MetaADEDB 2.0 @ LMMD
Febuxostat
(BQSJTQLCZDPROO-UHFFFAOYSA-N)
Structure
SMILES
N#Cc1cc(ccc1OCC(C)C)c1nc(c(s1)C(=O)O)C
Type(s)
Approved
ATC code(s)
M04AA03
Molecular Formula:
C16H16N2O3S
Molecular Weight:
316.375
Log P:
3.7232
Hydrogen Bond Acceptor:
6
Hydrogen Bond Donor:
1
TPSA:
111.45
CAS Number(s):
144060-53-7
Synonym(s)
1.
Febuxostat
2.
2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylic acid
3.
TEI 6720
4.
TEI-6720
5.
Uloric
6.
6720, TEI
7.
TEI6720
External Link(s)
MeSHD000069465
PubChem Compound134018
BindingDB50320491
ChEBI31596
CHEMBLCHEMBL1164729
DrugBankDB04854
DrugCentral1137
IUPHAR/BPS Guide to PHARMACOLOGY6817
KEGGdr:D01206
Therapeutic Target DatabaseD0A5SE
ZINC5423
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1GoutFAERS: 189
Canada Vigilance: 3
26968635CTD
SIDER
Canada Vigilance
US FAERS
2NauseaFAERS: 87SIDER
US FAERS
3Drug ineffectiveFAERS: 78
Canada Vigilance: 4
Canada Vigilance
US FAERS
4ArthralgiaFAERS: 66SIDER
US FAERS
5DizzinessFAERS: 54SIDER
US FAERS
6Blood creatinine increasedFAERS: 47SIDER
US FAERS
7HeadacheFAERS: 39SIDER
US FAERS
8PruritusFAERS: 38SIDER
US FAERS
9Myocardial InfarctionFAERS: 30SIDER
US FAERS
10No adverse eventFAERS: 30US FAERS
11VomitingFAERS: 30SIDER
US FAERS
12UrticariaFAERS: 28SIDER
US FAERS
13Stevens-Johnson SyndromeFAERS: 27SIDER
US FAERS
14Chest PainFAERS: 25SIDER
US FAERS
15FatigueFAERS: 25SIDER
US FAERS
16Abdominal discomfortFAERS: 24SIDER
US FAERS
17MyalgiaFAERS: 23SIDER
US FAERS
18HypersensitivityFAERS: 22SIDER
US FAERS
19Cerebrovascular accidentFAERS: 19SIDER
US FAERS
20MalaiseFAERS: 19US FAERS
21Alanine Aminotransferase IncreasedFAERS: 16US FAERS
22ErythemaFAERS: 15SIDER
US FAERS
23Wrong technique in product usage processFAERS: 15US FAERS
24AstheniaFAERS: 14
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
25Blood creatine phosphokinase increasedFAERS: 14US FAERS
26PalpitationsFAERS: 14SIDER
US FAERS
27PainFAERS: 13SIDER
US FAERS
28Peripheral swellingFAERS: 13
Canada Vigilance: 1
Canada Vigilance
US FAERS
29jaundiceFAERS: 13SIDER
US FAERS
30AlopeciaFAERS: 11SIDER
US FAERS
31Aspartate Aminotransferase IncreasedFAERS: 11US FAERS
32ChromaturiaFAERS: 11US FAERS
33Joint swellingFAERS: 11SIDER
US FAERS
34PancreatitisFAERS: 11SIDER
US FAERS
35PneumoniaFAERS: 11US FAERS
36ThrombocytopeniaFAERS: 11SIDER
US FAERS
37Abdominal PainFAERS: 10SIDER
US FAERS
38RhabdomyolysisFAERS: 10
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
39SwellingFAERS: 10US FAERS
40Acute kidney injuryFAERS: 9US FAERS
41Acute myocardial infarctionFAERS: 9
Canada Vigilance: 1
Canada Vigilance
US FAERS
42ChillsFAERS: 9US FAERS
43Drug prescribing errorFAERS: 9US FAERS
44NephrolithiasisFAERS: 9SIDER
US FAERS
45SomnolenceFAERS: 9SIDER
