MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Tuberculosis, Multidrug-Resistant

(UMLS:C0206526)

Definition:: Tuberculosis resistant to chemotherapy with two or more ANTITUBERCULAR AGENTS, including at least ISONIAZID and RIFAMPICIN. The problem of resistance is particularly troublesome in tuberculous OPPORTUNISTIC INFECTIONS associated with HIV INFECTIONS. It requires the use of second line drugs which are more toxic than the first line regimens. TB with isolates that have developed further resistance to at least three of the six classes of second line drugs is defined as EXTENSIVELY DRUG-RESISTANT TUBERCULOSIS.
UMLS ID:: C0206526
MeSH ID:: D018088

Classification:

Name:

Bacterial Infections and Mycoses
MeSH Tree Number(s):: C01.252.410.040.552.846.775

Synonym(s)

Tuberculosis, Multidrug-Resistant

MDR TB

MDR-TB

Multidrug resistant tuberculosis

Multidrug-Resistant TB

Multidrug-Resistant Tuberculosis

Multidrug-resistant tuberculosis

TUBERCULOSIS MULTI DRUG RESISTANT

mdr tuberculosis

10.

multi drug resistant tuberculosis

11.

multi-drug resistant tuberculosis

12.

multi-drug-resistant tuberculosis

13.

multidrug resistant tuberculosis

14.

