MetaADEDB 2.0 @ LMMD
olaparib
(FDLYAMZZIXQODN-UHFFFAOYSA-N)
Structure
SMILES
O=C(N1CCN(CC1)C(=O)c1cc(ccc1F)Cc1n[nH]c(=O)c2c1cccc2)C1CC1
Type(s)
Approved
ATC code(s)
L01XX46
Molecular Formula:
C24H23FN4O3
Molecular Weight:
434.463
Log P:
2.2232
Hydrogen Bond Acceptor:
6
Hydrogen Bond Donor:
1
TPSA:
86.37
CAS Number(s):
763113-22-0; 937799-91-2
Synonym(s)
1.
olaparib
2.
AZD 2281
3.
AZD-2281
4.
AZD221
5.
AZD2281
6.
Lynparza
External Link(s)
MeSHC531550
PubChem Compound23725625
BindingDB27566
ChEBI83766
CHEMBLCHEMBL521686
DrugBankDB09074
DrugCentral4907
IUPHAR/BPS Guide to PHARMACOLOGY7519
KEGGdr:D09730
Therapeutic Target DatabaseD0J9HW
ZINC40430143
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1NauseaFAERS: 309
Canada Vigilance: 5
Canada Vigilance
US FAERS
2Malignant neoplasm progressionFAERS: 287
Canada Vigilance: 7
Canada Vigilance
US FAERS
3FatigueFAERS: 208
Canada Vigilance: 7
Canada Vigilance
US FAERS
4Product use issueFAERS: 132US FAERS
5VomitingFAERS: 132
Canada Vigilance: 2
Canada Vigilance
US FAERS
6Product use in unapproved indicationFAERS: 98
Canada Vigilance: 1
Canada Vigilance
US FAERS
7Disease ProgressionFAERS: 86US FAERS
8MYELODYSPLASTIC SYNDROMEFAERS: 55
Canada Vigilance: 1
Canada Vigilance
US FAERS
9MalaiseFAERS: 55US FAERS
10HeadacheFAERS: 47
Canada Vigilance: 1
Canada Vigilance
US FAERS
11ThrombocytopeniaFAERS: 47
Canada Vigilance: 5
Canada Vigilance
US FAERS
12AstheniaFAERS: 44
Canada Vigilance: 3
Canada Vigilance
US FAERS
13ArthralgiaFAERS: 40US FAERS
14PainFAERS: 39
Canada Vigilance: 1
Canada Vigilance
US FAERS
15ConstipationFAERS: 33US FAERS
16Abdominal discomfortFAERS: 32US FAERS
17Abdominal PainFAERS: 31
Canada Vigilance: 2
Canada Vigilance
US FAERS
18PancytopeniaFAERS: 30US FAERS
19DizzinessFAERS: 29
Canada Vigilance: 3
Canada Vigilance
US FAERS
20White blood cell count decreasedFAERS: 29
Canada Vigilance: 2
Canada Vigilance
US FAERS
21Blood creatinine increasedFAERS: 28
Canada Vigilance: 3
Canada Vigilance
US FAERS
22Drug ineffectiveFAERS: 26
Canada Vigilance: 2
Canada Vigilance
US FAERS
23DyspepsiaFAERS: 26US FAERS
24DysgeusiaFAERS: 25US FAERS
25Intestinal ObstructionFAERS: 24US FAERS
26Weight decreasedFAERS: 24
Canada Vigilance: 2
Canada Vigilance
US FAERS
27AscitesFAERS: 23US FAERS
28Back PainFAERS: 23US FAERS
29NeutropeniaFAERS: 23
Canada Vigilance: 3
Canada Vigilance
US FAERS
30PneumoniaFAERS: 23US FAERS
31IleusFAERS: 22US FAERS
32Intentional product misuseFAERS: 22US FAERS
33MyalgiaFAERS: 22US FAERS
34General physical health deteriorationFAERS: 19US FAERS
35DehydrationFAERS: 18
Canada Vigilance: 1
Canada Vigilance
US FAERS
36Drug dose omissionFAERS: 18US FAERS
37Peripheral swellingFAERS: 18
Canada Vigilance: 1
Canada Vigilance
US FAERS
38Disease recurrenceFAERS: 17
Canada Vigilance: 1
Canada Vigilance
US FAERS
