MetaADEDB 2.0 @ LMMD
Bendamustine Hydrochloride
(YTKUWDBFDASYHO-UHFFFAOYSA-N)
Structure
SMILES
ClCCN(c1ccc2c(c1)nc(n2C)CCCC(=O)O)CCCl
Type(s)
Approved; Investigational
ATC code(s)
L01AA09
Molecular Formula:
C16H21Cl2N3O2
Molecular Weight:
358.263
Log P:
3.2646
Hydrogen Bond Acceptor:
5
Hydrogen Bond Donor:
1
TPSA:
58.36
CAS Number(s):
16506-27-7
Synonym(s)
1.
Bendamustine Hydrochloride
2.
Bendamustin
3.
Bendamustine
4.
Cytostasan
5.
IMET 3393
6.
Ribomustin
7.
Treanda
8.
Zimet 3393
9.
Hydrochloride, Bendamustine
External Link(s)
MeSHD000069461
PubChem Compound65628
BindingDB173621
ChEBI135515
CHEMBLCHEMBL487253
DrugBankDB06769
DrugCentral302
IUPHAR/BPS Guide to PHARMACOLOGY7478
KEGGdr:D07085
dr:D07501
Therapeutic Target DatabaseD01CYA
ZINC4214955
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1PancytopeniaFAERS: 8SIDER
US FAERS
2PneumoniaFAERS: 7SIDER
US FAERS
3HypotensionFAERS: 6SIDER
US FAERS
4NauseaFAERS: 6OFFSIDES
SIDER
US FAERS
5FatigueFAERS: 5OFFSIDES
SIDER
US FAERS
6Febrile NeutropeniaFAERS: 5SIDER
US FAERS
7NeutropeniaFAERS: 5SIDER
US FAERS
8VomitingFAERS: 5SIDER
US FAERS
9ChillsFAERS: 4SIDER
US FAERS
10Disease ProgressionFAERS: 4US FAERS
11ThrombocytopeniaFAERS: 4SIDER
US FAERS
12General physical health deteriorationFAERS: 3OFFSIDES
US FAERS
13LeukopeniaFAERS: 3SIDER
US FAERS
14Pulmonary EmbolismFAERS: 3US FAERS
15Unresponsive to stimuliFAERS: 3US FAERS
16AphasiaFAERS: 2US FAERS
17ArthralgiaFAERS: 2SIDER
US FAERS
18AstheniaFAERS: 2OFFSIDES
SIDER
US FAERS
19Atrial FibrillationFAERS: 2US FAERS
20Blood creatinine increasedFAERS: 2SIDER
US FAERS
21Chest PainFAERS: 2SIDER
US FAERS
22EncephalitisFAERS: 2US FAERS
23EnterocolitisFAERS: 2US FAERS
24HepatitisFAERS: 2US FAERS
25HepatotoxicityFAERS: 2US FAERS
26InfectionFAERS: 2OFFSIDES
SIDER
US FAERS
27Lobar PneumoniaFAERS: 2US FAERS
28MalaiseFAERS: 2SIDER
US FAERS
29Nephrogenic Diabetes InsipidusFAERS: 2US FAERS
30PalpitationsFAERS: 2US FAERS
31PneumonitisFAERS: 2US FAERS
32PolyneuropathyFAERS: 2US FAERS
33PruritusFAERS: 2SIDER
US FAERS
34Pulmonary toxicityFAERS: 2US FAERS
35RetinitisFAERS: 2US FAERS
36Stevens-Johnson SyndromeFAERS: 2US FAERS
37SyncopeFAERS: 2US FAERS
38TachycardiaFAERS: 2SIDER
US FAERS
39Troponin increasedFAERS: 2US FAERS
40Abdominal PainFAERS: 1SIDER
US FAERS
41Acute kidney injuryFAERS: 1US FAERS
42Acute myocardial infarctionFAERS: 1US FAERS
43AdenocarcinomaFAERS: 1US FAERS
44AkathisiaFAERS: 1US FAERS
45Alanine Aminotransferase IncreasedFAERS: 1US FAERS
46AmnesiaFAERS: 1US FAERS
47Anaphylactic shockFAERS: 1SIDER
US FAERS
48Angina PectorisFAERS: 1US FAERS
49AngioedemaFAERS: 1US FAERS
50AnuriaFAERS: 1US FAERS
51AphagiaFAERS: 1OFFSIDES
US FAERS
52Aspartate Aminotransferase IncreasedFAERS: 1SIDER
US FAERS
53AsthmaFAERS: 1US FAERS
54AtaxiaFAERS: 1US FAERS
55Back PainFAERS: 1SIDER
US FAERS
56Blastic plasmacytoid dendritic cell neoplasiaFAERS: 1US FAERS
57Blood albumin decreasedFAERS: 1US FAERS
58Blood count abnormalFAERS: 1US FAERS
59Blood glucose decreasedFAERS: 1US FAERS
60Blood lactate dehydrogenase increasedFAERS: 1US FAERS
61Blood uric acid decreasedFAERS: 1US FAERS
62Bone marrow infiltrationFAERS: 1US FAERS
63BradycardiaFAERS: 1US FAERS
64Brain natriuretic peptide increasedFAERS: 1US FAERS
65BronchitisFAERS: 1US FAERS
66CD4 Lymphocytes DecreasedFAERS: 1US FAERS
67Cardiac ArrestFAERS: 1US FAERS
68CardiomegalyFAERS: 1US FAERS
69Chest discomfortFAERS: 1US FAERS
70CholestasisFAERS: 1US FAERS
71ConstipationFAERS: 1SIDER
US FAERS
72Coronary Artery DiseaseFAERS: 1US FAERS
73DeafnessFAERS: 1US FAERS
74Drug ineffectiveFAERS: 1US FAERS
75Electrocardiogram ST segment abnormalFAERS: 1US FAERS
76Electrolyte imbalanceFAERS: 1US FAERS
77EmbolismFAERS: 1US FAERS
78EnteritisFAERS: 1US FAERS
