MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Methamphetamine

(MYWUZJCMWCOHBA-VIFPVBQESA-N)

Structure

SMILES: CN[C@H](Cc1ccccc1)C
Type(s): Approved; Illicit
ATC code(s): N06BA03
Molecular Formula:: C10H15N
Molecular Weight:: 149.233
Log P:: 2.2279
Hydrogen Bond Acceptor:: 1
Hydrogen Bond Donor:: 1
TPSA:: 12.03
CAS Number(s):: 537-46-2

Synonym(s)

Methamphetamine

Deoxyephedrine

Desoxyephedrine

Desoxyn

Madrine

Metamfetamine

Methamphetamine Hydrochloride

Methylamphetamine

N-Methylamphetamine

10.

Hydrochloride, Methamphetamine

11.

N Methylamphetamine

External Link(s)

MeSH	D008694
PubChem Compound	10836
BindingDB	50359499
ChEBI	6809
CHEMBL	CHEMBL1201201
DrugBank	DB01577
DrugCentral	1732
KEGG	cpd:C07164 dr:D08187
Therapeutic Target Database	D03FPU D0P6UB
ZINC	6021043

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Drug abuse	FAERS: 31		US FAERS
2	Toxicity to various agents	FAERS: 10 Canada Vigilance: 5		Canada Vigilance US FAERS
3	Pulmonary arterial hypertension	FAERS: 6		OFFSIDES US FAERS
4	Agitation	FAERS: 4		SIDER US FAERS
5	Maternal exposure during pregnancy	FAERS: 4		US FAERS
6	Pulmonary Hypertension	FAERS: 4		OFFSIDES US FAERS
7	Sepsis	FAERS: 4		US FAERS
8	Cardiac Arrest	FAERS: 3		US FAERS
9	Duodenal ulcer repair	FAERS: 3		US FAERS
10	Exposure during breast feeding	FAERS: 3		US FAERS
11	Respiratory Failure	FAERS: 3		US FAERS
12	Rhabdomyolysis	FAERS: 3	848798 7978734 15289744	CTD OFFSIDES US FAERS
13	Septic Shock	FAERS: 3		US FAERS
14	Tachycardia	FAERS: 3	View details 12738029 15289744 15925741 16563028 18976881	CTD SIDER US FAERS
15	Choreoathetosis	FAERS: 2		US FAERS
16	Depressed mood	FAERS: 2		OFFSIDES US FAERS
17	Drug withdrawal syndrome	FAERS: 2		US FAERS
18	Duodenal ulcer perforation	FAERS: 2		US FAERS
19	Hypoxia	FAERS: 2		US FAERS
20	Intentional self-injury	FAERS: 2		OFFSIDES US FAERS
21	Mydriasis	FAERS: 2		US FAERS
22	Myoclonus	FAERS: 2		US FAERS
23	Overdose	FAERS: 2 Canada Vigilance: 1		Canada Vigilance OFFSIDES US FAERS
24	Respiratory distress	FAERS: 2		US FAERS
25	Restlessness	FAERS: 2		US FAERS
26	Right Ventricular Dysfunction	FAERS: 2		US FAERS
27	Right ventricular failure	FAERS: 2		US FAERS
28	Shock	FAERS: 2	848798	CTD US FAERS
29	Abdominal Abscess	FAERS: 1		US FAERS
30	Acute kidney injury	FAERS: 1		US FAERS
31	Alanine Aminotransferase Increased	FAERS: 1		US FAERS
32	Anxiety	FAERS: 1		US FAERS
33	Arthralgia	FAERS: 1		US FAERS
34	Aspartate Aminotransferase Increased	FAERS: 1		US FAERS
35	Asphyxia	FAERS: 1		US FAERS
36	Atelectasis	FAERS: 1		US FAERS
37	Atypical pneumonia	FAERS: 1		US FAERS
38	Blood creatine phosphokinase MB increased	FAERS: 1		OFFSIDES US FAERS
39	Blood creatine phosphokinase increased	FAERS: 1		OFFSIDES US FAERS
40	Blood potassium increased	FAERS: 1		US FAERS
41	Bronchopulmonary Dysplasia	FAERS: 1		US FAERS
42	Cardiac ventricular thrombosis	FAERS: 1		US FAERS
43	Cardiotoxicity	FAERS: 1		US FAERS
44	Caudal Regression Syndrome	FAERS: 1		US FAERS
45	Chest Pain	FAERS: 1 Canada Vigilance: 1	18091405 19081702	CTD Canada Vigilance US FAERS
