MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Pentamidine

(XDRYMKDFEDOLFX-UHFFFAOYSA-N)

Structure

SMILES: NC(=N)c1ccc(cc1)OCCCCCOc1ccc(cc1)C(=N)N
Type(s): Approved; Investigational
ATC code(s): P01CX01
Molecular Formula:: C19H24N4O2
Molecular Weight:: 340.419
Log P:: 4.4829
Hydrogen Bond Acceptor:: 6
Hydrogen Bond Donor:: 4
TPSA:: 118.2
CAS Number(s):: 100-33-4

Synonym(s)

Pentamidine

Pentamidine Isethionate

Diamidine

Lomidine

NebuPent

Pentacarinat

Pentam

Pentamidin

Pentamidine Mesylate

External Link(s)

MeSH	D010419
PubChem Compound	4735
BindingDB	50015245 45440
ChEBI	45081
CHEMBL	CHEMBL55
DrugBank	DB00738
DrugCentral	2090
KEGG	cpd:C07420 dr:D08333
Therapeutic Target Database	D05EAM
ZINC	1530775

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Abdominal Pain	FAERS: 1		SIDER US FAERS
2	Alopecia	FAERS: 1		US FAERS
3	Anaphylactic shock	FAERS: 1		SIDER US FAERS
4	Blood potassium decreased	FAERS: 1		US FAERS
5	Cardiac Arrest	FAERS: 1		US FAERS
6	Constipation	FAERS: 1		SIDER US FAERS
7	Diabetes Mellitus	FAERS: 1	1859238	CTD SIDER US FAERS
8	Flushing	FAERS: 1		SIDER US FAERS
9	Headache	FAERS: 1		SIDER US FAERS
10	Hypophagia	FAERS: 1		US FAERS
11	Hypotension	FAERS: 1	View details 3260759 4026103 7481974 9026843 19652455 29128607	CTD SIDER US FAERS
12	Night sweats	FAERS: 1		SIDER US FAERS
13	Product use in unapproved indication	FAERS: 1		US FAERS
14	Tremor	FAERS: 1		SIDER US FAERS
15	Ventricular Fibrillation	FAERS: 1	1589716	CTD US FAERS
16	Vomiting	FAERS: 1	2566818 2865637 3490958	CTD SIDER US FAERS
17	AIDS-Related Opportunistic Infections		View details 1388884 2773964 3485027 3490958 4022063 7481974 10332545 11806628	CTD
18	Abdominal Cramps			SIDER
19	Abscess			SIDER
20	Acanthamoeba Keratitis		17225099	CTD
21	Acidosis			OFFSIDES
22	Acquired Immunodeficiency Syndrome		1972225	CTD
23	Acute kidney injury		View details 2334159 2566818 2773964 3878136	CTD
24	Acute otitis media			OFFSIDES
25	Ageusia			SIDER
26	Alanine Aminotransferase Increased			OFFSIDES
27	Amebiasis		17225099	CTD
28	Amnesia			SIDER
29	Anemia, Hemolytic		10332545	CTD
30	Anemia, Megaloblastic		11801480	CTD
31	Angioedema			OFFSIDES SIDER
32	Anorexia			OFFSIDES SIDER
33	Anosmia			SIDER
34	Antidepressant drug clearance decreased			OFFSIDES
35	Anxiety			SIDER
36	Arthralgia			SIDER
37	Ascites			OFFSIDES
38	Asthenia			OFFSIDES SIDER
39	Asthma			SIDER
40	Atrial tachycardia			OFFSIDES
41	Atrioventricular Block		7967903	CTD
42	Azotemia		View details 1424505 1519856 1859238 3259989 3487266 3490958	CTD
43	BK virus infection			OFFSIDES
44	Babesiosis		7194615	CTD
45	Bilirubin conjugated increased			OFFSIDES
46	Blast cells present			OFFSIDES
47	Blepharitis			OFFSIDES SIDER
48	Blood alkaline phosphatase increased			OFFSIDES
49	Blood cholesterol			OFFSIDES
50	Blood creatinine increased			SIDER
51	Blood lactate dehydrogenase increased			OFFSIDES
52	Blood triglycerides increased			OFFSIDES
53	Blood urea increased			OFFSIDES SIDER
54	Body odor			SIDER
55	Bone marrow depression			OFFSIDES
56	Bradycardia		9026843 9372331	CTD OFFSIDES SIDER
