MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

trimethobenzamide

(FEZBIKUBAYAZIU-UHFFFAOYSA-N)

Structure

SMILES: COc1cc(cc(c1OC)OC)C(=O)NCc1ccc(cc1)OCCN(C)C
Type(s): Approved; Investigational
ATC code(s): R06AA10
Molecular Formula:: C21H28N2O5
Molecular Weight:: 388.457
Log P:: 2.9737
Hydrogen Bond Acceptor:: 7
Hydrogen Bond Donor:: 1
TPSA:: 69.26
CAS Number(s):: 138-56-7; 554-92-7

Synonym(s)

trimethobenzamide

T-Gen

Tebamide

Ticon

Tigan

trimethobenzamide monohydrochloride

External Link(s)

MeSH	C100146
PubChem Compound	5577
ChEBI	27796
CHEMBL	CHEMBL1201256
DrugBank	DB00662
DrugCentral	2754
IUPHAR/BPS Guide to PHARMACOLOGY	7614
KEGG	cpd:C07178 dr:D08643
Therapeutic Target Database	D0A8FB
ZINC	538509

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Injection site pain	FAERS: 1		US FAERS
2	Abasia			OFFSIDES
3	Abdominal Pain			OFFSIDES
4	Abdominal discomfort			OFFSIDES
5	Abdominal tenderness			OFFSIDES
6	Abscess			OFFSIDES
7	Abuse			OFFSIDES
8	Accidental overdose			OFFSIDES
9	Acute bronchitis			OFFSIDES
10	Acute respiratory failure			OFFSIDES
11	Amnesia			OFFSIDES
12	Anhidrosis			OFFSIDES
13	Anticonvulsant drug level decreased			OFFSIDES
14	Anxiety			OFFSIDES
15	Apathy			OFFSIDES
16	Arteriogram coronary abnormal			OFFSIDES
17	Arthropathy			OFFSIDES
18	Asthenia			OFFSIDES
19	Band neutrophil count increased			OFFSIDES
20	Barium enema abnormal			OFFSIDES
21	Blood Glucose			OFFSIDES
22	Blood cholesterol			OFFSIDES
23	Blood parathyroid hormone increased			OFFSIDES
24	Blood phosphorus increased			OFFSIDES
25	Blood potassium decreased			OFFSIDES
26	Blood pressure immeasurable			OFFSIDES
27	Blood triglycerides increased			OFFSIDES
28	Blurred vision			OFFSIDES
29	Cerebral disorder			OFFSIDES
30	Chest Pain			OFFSIDES
31	Chronic ulcerative colitis			OFFSIDES
32	Clostridium difficile colitis			OFFSIDES
33	Cluster Headache			OFFSIDES
34	Cold sweat			OFFSIDES
35	Colitis			OFFSIDES
36	Completed Suicide			OFFSIDES
37	Confabulation			OFFSIDES
38	Craniosynostosis			OFFSIDES
39	Crying			OFFSIDES
40	Dehydration			OFFSIDES
41	Dental abscess			OFFSIDES
42	Dependence			OFFSIDES
43	Device leakage			OFFSIDES
44	Diarrhea			OFFSIDES
45	Diplopia			OFFSIDES
46	Disease Progression			OFFSIDES
47	Disorientation			SIDER
48	Diverticulitis			OFFSIDES
49	Diverticulum			OFFSIDES
50	Dizziness			OFFSIDES SIDER
51	Drowsiness			OFFSIDES SIDER
52	Drug Tolerance			OFFSIDES
53	Drug abuser			OFFSIDES
54	Drug addict			OFFSIDES
55	Drug exposure during pregnancy			OFFSIDES
56	Drug ineffective			OFFSIDES
57	Drug withdrawal headache			OFFSIDES
58	Duodenal ulcer perforation			OFFSIDES
59	Dysthymic Disorder			OFFSIDES
60	Dysuria			OFFSIDES
61	Electrocardiogram ST segment abnormal			OFFSIDES
62	Euphoric mood			OFFSIDES
63	Fatigue			OFFSIDES
64	Feeling abnormal			OFFSIDES
65	Fibromyalgia			OFFSIDES
66	Flat affect			OFFSIDES
67	Formication			OFFSIDES
68	Gastroenteritis			OFFSIDES
69	Gastrointestinal perforation			OFFSIDES
70	Headache			SIDER
71	Hepatitis C			OFFSIDES
72	Hypersensitivity			SIDER
73	Hypotension			SIDER
74	Impaired driving ability			OFFSIDES
75	Incorrect route of drug administration			OFFSIDES
76	Infection			OFFSIDES
77	Injection site pruritus			OFFSIDES
78	Intention tremor			OFFSIDES
79	Intervertebral Disc Degeneration			OFFSIDES
80	Intervertebral disc disorder			OFFSIDES
81	Intestinal Obstruction			OFFSIDES
82	Keratitis sicca			OFFSIDES
83	Labile hypertension			OFFSIDES
84	Lethargy			OFFSIDES
85	Leukopenia neonatal			OFFSIDES
86	Limb injury			OFFSIDES
87	Lipase			OFFSIDES
88	Medical device complication			OFFSIDES
89	Multiple drug overdose			OFFSIDES
90	Nausea		8726538	CTD OFFSIDES
91	Nephrolithiasis			OFFSIDES
92	Nervous tension			OFFSIDES
93	Occult blood positive			OFFSIDES
94	Opisthotonus			SIDER
95	Pain			OFFSIDES
96	Pallor			OFFSIDES
97	Pancreatitis			OFFSIDES
98	Pericardial effusion			OFFSIDES
99	Pharmaceutical product complaint			OFFSIDES
100	Pharyngolaryngeal Pain			OFFSIDES
101	Prenatal Exposure Delayed Effects		4050288	CTD
102	Productive Cough			OFFSIDES
103	Prune Belly Syndrome		4050288	CTD
104	Psychiatric symptom			OFFSIDES
105	Pulmonary Hypertension			OFFSIDES
106	Renal Artery Stenosis			OFFSIDES
107	Renal cyst			OFFSIDES
108	Respiratory Failure			OFFSIDES
109	Sacroiliitis			OFFSIDES
110	Sinus bradycardia			OFFSIDES
111	Sinusitis			OFFSIDES
112	Somnolence			SIDER
113	Spinal column stenosis			OFFSIDES
114	Spinal cord infection			OFFSIDES
115	Spondylolisthesis			OFFSIDES
116	Stress			OFFSIDES
117	Synovial Cyst			OFFSIDES
118	Tardive Dyskinesia			OFFSIDES
119	Tension Headache			OFFSIDES
120	Thrombophlebitis			OFFSIDES
121	Troponin I increased			OFFSIDES
122	Troponin increased			OFFSIDES
123	Unevaluable event			OFFSIDES
124	Unresponsive to stimuli			OFFSIDES
125	Visual disturbance			OFFSIDES
126	Weight Gain			OFFSIDES
127	colonoscopy			OFFSIDES
128	jaundice			SIDER

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