ibandronic Acid	FAERS: 1	US FAERS
47	Interferon alpha-2	FAERS: 1	US FAERS
48	LCZ 696	FAERS: 1	US FAERS
49	Lenalidomide	FAERS: 1	US FAERS
50	Linezolid	FAERS: 1	US FAERS
51	Methylphenidate	FAERS: 1	US FAERS
52	Morphine	FAERS: 1	US FAERS
53	N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine	FAERS: 1	US FAERS
54	PCI 32765	FAERS: 1 Canada Vigilance: 1	Canada Vigilance US FAERS
55	Pamidronate	FAERS: 1	OFFSIDES US FAERS
56	Rivaroxaban	FAERS: 1	OFFSIDES US FAERS
57	Rosuvastatin Calcium	FAERS: 1	US FAERS
58	Sirolimus	FAERS: 1	OFFSIDES US FAERS
59	Tadenan	FAERS: 1	US FAERS
60	Vitamin B 12	FAERS: 1	US FAERS
61	apremilast	FAERS: 1	US FAERS
62	ecallantide	FAERS: 1	US FAERS
63	empagliflozin	FAERS: 1	US FAERS
64	etonogestrel	FAERS: 1	US FAERS
65	gemcitabine	FAERS: 1	US FAERS
66	insulin glulisine	FAERS: 1	US FAERS
67	liposomal amphotericin B	FAERS: 1	US FAERS
68	macitentan	FAERS: 1	US FAERS
69	reviparin	FAERS: 1	US FAERS
70	romidepsin	FAERS: 1	US FAERS
71	torezolid phosphate	FAERS: 1	US FAERS
72	venetoclax	FAERS: 1	US FAERS
73	Acetaminophen		OFFSIDES
74	Acyclovir		OFFSIDES
75	Ascorbic Acid		OFFSIDES
76	Aztreonam		OFFSIDES
77	Calcium Compounds		OFFSIDES
78	Capecitabine		OFFSIDES
79	Ceftazidime		OFFSIDES
80	Celecoxib		SIDER
81	Chlorpropamide		OFFSIDES
82	Cinacalcet		OFFSIDES
83	Clindamycin		OFFSIDES
84	Clotrimazole		OFFSIDES
85	Cyclophosphamide		OFFSIDES
86	Diazepam		OFFSIDES
87	Digitoxin		OFFSIDES
88	Dioctyl Sulfosuccinic Acid		OFFSIDES
89	Doxycycline		OFFSIDES
90	Finasteride		OFFSIDES
91	Fludrocortisone		OFFSIDES
92	Gabapentin		OFFSIDES
93	Ganciclovir		OFFSIDES
94	Goserelin		OFFSIDES
95	Hydrochlorothiazide		OFFSIDES
96	Letrozole		OFFSIDES
97	Melphalan		OFFSIDES
98	Metaproterenol		OFFSIDES
99	Methylprednisolone Hemisuccinate		OFFSIDES
100	Mitomycin		OFFSIDES
101	Mitoxantrone		OFFSIDES
102	Naproxen		OFFSIDES
103	Nitrendipine		OFFSIDES
104	Norethindrone Acetate		OFFSIDES
105	Paclitaxel		OFFSIDES
106	Penicillin V		OFFSIDES
107	Phenobarbital		OFFSIDES
108	Phenprocoumon		OFFSIDES
109	Pyridostigmine Bromide		OFFSIDES
110	Pyridoxal Phosphate		OFFSIDES
111	Rilmenidine		OFFSIDES
112	Salicylic Acid	Canada Vigilance: 1	Canada Vigilance
113	Sevelamer		OFFSIDES
114	Sorafenib		OFFSIDES
115	Sulfate		OFFSIDES
116	Tamoxifen		OFFSIDES
117	Tazobactam		OFFSIDES
118	Terazosin		OFFSIDES
119	Tetracycline		OFFSIDES
120	Thiamine		OFFSIDES
121	Tramadol		OFFSIDES
122	Triiodothyronine		OFFSIDES
123	Triprolidine		OFFSIDES
124	Vincristine		OFFSIDES
125	Vinorelbine		OFFSIDES
126	Vorinostat		OFFSIDES
127	binedaline		OFFSIDES
128	calcium acetate		OFFSIDES
129	chlorhexidine gluconate		OFFSIDES
130	exemestane		OFFSIDES
131	nimesulide		OFFSIDES
132	valdecoxib		SIDER

Similar ADE(s)

	Name	Semantic Similarity
1	Pelvic Infection	42.9%
2	Wound Infection	42.9%
3	Community-Acquired Infections	42.9%
4	Eye Infection	30%
5	Respiratory Tract Infections	30%
6	Bone Diseases, Infectious	28.6%
7	Pregnancy Complications, Infectious	28.6%
8	Skin Diseases, Infectious	28.6%
9	Arthritis, Infectious	27.9%
10	Suppuration	27.9%
11	Cross Infection	27.6%
12	Septicemia	27.6%
13	Sepsis	27.6%
14	Endotoxemia	27.3%
15	Psoas Abscess	25.4%
16	Abdominal Abscess	25.4%
17	Cellulitis	24.5%
