MetaADEDB 2.0 @ LMMD
Busulfan
(COVZYZSDYWQREU-UHFFFAOYSA-N)
Structure
SMILES
CS(=O)(=O)OCCCCOS(=O)(=O)C
Type(s)
Approved; Investigational
ATC code(s)
L01AB01
Molecular Formula:
C6H14O6S2
Molecular Weight:
246.302
Log P:
1.8806
Hydrogen Bond Acceptor:
6
Hydrogen Bond Donor:
0
TPSA:
103.5
CAS Number(s):
55-98-1
Synonym(s)
1.
Busulfan
2.
Busulphan
3.
Busulfan Wellcome
4.
Busulfex
5.
Glyzophrol
6.
Myelosan
7.
Mylecytan
8.
Myleran
9.
Myléran
10.
n-Butane-1,3-di(methylsulfonate)
11.
Wellcome, Busulfan
External Link(s)
MeSHD002066
PubChem Compound2478
BindingDB50237623
ChEBI28901
CHEMBLCHEMBL820
DrugBankDB01008
DrugCentral438
IUPHAR/BPS Guide to PHARMACOLOGY7136
KEGGcpd:C06862
dr:D00248
Therapeutic Target DatabaseD07SUG
ZINC1530572
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Ovarian failureFAERS: 20OFFSIDES
US FAERS
2StomatitisFAERS: 1911019834CTD
SIDER
US FAERS
3SepsisFAERS: 18SIDER
US FAERS
4NauseaFAERS: 17OFFSIDES
SIDER
US FAERS
5NeutropeniaFAERS: 1316543071CTD
SIDER
US FAERS
6AnorexiaFAERS: 12OFFSIDES
SIDER
US FAERS
7VomitingFAERS: 12
Canada Vigilance: 1		9544829CTD
SIDER
Canada Vigilance
US FAERS
8Febrile NeutropeniaFAERS: 11OFFSIDES
SIDER
US FAERS
9MalaiseFAERS: 11US FAERS
10ThrombocytopeniaFAERS: 11
Canada Vigilance: 3		4691200
16543071		CTD
SIDER
Canada Vigilance
US FAERS
11Product use in unapproved indicationFAERS: 10US FAERS
12Venoocclusive diseaseFAERS: 10OFFSIDES
SIDER
US FAERS
13Deep Vein ThrombosisFAERS: 7US FAERS
14Disease recurrenceFAERS: 7OFFSIDES
US FAERS
15Bone marrow transplant rejectionFAERS: 6OFFSIDES
US FAERS
16Disease ProgressionFAERS: 6OFFSIDES
US FAERS
17FatigueFAERS: 6SIDER
US FAERS
18PneumoniaFAERS: 6SIDER
US FAERS
19Blood lactate dehydrogenase increasedFAERS: 5US FAERS
20Drug administration errorFAERS: 5US FAERS
21General physical health deteriorationFAERS: 5US FAERS
22No adverse eventFAERS: 5US FAERS
23Pneumocystis jiroveci pneumoniaFAERS: 5US FAERS
24Respiratory FailureFAERS: 5SIDER
US FAERS
25Alanine Aminotransferase IncreasedFAERS: 4SIDER
US FAERS
26AscitesFAERS: 4267281
1958475		CTD
OFFSIDES
SIDER
US FAERS
27AstheniaFAERS: 4SIDER
US FAERS
28HypotensionFAERS: 4SIDER
US FAERS
29Mental status changesFAERS: 4US FAERS
30Product quality issueFAERS: 4US FAERS
31Pulmonary HypertensionFAERS: 4OFFSIDES
US FAERS
32Septic ShockFAERS: 4US FAERS
33Stem cell transplantFAERS: 4OFFSIDES
US FAERS
34TachycardiaFAERS: 4SIDER
US FAERS
35Aspartate Aminotransferase IncreasedFAERS: 3SIDER
US FAERS
36Bronchopulmonary AspergillosisFAERS: 3US FAERS
37Cardiac ArrestFAERS: 3US FAERS
38Disseminated Intravascular CoagulationFAERS: 3OFFSIDES
US FAERS
39DizzinessFAERS: 3SIDER
US FAERS
40Drug ineffectiveFAERS: 3OFFSIDES
US FAERS
41Engraft failureFAERS: 3OFFSIDES
US FAERS
42EpilepsyFAERS: 32041395CTD
US FAERS
43Gamma-Glutamyltransferase IncreasedFAERS: 3OFFSIDES
SIDER
US FAERS
44HeadacheFAERS: 3SIDER
US FAERS
45HepatomegalyFAERS: 3SIDER
US FAERS
