MetaADEDB 2.0 @ LMMD
Cladribine
(PTOAARAWEBMLNO-KVQBGUIXSA-N)
Structure
SMILES
OC[C@H]1O[C@H](C[C@@H]1O)n1cnc2c1nc(Cl)nc2N
Type(s)
Approved; Investigational
ATC code(s)
L01BB04; L04AA40
Molecular Formula:
C10H12ClN5O3
Molecular Weight:
285.687
Log P:
0.2838
Hydrogen Bond Acceptor:
8
Hydrogen Bond Donor:
3
TPSA:
119.31
CAS Number(s):
4291-63-8
Synonym(s)
1.
Cladribine
2.
2-Chloro-2'-deoxyadenosine
3.
2-Chlorodeoxyadenosine
4.
2'-Deoxy-2-chloroadenosine
5.
Leustatin
External Link(s)
MeSHD017338
PubChem Compound20279
BindingDB38920
ChEBI567361
CHEMBLCHEMBL1619
DrugBankDB00242
DrugCentral667
IUPHAR/BPS Guide to PHARMACOLOGY4799
KEGGdr:D01370
Therapeutic Target DatabaseD05GJW
ZINC3798064
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1White blood cell count decreasedFAERS: 17
Canada Vigilance: 3
Canada Vigilance
US FAERS
2ThrombocytopeniaFAERS: 13

View details

CTD
SIDER
US FAERS
3PancytopeniaFAERS: 1216398735CTD
SIDER
US FAERS
4SepsisFAERS: 12SIDER
US FAERS
5MYELODYSPLASTIC SYNDROMEFAERS: 11SIDER
US FAERS
6Febrile NeutropeniaFAERS: 10SIDER
US FAERS
7Multiple sclerosis relapseFAERS: 10
Canada Vigilance: 2
Canada Vigilance
US FAERS
8HeadacheFAERS: 8
Canada Vigilance: 3
Canada Vigilance
SIDER
US FAERS
9Incorrect route of drug administrationFAERS: 8US FAERS
10No adverse eventFAERS: 8US FAERS
11LeukopeniaFAERS: 7US FAERS
12FatigueFAERS: 6
Canada Vigilance: 7
Canada Vigilance
SIDER
US FAERS
13InfectionFAERS: 6
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
14LymphopeniaFAERS: 67850921CTD
SIDER
US FAERS
15NauseaFAERS: 6
Canada Vigilance: 8
7850921
15654901
CTD
SIDER
Canada Vigilance
US FAERS
16NeutropeniaFAERS: 6
Canada Vigilance: 1
7655003
7971251
15654901
CTD
SIDER
Canada Vigilance
US FAERS
17PneumoniaFAERS: 6
Canada Vigilance: 2
Canada Vigilance
SIDER
US FAERS
18Drug ineffectiveFAERS: 5
Canada Vigilance: 5
Canada Vigilance
OFFSIDES
US FAERS
19ErythemaFAERS: 5OFFSIDES
SIDER
US FAERS
20Incorrect drug administration rateFAERS: 5US FAERS
21Bone marrow depressionFAERS: 4OFFSIDES
US FAERS
22Disseminated Intravascular CoagulationFAERS: 4
Canada Vigilance: 1
10792402CTD
Canada Vigilance
US FAERS
23LethargyFAERS: 4SIDER
US FAERS
24Lymphocyte count decreasedFAERS: 4
Canada Vigilance: 5
Canada Vigilance
OFFSIDES
US FAERS
25NasopharyngitisFAERS: 4
Canada Vigilance: 2
Canada Vigilance
US FAERS
26Accidental overdoseFAERS: 3OFFSIDES
US FAERS
27AscitesFAERS: 3OFFSIDES
US FAERS
28Blood creatinine increasedFAERS: 3US FAERS
29HypotensionFAERS: 3
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
30Lower respiratory tract infectionFAERS: 3
Canada Vigilance: 1
Canada Vigilance
US FAERS
31Neutrophil count decreasedFAERS: 3OFFSIDES
US FAERS
32Product use issueFAERS: 3US FAERS
33StomatitisFAERS: 3US FAERS
34VasculitisFAERS: 3US FAERS
35Alanine Aminotransferase IncreasedFAERS: 2OFFSIDES
US FAERS
36AlopeciaFAERS: 2
Canada Vigilance: 3
Canada Vigilance
SIDER
US FAERS
37AnuriaFAERS: 2OFFSIDES