18	Ulcerative stomatitis	23.9%
19	Bacterial Infections	23.1%
20	Mycoses	23.1%
21	Opportunistic Infections	23.1%
22	Dermatomycoses	22.4%
23	Skin Diseases, Bacterial	22.4%
24	Bacteremia	22.1%
25	Hidradenitis Suppurativa	21.5%
26	Urinary tract infection	21.1%
27	Endophthalmitis	20.9%
28	Peritonitis	20.9%
29	Osteomyelitis	20.5%
30	Periostitis	20.5%
31	Surgical Wound Infection	20.5%
32	Abscess	20.2%
33	Adnexitis	20.2%
34	Empyema	20.2%
35	Pelvic Inflammatory Disease	20.2%
36	Fungemia	20.1%
37	Pertussis	19.7%
38	Mycetoma	19.1%
39	Joint Tuberculosis	18.6%
40	Tuberculosis, Osteoarticular	18.6%
41	Bone Tuberculosis	18.6%
42	Bacterial Endocarditis	18.1%
43	Candidiasis, Chronic Mucocutaneous	18%
44	Cutaneous Candidiasis	18%
45	Chromoblastomycosis	17.5%
46	Dermatophytosis	17.5%
47	Sporotrichosis	17.5%
48	Tinea	17.5%
49	Tinea Versicolor	17.5%
50	Trichophytosis	17.5%
51	Hyalohyphomycosis	17.5%
52	Sexually Transmitted Diseases	17.4%
53	Erysipelas	17.2%
54	Staphylococcal Skin Infections	17.2%
55	Erythrasma	16.8%
56	Diverticulitis	16.7%
57	Candidemia	16.3%
58	Superinfection	15.8%
59	Brain Abscess	15.6%
60	Corneal Ulcer	15.5%
61	Liver Abscess	15.4%
62	Puerperal Infection	15.3%
63	Spondylitis	15.3%
64	Impetigo	15.2%
65	Fusariosis	15.2%
66	Appendicitis	15.1%
67	Bacteriuria	15.1%
68	Pyuria	15.1%
69	Pyomyositis	15.1%
70	Panophthalmitis	15%
71	Central Nervous System Infection	15%
72	Staphylococcal Scalded Skin Syndrome	15%
73	Endotoxic shock	14.9%
74	Septic Shock	14.9%
75	Toxic Shock Syndrome	14.9%
76	Syphilis	14.5%
77	Ecthyma	14.4%
78	Subacute Bacterial Endocarditis	14.4%
79	Aspergillosis	14.3%
80	Candidiasis	14.3%
81	Coccidioidomycosis	14.3%
82	Histoplasmosis	14.3%
83	Hordeolum	14.3%
84	Paracoccidioidomycosis	14.3%
85	Zygomycosis	14.3%
86	Gram-Negative Bacterial Infections	14.3%
87	Gram-Positive Bacterial Infections	14.3%
88	Phaeohyphomycosis	14.3%
89	Pneumocystis Infections	14.3%
90	Chlamydia Infections	14.2%
91	Gonorrhea	14.2%
92	Erythema Chronicum Migrans	14.1%
93	Bacterial conjunctivitis	14.1%
94	Central Nervous System Bacterial Infections	14%
95	carbuncle	13.9%
96	Borrelia Infections	13.6%
97	Leptospirosis	13.6%
98	Lung Abscess	13%
99	Blastomycosis	12.9%
100	Diverticulum	12.7%
101	Diverticulosis	12.7%
102	Furunculosis	12.7%
103	furuncle	12.7%
104	Tuberculosis, Spinal	12.5%
105	Lymphogranuloma Venereum	12.4%
106	Discitis	12.4%
107	Lyme Disease	12.4%
108	Mastoiditis	12.4%
109	Relapsing Fever	12.4%
110	Petrositis	12.4%
111	Tinea Capitis	12.2%
112	Onychomycosis	12.2%
113	Arthritis, Reactive	11.8%
114	Human Ehrlichiosis	11.1%
115	Ophthalmia Neonatorum	10.8%
116	Trachoma	10.8%
117	Rhinoscleroma	10.8%
118	Lyme Neuroborreliosis	10.6%
119	Japanese Spotted Fever	10.5%
120	Actinomycetales Infections	10.3%
121	Bordetella Infections	10.3%
122	Brucellosis	10.3%
123	Campylobacter infection	10.3%
124	Clostridium Infections	10.3%
125	Enterobacteriaceae Infections	10.3%
126	Listeriosis	10.3%
127	Mucormycosis	10.3%
128	Pseudomonas Infections	10.3%
129	Q Fever	10.3%
130	Staphylococcal Infections	10.3%
131	Streptococcal Infections	10.3%
132	Vibrio Infections	10.3%
133	Helicobacter Infections	10.3%
134	Bacillaceae Infections	10.3%
135	Neisseriaceae Infections	10.3%