46HypoxiaFAERS: 3SIDER
US FAERS
47InfectionFAERS: 3OFFSIDES
SIDER
US FAERS
48Multiple MyelomaFAERS: 310955873CTD
US FAERS
49Neutrophil count decreasedFAERS: 3US FAERS
50PhlebitisFAERS: 3US FAERS
51Product depositFAERS: 3US FAERS
52Respiratory distressFAERS: 3US FAERS
53ShockFAERS: 3US FAERS
54SyncopeFAERS: 3US FAERS
55Toxicity to various agentsFAERS: 3US FAERS
56White blood cell count decreasedFAERS: 3US FAERS
57Acute respiratory failureFAERS: 2US FAERS
58Autoimmune hepatitisFAERS: 2US FAERS
59Blood stem cell transplant failureFAERS: 2US FAERS
60Candida sepsisFAERS: 2OFFSIDES
US FAERS
61Complications of bone marrow transplantFAERS: 2OFFSIDES
US FAERS
62Cord blood transplant therapyFAERS: 2OFFSIDES
US FAERS
63Device related infectionFAERS: 2OFFSIDES
US FAERS
64Drug toxicityFAERS: 2OFFSIDES
US FAERS
65GastritisFAERS: 2US FAERS
66Injection site extravasationFAERS: 2US FAERS
67LeukocytosisFAERS: 2US FAERS
68PeritonitisFAERS: 2US FAERS
69PolyneuropathyFAERS: 2US FAERS
70Premature MenopauseFAERS: 2US FAERS
71Product storage errorFAERS: 2US FAERS
72Product use issueFAERS: 2US FAERS
73Skin irritationFAERS: 2US FAERS
74Stenotrophomonas infectionFAERS: 2OFFSIDES
US FAERS
75Sudden deathFAERS: 2US FAERS
76Therapeutic response unexpectedFAERS: 2US FAERS
77Urinary IncontinenceFAERS: 2US FAERS
78VasculitisFAERS: 2US FAERS
79Abdominal PainFAERS: 13376924CTD
SIDER
US FAERS
80Accidental exposureFAERS: 1US FAERS
81Accidental overdoseFAERS: 1US FAERS
82Acute graft versus host disease in intestineFAERS: 1OFFSIDES
US FAERS
83Adverse eventFAERS: 1US FAERS
84AgeusiaFAERS: 1US FAERS
85Altered state of consciousnessFAERS: 1US FAERS
86AmnesiaFAERS: 1US FAERS
87Anaphylactic shockFAERS: 1US FAERS
88Aphthous StomatitisFAERS: 1OFFSIDES
US FAERS
89Arterial InjuryFAERS: 1US FAERS
90AspergillosisFAERS: 1US FAERS
91Autoimmune thrombocytopeniaFAERS: 1US FAERS
92BK virus infectionFAERS: 1OFFSIDES
US FAERS
93Back PainFAERS: 1SIDER
US FAERS
94Bacterial sepsisFAERS: 1OFFSIDES
US FAERS
95Bence Jones protein urine presentFAERS: 1US FAERS
96Blood alkaline phosphatase increasedFAERS: 1US FAERS
97Blood follicle stimulating hormone increasedFAERS: 1US FAERS
98Blood glucose increasedFAERS: 1US FAERS
99Blood pH increasedFAERS: 1US FAERS
100BronchiectasisFAERS: 1OFFSIDES
US FAERS
101BronchopneumoniaFAERS: 1US FAERS
102CandidiasisFAERS: 1US FAERS
103Capillary Leak SyndromeFAERS: 1OFFSIDES
SIDER
US FAERS
104CardiomegalyFAERS: 1SIDER
US FAERS
105CardiotoxicityFAERS: 1US FAERS
106Catheter related complicationFAERS: 1US FAERS
107Cerebrovascular accidentFAERS: 1US FAERS
108Chemical burn of skinFAERS: 1US FAERS
109CholecystitisFAERS: 17612498CTD
US FAERS
110Circumstance or information capable of leading to medication errorFAERS: 1US FAERS
111Clostridium colitisFAERS: 1US FAERS
112Coagulation factor XIII level decreasedFAERS: 1US FAERS
113CytopeniaFAERS: 1SIDER
US FAERS
114DeafnessFAERS: 1US FAERS