46	Clostridium difficile colitis	FAERS: 1		OFFSIDES US FAERS
47	Disseminated Intravascular Coagulation	FAERS: 1	848798	CTD US FAERS
48	Drug screen positive	FAERS: 1		OFFSIDES US FAERS
49	Duodenal perforation	FAERS: 1		US FAERS
50	Enterococcus test positive	FAERS: 1		US FAERS
51	Eye excision	FAERS: 1		US FAERS
52	Headache	FAERS: 1	848798 8892555	CTD SIDER US FAERS
53	Hepatic Encephalopathy	FAERS: 1		US FAERS
54	Hepatic Infarction	FAERS: 1		US FAERS
55	Hypertensive crisis	FAERS: 1		US FAERS
56	Ileal Stenosis	FAERS: 1		US FAERS
57	Impaired gastric emptying	FAERS: 1		US FAERS
58	Intentional product misuse	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
59	Intestinal fibrosis	FAERS: 1		US FAERS
60	Joint injury	FAERS: 1		US FAERS
61	Lateral Medullary Syndrome	FAERS: 1		US FAERS
62	Leukocytosis	FAERS: 1		US FAERS
63	Lung Abscess	FAERS: 1		OFFSIDES US FAERS
64	Mental status changes	FAERS: 1		US FAERS
65	Mesenteric abscess	FAERS: 1		US FAERS
66	Metabolic acidosis	FAERS: 1		US FAERS
67	Narcolepsy	FAERS: 1	8341891	CTD US FAERS
68	Nausea	FAERS: 1	848798	CTD US FAERS
69	Necrosis	FAERS: 1	11905041 27288563	CTD US FAERS
70	Neonatal respiratory failure	FAERS: 1		US FAERS
71	Nystagmus	FAERS: 1		US FAERS
72	Osteoporosis	FAERS: 1	19398174	CTD US FAERS
73	PHACES syndrome	FAERS: 1		US FAERS
74	Pelvic abscess	FAERS: 1		US FAERS
75	Pneumatosis intestinalis	FAERS: 1		US FAERS
76	Pneumonia	FAERS: 1		US FAERS
77	Pneumothorax	FAERS: 1		US FAERS
78	Portal venous gas	FAERS: 1		US FAERS
79	Product substitution issue	FAERS: 1		US FAERS
80	Product use issue	FAERS: 1		US FAERS
81	Proteinuria	FAERS: 1		US FAERS
82	Pruritus	FAERS: 1		US FAERS
83	Pseudovasculitis	FAERS: 1		US FAERS
84	Pulmonary Embolism	FAERS: 1		US FAERS
85	Pulmonary renal syndrome	FAERS: 1		US FAERS
86	Pulmonary toxicity	FAERS: 1		US FAERS
87	Rectal Prolapse	FAERS: 1		US FAERS
88	Renal tubular necrosis	FAERS: 1		US FAERS
89	Renal vasculitis	FAERS: 1		US FAERS
90	Retinopathy of Prematurity	FAERS: 1		US FAERS
91	Reversible cerebral vasoconstriction syndrome	FAERS: 1		US FAERS
92	Serotonin Syndrome	FAERS: 1		US FAERS
93	Somnolence	FAERS: 1		US FAERS
94	Splenectomy	FAERS: 1		US FAERS
95	Splenic Infarction	FAERS: 1		US FAERS
96	Staphylococcus test positive	FAERS: 1		US FAERS
97	Stillbirth	FAERS: 1		US FAERS
98	Stress	FAERS: 1		US FAERS
99	Sudden death	FAERS: 1		US FAERS
100	Sudden infant death syndrome	FAERS: 1		US FAERS
101	Sympathomimetic Effect	FAERS: 1		US FAERS
102	Tablet issue	FAERS: 1		US FAERS
103	Traumatic liver injury	FAERS: 1		US FAERS
104	Tremor	FAERS: 1	6539921	CTD SIDER US FAERS
105	Tubo-ovarian abscess	FAERS: 1		US FAERS
106	Uterine contractions during pregnancy	FAERS: 1		US FAERS
107	Vascular pseudoaneurysm ruptured	FAERS: 1		US FAERS
108	Ventricular hypokinesia	FAERS: 1		US FAERS
109	Vomiting	FAERS: 1	848798	CTD US FAERS
110	AIDS Dementia Complex		11519485	CTD
111	Abdominal Pain		848798	CTD
112	Abnormalities, Drug-Induced		View details 17162495 19369643 19464935 19564919	CTD