US FAERS
46AnxietyFAERS: 8SIDER
US FAERS
47DysuriaFAERS: 8US FAERS
48Feeling abnormalFAERS: 8SIDER
US FAERS
49ConstipationFAERS: 7SIDER
US FAERS
50Creatinine renal clearance decreasedFAERS: 7US FAERS
51DysgeusiaFAERS: 7SIDER
US FAERS
52OverdoseFAERS: 7US FAERS
53SepsisFAERS: 7US FAERS
54White blood cell count decreasedFAERS: 7US FAERS
55Adverse eventFAERS: 6US FAERS
56Blood potassium increasedFAERS: 6SIDER
US FAERS
57Blood triglycerides increasedFAERS: 6SIDER
US FAERS
58Gamma-Glutamyltransferase IncreasedFAERS: 6US FAERS
59NasopharyngitisFAERS: 6US FAERS
60Oropharyngeal painFAERS: 6US FAERS
61TremorFAERS: 6SIDER
US FAERS
62Visual ImpairmentFAERS: 6US FAERS
63Atrial FibrillationFAERS: 5SIDER
US FAERS
64Blood glucose increasedFAERS: 5SIDER
US FAERS
65Blood urea increasedFAERS: 5SIDER
US FAERS
66Blood uric acid abnormalFAERS: 5US FAERS
67Blood uric acid decreasedFAERS: 5US FAERS
68DehydrationFAERS: 5SIDER
US FAERS
69General physical health deteriorationFAERS: 5US FAERS
70TinnitusFAERS: 5SIDER
US FAERS
71Blood potassium decreasedFAERS: 4US FAERS
72Burning sensationFAERS: 4US FAERS
73Chest discomfortFAERS: 4SIDER
US FAERS
74Deep Vein ThrombosisFAERS: 4US FAERS
75Erectile dysfunctionFAERS: 4SIDER
US FAERS
76InflammationFAERS: 426036690CTD
US FAERS
77Lip swellingFAERS: 4US FAERS
78Musculoskeletal PainFAERS: 4SIDER
US FAERS
79Neck PainFAERS: 4US FAERS
80NervousnessFAERS: 4SIDER
US FAERS
81PancytopeniaFAERS: 4SIDER
US FAERS
82Prescribed overdoseFAERS: 4US FAERS
83PsoriasisFAERS: 4US FAERS
84Pulmonary EmbolismFAERS: 4US FAERS
85Skin reactionFAERS: 4US FAERS
86TachycardiaFAERS: 4SIDER
US FAERS
87Urinary RetentionFAERS: 4US FAERS
88AmnesiaFAERS: 3US FAERS
89Back PainFAERS: 3US FAERS
90Blood lactate dehydrogenase increasedFAERS: 3SIDER
US FAERS
91Bone painFAERS: 3US FAERS
92Cardiac ArrestFAERS: 3
Canada Vigilance: 1
Canada Vigilance
US FAERS
93CellulitisFAERS: 3US FAERS
94DyspepsiaFAERS: 3SIDER
US FAERS
95EpistaxisFAERS: 3SIDER
US FAERS
96HemiparesisFAERS: 3SIDER
US FAERS
97Hypertensive crisisFAERS: 3US FAERS
98Joint stiffnessFAERS: 3SIDER
US FAERS
99LymphomaFAERS: 3US FAERS
100Night sweatsFAERS: 3US FAERS
101Pericardial effusionFAERS: 3US FAERS
102PresyncopeFAERS: 3US FAERS
103Respiratory FailureFAERS: 3US FAERS
104Skin lesionFAERS: 3SIDER
US FAERS
105SyncopeFAERS: 3US FAERS
106Therapy cessationFAERS: 3US FAERS
107Unresponsive to stimuliFAERS: 3US FAERS
108Urinary IncontinenceFAERS: 3US FAERS
109Urinary tract infectionFAERS: 3US FAERS
110VasculitisFAERS: 3US FAERS
111Weight decreasedFAERS: 3SIDER
US FAERS
112Altered state of consciousnessFAERS: 2US FAERS
113Anaphylactic shockFAERS: 2SIDER
US FAERS
114AngioedemaFAERS: 2SIDER
US FAERS
115AphasiaFAERS: 2US FAERS