US FAERS
38AspergillosisFAERS: 2US FAERS
39Basal cell carcinomaFAERS: 2US FAERS
40Bronchopulmonary AspergillosisFAERS: 2US FAERS
41Colony stimulating factor therapyFAERS: 2US FAERS
42ConstipationFAERS: 2SIDER
US FAERS
43Diffuse Large B-Cell LymphomaFAERS: 2US FAERS
44DizzinessFAERS: 2
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
45Ejection Fraction DecreasedFAERS: 2US FAERS
46Enteropathy-Associated T-Cell LymphomaFAERS: 2US FAERS
47ExtravasationFAERS: 2SIDER
US FAERS
48Gastrointestinal inflammationFAERS: 2US FAERS
49GlioblastomaFAERS: 2US FAERS
50Hepatitis BFAERS: 2OFFSIDES
US FAERS
51HypersensitivityFAERS: 2SIDER
US FAERS
52Injection Site ReactionFAERS: 2SIDER
US FAERS
53LymphomaFAERS: 2OFFSIDES
US FAERS
54MalaiseFAERS: 2SIDER
US FAERS
55Malignant neoplasm progressionFAERS: 2OFFSIDES
US FAERS
56Mental impairmentFAERS: 2US FAERS
57Neutropenic sepsisFAERS: 2US FAERS
58PainFAERS: 2
Canada Vigilance: 5
Canada Vigilance
SIDER
US FAERS
59Platelet TransfusionFAERS: 2US FAERS
60PneumonitisFAERS: 2US FAERS
61Respiratory FailureFAERS: 2OFFSIDES
US FAERS
62Septic ShockFAERS: 2SIDER
US FAERS
63TachycardiaFAERS: 2SIDER
US FAERS
64Toxicity to various agentsFAERS: 2US FAERS
65Transaminases abnormalFAERS: 2US FAERS
66Urinary tract infectionFAERS: 2
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
67Ventricular hypokinesiaFAERS: 2OFFSIDES
US FAERS
68Weight decreasedFAERS: 2
Canada Vigilance: 2
Canada Vigilance
US FAERS
69Abdominal PainFAERS: 1
Canada Vigilance: 2
Canada Vigilance
SIDER
US FAERS
70Actinic keratosisFAERS: 1US FAERS
71Acute hepatitis CFAERS: 1US FAERS
72Adverse eventFAERS: 1US FAERS
73AgranulocytosisFAERS: 17850921CTD
US FAERS
74AngerFAERS: 1US FAERS
75AphoniaFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
76ArthralgiaFAERS: 1SIDER
US FAERS
77Aspartate Aminotransferase IncreasedFAERS: 1US FAERS
78AsthenopiaFAERS: 1US FAERS
79AutoscopyFAERS: 1US FAERS
80Bladder NeoplasmFAERS: 1US FAERS
81BlindnessFAERS: 17911736CTD
US FAERS
82Blood albumin decreasedFAERS: 1OFFSIDES
US FAERS
83Blood albumin increasedFAERS: 1US FAERS
84Blood creatine phosphokinase increasedFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
85Blood iron increasedFAERS: 1US FAERS
86Blood lactate dehydrogenase abnormalFAERS: 1US FAERS
87Blood product transfusion dependentFAERS: 1US FAERS
88Bone painFAERS: 1SIDER
US FAERS
89BronchospasmFAERS: 1US FAERS
90Capillary Leak SyndromeFAERS: 1US FAERS
91ChillsFAERS: 1SIDER
US FAERS
92CholelithiasisFAERS: 1US FAERS
93Chronic sinusitisFAERS: 1US FAERS
94Contraindicated product administeredFAERS: 1US FAERS
95CystitisFAERS: 1
Canada Vigilance: 2
Canada Vigilance
US FAERS
96Cytomegalovirus gastrointestinal infectionFAERS: 1US FAERS
97DeafnessFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
98Depressed moodFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
99Device deployment issueFAERS: 1US FAERS
100Device related infectionFAERS: 1US FAERS