39NasopharyngitisFAERS: 17US FAERS
40PruritusFAERS: 17US FAERS
41PneumonitisFAERS: 15
Canada Vigilance: 2
Canada Vigilance
US FAERS
42HaematotoxicityFAERS: 14US FAERS
43Neutrophil count decreasedFAERS: 13
Canada Vigilance: 1
Canada Vigilance
US FAERS
44Chest PainFAERS: 12US FAERS
45ChillsFAERS: 12US FAERS
46Toxicity to various agentsFAERS: 12US FAERS
47ErythemaFAERS: 11US FAERS
48Feeling abnormalFAERS: 11US FAERS
49MetastasisFAERS: 11US FAERS
50Product dose omissionFAERS: 11
Canada Vigilance: 1
Canada Vigilance
US FAERS
51Bone painFAERS: 10US FAERS
52Febrile NeutropeniaFAERS: 10US FAERS
53Full blood count decreasedFAERS: 10US FAERS
54InfluenzaFAERS: 10US FAERS
55Urinary tract infectionFAERS: 10US FAERS
56UrticariaFAERS: 10US FAERS
57AlopeciaFAERS: 9US FAERS
58Blood count abnormalFAERS: 9US FAERS
59HypersensitivityFAERS: 9
Canada Vigilance: 1
Canada Vigilance
US FAERS
60Memory impairmentFAERS: 9US FAERS
61SomnolenceFAERS: 9
Canada Vigilance: 1
Canada Vigilance
US FAERS
62Adverse eventFAERS: 8US FAERS
63Alanine Aminotransferase IncreasedFAERS: 8US FAERS
64Cerebrovascular accidentFAERS: 8
Canada Vigilance: 1
Canada Vigilance
US FAERS
65FlatulenceFAERS: 8US FAERS
66StomatitisFAERS: 8
Canada Vigilance: 1
Canada Vigilance
US FAERS
67Therapy cessationFAERS: 8US FAERS
68TremorFAERS: 8US FAERS
69Blood magnesium decreasedFAERS: 7US FAERS
70Drug resistanceFAERS: 7US FAERS
71Dry skinFAERS: 7US FAERS
72DysphoniaFAERS: 7US FAERS
73FlushingFAERS: 7US FAERS
74LeukopeniaFAERS: 7US FAERS
75Pancreatic carcinomaFAERS: 7US FAERS
76Product difficult to swallowFAERS: 7US FAERS
77Respiratory FailureFAERS: 7US FAERS
78Acute kidney injuryFAERS: 6US FAERS
79Aspartate Aminotransferase IncreasedFAERS: 6US FAERS
80Atrial FibrillationFAERS: 6US FAERS
81EpistaxisFAERS: 6US FAERS
82HypophagiaFAERS: 6US FAERS
83HypotensionFAERS: 6US FAERS
84InfectionFAERS: 6US FAERS
85Joint swellingFAERS: 6US FAERS
86LymphadenopathyFAERS: 6US FAERS
87AcneFAERS: 5US FAERS
88ArthritisFAERS: 5US FAERS
89Blood alkaline phosphatase increasedFAERS: 5US FAERS
90CataractFAERS: 5US FAERS
91CholelithiasisFAERS: 5US FAERS
92CytopeniaFAERS: 5US FAERS
93Erythema MultiformeFAERS: 5US FAERS
94InflammationFAERS: 5US FAERS
95RetchingFAERS: 5US FAERS
96Transaminases increasedFAERS: 5US FAERS
97Visual ImpairmentFAERS: 5US FAERS
98AngioedemaFAERS: 4US FAERS
99Blood glucose increasedFAERS: 4US FAERS
100Blood potassium decreasedFAERS: 4
Canada Vigilance: 1
Canada Vigilance
US FAERS
101BronchitisFAERS: 4US FAERS
102Cardiac discomfortFAERS: 4US FAERS
103Chest discomfortFAERS: 4US FAERS
104CystitisFAERS: 4US FAERS
105Deep Vein ThrombosisFAERS: 4US FAERS
106Escherichia infectionFAERS: 4US FAERS
107HypertransaminasaemiaFAERS: 4US FAERS
108Intestinal PerforationFAERS: 4US FAERS
109Metastases to pelvisFAERS: 4US FAERS
110Musculoskeletal stiffnessFAERS: 4US FAERS