116ArthritisFAERS: 2SIDER
US FAERS
117BedriddenFAERS: 2US FAERS
118Blood cholesterol increasedFAERS: 2US FAERS
119Blood creatinine abnormalFAERS: 2US FAERS
120Blood urine presentFAERS: 2US FAERS
121Cold sweatFAERS: 2US FAERS
122Coronary Artery DiseaseFAERS: 2US FAERS
123CystFAERS: 2US FAERS
124DementiaFAERS: 2US FAERS
125DisorientationFAERS: 2US FAERS
126DiverticulitisFAERS: 2US FAERS
127DysarthriaFAERS: 2US FAERS
128Exfoliative rashFAERS: 2SIDER
US FAERS
129Eye painFAERS: 2US FAERS
130Feeling ColdFAERS: 2US FAERS
131Fluid overloadFAERS: 2US FAERS
132FlushingFAERS: 2SIDER
US FAERS
133GangreneFAERS: 2US FAERS
134HepatitisFAERS: 2SIDER
US FAERS
135HepatomegalyFAERS: 2SIDER
US FAERS
136HypotensionFAERS: 2SIDER
US FAERS
137InfectionFAERS: 2SIDER
US FAERS
138LethargyFAERS: 2SIDER
US FAERS
139LeukopeniaFAERS: 2SIDER
US FAERS
140Musculoskeletal stiffnessFAERS: 2SIDER
US FAERS
141MyopathyFAERS: 2
Canada Vigilance: 1
Canada Vigilance
US FAERS
142MyositisFAERS: 2US FAERS
143NeutropeniaFAERS: 2SIDER
US FAERS
144OliguriaFAERS: 2US FAERS
145Oropharyngeal blisteringFAERS: 2US FAERS
146Pancreatic InsufficiencyFAERS: 2US FAERS
147Polymyalgia RheumaticaFAERS: 2US FAERS
148Product use issueFAERS: 2US FAERS
149ProteinuriaFAERS: 2SIDER
US FAERS
150Rash erythematousFAERS: 2SIDER
US FAERS
151Renal ColicFAERS: 2US FAERS
152Skin ErosionFAERS: 2US FAERS
153Skin UlcerFAERS: 2US FAERS
154Skin irritationFAERS: 2US FAERS
155StomatitisFAERS: 2SIDER
US FAERS
156ThirstFAERS: 2SIDER
US FAERS
157Throat irritationFAERS: 2SIDER
US FAERS
158Transaminases increasedFAERS: 2US FAERS
159Troponin increasedFAERS: 2US FAERS
160Urine flow decreasedFAERS: 2US FAERS
161VIIth nerve paralysisFAERS: 2US FAERS
162WheezingFAERS: 2US FAERS
163treatment failureFAERS: 2US FAERS
164AbasiaFAERS: 1US FAERS
165Abdominal massFAERS: 1US FAERS
166AcarodermatitisFAERS: 1US FAERS
167Accidental exposure to product by childFAERS: 1US FAERS
168Accidental overdoseFAERS: 1US FAERS
169Acute Coronary SyndromeFAERS: 1
Canada Vigilance: 2
Canada Vigilance
SIDER
US FAERS
170AgeusiaFAERS: 1US FAERS
171AgranulocytosisFAERS: 1US FAERS
172Alcohol interactionFAERS: 1US FAERS
173Alopecia AreataFAERS: 1US FAERS
174Amaurosis FugaxFAERS: 1US FAERS
175Amylase increasedFAERS: 1SIDER
US FAERS
176Amyotrophic Lateral SclerosisFAERS: 1US FAERS
177Angina PectorisFAERS: 1SIDER
US FAERS
178AngiocardiogramFAERS: 1US FAERS
179AnuriaFAERS: 1US FAERS
180Aortic AneurysmFAERS: 1US FAERS
181Aortic embolusFAERS: 1US FAERS
182ArthropathyFAERS: 1US FAERS
183AstigmatismFAERS: 1US FAERS
184Atrial FlutterFAERS: 1US FAERS
185Atrioventricular BlockFAERS: 1US FAERS
186Bladder painFAERS: 1US FAERS
187Blood alkaline phosphatase increasedFAERS: 1SIDER
US FAERS