multidrug-resistant tuberculosis

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Aminosalicylic Acid	18283911	CTD
2	Cycloserine	8399888 15182146 18283911	CTD
3	Ethambutol	1096388 16178466	CTD
4	Ethionamide	18283911	CTD
5	Gatifloxacin	18283911	CTD
6	Isoniazid	16178466 23764483	CTD
7	Kanamycin	18283911	CTD
8	Ofloxacin	8399888 16178466	CTD
9	Pyrazinamide	18283911	CTD
10	Rifampin	1096388 23764483	CTD
11	Tolcapone	19578428	CTD
12	bedaquiline	29258954	CTD
13	entacapone	19578428	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Lymph Node Tuberculosis	49.6%
2	Tuberculosis, Miliary	49.6%
3	Latent Tuberculosis	49.6%
4	Leprosy	36.8%
5	Mycobacterium Infections, Nontuberculous	36.8%
6	Mycobacterium abscessus Infection	36.8%
7	Tuberculosis, Gastrointestinal	34.4%
8	Tuberculosis, Central Nervous System	33.3%
9	Actinomycosis	29.9%
10	Corynebacterium Infections	29.9%
11	Nocardia Infections	29.9%
12	Pulmonary Nocardiosis	29.9%
13	Joint Tuberculosis	27.3%
14	Tuberculosis, Osteoarticular	27.3%
15	Bone Tuberculosis	27.3%
16	Tuberculosis, Pulmonary	26.4%
17	Clostridium Infections	25.5%
18	Listeriosis	25.5%
19	Staphylococcal Infections	25.5%
20	Streptococcal Infections	25.5%
21	Bacillaceae Infections	25.5%
22	Clostridium difficile infection	25.5%
23	Mycobacterium avium-intracellulare Infection	24.4%
24	Leprosy, Multibacillary	24.4%
25	Gram-Negative Bacterial Infections	21.3%
26	Erysipelothrix infection	18.4%
27	Borderline leprosy	18.3%
28	Leprosy, Lepromatous	18.3%
29	Tuberculoid leprosy	18.3%
30	Diphtheria	17.8%
31	Tuberculosis, Spinal	15.9%
32	Mycoses	14.8%
33	Infection	14.8%
34	Borrelia Infections	14.7%
35	Leptospirosis	14.7%
36	Tuberculosis, Meningeal	14.5%
37	Central Nervous System Bacterial Infections	14.4%
38	Bacterial Vaginosis	14%
39	Gas Gangrene	13.9%
40	Pneumococcal Infections	13.9%
41	Scarlet Fever	13.9%
42	Tetanus	13.9%
43	Tuberculosis, Renal	12.9%
44	Skin Diseases, Bacterial	12.5%
45	Erythrasma	12.4%
46	Bacteremia	12.4%
47	Erythema Induratum	11.4%
48	Bordetella Infections	10.9%
49	Brucellosis	10.9%
50	Campylobacter infection	10.9%
51	Enterobacteriaceae Infections	10.9%
52	Pseudomonas Infections	10.9%
53	Q Fever	10.9%
54	Vibrio Infections	10.9%
55	Helicobacter Infections	10.9%
56	Neisseriaceae Infections	10.9%
57	Burkholderia Infections	10.9%
58	Flavobacteriaceae Infections	10.9%
59	Moraxellaceae Infections	10.9%
60	Burkholderia cepacia Infection	10.9%
61	Erysipelas	10.8%
62	Staphylococcal Skin Infections	10.8%
63	Pneumonia, Bacterial	10.6%
64	Bacterial Endocarditis	10.2%
65	Central Nervous System Infection	9.9%
66	Impetigo	9.8%
67	Mycetoma	9.2%
68	Ecthyma	9.1%
69	Subacute Bacterial Endocarditis	9.1%
70	Lyme Disease	9%
71	Relapsing Fever	9%
72	Meningitis, Listeria	8%
73	Human Ehrlichiosis	8%
74	Rheumatic Fever	7.2%
75	Neurosyphilis	7.2%
76	Lyme Neuroborreliosis	7.2%
77	Syphilis	7.1%
78	Aspergillosis	7.1%
79	Candidiasis	7.1%
80	Coccidioidomycosis	7.1%
81	Histoplasmosis	7.1%
82	Paracoccidioidomycosis	7.1%
83	Pelvic Infection	7.1%
84	Wound Infection	7.1%
85	Zygomycosis	7.1%
86	Soft Tissue Infection	7.1%
87	Community-Acquired Infections	7.1%
88	Phaeohyphomycosis	7.1%
89	Pneumocystis Infections	7.1%
90	Enterocolitis, Pseudomembranous	7%
91	pseudomembranous colitis	7%
92	Human anaplasmosis	6.4%
93	Japanese Spotted Fever	6.4%
94	Chlamydia Infections	6.3%
95	Gonorrhea	6.3%
96	Staphylococcal Scalded Skin Syndrome	6.2%
97	Acinetobacter Infections	6%
98	Bacteroides Infections	6%
99	Cholera	6%
100	Escherichia coli Infections	6%
101	Haemophilus Infections	6%