57	Bronchitis			SIDER
58	Bronchospasm			SIDER
59	CD4 Lymphocytes Decreased			OFFSIDES
60	Cardioactive drug level			OFFSIDES
61	Cardiotoxicity			OFFSIDES
62	Caustic injury			OFFSIDES
63	Cerebrovascular accident			SIDER
64	Cheilitis			OFFSIDES
65	Chemical and Drug Induced Liver Injury		3490958 7481974	CTD
66	Chest Pain			SIDER
67	Chest discomfort			SIDER
68	Chest tightness			SIDER
69	Chills			SIDER
70	Choking sensation			OFFSIDES
71	Cholangiolitis			OFFSIDES
72	Cholecystitis			OFFSIDES
73	Colitis			SIDER
74	Conjunctivitis			SIDER
75	Craniosynostosis			OFFSIDES
76	Creatinine increased			SIDER
77	Cyanosis			SIDER
78	Cytomegalovirus Retinitis			SIDER
79	Cytomegalovirus chorioretinitis			SIDER
80	Cytopenia			SIDER
81	Dehydration			OFFSIDES
82	Dermatitis			SIDER
83	Diabetes			OFFSIDES
84	Diarrhea		2566818	CTD OFFSIDES
85	Discomfort			SIDER
86	Disease Progression			OFFSIDES
87	Dizziness			SIDER
88	Drowsiness			SIDER
89	Dry skin			SIDER
90	Dysgeusia			SIDER
91	Dyspepsia			SIDER
92	Dystonia			OFFSIDES
93	Encephalitis		17225099	CTD
94	Eosinophilia			SIDER
95	Epstein-Barr virus antigen positive			OFFSIDES
96	Erythema Multiforme			SIDER
97	Erythema			SIDER
98	Escherichia infection			OFFSIDES
99	Exanthema		2566818	CTD
100	Extrapulmonary pneumocystosis			SIDER
101	Extravasation			SIDER
102	Eye pain			SIDER
103	Eyelid margin crusting			OFFSIDES
104	Factor VIII Deficiency			OFFSIDES
105	Fat redistribution			OFFSIDES
106	Fatigue			SIDER
107	Feeling abnormal			SIDER
108	Flank Pain			SIDER
109	Folliculitis			OFFSIDES
110	Gagging			SIDER
111	Gamma-Glutamyltransferase Increased			OFFSIDES
112	Gastric ulcer			OFFSIDES SIDER
113	Gastritis			SIDER
114	Gastrointestinal Pain			SIDER
115	Gastrointestinal mucosal disorder			OFFSIDES
116	Gingival Hyperplasia			OFFSIDES
117	Gingivectomy			OFFSIDES
118	Gingivitis			SIDER
119	Glucose Metabolism Disorders		7481974	CTD
120	Glycosuria		8442906	CTD
121	Gout			SIDER
122	HIV Infections		9315796	CTD
123	Heart Block		15927910	CTD
124	Hematuria		1388884 3487266 7779908	CTD
125	Hemoglobinuria		10332545	CTD
126	Hemorrhage		2566818	CTD
127	Hepatitis		3006295	CTD OFFSIDES SIDER
128	Hepatomegaly			SIDER
129	Hepatotoxicity			OFFSIDES
130	Herpes NOS			SIDER
131	Histoplasmosis			SIDER
132	Hydronephrosis			OFFSIDES
133	Hyperkalemia		1763529 2773964	CTD
134	Hypersensitivity			SIDER
135	Hyperventilation			SIDER
136	Hypesthesia		2032443 17164393	CTD
137	Hypocalcemia		2393042	CTD
138	Hypoglycemia		View details 1424505 1519856 2566818 3259989 3260759 3485027 3487333 3490958	CTD
139	Impetigo			OFFSIDES
140	Incontinence			SIDER
141	Induration			SIDER
142	Infection			SIDER
143	Influenza			SIDER
144	Ketoacidosis			SIDER
145	Kidney Diseases		View details 1217775 1589716 1763529 3260759 3485027 4022063 7481974 10332545	CTD
146	Kidney Failure			OFFSIDES
147	Laryngitis			SIDER
148	Laryngospasm			SIDER
149	Leg edema			SIDER
150	Leishmaniasis, Cutaneous		View details 8889330 10617787 11806628 12453009	CTD
151	Leishmaniasis, Visceral		View details 1659303 1859238 3006295 6868096 7498017 7715298 10467834 12803856 16131481	CTD