111Neck PainFAERS: 4US FAERS
112No adverse eventFAERS: 4
Canada Vigilance: 1
Canada Vigilance
US FAERS
113Product use complaintFAERS: 4US FAERS
114treatment failureFAERS: 4US FAERS
115Acquired gene mutationFAERS: 3US FAERS
116AnxietyFAERS: 3US FAERS
117AtaxiaFAERS: 3US FAERS
118Blast cell count increasedFAERS: 3US FAERS
119Blood electrolytes decreasedFAERS: 3US FAERS
120CellulitisFAERS: 3US FAERS
121Circumstance or information capable of leading to medication errorFAERS: 3US FAERS
122DiverticulitisFAERS: 3US FAERS
123DysuriaFAERS: 3US FAERS
124EructationFAERS: 3US FAERS
125FractureFAERS: 3US FAERS
126Gamma-Glutamyltransferase IncreasedFAERS: 3US FAERS
127HepatotoxicityFAERS: 3US FAERS
128Histiocytosis haematophagicFAERS: 3US FAERS
129HypokinesiaFAERS: 3US FAERS
130Intentional product use issueFAERS: 3US FAERS
131Lip swellingFAERS: 3US FAERS
132Lymphangiosis carcinomatosaFAERS: 3US FAERS
133Lymphocyte count decreasedFAERS: 3US FAERS
134MeningitisFAERS: 3US FAERS
135Metastases to abdominal cavityFAERS: 3US FAERS
136Musculoskeletal PainFAERS: 3US FAERS
137Myocardial InfarctionFAERS: 3US FAERS
138NeuralgiaFAERS: 3US FAERS
139Night sweatsFAERS: 3US FAERS
140NoduleFAERS: 3US FAERS
141Oral painFAERS: 3US FAERS
142Oropharyngeal painFAERS: 3US FAERS
143Pericardial effusionFAERS: 3US FAERS
144Physical deconditioningFAERS: 3US FAERS
145Product storage errorFAERS: 3US FAERS
146Pulmonary EmbolismFAERS: 3US FAERS
147RestlessnessFAERS: 3US FAERS
148RhinitisFAERS: 3US FAERS
149SepsisFAERS: 3
Canada Vigilance: 1
Canada Vigilance
US FAERS
150StressFAERS: 3US FAERS
151SubileusFAERS: 3US FAERS
152SwellingFAERS: 3US FAERS
153SyncopeFAERS: 3US FAERS
154ThirstFAERS: 3US FAERS
155Throat irritationFAERS: 3US FAERS
156ThrombosisFAERS: 3US FAERS
157Upper-airway cough syndromeFAERS: 3US FAERS
158VasculitisFAERS: 3US FAERS
159AbscessFAERS: 2US FAERS
160AgitationFAERS: 2US FAERS
161AphasiaFAERS: 2US FAERS
162Biliary dilatationFAERS: 2US FAERS
163Blood creatinine decreasedFAERS: 2US FAERS
164Blood iron decreasedFAERS: 2US FAERS
165Bone marrow toxicityFAERS: 2US FAERS
166Cerebral disorderFAERS: 2US FAERS
167Clostridium difficile infectionFAERS: 2US FAERS
168ColitisFAERS: 2
Canada Vigilance: 1
Canada Vigilance
US FAERS
169CystFAERS: 2US FAERS
170DermatomyositisFAERS: 2US FAERS
171DiscomfortFAERS: 2US FAERS
172EcchymosisFAERS: 2US FAERS
173Electrolyte imbalanceFAERS: 2US FAERS
174EmbolismFAERS: 2US FAERS
175Emotional disorderFAERS: 2US FAERS
176EncephalitisFAERS: 2US FAERS
177ErythroblastosisFAERS: 2US FAERS
178Febrile infectionFAERS: 2US FAERS
179Food PoisoningFAERS: 2US FAERS
180Full blood count abnormalFAERS: 2US FAERS
181GastritisFAERS: 2US FAERS
182HordeolumFAERS: 2US FAERS
183HungerFAERS: 2US FAERS
184HypersomniaFAERS: 2US FAERS
185Incorrect dose administeredFAERS: 2US FAERS