113	Abruptio Placentae		11732233	CTD
114	Abuse			OFFSIDES
115	Accidental death			OFFSIDES
116	Accidental overdose	Canada Vigilance: 2		Canada Vigilance
117	Acidosis			OFFSIDES
118	Acute Coronary Syndrome		12745036 17404411	CTD OFFSIDES
119	Agitated depression			OFFSIDES
120	Agoraphobia		9131885	CTD
121	Alcohol consumption			OFFSIDES
122	Alveolitis			OFFSIDES
123	Amphetamine-Related Disorders		View details 2272810 8940805 9205790 10605878 10844042 11130157 11408539 11672493 12095072 12151750 12584481 15058092 15085091 15542708 15542752 15715821 16140168 16393734 16621383 17035931 17105910 17119930 17389081 17481706 17728435 17875025 18282747 18368606 18493748 18563365 18800068 19010609 19197004 19269234 19359780 19363377 19371575 19501481 19560473 19648469 19839966 19883738 20636650 20731630 21798282 23820845 23934209	CTD
124	Aneurysm, Dissecting		14705845 17803574	CTD
125	Aneurysm, Ruptured		9182220	CTD
126	Anger			OFFSIDES
127	Angina, Unstable		15011896	CTD
128	Anorexia		6582023 15289744	CTD OFFSIDES
129	Antisocial Personality Disorder		23433219	CTD
130	Anxiety Disorders		View details 14604449 14706946 15289744 18368606 20148307 20358305	CTD
131	Apoptosis			OFFSIDES
132	Atherosclerosis		19132558	CTD
133	Athetosis		7978734	CTD
134	Atrioventricular Block		11905041	CTD
135	Aura			OFFSIDES
136	Automatism			OFFSIDES
137	Azotemia		848798	CTD
138	Basal Ganglia Diseases		9179395 15644446	CTD
139	Bipolar Disorder		23433219	CTD
140	Blood sodium increased			OFFSIDES
141	Body Temperature			OFFSIDES
142	Brain Damage, Chronic		15229250 29802913	CTD
143	Brain Diseases		View details 3947981 7513362 12684743 15542708 15847821 16784740 16839653 17921879 18076959 18282668 18773954 19369643	CTD
144	Brain Hypoxia			OFFSIDES
145	Brain Injuries		19564919	CTD
146	Brain Ischemia		19797780	CTD
147	Bruxism		16317979	CTD
148	Cardiac Hypertrophy			OFFSIDES
149	Cardiomegaly		View details 7590547 10978632 11905041 12738029	CTD
150	Cardiomyopathies		View details 7590547 14705845 15289744 17275458 19906310	CTD
151	Cardiomyopathy, Dilated		1996001 2612079 19330818	CTD
152	Cardiovascular Diseases		18368606 19426289 19604654	CTD
153	Catalepsy		7194019 8808155	CTD
154	Cataract		19464935	CTD
155	Cerebral Hemorrhage		View details 1712924 3219243 3790361 5416024 6848096 8137834 9182220 19132558	CTD
156	Cerebral Infarction		2915804	CTD
157	Cerebral Palsy			OFFSIDES
158	Cerebrovascular Disorders		4980784 18368606 19604654	CTD
159	Cervical dysplasia			OFFSIDES
160	Chemical and Drug Induced Liver Injury		23820845 28341135 30450033	CTD
161	Chills		848798	CTD
162	Cholestasis		18633333	CTD
163	Chorea		7978734	CTD
164	Cocaine-Related Disorders		17071819 19058926	CTD
165	Cognition Disorders		View details 8564732 11000918 11751032 11831501 11831502 12724464 14706488 15488342 15644446 15851720 16163532 17035931 17060582 17291662 17493054 17992686 18493748 18541986 19028488 19037812 19339145 19394959 19397848 19900489 19968830 20198527 20409426 20640405 25290377 25313882	CTD
166	Colitis, Ischemic		1761842 2054019 9800164	CTD