152	Leishmaniasis		15340016 21809846 29128607	CTD
153	Lethargy			SIDER
154	Leukopenia neonatal			OFFSIDES
155	Leukopenia		1519856 29128607	CTD SIDER
156	Lightheadedness			SIDER
157	Lip erosion			OFFSIDES
158	Lipase			OFFSIDES
159	Lipodystrophy acquired			OFFSIDES
160	Liver diseases		1519856	CTD
161	Liver transplant rejection			OFFSIDES
162	Local reaction			SIDER
163	Long QT Syndrome		View details 3263912 3499072 8306734 9026843 9372331 12380935 15711590 16278312 19652455 24052561	CTD
164	Lung Diseases, Interstitial		294951	CTD
165	Memory Loss			SIDER
166	Mental status changes			OFFSIDES
167	Mood swings			SIDER
168	Mouth Diseases		17164393	CTD
169	Muscle Weakness			OFFSIDES
170	Muscle necrosis			SIDER
171	Musculoskeletal discomfort			OFFSIDES SIDER
172	Myalgia			SIDER
173	Myocardial Stunning		7481974 8291847	CTD
174	Myoglobinuria		3878136	CTD
175	Nausea		2566818 3490958	CTD SIDER
176	Necrosis			SIDER
177	Nephritis		3006295	CTD SIDER
178	Nephrotic Syndrome		1859238	CTD
179	Nervousness			SIDER
180	Neuralgia			SIDER
181	Neuropathy			SIDER
182	Neutropenia		2967659	CTD SIDER
183	Ocular icterus			OFFSIDES
184	Oral candidiasis			SIDER
185	Pain		3490958 7194615	CTD SIDER
186	Palpitations			SIDER
187	Pancreatic Diseases		1217775 7481974 10332545	CTD
188	Pancreatitis		29128607	CTD OFFSIDES SIDER
189	Pancytopenia			SIDER
190	Paranoia			SIDER
191	Paresthesia of limbs			SIDER
192	Pharyngitis			SIDER
193	Phlebitis			SIDER
194	Pleurisy			SIDER
195	Pneumocystis Infections		2773964 29128607	CTD
196	Pneumocystis jiroveci pneumonia			OFFSIDES
197	Pneumothorax			SIDER
198	Portal Hypertension			OFFSIDES
199	Proteinuria		8442906	CTD
200	Pruritus			SIDER
201	Pulmonary congestion			SIDER
202	Quadriparesis			OFFSIDES
203	Rales			SIDER
204	Renal Insufficiency		2393042 2572780	CTD
205	Renal pain			SIDER
206	Respiratory Failure			OFFSIDES
207	Respiratory tract congestion			OFFSIDES SIDER
208	Retching			SIDER
209	Rhabdomyolysis			SIDER
210	Rhinitis			SIDER
211	Sciatic Neuropathy		2996869	CTD
212	Sepsis			SIDER
213	Shock			SIDER
214	Sinus operation			OFFSIDES
215	Sinusitis			OFFSIDES SIDER
216	Skin lesion			OFFSIDES
217	Somnolence			SIDER
218	Splenomegaly			SIDER
219	Stevens-Johnson Syndrome		25811541	CTD SIDER
220	Stomatitis			SIDER
221	Stress			OFFSIDES
222	Syncope		9042004	CTD SIDER
223	Synostosis			OFFSIDES
224	Tachycardia, Ventricular		3364459	CTD
225	Tachycardia			SIDER
226	Taste Disorders		7734721	CTD
227	Tension			SIDER
228	Thrombocytopenia			SIDER
229	Tonsillitis			SIDER
230	Tooth Loss			OFFSIDES
231	Torsades de Pointes		View details 1416342 1477438 2220597 2321077 2783374 3263912 3499072 7476792 7481974 8306734 8475949 9042004 9372331 12380935 16278312	CTD
232	Transaminases increased			OFFSIDES
233	Trypanosomiasis		15340016	CTD
234	Tuberculosis			SIDER
235	Urticaria			SIDER
236	Vasculitis			SIDER
237	Vertigo			SIDER
238	Vestibular Diseases		18408970	CTD
239	Wheezing			SIDER
240	Wound Debridement			OFFSIDES
241	bad taste			SIDER

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