186Intestinal metastasisFAERS: 2US FAERS
187Large intestinal stenosisFAERS: 2US FAERS
188Limb discomfortFAERS: 2US FAERS
189Lower respiratory tract infectionFAERS: 2US FAERS
190LymphoceleFAERS: 2US FAERS
191Musculoskeletal chest painFAERS: 2US FAERS
192ObesityFAERS: 2US FAERS
193Oncologic complicationFAERS: 2US FAERS
194OnychoclasisFAERS: 2US FAERS
195Ovarian cancer stage IVFAERS: 2US FAERS
196Platelet count abnormalFAERS: 2US FAERS
197PleurisyFAERS: 2US FAERS
198Product administration interruptedFAERS: 2US FAERS
199Product quality issueFAERS: 2US FAERS
200Product used for unknown indicationFAERS: 2US FAERS
201Productive CoughFAERS: 2US FAERS
202Prostatic specific antigen decreasedFAERS: 2US FAERS
203Pulmonary congestionFAERS: 2US FAERS
204PyelonephritisFAERS: 2US FAERS
205Red blood cell nucleated morphology presentFAERS: 2US FAERS
206Refractory cytopenia with multilineage dysplasiaFAERS: 2US FAERS
207SneezingFAERS: 2US FAERS
208SunburnFAERS: 2US FAERS
209White blood cell count abnormalFAERS: 2US FAERS
210Wrong technique in product usage processFAERS: 2US FAERS
211Abdominal InfectionFAERS: 1US FAERS
212Abdominal adhesionsFAERS: 1US FAERS
213Abdominal massFAERS: 1US FAERS
214Abdominal tendernessFAERS: 1US FAERS
215Accidental exposure to productFAERS: 1US FAERS
216Acute myocardial infarctionFAERS: 1US FAERS
217Acute respiratory failureFAERS: 1US FAERS
218AgeusiaFAERS: 1US FAERS
219AmnesiaFAERS: 1US FAERS
220Anal FistulaFAERS: 1US FAERS
221Anaphylactic shockFAERS: 1US FAERS
222Anaphylactoid ReactionFAERS: 1US FAERS
223AphoniaFAERS: 1US FAERS
224AppendicitisFAERS: 1US FAERS
225AsthmaFAERS: 1US FAERS
226BRCA1 gene mutationFAERS: 1US FAERS
227Bacterial test positiveFAERS: 1US FAERS
228Basal cell carcinomaFAERS: 1US FAERS
229Biliary sepsisFAERS: 1US FAERS
230BlindnessFAERS: 1US FAERS
231Blood chloride decreasedFAERS: 1US FAERS
232Blood cholesterol increasedFAERS: 1US FAERS
233Blood creatine abnormalFAERS: 1US FAERS
234Blood creatine increasedFAERS: 1US FAERS
235Blood creatine phosphokinase increasedFAERS: 1US FAERS
236Blood glucose decreasedFAERS: 1US FAERS
237Blood potassium increasedFAERS: 1US FAERS
238Blood sodium abnormalFAERS: 1US FAERS
239Blood sodium decreasedFAERS: 1US FAERS
240Blood thyroid stimulating hormone decreasedFAERS: 1US FAERS
241Blood thyroid stimulating hormone increasedFAERS: 1US FAERS
242Blood urea increasedFAERS: 1US FAERS
243Brain scan abnormalFAERS: 1US FAERS
244BronchopneumopathyFAERS: 1US FAERS
245Bronchopulmonary AspergillosisFAERS: 1US FAERS
246Burning sensationFAERS: 1US FAERS
247Carbohydrate antigen 15-3 increasedFAERS: 1US FAERS
248Carbohydrate antigen 19-9 increasedFAERS: 1US FAERS
249Cardiac ArrestFAERS: 1US FAERS
250Cardiac TamponadeFAERS: 1US FAERS
251Cardiac dysfunctionFAERS: 1US FAERS
252CheilitisFAERS: 1US FAERS
253ChromaturiaFAERS: 1US FAERS