167	Colitis			OFFSIDES
168	Completed Suicide	Canada Vigilance: 2		Canada Vigilance OFFSIDES
169	Conduct Disorder		16393734	CTD
170	Consciousness Disorders		9636942	CTD
171	Constipation			SIDER
172	Contact Dermatitis			OFFSIDES
173	Continuous Positive Airway Pressure			OFFSIDES
174	Corneal Ulcer		19384581	CTD
175	Delirium		9636942 15289744	CTD
176	Demyelination			OFFSIDES
177	Dental caries		View details 16149403 16317979 16324229 16355653 17936956 20098969	CTD
178	Depressive disorder		View details 9131885 14604449 14706946 15738315 16393734 16563028 17105910 17875025 18284102 18368606 19153017 20064699 20358305 20659059 20840201 24072398	CTD
179	Disruptive, Impulse Control, and Conduct Disorders		View details 15488344 16135337 16163532 16389202 16915378 17035931 19097704 20096794 20148788	CTD
180	Dizziness		848798	CTD SIDER
181	Drug abuser			OFFSIDES
182	Drug toxicity			OFFSIDES
183	Dysarthria		19797780	CTD
184	Dyskinesia, Drug-Induced		810889 11519485	CTD
185	Dyspepsia			SIDER
186	Dysthymic Disorder			OFFSIDES
187	Dystonia			OFFSIDES
188	Edema		11933563	CTD
189	Ejection Fraction Decreased			OFFSIDES
190	Emotional distress			OFFSIDES
191	Encephalitis		26283214	CTD
192	Endophthalmitis		19384581	CTD
193	Eosinophilia		11933563	CTD
194	Erectile dysfunction			SIDER
195	Euphoric mood			SIDER
196	Fatty Liver			OFFSIDES
197	Feelings of worthlessness			OFFSIDES
198	Fetal Growth Retardation		15272773	CTD
199	Fever		View details 848798 8858965 9427479 9495865 9739098 10433983 10698006 10773198 10884597 10983851 11006970 11032899 11553669 12030189 12144937 12459932 12684743 12736362 12828572 12835119 12907309 14980734 15029472 15163680 15276877 15289744 15686480 16088948 16784740 16844102 16876329 16884865 16940771 16952162 17608141 17637607 17686046 18076959 18088364 18277051 18282668 18410508 18773954 18946735 19834288 19879056 20698032 20722968 20950675 21130800 21645582 22978492 26283213 27565679	CTD
200	Flight of ideas			OFFSIDES
201	Gait Disorders, Neurologic		18076959	CTD
202	Gastrointestinal Diseases		8341891	CTD
203	Gliosis		View details 11093760 11711870 12144937 12871582 15081587 18643795	CTD
204	Growth Disorders		12584481	CTD
205	HIV Infections		View details 12501899 16186088 16884330 17111217 17548765 19704399 20659059	CTD
206	Hallucinations		View details 1632581 2272810 9004055 9543311 9636942 10362445 10831490 11951147 14604449 14672249 17105910 18393050 18464001 19266373	CTD
207	Heart Diseases		11907169 12899434 17565561	CTD
208	Heart failure		19436660	CTD
209	Hemiplegia			OFFSIDES
210	Hepatitis B positive			OFFSIDES
211	Hepatitis C			OFFSIDES
212	Hepatitis	Canada Vigilance: 1		Canada Vigilance
213	Hordeolum			OFFSIDES
214	Human papilloma virus test positive			OFFSIDES
215	Hyperalgesia		19937742	CTD
216	Hypersensitivity		22514626	CTD SIDER
217	Hypertensive heart disease			OFFSIDES
218	Hypertrophy		10978632	CTD
219	Hypokinesia		26283213	CTD
220	Hypophagia			OFFSIDES
221	Hypoxia-Ischemia, Brain		24412707	CTD
222	Immune System Diseases		12738029	CTD
223	Implant site infection			OFFSIDES