115DehydrationFAERS: 1US FAERS
116Diabetes MellitusFAERS: 1US FAERS
117Drug abuseFAERS: 1US FAERS
118Drug dispensing errorFAERS: 1US FAERS
119Drug dose omissionFAERS: 1US FAERS
120DysuriaFAERS: 112913734CTD
SIDER
US FAERS
121EchopraxiaFAERS: 1US FAERS
122Electrocardiogram abnormalFAERS: 1US FAERS
123Electroencephalogram abnormalFAERS: 1US FAERS
124EnteritisFAERS: 1OFFSIDES
US FAERS
125EnterocolitisFAERS: 1US FAERS
126Escherichia urinary tract infectionFAERS: 1US FAERS
127ExtravasationFAERS: 1SIDER
US FAERS
128GastroenteritisFAERS: 1US FAERS
129Gastrointestinal candidiasisFAERS: 1US FAERS
130GlossoptosisFAERS: 1US FAERS
131Graft versus host disease in intestineFAERS: 1US FAERS
132Hepatic congestionFAERS: 1OFFSIDES
US FAERS
133Hepatic vein occlusionFAERS: 1US FAERS
134HepatotoxicityFAERS: 1OFFSIDES
US FAERS
135HypogonadismFAERS: 1SIDER
US FAERS
136HypothyroidismFAERS: 1US FAERS
137Immune reconstitution syndromeFAERS: 1OFFSIDES
US FAERS
138ImmunosuppressionFAERS: 1US FAERS
139Incorrect dose administeredFAERS: 1US FAERS
140Incorrect product administration durationFAERS: 1US FAERS
141Insurance issueFAERS: 1US FAERS
142Intentional drug misuseFAERS: 1US FAERS
143Klebsiella sepsisFAERS: 1US FAERS
144Lung infection pseudomonalFAERS: 1OFFSIDES
US FAERS
145Lymphocyte count decreasedFAERS: 1US FAERS
146MYELODYSPLASTIC SYNDROMEFAERS: 1US FAERS
147Mallory-Weiss SyndromeFAERS: 1US FAERS
148Medical device complicationFAERS: 1US FAERS
149MyopathyFAERS: 1US FAERS
150Neurological decompensationFAERS: 1US FAERS
151OsteolysisFAERS: 1US FAERS
152OsteopeniaFAERS: 1US FAERS
153OsteoporosisFAERS: 1OFFSIDES
US FAERS
154OverdoseFAERS: 1US FAERS
155PancreatitisFAERS: 1SIDER
US FAERS
156PancytopeniaFAERS: 1
Canada Vigilance: 1		3165601
9051142
20102258		CTD
SIDER
Canada Vigilance
US FAERS
157Performance status decreasedFAERS: 1US FAERS
158Perianal abscessFAERS: 1US FAERS
159Pharyngitis bacterialFAERS: 1US FAERS
160PharyngitisFAERS: 1SIDER
US FAERS
161PneumonitisFAERS: 1US FAERS
162PneumothoraxFAERS: 1SIDER
US FAERS
163Poor quality drug administeredFAERS: 1US FAERS
164Post procedural complicationFAERS: 1US FAERS
165PruritusFAERS: 1SIDER
US FAERS
166Pseudomonal sepsisFAERS: 1US FAERS
167Pulmonary EmbolismFAERS: 1US FAERS
168Pulmonary FibrosisFAERS: 1
Canada Vigilance: 1		4301103CTD
SIDER
Canada Vigilance
US FAERS
169Pulmonary arterial hypertensionFAERS: 1OFFSIDES
US FAERS
170Pulmonary congestionFAERS: 1US FAERS
171Pulmonary microemboliFAERS: 1US FAERS
172Pulmonary toxicityFAERS: 1SIDER
US FAERS
173Pulmonary vein occlusionFAERS: 1US FAERS
174Respiratory arrestFAERS: 1US FAERS
175Skin UlcerFAERS: 1US FAERS
176Skin lesionFAERS: 1US FAERS
177Staphylococcal pharyngitisFAERS: 1US FAERS
178Therapy changeFAERS: 1US FAERS
179Thrombocytopenic purpuraFAERS: 1US FAERS
180Transaminases increasedFAERS: 1SIDER
US FAERS
181Transplantation complicationFAERS: 1US FAERS
182Urinary tract infectionFAERS: 1US FAERS