101Diabetes InsipidusFAERS: 1US FAERS
102DisorientationFAERS: 1SIDER
US FAERS
103Diverticular perforationFAERS: 1OFFSIDES
US FAERS
104EpilepsyFAERS: 1SIDER
US FAERS
105Epstein-Barr virus antibody positiveFAERS: 1US FAERS
106Epstein-Barr virus associated lymphomaFAERS: 1US FAERS
107Erythema MultiformeFAERS: 110792402CTD
OFFSIDES
SIDER
US FAERS
108External ear painFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
109Feeling abnormalFAERS: 1SIDER
US FAERS
110Full blood count decreasedFAERS: 1US FAERS
111Gamma-Glutamyltransferase IncreasedFAERS: 1
Canada Vigilance: 1
Canada Vigilance
OFFSIDES
US FAERS
112Gastrointestinal viral infectionFAERS: 1US FAERS
113General physical health deteriorationFAERS: 1US FAERS
114HaematotoxicityFAERS: 1US FAERS
115HepatomegalyFAERS: 1US FAERS
116HepatotoxicityFAERS: 1US FAERS
117HydronephrosisFAERS: 1US FAERS
118Hypereosinophilic syndromeFAERS: 1US FAERS
119HypertransaminasaemiaFAERS: 1OFFSIDES
US FAERS
120HypoperfusionFAERS: 1US FAERS
121HypophagiaFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
122HypopituitarismFAERS: 1US FAERS
123HypoxiaFAERS: 1US FAERS
124ImmunosuppressionFAERS: 1US FAERS
125Inappropriate schedule of drug administrationFAERS: 1US FAERS
126Incorrect dose administeredFAERS: 1US FAERS
127Infection reactivationFAERS: 1US FAERS
128InfluenzaFAERS: 1
Canada Vigilance: 2
Canada Vigilance
US FAERS
129Injection site inflammationFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
130ListeriosisFAERS: 1US FAERS
131Lobar PneumoniaFAERS: 1US FAERS
132LymphadenopathyFAERS: 1US FAERS
133Lymphocyte percentage decreasedFAERS: 1US FAERS
134Maternal exposure timing unspecifiedFAERS: 1US FAERS
135Mediastinal effusionFAERS: 1US FAERS
136MenorrhagiaFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
137MetastasisFAERS: 1US FAERS
138Metastatic Renal Cell CarcinomaFAERS: 1US FAERS
139Multiple SclerosisFAERS: 1
Canada Vigilance: 1
12898844CTD
Canada Vigilance
US FAERS
140Musculoskeletal discomfortFAERS: 1SIDER
US FAERS
141Musculoskeletal stiffnessFAERS: 1US FAERS
142MyalgiaFAERS: 1SIDER
US FAERS
143Myasthenia GravisFAERS: 1US FAERS
144Nerve injuryFAERS: 1US FAERS
145Non-Hodgkin's lymphoma refractoryFAERS: 1OFFSIDES
US FAERS
146OrchitisFAERS: 1US FAERS
147Oropharyngeal swellingFAERS: 1US FAERS
148Ovarian failureFAERS: 1US FAERS
149PalpitationsFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
150Pelvic massFAERS: 1US FAERS
151PemphigusFAERS: 1US FAERS
152Performance status decreasedFAERS: 1US FAERS
153Pharmaceutical product complaintFAERS: 1US FAERS
154PlasmapheresisFAERS: 1US FAERS
155Pneumococcal sepsisFAERS: 1US FAERS
156Poor quality sleepFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
157Portal Vein ThrombosisFAERS: 1US FAERS
158PresyncopeFAERS: 1US FAERS
159Pulmonary EmbolismFAERS: 1SIDER
US FAERS
160PyelonephritisFAERS: 1US FAERS
161Renal tubular disorderFAERS: 1US FAERS
162Respiratory distressFAERS: 1US FAERS