224	Incorrect route of drug administration			OFFSIDES
225	Infection			OFFSIDES
226	Injection site scar			OFFSIDES
227	Injury asphyxiation			OFFSIDES
228	Intentional drug misuse			OFFSIDES
229	Intentional misuse			OFFSIDES
230	Intervertebral disc disorder			OFFSIDES
231	Kidney Failure, Chronic		9794581	CTD
232	Lethargy			OFFSIDES
233	Liver Failure, Acute		12136967	CTD
234	Loop electrosurgical excision procedure			OFFSIDES
235	Lung diseases		12899434	CTD
236	Medical device removal			OFFSIDES
237	Memory Disorders		View details 10844042 12724464 14533139 14706488 15223095 15229250 15289744 15488342 15656761 15900317 16915378 17060582 17365096 17365250 17548765 17637607 17992686 19037812 19776303 20409426 20553881	CTD
238	Mental disorders		View details 43118 5625393 8506450 11083165 14870948 16192988 17426488 18976881	CTD
239	Mesenteric vascular insufficiency			OFFSIDES
240	Micronuclei, Chromosome-Defective		30910685	CTD
241	Middle insomnia			OFFSIDES
242	Mononeuritis			OFFSIDES
243	Mononeuropathies		165440	CTD
244	Mood Disorders		16563028 20198527	CTD
245	Mood disorder due to a general medical condition			OFFSIDES
246	Motor Neuron Disease		17453645	CTD
247	Motor Skills Disorders		18768699 25290377 25313882	CTD
248	Mouth Diseases		View details 16359093 18380848 19945523 20194387	CTD
249	Movement Disorders		17904249 20298714 20735886	CTD
250	Multiple drug overdose			OFFSIDES
251	Multiple drug overdose intentional			OFFSIDES
252	Murder			OFFSIDES
253	Muscle Rigidity		11174264	CTD
254	Musculoskeletal Pain			OFFSIDES
255	Myocardial Infarction		View details 2215590 9066872 14705845 15011896 15289744 16338525 17404411	CTD
256	Myocardial Ischemia		12738029	CTD
257	Myocardial fibrosis			OFFSIDES
258	Myoglobinuria		848798	CTD
259	Nerve Degeneration		View details 3947981 10684896 11754491 12684743 12871582 14657756 15337264 15542702 15935054 16403784 16650608 16784740 16952162 17060582 17234339 17493054 18435425 18643795 25090657 27288563	CTD
260	Neurobehavioral Manifestations		19426289 27565679	CTD
261	Neurotoxicity Syndromes		View details 12105090 12835119 18088364 19815352 20533999 22512859 23934209 30450033	CTD
262	Obsessive thoughts			OFFSIDES
263	Obsessive-Compulsive Disorder		10362445 20358305	CTD
264	Occupational Diseases		8892555	CTD
265	Palpitations			SIDER
266	Panic Disorder		9131885	CTD
267	Panophthalmitis		19384581	CTD
268	Paresthesia		848798	CTD
269	Parkinson Disease		19426289 20081231	CTD
270	Perceptual Disorders		17035931	CTD
271	Peripheral Vascular Diseases		165440	CTD
272	Physical disability			OFFSIDES
273	Pleurisy			OFFSIDES
274	Poisoning		11174264	CTD
275	Polysubstance abuse			OFFSIDES
276	Postmortem blood drug level increased	Canada Vigilance: 1		Canada Vigilance
277	Prenatal Exposure Delayed Effects		View details 15272773 15935622 15936828 16842764 18061406 18768699 19369643 19464935 21067979	CTD
278	Prenatal Injuries		18633333	CTD
279	Psychomotor Agitation		View details 7978734 9636942 11174264 15289744 16563028	CTD
280	Psychomotor Disorders		15644446 22514626	CTD