183Ventricular hypertrophyFAERS: 1US FAERS
184pseudomembranous colitisFAERS: 1US FAERS
185treatment failureFAERS: 1OFFSIDES
US FAERS
186Abdominal massOFFSIDES
187Abdominal tendernessOFFSIDES
188Abnormalities, Drug-Induced17290349CTD
189Acid fast bacilli infectionOFFSIDES
190Acute graft versus host disease in liverOFFSIDES
191AgitationSIDER
192AgranulocytosisSIDER
193Alopecia10523796CTD
OFFSIDES
SIDER
194AmenorrheaOFFSIDES
195AmphetaminesOFFSIDES
196Anal discomfortSIDER
197Angiotensin converting enzyme increasedOFFSIDES
198AnhidrosisSIDER
199Anorectal discomfortSIDER
200Anti-thyroid antibody positiveOFFSIDES
201AnxietySIDER
202Aortic AneurysmOFFSIDES
203ApathyOFFSIDES
204ApneaOFFSIDES
205Arterial thrombosisOFFSIDES
206ArthralgiaSIDER
207AsthmaOFFSIDES
SIDER
208AtelectasisSIDER
209Atrial FibrillationSIDER
210Atrial arrhythmiaSIDER
211B-lymphocyte abnormalitiesOFFSIDES
212Basal ganglion degenerationOFFSIDES
213Bladder painSIDER
214Bladder spasmOFFSIDES
215Blood Platelet Disorders4930389CTD
216Blood and lymphatic system disordersSIDER
217Blood bilirubin abnormalOFFSIDES
218Blood bilirubin unconjugated increasedOFFSIDES
219Blood creatine phosphokinase MB increasedOFFSIDES
220Blood creatinine increasedSIDER
221Blood fibrinogenOFFSIDES
222Blood glucose fluctuationOFFSIDES
223Blood immunoglobulin G increasedOFFSIDES
224Blood magnesium decreasedOFFSIDES
225Blood sodiumOFFSIDES
226Blood urea increasedSIDER
227Blood uric acidOFFSIDES
228Bone Marrow Diseases119414
11917947		CTD
229Bone SarcomaOFFSIDES
230Bone marrow depressionOFFSIDES
SIDER
231Bone scan abnormalOFFSIDES
232BradycardiaSIDER
233Brain AbscessOFFSIDES
234Brain scan abnormalOFFSIDES
235Bronchoalveolar LavageOFFSIDES
236Bronchoalveolar lavage abnormalOFFSIDES
237CSF bacteria identifiedOFFSIDES
238Cardiac TamponadeSIDER
239Cardiomyopathies1054099CTD
240Cataract operationOFFSIDES
241CataractOFFSIDES
SIDER
242Catheter sepsisOFFSIDES
243Cervical laser therapyOFFSIDES
244CheilosisSIDER
245Chemical and Drug Induced Liver Injury

View details

267281
272822
2344115
3332186
3376924
8640171
10523796
11019834
11551021
12134100
12374454
14595385
15886082
17132762
28437613
 		CTD
246Chest PainSIDER
247ChillsSIDER
248ChimerismOFFSIDES
249CholangiolitisOFFSIDES
250Cholestasis3376924CTD
251Chronic Obstructive Airway DiseaseOFFSIDES
252ColectomyOFFSIDES
253Colon adenomaOFFSIDES
254Congenital tricuspid valve incompetenceOFFSIDES
255ConstipationSIDER
256Corneal thinningSIDER
257Creatinine increasedSIDER
258Cutaneous CandidiasisOFFSIDES
259Cystitis viralOFFSIDES
260Cystitis

View details

3332186
6576177
7269015
14625581
 		CTD
SIDER
261Cytomegalovirus chorioretinitisOFFSIDES
262Cytomegalovirus enterocolitisOFFSIDES
263Cytomegalovirus gastroenteritisOFFSIDES
264Cytomegalovirus test positiveOFFSIDES
265Deafness NeurosensoryOFFSIDES
266Delayed PubertyOFFSIDES
SIDER
267DeliriumSIDER
268DemyelinationOFFSIDES
269Denervation atrophyOFFSIDES