254Colon cancer recurrentFAERS: 1US FAERS
255Creatinine renal clearance decreasedFAERS: 1US FAERS
256CystoceleFAERS: 1US FAERS
257Cytokine Release SyndromeFAERS: 1US FAERS
258Dark circles under eyesFAERS: 1US FAERS
259DeafnessFAERS: 1US FAERS
260Dental Restoration FailureFAERS: 1US FAERS
261DermatitisFAERS: 1US FAERS
262Diabetes MellitusFAERS: 1US FAERS
263DisorientationFAERS: 1US FAERS
264Drug abuseFAERS: 1US FAERS
265Drug dispensing errorFAERS: 1US FAERS
266Drug effect delayedFAERS: 1US FAERS
267Drug effect incompleteFAERS: 1US FAERS
268Drug effective for unapproved indicationFAERS: 1US FAERS
269Drug ineffective for unapproved indicationFAERS: 1US FAERS
270Ear discomfortFAERS: 1US FAERS
271EmpyemaFAERS: 1US FAERS
272EnteritisFAERS: 1US FAERS
273Escherichia sepsisFAERS: 1US FAERS
274EuthanasiaFAERS: 1US FAERS
275Feeling ColdFAERS: 1US FAERS
276Feeling of body temperature changeFAERS: 1US FAERS
277Flank PainFAERS: 1US FAERS
278Fluid overloadFAERS: 1US FAERS
279FrustrationFAERS: 1US FAERS
280Full blood count increasedFAERS: 1US FAERS
281Gastric ulcerFAERS: 1US FAERS
282GastroenteritisFAERS: 1US FAERS
283Gastrointestinal infectionFAERS: 1US FAERS
284Gastrointestinal toxicityFAERS: 1US FAERS
285Gastrostomy tube site complicationFAERS: 1US FAERS
286General physical condition abnormalFAERS: 1US FAERS
287Genital dischargeFAERS: 1US FAERS
288GoutFAERS: 1US FAERS
289Granuloma AnnulareFAERS: 1US FAERS
290HemiparesisFAERS: 1US FAERS
291Hepatic InfarctionFAERS: 1US FAERS
292HepatitisFAERS: 1US FAERS
293Hernial eventrationFAERS: 1US FAERS
294HyperacusisFAERS: 1US FAERS
295HyperchlorhydriaFAERS: 1US FAERS
296HypermetabolismFAERS: 1US FAERS
297HyperphagiaFAERS: 1US FAERS
298Hypertrophic CardiomyopathyFAERS: 1US FAERS
299Immune thrombocytopenic purpuraFAERS: 1US FAERS
300IncontinenceFAERS: 1US FAERS
301Intra-abdominal fluid collectionFAERS: 1US FAERS
302Intracranial AneurysmFAERS: 1US FAERS
303Investigation abnormalFAERS: 1US FAERS
304LacerationFAERS: 1US FAERS
305LaryngitisFAERS: 1US FAERS
306LethargyFAERS: 1US FAERS
307Limb injuryFAERS: 1US FAERS
308Loss of personal independence in daily activitiesFAERS: 1US FAERS
309Lyme DiseaseFAERS: 1US FAERS
310LymphopeniaFAERS: 1US FAERS
311MacrocytosisFAERS: 1US FAERS
312Malignant Bowel ObstructionFAERS: 1US FAERS
313Malignant ascitesFAERS: 1US FAERS
314Malignant neoplasm of uterine adnexaFAERS: 1US FAERS
315MalnutritionFAERS: 1US FAERS
316Mental status changesFAERS: 1US FAERS
317Metastases to abdominal wallFAERS: 1US FAERS
318Metastases to adrenalsFAERS: 1US FAERS
319Metastases to stomachFAERS: 1US FAERS
320Metastases to thoraxFAERS: 1US FAERS
321Metastatic NeoplasmFAERS: 1US FAERS
322Mouth swellingFAERS: 1US FAERS
323Multiple SclerosisFAERS: 1US FAERS
324Muscle tightnessFAERS: 1US FAERS
325ObstructionFAERS: 1US FAERS