281	Psychoses, Substance-Induced		View details 1273244 1632581 2074612 2579200 2793033 6860719 7978734 8177922 8319937 8564732 8878306 9004055 9205790 9543311 9636942 10200757 10362445 10386162 10831490 10840127 11584576 11951147 12944350 14604449 14672249 14978976 15058092 15289744 15542729 15542752 15633070 15644446 15658512 15764424 15892150 16563028 16915378 16968349 17105910 17875025 18368606 18393050 18464001 18541986 19097704 19426289 19968830 20068123 20358305 20404009 20636650 20636664 20659059 20705401 20840201 20851278 23433219	CTD
282	Psychotic Disorders		View details 1534132 9179395 12421355 19564919 20580787	CTD
283	Pulmonary Edema		1996001 11933563 14705845	CTD
284	Pulmonary congestion			OFFSIDES
285	Radiation associated pain			OFFSIDES
286	Radical hysterectomy			OFFSIDES
287	Renal Insufficiency		15289744	CTD
288	Respiratory Tract Diseases		8892555	CTD
289	Retinal Diseases		16963858 19384581 19948197	CTD
290	Risus sardonicus			OFFSIDES
291	Schizophrenia		View details 10840127 18262394 18751516 20621163 20636664	CTD
292	Scleritis		19384581	CTD
293	Seizures		View details 1880990 2215083 2217500 10456426 11519485 11711870 15289744 15935622 16542420 18061406 20599607 21067979 31163210	CTD
294	Sexually Transmitted Diseases		19295472	CTD
295	Shock, Cardiogenic		1996001 17404411	CTD
296	Sinusitis			OFFSIDES
297	Sleep Initiation and Maintenance Disorders		9636942 15289744	CTD
298	Speech Disorders		14604449	CTD
299	Staphylococcal Skin Infections		18217555	CTD
300	Status Epilepticus		16952162	CTD
301	Stereotypic Movement Disorder		7902980 24582730	CTD
302	Subarachnoid Hemorrhage		5416024 15577524 19132558	CTD
303	Substance Abuse, Intravenous		1273244 9636942 10362445	CTD
304	Substance Withdrawal Syndrome		View details 12584481 15542752 16128721 17105910 19426289	CTD
305	Substance-Related Disorders		View details 5520384 7978734 9636942 10611609 15738319 15904719 16210775 18400166 19361931 20393457 25290377	CTD
306	Syphilis		20679964	CTD
307	Tachycardia, Ventricular		12745036	CTD
308	Temporomandibular Joint Dysfunction Syndrome		18356857	CTD
309	Theft			OFFSIDES
310	Tinea Versicolor			OFFSIDES
311	Tonsillitis			OFFSIDES
312	Tooth Diseases		18380848 20194387	CTD
313	Toxicologic test abnormal			OFFSIDES
314	Transaminases			OFFSIDES
315	Trismus		16317979	CTD
316	Troponin I increased			OFFSIDES
317	Urinary Retention		14980339	CTD
318	Urine output increased			OFFSIDES
319	Urticaria			SIDER
320	VIIth nerve paralysis			OFFSIDES
321	Vasculitis, Central Nervous System		900566 17720598	CTD
322	Vasculitis		1712924 3219243 9794581	CTD
323	Vasospasm, Intracranial		2124040	CTD
324	Venous stasis			OFFSIDES
325	Ventricular Dysfunction, Left		17728543 19481142 20139112	CTD
326	Ventricular Dysfunction		2612079	CTD
327	Ventricular Fibrillation		12745036	CTD
328	Vision Disorders		19384581	CTD
329	Walking aid user			OFFSIDES
330	Xerosis			OFFSIDES
331	Xerostomia		View details 16317979 16355653 18356857 18380848	CTD

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