MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Tetanus

(UMLS:C0039614)

Definition:: A disease caused by tetanospasmin, a powerful protein toxin produced by CLOSTRIDIUM TETANI. Tetanus usually occurs after an acute injury, such as a puncture wound or laceration. Generalized tetanus, the most common form, is characterized by tetanic muscular contractions and hyperreflexia. Localized tetanus presents itself as a mild condition with manifestations restricted to muscles near the wound. It may progress to the generalized form.
UMLS ID:: C0039614
MeSH ID:: D013742

Classification:

Name:

Bacterial Infections and Mycoses
MeSH Tree Number(s):: C01.252.410.222.864

Synonym(s)

Tetanus

Infection caused by Clostridium tetani

Infection due to Clostridium tetani

TETANUS

clostridial tetanus

tetanus

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Vancomycin	FAERS: 4		US FAERS
2	Vancomycin	FAERS: 3		US FAERS
3	Deferasirox	FAERS: 2		OFFSIDES US FAERS
4	Imatinib Mesylate	FAERS: 2		US FAERS
5	Anastrozole	FAERS: 1		US FAERS
6	Atorvastatin	FAERS: 1		US FAERS
7	Buprenorphine	FAERS: 1		OFFSIDES US FAERS
8	Dasatinib	FAERS: 1		US FAERS
9	Digoxin	FAERS: 1		US FAERS
10	Dimethyl Fumarate	FAERS: 1		US FAERS
11	Oxytocin	FAERS: 1		OFFSIDES US FAERS
12	Zoledronic Acid	FAERS: 1		US FAERS
13	macitentan	FAERS: 1		US FAERS
14	Baclofen		9310810	CTD
15	Diazepam		View details 1006786 1204539 4182518 4257689 4705881 5518034	CTD
16	Fluphenazine	Canada Vigilance: 1		Canada Vigilance
17	Labetalol		6151891	CTD
18	Magnesium Sulfate		9709153	CTD
19	Metoclopramide			SIDER
20	Midazolam		2903605	CTD
21	Pancuronium		4257689	CTD
22	Paroxetine	Canada Vigilance: 1		Canada Vigilance
23	Prochlorperazine			SIDER
24	Propofol		2903605	CTD
25	Vecuronium Bromide		2903605	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Gas Gangrene	48.4%
2	Actinomycetales Infections	34.4%
3	Listeriosis	34.4%
4	Staphylococcal Infections	34.4%
5	Streptococcal Infections	34.4%
6	Bacillaceae Infections	34.4%
7	Gram-Negative Bacterial Infections	25.4%
8	Erysipelothrix infection	24.7%
9	Enterocolitis, Pseudomembranous	24.2%
10	pseudomembranous colitis	24.2%
11	Actinomycosis	22.6%
12	Corynebacterium Infections	22.6%
13	Mycobacterium Infections	22.6%
14	Nocardia Infections	22.6%
15	Pneumococcal Infections	22.6%
16	Scarlet Fever	22.6%
17	Pulmonary Nocardiosis	22.6%
18	Botulism	20%
19	Borrelia Infections	19.8%
20	Leptospirosis	19.8%
21	Central Nervous System Bacterial Infections	17.1%
22	Impetigo	17.1%
23	Diphtheria	16.8%
24	Leprosy	16.8%
25	Mycobacterium Infections, Nontuberculous	16.8%
26	Tuberculosis	16.8%
27	Mycobacterium abscessus Infection	16.8%
28	Bacterial Vaginosis	16.6%
29	Mycoses	16.4%
30	Infection	16.4%
31	Erysipelas	16.2%
32	Staphylococcal Skin Infections	16.2%
33	Skin Diseases, Bacterial	15.1%
34	Bacteremia	14.9%