326Optic NeuritisFAERS: 1US FAERS
327OsteoporosisFAERS: 1US FAERS
328Ovarian cancer stage IIIFAERS: 1US FAERS
329Pain of skinFAERS: 1US FAERS
330PallorFAERS: 1US FAERS
331Pancreatic carcinoma recurrentFAERS: 1US FAERS
332PancreatitisFAERS: 1US FAERS
333Paranasal sinus discomfortFAERS: 1US FAERS
334Pelvic PainFAERS: 1US FAERS
335PericarditisFAERS: 1US FAERS
336PeritonitisFAERS: 1US FAERS
337Platelet TransfusionFAERS: 1US FAERS
338PneumothoraxFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
339PolyarthritisFAERS: 1US FAERS
340PolyneuropathyFAERS: 1US FAERS
341Portal HypertensionFAERS: 1US FAERS
342Post procedural complicationFAERS: 1US FAERS
343Postoperative ileusFAERS: 1US FAERS
344PresyncopeFAERS: 1US FAERS
345Product administration errorFAERS: 1US FAERS
346Product dispensing errorFAERS: 1US FAERS
347Product physical issueFAERS: 1US FAERS
348Product preparation errorFAERS: 1US FAERS
349Product prescribing errorFAERS: 1US FAERS
350Product prescribing issueFAERS: 1US FAERS
351Product taste abnormalFAERS: 1US FAERS
352Prostate cancer recurrentFAERS: 1US FAERS
353Pulmonary FibrosisFAERS: 1US FAERS
354Pulmonary thrombosisFAERS: 1US FAERS
355Radiation associated painFAERS: 1US FAERS
356Radiation skin injuryFAERS: 1US FAERS
357Rash erythematousFAERS: 1US FAERS
358Red blood cell schistocytes presentFAERS: 1US FAERS
359Refractory cancerFAERS: 1US FAERS
360RegurgitationFAERS: 1US FAERS
361Renal cystFAERS: 1US FAERS
362Respiratory distressFAERS: 1US FAERS
363Respiratory tract congestionFAERS: 1US FAERS
364Restless Legs SyndromeFAERS: 1US FAERS
365Reticulocyte count decreasedFAERS: 1US FAERS
366SciaticaFAERS: 1US FAERS
367Sinus TachycardiaFAERS: 1US FAERS
368SinusitisFAERS: 1US FAERS
369Skin PapillomaFAERS: 1US FAERS
370Skin irritationFAERS: 1US FAERS
371Skin lacerationFAERS: 1US FAERS
372Skin reactionFAERS: 1US FAERS
373Skin tightnessFAERS: 1US FAERS
374Skin toxicityFAERS: 1US FAERS
375Splenic InfarctionFAERS: 1US FAERS
376Superior Vena Cava SyndromeFAERS: 1US FAERS
377TachycardiaFAERS: 1US FAERS
378Temperature intoleranceFAERS: 1US FAERS
379Therapeutic response changedFAERS: 1US FAERS
380Therapeutic response unexpectedFAERS: 1US FAERS
381Therapy non-responderFAERS: 1US FAERS
382Therapy partial responderFAERS: 1US FAERS
383TinnitusFAERS: 1US FAERS
384Tongue blisteringFAERS: 1US FAERS
385ToothacheFAERS: 1US FAERS
386Tumour haemorrhageFAERS: 1US FAERS
387Urinary IncontinenceFAERS: 1US FAERS
388Vaginal DischargeFAERS: 1US FAERS
389Ventricular FibrillationFAERS: 1US FAERS
390Viral upper respiratory tract infectionFAERS: 1US FAERS
391Vulvovaginal painFAERS: 1US FAERS
392Waist circumference increasedFAERS: 1US FAERS
393WheezingFAERS: 1US FAERS
394furuncleFAERS: 1US FAERS
395Therapy changeCanada Vigilance: 1Canada Vigilance
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