270Dental cariesOFFSIDES
271DermatitisSIDER
272Diabetes InsipidusOFFSIDES
273Diarrhea11019834CTD
OFFSIDES
274Discomfort rectalSIDER
275DiverticulosisOFFSIDES
276Drug Overdose2226734CTD
277Dry coughSIDER
278DyspepsiaSIDER
279DysphemiaOFFSIDES
280DysplasiaSIDER
281Dystrophic calcificationSIDER
282Ejection Fraction DecreasedSIDER
283EncephalitisOFFSIDES
284Endometrial Neoplasms6595258CTD
285Enlargement abdomenSIDER
286Enterococcal sepsisOFFSIDES
287Eosinophil percentage increasedOFFSIDES
288Eosinophilic pustular folliculitisOFFSIDES
289Epidural AbscessOFFSIDES
290EpistaxisSIDER
291Erectile dysfunctionSIDER
292Erythema MultiformeOFFSIDES
SIDER
293Erythema NodosumSIDER
294ErythemaOFFSIDES
SIDER
295Esophageal and Gastric Varices267281
2889964		CTD
296Failure to ThriveOFFSIDES
297Febrile infectionOFFSIDES
298Feeling abnormalSIDER
299Femoral artery thrombosisSIDER
300Fetal Growth Retardation17290349CTD
301Fever3376924CTD
302Fibrosis1054099
2635285		CTD
SIDER
303Fluid imbalanceOFFSIDES
304Fluid overloadSIDER
305FlushingSIDER
306Focal Nodular Hyperplasia15886082CTD
OFFSIDES
307Gastrointestinal Diseases10955873CTD
308Gastrointestinal Hemorrhage2889964CTD
309Gastrointestinal PainSIDER
310Gastrointestinal endoscopic therapyOFFSIDES
311Gastrointestinal mucosal exfoliationOFFSIDES
312Gastrointestinal toxicityOFFSIDES
313Gene MutationOFFSIDES
314GlossitisSIDER
315Graft dysfunctionOFFSIDES
316Graft lossOFFSIDES
317Granulocytes abnormalOFFSIDES
318Granulomatous liver diseaseOFFSIDES
319Heart Diseases2635285CTD
320Hematologic Neoplasms11019834
12374454
20861613		CTD
321Hematuria12913734
28744217		CTD
322HemiparesisOFFSIDES
323Hemorrhage6576177
7269015
12913734		CTD
324Hemorrhagic Disorders14625581CTD
325Hepatic Veno-Occlusive Disease

View details

1908340
2314142
2344115
3332186
8640171
10523796
10534061
11019834
11551021
12134100
12374454
12476274
12966370
14595385
14986274
15580502
17132762
18022574
18587430
18776081
19767780
20919852
 		CTD
326Hepatic necrosisOFFSIDES
SIDER
327Hepatitis COFFSIDES
328HepatosplenomegalyOFFSIDES
329HiccoughOFFSIDES
330Hodgkin Disease10955873CTD
331Human polyomavirus infectionOFFSIDES
332Hyperplasia2889964CTD
333HypersensitivitySIDER
334Hypertrophic CardiomyopathyOFFSIDES
335HyperventilationSIDER
336Ileal StenosisOFFSIDES
337IleusSIDER
338InfertilitySIDER
339InfestationSIDER
340InflammationSIDER
341Injection site inflammationSIDER
342Injection site painSIDER
343Intention tremorOFFSIDES
344Intestinal ObstructionOFFSIDES
345IntubationOFFSIDES
346Jaundice, Obstructive5278972
5280623		CTD
347Kidney Diseases10955873CTD
348Kidney FailureOFFSIDES
349LethargySIDER
350Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative1349249CTD
351Leukocyte Disorders2273607CTD
352Leukopenia3332186CTD
SIDER
353LeukoplakiaOFFSIDES
354LichenificationOFFSIDES
355Liver diseases10955873CTD
356Liver palpable subcostalOFFSIDES