35	Bordetella Infections	14.8%
36	Brucellosis	14.8%
37	Campylobacter infection	14.8%
38	Enterobacteriaceae Infections	14.8%
39	Pseudomonas Infections	14.8%
40	Q Fever	14.8%
41	Vibrio Infections	14.8%
42	Helicobacter Infections	14.8%
43	Neisseriaceae Infections	14.8%
44	Burkholderia Infections	14.8%
45	Flavobacteriaceae Infections	14.8%
46	Moraxellaceae Infections	14.8%
47	Burkholderia cepacia Infection	14.8%
48	Lyme Disease	14.5%
49	Relapsing Fever	14.5%
50	Mycobacterium avium-intracellulare Infection	13.9%
51	Lymph Node Tuberculosis	13.9%
52	Tuberculosis, Miliary	13.9%
53	Tuberculosis, Multidrug-Resistant	13.9%
54	Leprosy, Multibacillary	13.9%
55	Latent Tuberculosis	13.9%
56	Erythrasma	13.9%
57	Ecthyma	13.6%
58	Subacute Bacterial Endocarditis	13.6%
59	Human Ehrlichiosis	12.9%
60	Meningitis, Listeria	12.9%
61	Pneumonia, Bacterial	12.6%
62	Borderline leprosy	12.5%
63	Leprosy, Lepromatous	12.5%
64	Tuberculoid leprosy	12.5%
65	Extensively Drug-Resistant Tuberculosis	12.5%
66	Bacterial Endocarditis	12.2%
67	Lyme Neuroborreliosis	12.1%
68	Rheumatic Fever	11.7%
69	Neurosyphilis	11.6%
70	Rheumatic Heart Disease	11.6%
71	Staphylococcal Scalded Skin Syndrome	11.5%
72	Japanese Spotted Fever	11.2%
73	Central Nervous System Infection	10.8%
74	Mycetoma	10.8%
75	Syphilis	10.6%
76	Meningitis, Pneumococcal	10.6%
77	Human anaplasmosis	10.3%
78	Erythema Chronicum Migrans	9.9%
79	Furunculosis	9.8%
80	furuncle	9.8%
81	Acinetobacter Infections	9.7%
82	Bacteroides Infections	9.7%
83	Cholera	9.7%
84	Escherichia coli Infections	9.7%
85	Haemophilus Infections	9.7%
86	Klebsiella Infections	9.7%
87	Meningococcal Infections	9.7%
88	Mycoplasma Infections	9.7%
89	Pasteurella Infections	9.7%
90	Proteus Infections	9.7%
91	Rickettsia Infections	9.7%
92	Salmonella infections	9.7%
93	Scrub Typhus	9.7%
94	Serratia Infections	9.7%
95	Ureaplasma Infections	9.7%
96	Tuberculosis, Gastrointestinal	9.6%
97	Joint Tuberculosis	9.6%
98	Tuberculosis, Osteoarticular	9.6%
99	Bone Tuberculosis	9.6%
100	Tuberculosis, Central Nervous System	9.3%
101	carbuncle	9.2%
102	Chlamydia Infections	9.2%
103	Gonorrhea	9.2%
104	Rocky Mountain Spotted Fever	8.8%
105	Aspergillosis	8.5%
106	Candidiasis	8.5%
107	Coccidioidomycosis	8.5%
108	Histoplasmosis	8.5%
109	Paracoccidioidomycosis	8.5%
110	Pelvic Infection	8.5%
111	Wound Infection	8.5%
112	Zygomycosis	8.5%
113	Soft Tissue Infection	8.5%
114	Community-Acquired Infections	8.5%
115	Phaeohyphomycosis	8.5%
116	Pneumocystis Infections	8.5%
117	Ulcerative stomatitis	7.8%
118	Hidradenitis Suppurativa	7.6%
119	Pertussis	7.5%
120	Tuberculosis, Meningeal	7.4%
121	Syphilis, Congenital	7.4%
122	Meningitis, Bacterial	7.4%
123	Tuberculosis, Pulmonary	7.4%
124	Hordeolum	7.3%
125	Bacterial conjunctivitis	7.2%
126	Psittacosis	7.2%
127	Paratyphoid Fever	7.2%
128	Plague	7.2%
129	Typhoid Fever	7.2%