163Serology positiveFAERS: 1US FAERS
164SinusitisFAERS: 1US FAERS
165Skin PapillomaFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
166Squamous cell carcinomaFAERS: 1US FAERS
167Staphylococcal impetigoFAERS: 1US FAERS
168SyncopeFAERS: 1US FAERS
169SyphilisFAERS: 1US FAERS
170Therapeutic product effect incompleteFAERS: 1US FAERS
171Therapy non-responderFAERS: 1OFFSIDES
US FAERS
172Throat cancerFAERS: 1US FAERS
173TuberculosisFAERS: 1US FAERS
174Tumour haemorrhageFAERS: 1US FAERS
175VertigoFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
176VomitingFAERS: 1
Canada Vigilance: 1
7850921
15654901
CTD
SIDER
Canada Vigilance
US FAERS
177jaundiceFAERS: 1US FAERS
178Abdominal discomfortCanada Vigilance: 4Canada Vigilance
SIDER
179Abnormalities, Drug-Induced12115775CTD
180Administration site reactionSIDER
181AgeusiaCanada Vigilance: 1Canada Vigilance
182Altered state of consciousnessSIDER
183AmyloidosisSIDER
184Anemia, Hemolytic16398735CTD
185Anemia7655003
7850921
CTD
186Anorexia7850921CTD
OFFSIDES
SIDER
187AnosmiaCanada Vigilance: 1Canada Vigilance
188Anoxic EncephalopathyOFFSIDES
189AnxietyCanada Vigilance: 2Canada Vigilance
SIDER
190ArthritisSIDER
191AstheniaCanada Vigilance: 1Canada Vigilance
SIDER
192AtaxiaSIDER
193Atrial FibrillationSIDER
194Atrioventricular Block15561348CTD
195AutomatismOFFSIDES
196Back PainCanada Vigilance: 1Canada Vigilance
SIDER
197BlepharitisSIDER
198Blood alkaline phosphatase increasedCanada Vigilance: 1Canada Vigilance
OFFSIDES
199Blood and lymphatic system disordersSIDER
200Blood chloride decreasedOFFSIDES
201Blood lactate dehydrogenase increasedOFFSIDES
202Blood urea increasedOFFSIDES
203Bone Marrow Diseases7911736CTD
204Brain DeathOFFSIDES
205BronchitisCanada Vigilance: 1Canada Vigilance
206Bronchoalveolar LavageOFFSIDES
207BronchopneumoniaOFFSIDES
208Bulbar palsyOFFSIDES
209Burning sensationCanada Vigilance: 1Canada Vigilance
210BursitisCanada Vigilance: 1Canada Vigilance
211CD4 Lymphocytes DecreasedOFFSIDES
212CachexiaSIDER
213Catheter site cellulitisSIDER
214CellulitisSIDER
215Cerebrovascular accidentSIDER
216Chest PainSIDER
217ChimerismOFFSIDES
218CholecystitisSIDER
219Circumstance or information capable of leading to medication errorOFFSIDES
220Cold sweatOFFSIDES
221Conjunctival depositOFFSIDES
222ConjunctivitisSIDER
223Culture negativeSIDER
224CystSIDER
225Demyelinating Diseases7949097CTD
226DemyelinationOFFSIDES
227Depressed Level of ConsciousnessSIDER
228DermatitisSIDER
229Differential white blood cell count abnormalOFFSIDES
230DiscomfortSIDER
231Disease ProgressionOFFSIDES
232Disease complicationOFFSIDES
233Disease recurrenceOFFSIDES
234Dyspnea10792402CTD
235EcchymosisSIDER
236EnteritisOFFSIDES
237EosinophiliaSIDER
238EpistaxisSIDER
239EructationCanada Vigilance: 1Canada Vigilance
240Fatty LiverOFFSIDES
241Fetal Resorption12115775CTD
242Fever

View details

CTD
243FlatulenceSIDER
244FlushingCanada Vigilance: 1Canada Vigilance