188Blood cholinesterase decreasedFAERS: 1US FAERS
189Blood creatinine decreasedFAERS: 1US FAERS
190Blood magnesium decreasedFAERS: 1US FAERS
191Blood potassiumFAERS: 1US FAERS
192Blood sodium decreasedFAERS: 1US FAERS
193Bone marrow myelogram abnormalFAERS: 1US FAERS
194Borderline glaucomaFAERS: 1US FAERS
195Bowel movement irregularityFAERS: 1US FAERS
196BradycardiaFAERS: 1US FAERS
197BradyphreniaFAERS: 1US FAERS
198Breast tendernessFAERS: 1US FAERS
199BronchitisFAERS: 1SIDER
US FAERS
200BronchospasmFAERS: 1US FAERS
201Cardiac discomfortFAERS: 1US FAERS
202Cardiac dysfunctionFAERS: 1US FAERS
203Cerebellar infarctionFAERS: 1US FAERS
204Cerebral InfarctionFAERS: 1US FAERS
205CholelithiasisFAERS: 1SIDER
US FAERS
206CholestasisFAERS: 1US FAERS
207Completed SuicideFAERS: 1US FAERS
208Concomitant disease aggravatedFAERS: 1US FAERS
209Congenital cystic kidney diseaseFAERS: 1US FAERS
210CryingFAERS: 1US FAERS
211Cytolytic hepatitisFAERS: 1US FAERS
212DeafnessFAERS: 1SIDER
US FAERS
213DeformityFAERS: 1US FAERS
214DeliriumFAERS: 1US FAERS
215Depression suicidalFAERS: 1US FAERS
216Dermatitis acneiformFAERS: 1US FAERS
217Device malfunctionFAERS: 1US FAERS
218Diabetes MellitusFAERS: 1SIDER
US FAERS
219Diabetes mellitus inadequate controlFAERS: 1US FAERS
220Diabetic metabolic decompensationFAERS: 1US FAERS
221DiplegiaFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
222DiscomfortFAERS: 1SIDER
US FAERS
223Disease recurrenceFAERS: 1US FAERS
224Drug dose omissionFAERS: 1US FAERS
225Drug screen false positiveFAERS: 1US FAERS
226Duodenal ulcer perforationFAERS: 1US FAERS
227DysphoniaFAERS: 1US FAERS
228DystoniaFAERS: 1US FAERS
229Economic problemFAERS: 1US FAERS
230EczemaFAERS: 1SIDER
US FAERS
231Emotional distressFAERS: 1US FAERS
232EncephalitisFAERS: 1US FAERS
233EnteritisFAERS: 1US FAERS
234EosinophiliaFAERS: 1SIDER
US FAERS
235Erection increasedFAERS: 1US FAERS
236Erythema MultiformeFAERS: 1SIDER
US FAERS
237Expired product administeredFAERS: 1US FAERS
238Extremity contractureFAERS: 1US FAERS
239Eye irritationFAERS: 1SIDER
US FAERS
240Facial paralysisFAERS: 1US FAERS
241Febrile NeutropeniaFAERS: 1US FAERS
242Flank PainFAERS: 1US FAERS
243FractureFAERS: 1US FAERS
244Gastrointestinal PainFAERS: 1SIDER
US FAERS
245Gastrointestinal hypomotilityFAERS: 1US FAERS
246Gastrointestinal ulcerFAERS: 1US FAERS
247Genital rashFAERS: 1US FAERS
248GlaucomaFAERS: 1US FAERS
249GlomerulonephritisFAERS: 1US FAERS
250Head discomfortFAERS: 1US FAERS
251Hepatic necrosisFAERS: 1US FAERS
252Hepatitis A positiveFAERS: 1US FAERS
253Histiocytosis haematophagicFAERS: 1US FAERS
254Hospice CareFAERS: 1US FAERS
255HyperpyrexiaFAERS: 1US FAERS
256Hypertensive emergencyFAERS: 1US FAERS
257HypokinesiaFAERS: 1US FAERS