136	Burkholderia Infections	10.3%
137	Clostridium difficile infection	10.3%
138	Flavobacteriaceae Infections	10.3%
139	Moraxellaceae Infections	10.3%
140	Burkholderia cepacia Infection	10.3%
141	AIDS-Related Opportunistic Infections	10.3%
142	Neuroaspergillosis	10.1%
143	Retropharyngeal Abscess	10.1%
144	Tinea Pedis	10.1%
145	Epidural Abscess	10%
146	Neurosyphilis	9.9%
147	Peritonsillar Abscess	9.9%
148	Rocky Mountain Spotted Fever	9.6%
149	Otomycosis	9.5%
150	Piedra	9.3%
151	Central Nervous System Fungal Infections	9.3%
152	Erythema Induratum	9.3%
153	Invasive Pulmonary Aspergillosis	9.2%
154	Bacterial Vaginosis	9.1%
155	Human anaplasmosis	8.8%
156	Acinetobacter Infections	8.5%
157	Actinomycosis	8.5%
158	Bacteroides Infections	8.5%
159	Cholera	8.5%
160	Corynebacterium Infections	8.5%
161	Escherichia coli Infections	8.5%
162	Gas Gangrene	8.5%
163	Haemophilus Infections	8.5%
164	Klebsiella Infections	8.5%
165	Meningococcal Infections	8.5%
166	Mycobacterium Infections	8.5%
167	Mycoplasma Infections	8.5%
168	Nocardia Infections	8.5%
169	Pasteurella Infections	8.5%
170	Pneumococcal Infections	8.5%
171	Proteus Infections	8.5%
172	Rickettsia Infections	8.5%
173	Salmonella infections	8.5%
174	Scarlet Fever	8.5%
175	Scrub Typhus	8.5%
176	Tetanus	8.5%
177	Serratia Infections	8.5%
178	Ureaplasma Infections	8.5%
179	Pulmonary Nocardiosis	8.5%
180	Toxoplasmosis, Cerebral	8%
181	Diphtheria	7.6%
182	Leprosy	7.6%
183	Mycobacterium Infections, Nontuberculous	7.6%
184	Psittacosis	7.6%
185	Paratyphoid Fever	7.6%
186	Plague	7.6%
187	Syphilis, Congenital	7.6%
188	Tuberculosis	7.6%
189	Typhoid Fever	7.6%
190	TYPHUS	7.6%
191	Yersinia pseudotuberculosis Infections	7.6%
192	Bubonic Plague	7.6%
193	Mycobacterium abscessus Infection	7.6%
194	Erysipelothrix infection	7.3%
195	Meningitis, Cryptococcal	7.3%
196	Liver Abscess, Amebic	7.2%
197	Lung Diseases, Fungal	7.1%
198	Mycobacterium avium-intracellulare Infection	7.1%
199	Lymph Node Tuberculosis	7.1%
200	Tuberculosis, Miliary	7.1%
201	Tuberculosis, Multidrug-Resistant	7.1%
202	Leprosy, Multibacillary	7.1%
203	Latent Tuberculosis	7.1%
204	Oral candidiasis	7%
205	Pneumonia, Bacterial	6.9%
206	Borderline leprosy	6.9%
207	Leprosy, Lepromatous	6.9%
208	Tuberculoid leprosy	6.9%
209	Extensively Drug-Resistant Tuberculosis	6.9%
210	Pulmonary Aspergillosis	6.8%
211	Bronchopulmonary Aspergillosis	6.8%
212	Meningitis, Listeria	6.6%
213	Meningitis, Haemophilus	6.2%
214	Meningitis, Pneumococcal	6.2%
215	Salmonella Infections, Animal	5.4%
216	Rheumatic Heart Disease	5.1%
217	Meningitis, Bacterial	5%
218	Meningitis, Fungal	5%
219	Salmonella food poisoning	5%
220	Candidiasis, Vulvovaginal	4.9%
221	Tuberculosis, Meningeal	4.9%
222	Tuberculosis, Gastrointestinal	4.8%
223	Tuberculosis, Central Nervous System	4.7%
224	Rheumatic Fever	4.3%
225	Enterocolitis, Pseudomembranous	4.1%
226	pseudomembranous colitis	4.1%
227	Dysentery, Bacillary	4.1%
228	Tuberculosis, Pulmonary	3.7%
229	Botulism	3.4%
230	Waterhouse-Friderichsen Syndrome	2.8%
231	Aspergillosis, Allergic Bronchopulmonary	2.8%
232	Tuberculosis, Renal	2.3%
233	Lemierre Syndrome	2.1%

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