79ErysipelasFAERS: 1US FAERS
80FlushingFAERS: 1US FAERS
81Full blood count increasedFAERS: 1US FAERS
82Gastric ulcerFAERS: 1US FAERS
83GastritisFAERS: 1US FAERS
84HeadacheFAERS: 1SIDER
US FAERS
85Hepatitis BFAERS: 1US FAERS
86HepatosplenomegalyFAERS: 1US FAERS
87Histiocytosis haematophagicFAERS: 1US FAERS
88Hodgkin's disease nodular sclerosis recurrentFAERS: 1US FAERS
89HyperpyrexiaFAERS: 1US FAERS
90HypophagiaFAERS: 1OFFSIDES
US FAERS
91IleusFAERS: 1US FAERS
92Infusion Site ExtravasationFAERS: 1US FAERS
93Injection site painFAERS: 1US FAERS
94Injection site vasculitisFAERS: 1US FAERS
95Intestinal Pseudo-ObstructionFAERS: 1US FAERS
96LeukocytosisFAERS: 1US FAERS
97LymphadenopathyFAERS: 1US FAERS
98LymphopeniaFAERS: 1US FAERS
99Malignant neoplasm progressionFAERS: 1US FAERS
100Mental status changesFAERS: 1US FAERS
101Myocardial InfarctionFAERS: 1US FAERS
102Neutrophil count decreasedFAERS: 1US FAERS
103Oncologic complicationFAERS: 1US FAERS
104Oropharyngeal painFAERS: 1OFFSIDES
US FAERS
105Paraneoplastic pemphigusFAERS: 1US FAERS
106Pericardial effusionFAERS: 1US FAERS
107Pneumocystis jiroveci pneumoniaFAERS: 1US FAERS
108Prescribed overdoseFAERS: 1US FAERS
109Procalcitonin increasedFAERS: 1US FAERS
110Product use in unapproved indicationFAERS: 1US FAERS
111Productive CoughFAERS: 1US FAERS
112Respiratory DepressionFAERS: 1US FAERS
113Respiratory FailureFAERS: 1US FAERS
114Rheumatoid ArthritisFAERS: 1US FAERS
115SepsisFAERS: 1SIDER
US FAERS
116Sinus TachycardiaFAERS: 1US FAERS
117Skin reactionFAERS: 1US FAERS
118Suprapubic painFAERS: 1US FAERS
119Toxic Epidermal NecrolysisFAERS: 1US FAERS
120TracheobronchitisFAERS: 1US FAERS
121Urinary tract infectionFAERS: 1SIDER
US FAERS
122Visual ImpairmentFAERS: 1US FAERS
123WheezingFAERS: 1SIDER
US FAERS
124White blood cell count decreasedFAERS: 1SIDER
US FAERS
125Allergic pharyngitisOFFSIDES
126AlveolitisOFFSIDES
127AnorexiaSIDER
128AnxietySIDER
129AtelectasisOFFSIDES
130Atypical pneumoniaSIDER
131Biopsy bone abnormalOFFSIDES
132Bone painSIDER
133Bronchoalveolar LavageOFFSIDES
134BronchoscopyOFFSIDES
135Capillary Leak SyndromeOFFSIDES
136Catheter site painSIDER
137Cerebral aspergillosisOFFSIDES
138Creatinine increasedSIDER
139CyanosisOFFSIDES
140DehydrationSIDER
141DermatitisSIDER
142DiscomfortSIDER
143DizzinessSIDER
144Dry skinSIDER
145Duodenal UlcerOFFSIDES
146DuodenitisOFFSIDES
147DysgeusiaSIDER
148DyspepsiaSIDER
149Erosive gastritisOFFSIDES
150ErythemaSIDER
151Escherichia urinary tract infectionOFFSIDES
152ExophthalmosOFFSIDES
153ExtravasationSIDER
154Failure to ThriveOFFSIDES
155Feeling abnormalSIDER
156Gastrointestinal PainSIDER
157GlaucomaOFFSIDES
158HypersensitivitySIDER
159Hypertensive crisisSIDER
160InfestationSIDER
161Infusion site painSIDER
162LeukostasisOFFSIDES
163Lymphocyte count decreasedSIDER
164LymphomaOFFSIDES
165MYELODYSPLASTIC SYNDROMESIDER
166MalnutritionSIDER
167Musculoskeletal discomfortSIDER
168Mycosis FungoidesOFFSIDES
169MyelosuppressionSIDER
170NasopharyngitisSIDER
171Night sweatsSIDER
172Optic NeuropathyOFFSIDES
173Oral candidiasisSIDER
174OverdoseOFFSIDES
175PainSIDER
176ParophthalmiaOFFSIDES
177PertussisOFFSIDES
178Pharyngolaryngeal PainSIDER
179PhlebitisSIDER
180PneumothoraxOFFSIDES
181Pulmonary FibrosisSIDER
182Pulmonary sepsisOFFSIDES
183Reactive perforating collagenosisOFFSIDES
184RhonchiOFFSIDES
185SinusitisSIDER
186Skin necrosisSIDER
187SomnolenceSIDER
188StomatitisSIDER
189Supraventricular tachycardiaOFFSIDES
190SwellingSIDER
191Systemic mycosisOFFSIDES
192Taste DisordersSIDER
193Transaminases increasedOFFSIDES
194Venous thrombosis limbOFFSIDES
195Weight decreasedSIDER
196nervous system disorderSIDER
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