357Lung Diseases, Interstitial10523796CTD
358Lung cystOFFSIDES
359Lymphoma, Non-Hodgkin10955873
19767780		CTD
360LymphomaOFFSIDES
SIDER
361Malignant neoplasm progressionOFFSIDES
362MalnutritionSIDER
363Medulloblastoma14595385CTD
364MeningiomaOFFSIDES
365MenopauseSIDER
366Microcephaly17290349CTD
367Microphthalmos17290349CTD
368Mucoepidermoid CarcinomaOFFSIDES
369Multi-organ disorderOFFSIDES
370Musculoskeletal discomfortSIDER
371Mutagenic effectOFFSIDES
372MyalgiaSIDER
373Myasthenia Gravis119414
5244541		CTD
SIDER
374Mycobacterium chelonei infectionOFFSIDES
375Myeloblast count increasedOFFSIDES
376MyelodysplasiaOFFSIDES
377Myelodysplastic syndrome transformationOFFSIDES
378Myeloma recurrenceOFFSIDES
379MyelosuppressionSIDER
380Myoclonus2596777CTD
381Nail InfectionOFFSIDES
382Nasal FlaringOFFSIDES
383NecrosisSIDER
384Neoplasm Metastasis4301103CTD
385NervousnessSIDER
386Neuroblastoma14595385CTD
OFFSIDES
387NeurodermatitisOFFSIDES
388OliguriaSIDER
389OphthalmoplegiaOFFSIDES
390OrchitisOFFSIDES
391OsteosclerosisOFFSIDES
392Pain12913734CTD
SIDER
393ParotitisOFFSIDES
394Pericardial effusion4691200CTD
SIDER
395PericarditisSIDER
396Peripheral artery thrombosisSIDER
397Pituitary Diseases4166648CTD
398Platelet TransfusionOFFSIDES
399Pneumococcal sepsisOFFSIDES
400Polycythemia Vera4691200CTD
401Porphyria Cutanea TardaSIDER
402Porphyria non-acuteSIDER
403Pulmonary ossificationSIDER
404Purulent dischargeOFFSIDES
405RalesSIDER
406Restrictive cardiomyopathySIDER
407Restrictive pulmonary diseaseOFFSIDES
408Reticulocyte count decreasedOFFSIDES
409Reticulocyte count increasedOFFSIDES
410RhinitisSIDER
411Right ventricular systolic pressure decreasedOFFSIDES
412SarcoidosisOFFSIDES
413Scedosporium infectionOFFSIDES
414Seizures

View details

1606341
2070145
2400986
6151067
7475702
9404924
12098063
 		CTD
415Serum SicknessSIDER
416SinusitisSIDER
417Skin hypertrophyOFFSIDES
418Sleep Wake Disorders20861613CTD
419SomnolenceSIDER
420SoporOFFSIDES
421Splenomegaly2332518CTD
422Status Epilepticus14631624CTD
423Stenotrophomonas sepsisOFFSIDES
424TendinitisOFFSIDES
425TensionSIDER
426Testicular Diseases16903937
26524245
28578006		CTD
427Testicular massOFFSIDES
428Thrombocythemia, Essential9051142CTD
429ThrombocytosisCanada Vigilance: 115886082CTD
Canada Vigilance
430Thromboembolism19636672CTD
431ThrombosisSIDER
432Tracheostomy malfunctionOFFSIDES
433Transfusion-transmitted infectious diseaseOFFSIDES
434Unresponsive to pain stimuliOFFSIDES
435Ureteral stent insertionOFFSIDES
436UrethritisOFFSIDES
437UrticariaCanada Vigilance: 1Canada Vigilance
SIDER
438Vasodilation procedureSIDER
439VasodilationSIDER
440Vasoplegia syndromeOFFSIDES
441Vesiculobullous rashSIDER
442Viral DNA test positiveOFFSIDES
443Weight GainOFFSIDES
444Weight decreasedSIDER
445bone marrow fibrosisOFFSIDES
446jaundice267281CTD
SIDER
447liposarcomaOFFSIDES
448nervous system disorderSIDER
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