102	Klebsiella Infections	6%
103	Meningococcal Infections	6%
104	Mycoplasma Infections	6%
105	Pasteurella Infections	6%
106	Proteus Infections	6%
107	Rickettsia Infections	6%
108	Salmonella infections	6%
109	Scrub Typhus	6%
110	Serratia Infections	6%
111	Ureaplasma Infections	6%
112	Erythema Chronicum Migrans	5.9%
113	Botulism	5.8%
114	Rheumatic Heart Disease	5.8%
115	Meningitis, Pneumococcal	5.7%
116	Hidradenitis Suppurativa	5.5%
117	Meningitis, Bacterial	5.5%
118	Dermatomycoses	5.4%
119	Hordeolum	5.3%
120	Ulcerative stomatitis	5.3%
121	Furunculosis	5.3%
122	furuncle	5.3%
123	Bacterial conjunctivitis	5.2%
124	Eye Infection	5.1%
125	Respiratory Tract Infections	5.1%
126	Pertussis	5%
127	Bone Diseases, Infectious	4.8%
128	Otomycosis	4.8%
129	Pregnancy Complications, Infectious	4.8%
130	Skin Diseases, Infectious	4.8%
131	Arthritis, Infectious	4.7%
132	Piedra	4.7%
133	Central Nervous System Fungal Infections	4.7%
134	Suppuration	4.7%
135	Cross Infection	4.7%
136	Septicemia	4.7%
137	Sepsis	4.7%
138	Rhinoscleroma	4.3%
139	Rocky Mountain Spotted Fever	3.9%
140	Opportunistic Infections	3.9%
141	carbuncle	3.9%
142	Meningitis, Haemophilus	3.8%
143	Candidiasis, Chronic Mucocutaneous	3.7%
144	Cutaneous Candidiasis	3.7%
145	Lung Diseases, Fungal	3.7%
146	Syphilis, Congenital	3.7%
147	Neuroaspergillosis	3.7%
148	Fungemia	3.7%
149	Brain Abscess	3.6%
150	Mucormycosis	3.6%
151	Urinary tract infection	3.6%
152	Lymphogranuloma Venereum	3.6%
153	Psittacosis	3.6%
154	Paratyphoid Fever	3.6%
155	Plague	3.6%
156	Typhoid Fever	3.6%
157	TYPHUS	3.6%
158	Yersinia pseudotuberculosis Infections	3.6%
159	Bubonic Plague	3.6%
160	Ophthalmia Neonatorum	3.1%
161	Trachoma	3.1%
162	Dysentery, Bacillary	3%
163	Sexually Transmitted Diseases	3%
164	Cellulitis	3%
165	Chromoblastomycosis	2.8%
166	Dermatophytosis	2.8%
167	Sporotrichosis	2.8%
168	Tinea	2.8%
169	Tinea Versicolor	2.8%
170	Trichophytosis	2.8%
171	Invasive Pulmonary Aspergillosis	2.8%
172	Hyalohyphomycosis	2.8%
173	Endotoxemia	2.8%
174	Blastomycosis	2.7%
175	Candidemia	2.7%
176	Panophthalmitis	2.6%
177	Salmonella Infections, Animal	2.6%
178	Oral candidiasis	2.5%
179	Endophthalmitis	2.5%
180	Peritonitis	2.5%
181	Osteomyelitis	2.5%
182	Periostitis	2.5%
183	Surgical Wound Infection	2.5%
184	Pulmonary Aspergillosis	2.5%
185	Bronchopulmonary Aspergillosis	2.5%
186	Abscess	2.4%
187	Adnexitis	2.4%
188	Empyema	2.4%
189	Pelvic Inflammatory Disease	2.4%
190	Salmonella food poisoning	2.4%
191	Meningitis, Cryptococcal	2.3%
192	Psoas Abscess	2%
193	Abdominal Abscess	2%
194	Superinfection	1.9%
195	Corneal Ulcer	1.9%
196	Puerperal Infection	1.8%
197	Spondylitis	1.8%
198	Appendicitis	1.8%
199	Bacteriuria	1.8%
200	Pyuria	1.8%
201	Meningitis, Fungal	1.8%
202	Pyomyositis	1.8%
203	Endotoxic shock	1.8%
204	Septic Shock	1.8%
205	Toxic Shock Syndrome	1.8%
206	Candidiasis, Vulvovaginal	1.8%
207	Fusariosis	1.6%
208	Arthritis, Reactive	1.4%
209	Diverticulitis	1.3%
210	Tinea Capitis	1.3%
211	Onychomycosis	1.3%
212	AIDS-Related Opportunistic Infections	1.3%
213	Toxoplasmosis, Cerebral	1.2%
214	Waterhouse-Friderichsen Syndrome	1.2%
215	Tinea Pedis	1.1%
216	Lung Abscess	1.1%
217	Lemierre Syndrome	1.1%
218	Diverticulum	1%
219	Diverticulosis	1%
220	Discitis	1%
221	Mastoiditis	1%
222	Petrositis	1%
223	Liver Abscess	0.8%
224	Retropharyngeal Abscess	0.8%
225	Epidural Abscess	0.8%
226	Peritonsillar Abscess	0.8%
227	Aspergillosis, Allergic Bronchopulmonary	0.7%
228	Liver Abscess, Amebic	0.3%

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