130	TYPHUS	7.2%
131	Yersinia pseudotuberculosis Infections	7.2%
132	Bubonic Plague	7.2%
133	Meningitis, Haemophilus	6.7%
134	Dermatomycoses	6.7%
135	Rhinoscleroma	6.5%
136	Lymphogranuloma Venereum	6.4%
137	Tuberculosis, Spinal	6.3%
138	Erythema Induratum	6.2%
139	Eye Infection	6%
140	Respiratory Tract Infections	6%
141	Bone Diseases, Infectious	5.7%
142	Otomycosis	5.7%
143	Pregnancy Complications, Infectious	5.7%
144	Skin Diseases, Infectious	5.7%
145	Arthritis, Infectious	5.6%
146	Piedra	5.6%
147	Central Nervous System Fungal Infections	5.6%
148	Suppuration	5.6%
149	Ophthalmia Neonatorum	5.6%
150	Trachoma	5.6%
151	Cross Infection	5.6%
152	Septicemia	5.6%
153	Sepsis	5.6%
154	Candidiasis, Chronic Mucocutaneous	5.2%
155	Cutaneous Candidiasis	5.2%
156	Salmonella Infections, Animal	5.2%
157	Mucormycosis	4.9%
158	Neuroaspergillosis	4.9%
159	Fungemia	4.9%
160	Salmonella food poisoning	4.9%
161	Dysentery, Bacillary	4.8%
162	Opportunistic Infections	4.7%
163	Brain Abscess	4.7%
164	Panophthalmitis	4.4%
165	Lung Diseases, Fungal	4.3%
166	Tuberculosis, Renal	4.3%
167	Candidemia	4.3%
168	Urinary tract infection	4.3%
169	Chromoblastomycosis	4.1%
170	Dermatophytosis	4.1%
171	Sporotrichosis	4.1%
172	Tinea	4.1%
173	Tinea Versicolor	4.1%
174	Trichophytosis	4.1%
175	Invasive Pulmonary Aspergillosis	4.1%
176	Hyalohyphomycosis	4.1%
177	Endotoxemia	4%
178	Cellulitis	4%
179	Blastomycosis	3.8%
180	Sexually Transmitted Diseases	3.5%
181	Oral candidiasis	3.4%
182	Endophthalmitis	3.4%
183	Peritonitis	3.4%
184	Osteomyelitis	3.3%
185	Periostitis	3.3%
186	Surgical Wound Infection	3.3%
187	Pulmonary Aspergillosis	3.3%
188	Bronchopulmonary Aspergillosis	3.3%
189	Abscess	3.3%
190	Adnexitis	3.3%
191	Empyema	3.3%
192	Pelvic Inflammatory Disease	3.3%
193	Meningitis, Cryptococcal	3.2%
194	Psoas Abscess	3.2%
195	Abdominal Abscess	3.2%
196	Fusariosis	2.8%
197	Waterhouse-Friderichsen Syndrome	2.7%
198	Superinfection	2.6%
199	Corneal Ulcer	2.5%
200	Puerperal Infection	2.5%
201	Spondylitis	2.5%
202	Appendicitis	2.5%
203	Bacteriuria	2.5%
204	Pyuria	2.5%
205	Meningitis, Fungal	2.5%
206	Pyomyositis	2.5%
207	Endotoxic shock	2.4%
208	Septic Shock	2.4%
209	Toxic Shock Syndrome	2.4%
210	Candidiasis, Vulvovaginal	2.4%
211	Tinea Capitis	2.3%
212	Onychomycosis	2.3%
213	Diverticulitis	2.2%
214	Lemierre Syndrome	2.1%
215	Arthritis, Reactive	1.9%
216	Tinea Pedis	1.9%
217	Toxoplasmosis, Cerebral	1.8%
218	Lung Abscess	1.7%
219	AIDS-Related Opportunistic Infections	1.7%
220	Liver Abscess	1.7%
221	Diverticulum	1.7%
222	Diverticulosis	1.7%
223	Discitis	1.6%
224	Mastoiditis	1.6%
225	Petrositis	1.6%
226	Retropharyngeal Abscess	1.3%
227	Epidural Abscess	1.3%
228	Peritonsillar Abscess	1.3%
229	Aspergillosis, Allergic Bronchopulmonary	1.1%
230	Liver Abscess, Amebic	0.7%

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