258HyposideraemiaFAERS: 1US FAERS
259HypoventilationFAERS: 1US FAERS
260HysterectomyFAERS: 1US FAERS
261IleusFAERS: 1US FAERS
262IlliteracyFAERS: 1US FAERS
263Immune thrombocytopenic purpuraFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
264Impaired work abilityFAERS: 1US FAERS
265Inappropriate schedule of drug administrationFAERS: 1US FAERS
266IncontinenceFAERS: 1SIDER
US FAERS
267Incorrect dose administeredFAERS: 1US FAERS
268Incorrect drug administration durationFAERS: 1US FAERS
269Inhibitory drug interactionFAERS: 1US FAERS
270Intentional product use issueFAERS: 1US FAERS
271Intestinal ObstructionFAERS: 1US FAERS
272Intestinal infarctionFAERS: 1US FAERS
273Lactose IntoleranceFAERS: 1US FAERS
274Large intestinal polypectomyFAERS: 1US FAERS
275LaryngitisFAERS: 1US FAERS
276Libido disorderFAERS: 1US FAERS
277Limb discomfortFAERS: 1US FAERS
278Lipase increasedFAERS: 1US FAERS
279Lymphocyte stimulation test negativeFAERS: 1US FAERS
280MYELODYSPLASTIC SYNDROMEFAERS: 1US FAERS
281Memory impairmentFAERS: 1US FAERS
282MeningitisFAERS: 1US FAERS
283Meniscus injuryFAERS: 1US FAERS
284Mental status changesFAERS: 1US FAERS
285Mouth swellingFAERS: 1US FAERS
286Muscle FatigueFAERS: 1US FAERS
287Muscle tightnessFAERS: 1SIDER
US FAERS
288Myofascial spasmFAERS: 1US FAERS
289Myoglobin blood increasedFAERS: 1US FAERS
290Nasal discomfortFAERS: 1US FAERS
291NephritisFAERS: 1US FAERS
292Nephrotic SyndromeFAERS: 1US FAERS
293Neuromuscular painFAERS: 1US FAERS
294Neutrophil count decreasedFAERS: 1SIDER
US FAERS
295Nipple painFAERS: 1US FAERS
296NoduleFAERS: 1US FAERS
297Non-cardiac chest painFAERS: 1US FAERS
298Opiates positiveFAERS: 1US FAERS
299Optic NeuritisFAERS: 1US FAERS
300Pain of skinFAERS: 1US FAERS
301PallorFAERS: 1US FAERS
302Pancreatic carcinomaFAERS: 1US FAERS
303ParanoiaFAERS: 1US FAERS
304ParotidectomyFAERS: 1US FAERS
305Perianal erythemaFAERS: 1US FAERS
306Peripheral arterial occlusive diseaseFAERS: 1US FAERS
307PiloerectionFAERS: 1US FAERS
308PoisoningFAERS: 1US FAERS
309PolydipsiaFAERS: 1US FAERS
310PolyneuropathyFAERS: 1US FAERS
311PolyuriaFAERS: 1US FAERS
312Porphyrins urine increasedFAERS: 1US FAERS
313Portal Vein ThrombosisFAERS: 1US FAERS
314Post procedural myocardial infarctionFAERS: 1US FAERS
315PregnancyFAERS: 1US FAERS
316Product appearance confusionFAERS: 1US FAERS
317Product dispensing errorFAERS: 1US FAERS
318Product physical issueFAERS: 1US FAERS
319Product quality issueFAERS: 1US FAERS
320Pulmonary FibrosisFAERS: 1US FAERS
321PurpuraFAERS: 1SIDER
US FAERS
322Quality of life decreasedFAERS: 1US FAERS
323Renal painFAERS: 1US FAERS
324Respiratory distressFAERS: 1US FAERS
325Respiratory tract congestionFAERS: 1SIDER
US FAERS