245GangreneCanada Vigilance: 1Canada Vigilance
246Gastrointestinal PainSIDER
247Graft dysfunctionOFFSIDES
248Guillain-Barre Syndrome11342351CTD
249Heart failure9322907CTD
250Hernia12115775CTD
251Herpes NOSSIDER
252HypereosinophiliaSIDER
253HypersomniaCanada Vigilance: 2Canada Vigilance
254IleusSIDER
255IncontinenceOFFSIDES
256InfarctionSIDER
257InfestationSIDER
258InflammationSIDER
259Infusion site reactionSIDER
260Leukopenia neonatalOFFSIDES
261LeukostasisOFFSIDES
262Lung Neoplasms21720004CTD
263Lymphoma, T-Cell, Cutaneous7948311CTD
264Lymphoplasmacytoid lymphoma/immunocytomaOFFSIDES
265MalnutritionSIDER
266Metabolic acidosisSIDER
267Microphthalmos12115775CTD
268MononeuritisOFFSIDES
269Muscle SpasticityCanada Vigilance: 1Canada Vigilance
270Musculoskeletal PainSIDER
271MyelitisOFFSIDES
272MyelodysplasiaOFFSIDES
273MyelosuppressionSIDER
274Necrosis9619762CTD
275NephrolithiasisCanada Vigilance: 2Canada Vigilance
276NeuritisSIDER
277Neutropenic colitisOFFSIDES
278Optic AtrophyOFFSIDES
279Optic NeuritisCanada Vigilance: 1Canada Vigilance
OFFSIDES
280Oral candidiasisSIDER
281Oral painCanada Vigilance: 1Canada Vigilance
282Oropharyngeal painCanada Vigilance: 1Canada Vigilance
283Pain of skinSIDER
284ParaparesisOFFSIDES
SIDER
285ParaplegiaOFFSIDES
286PericarditisCanada Vigilance: 1Canada Vigilance
287Peripheral Nervous System Diseases7949097
8726418
CTD
288Peripheral motor neuropathySIDER
289PetechiaeSIDER
290PharyngitisSIDER
291PhlebitisCanada Vigilance: 1Canada Vigilance
SIDER
292Pneumocystis jiroveci pneumoniaOFFSIDES
293PolyneuropathySIDER
294Poor quality product administeredCanada Vigilance: 1Canada Vigilance
295Primary Myelofibrosis15654901CTD
296Product storage errorCanada Vigilance: 1Canada Vigilance
297Productive CoughCanada Vigilance: 2Canada Vigilance
298Protein total decreasedOFFSIDES
299PruritusSIDER
300Pulmonary FibrosisSIDER
301PurpuraSIDER
302QuadriparesisSIDER
303RalesSIDER
304Rash erythematousSIDER
305RednessSIDER
306Reticulocyte count increasedOFFSIDES
307RhabdomyolysisOFFSIDES
308SepticemiaSIDER
309SomnolenceSIDER
310Stem cell transplantOFFSIDES
311Stevens-Johnson Syndrome25811541CTD
SIDER
312StressCanada Vigilance: 1Canada Vigilance
313SwellingSIDER
314Systemic Vasculitis12181031CTD
315T-Lymphocytopenia9684936CTD
316Thermal burnCanada Vigilance: 1Canada Vigilance
317ThrombosisSIDER
318Tooth LossCanada Vigilance: 1Canada Vigilance
319Toxic Epidermal NecrolysisSIDER
320Transaminases increasedOFFSIDES
321Treatment related secondary malignancyOFFSIDES
322Troponin increasedOFFSIDES
323Urinary tract infection enterococcalOFFSIDES
324UrticariaSIDER
325Vascular purpuraSIDER
326VasospasmCanada Vigilance: 1Canada Vigilance
327Visual ImpairmentCanada Vigilance: 1Canada Vigilance
328Waldenstrom Macroglobulinemia7948311
10721776
16432856
CTD
329WheezingSIDER
330nervous system disorderSIDER
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