326Retinal Artery OcclusionFAERS: 1US FAERS
327Rheumatoid ArthritisFAERS: 1US FAERS
328RosaceaFAERS: 1US FAERS
329ScabFAERS: 1US FAERS
330SinusitisFAERS: 1US FAERS
331Skin WrinklingFAERS: 1US FAERS
332Skin tightnessFAERS: 1US FAERS
333Splenic RuptureFAERS: 1US FAERS
334StaringFAERS: 1US FAERS
335StressFAERS: 1US FAERS
336Sudden deathFAERS: 1US FAERS
337Suture related complicationFAERS: 1US FAERS
338Therapeutic response unexpectedFAERS: 1US FAERS
339ThrombophlebitisFAERS: 1US FAERS
340ThrombosisFAERS: 1US FAERS
341ThyroiditisFAERS: 1US FAERS
342Toxic Epidermal NecrolysisFAERS: 1SIDER
US FAERS
343UlcerFAERS: 1US FAERS
344Unevaluable eventFAERS: 1US FAERS
345Urine output increasedFAERS: 1SIDER
US FAERS
346Vasculitic rashFAERS: 1US FAERS
347Venous ThrombosisFAERS: 1US FAERS
348VertigoFAERS: 1SIDER
US FAERS
349Walking aid userFAERS: 1US FAERS
350nervous system disorderFAERS: 1SIDER
US FAERS
351AgitationSIDER
352AnorexiaSIDER
353Blood and lymphatic system disordersSIDER
354Blood creatine increasedSIDER
355Blood sodium increasedSIDER
356Blood thyroid stimulating hormone increasedSIDER
357BursitisSIDER
358Cardiac FlutterSIDER
359Cardiotoxicity26036690CTD
360Cardiovascular Diseases21449597CTD
361CholecystitisSIDER
362Coagulation test abnormalSIDER
363Creatine increasedSIDER
364Creatinine increasedSIDER
365DermatitisSIDER
366Disturbance in sexual arousalSIDER
367Ear and labyrinth disordersSIDER
368EcchymosisSIDER
369Edema, Cardiac26036690CTD
370Electrocardiogram abnormalSIDER
371Electroencephalogram abnormalSIDER
372Endomyocardial Fibrosis26036690CTD
373FlatulenceSIDER
374Gastric pH decreasedSIDER
375GastritisSIDER
376Gastrointestinal discomfortSIDER
377Glucose increasedSIDER
378Gout flareSIDER
379Guillain-Barre SyndromeSIDER
380Haptoglobin increasedCanada Vigilance: 1Canada Vigilance
381HyperchlorhydriaSIDER
382InfestationSIDER
383Influenza-like symptomsSIDER
384Lactic dehydrogenase activity increasedSIDER
385LeukocytosisSIDER
386Lymphocyte count decreasedSIDER
387MalnutritionSIDER
388Mechanical urticariaSIDER
389Mental RetardationSIDER
390Musculoskeletal discomfortSIDER
391Paranasal sinus hypersecretionSIDER
392Peptic UlcerSIDER
393Personality ChangeSIDER
394PetechiaeSIDER
395Potassium increasedSIDER
396Protein urine presentSIDER
397PrurigoSIDER
398Rash follicularSIDER
399ShockSIDER
400Sinus bradycardiaSIDER
401SneezingCanada Vigilance: 1Canada Vigilance
SIDER
402Sodium highSIDER
403SplenomegalySIDER
404StiffnessSIDER
405TensionSIDER
406Therapeutic product effect decreasedCanada Vigilance: 1Canada Vigilance
407Traumatic liver injurySIDER
408Urinary tract obstructionCanada Vigilance: 1Canada Vigilance
409Vascular purpuraSIDER
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