MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Isoproterenol

(JWZZKOKVBUJMES-UHFFFAOYSA-N)

Structure

SMILES: CC(NCC(c1ccc(c(c1)O)O)O)C
Type(s): Approved; Investigational
ATC code(s): C01CA02; R03AB02; R03AK02; R03CB01; R03CB51
Molecular Formula:: C11H17NO3
Molecular Weight:: 211.258
Log P:: 1.5201
Hydrogen Bond Acceptor:: 4
Hydrogen Bond Donor:: 4
TPSA:: 72.72
CAS Number(s):: 7683-59-2

Synonym(s)

Isoproterenol

Isoprenaline

Isopropylarterenol

4-(1-Hydroxy-2-((1-methylethyl)amino)ethyl)-1,2-benzenediol

Euspiran

Isadrin

Isadrine

Isopropyl Noradrenaline

Isopropylnoradrenaline

10.

Isopropylnorepinephrine

11.

Isoproterenol Hydrochloride

12.

Isoproterenol Sulfate

13.

Isuprel

14.

Izadrin

15.

Norisodrine

16.

Novodrin

17.

Hydrochloride, Isoproterenol

18.

Noradrenaline, Isopropyl

19.

Sulfate, Isoproterenol

External Link(s)

MeSH	D007545
PubChem Compound	3779
BindingDB	25392
ChEBI	64317
CHEMBL	CHEMBL434
DrugBank	DB01064
DrugCentral	1499
IUPHAR/BPS Guide to PHARMACOLOGY	536
KEGG	cpd:C07056 dr:D08090
Therapeutic Target Database	D0I8FI D0IF0C D0P1IS

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Expired drug administered	FAERS: 1		US FAERS
2	Malaise	FAERS: 1		US FAERS
3	Adams-Stokes Syndrome		5639626 6028741	CTD
4	Angina Pectoris		View details 918610 4368278 6305298 8271529 11128043 11791009	CTD SIDER
5	Asthenia			SIDER
6	Asthma		View details 1572199 2878599 4921234 6435488	CTD
7	Atrial Fibrillation		2036596	CTD
8	Atrial Flutter		691277	CTD
9	Atrioventricular Block		2444941 5639626	CTD
10	Bradycardia		View details 1927872 1983399 6028741 6542785 6740701 8399252 9022833 10721819 11242812 12420050 15329512 16216767 18218783 18329740	CTD
11	Bronchial Diseases		4589083	CTD
12	Bronchospasm			SIDER
13	Cardiac Arrest			SIDER
14	Cardiomegaly		View details 143367 143922 146398 148363 155867 157665 188421 210840 211764 221204 894732 1319337 1453538 1719221 1752259 1832104 1840475 2151337 2176088 2436403 2527639 2562064 2959998 2962704 2974281 3024615 3158047 4226214 4265104 4276488 4283606 6048021 6099802 6203632 6208988 6217347 6218830 6229991 6230880 6241890 6241897 6445987 6448044 7494559 7524366 7544033 7905536 8077211 8184922 8292059 8541062 8793698 8896075 8896089 9486938 9777039 9788834 10066715 10412557 10547078 10591028 10721819 10831235 10886724 10997724 11061329 11179087 11248077 11500747 11592866 11709406 12224825 12688410 12732584 12775975 12883319 12963636 15167265 15302781 15576649 15813973 15870116 16188065 16327176 16731636 17030629 17201739 17350036 17487232 17558183 18089841 18194989 18373958 18534575 18625706 18725507 18812163 18816294 19023134 19136528 19168511 19181756 19299911 19826179 19893015 20003209 20190099 20409916 20562518 20616315 20873559 23288202 24117263 25139994 25537132 26995004 27174236 27867086 27890915 28816235 30623541 31009642	CTD
15	Cardiomyopathies		View details 129835 575492 1197879 1588003 2128759 2143151 2617945 2627901 2848969 3130838 3446201 4020877 4020881 4226214 4640113 4773536 5023836 5387726 6048021 6255219 6642587 6703405 7065160 7133771 7135265 7329030 7367325 7494559 7580098 8606520 9861301 10533957 10932797 11586415 12213972 12577380 17008600 17991491 18424012 18808529 18987407 19628585 19660444 20211217 21191138 23536361 24201307 25537132	CTD
16	Cardiotoxicity		22391854 23872883 26996544	CTD
17	Chromosome Breakage		30152906	CTD
18	Coronary artery insufficiency			SIDER
19	Dizziness			SIDER
20	Edema, Cardiac		19854236	CTD
21	Edema		View details 7494559 23558518 26996544 27527349	CTD
22	Endomyocardial Fibrosis		View details 21076021 24117263 26692091 30623541	CTD
23	Fibrosis		View details 2151337 2176088 2527639 3155884 6230880 6255219 8592101 10615017 10831235 12224825 12732584 12963636 18373958 18806606 19168511 19181756 19527710 19826179 19893015 21570962 21854795 24286936 28526319 31009642	CTD
24	Flushing			SIDER
25	Headache			SIDER
26	Heart Block		3224354 6028741	CTD
27	Heart Diseases		View details 32314 62047 588200 656315 663362 929597 947298 949029 1214589 2047568 2727390 3013153 3158144 3712522 3789466 4381147 4396891 4402017 4644952 4827999 6228730 6293707 6542785 6622555 6869082 7298064 7311631 7436998 7915431 9788755 11064274 15282950 17045618 17182065 17654401 19549929 19641666 19714493 19812120 19957885 20604842 21960663 24286936 24945829 24954035 26972669 29355689	CTD
28	Heart Injuries		22878004	CTD
29	Heart failure		View details 1129332 3159365 6704950 7226440 7323063 9539862 9861301 10615017 12215284 12963636 15009959 15849448 16716347 16723803 17509559 17961425 17996136 18097624 18214293 18384769 18534575 18540190 18783386 19168511 19527710 19665014 19791472 19909738 20572026 20654104 20723002 21570962 22908232 24026955 27174236 27890915	CTD
30	Hemorrhage		15683744	CTD
31	Hyperalgesia		230543 2998815	CTD
32	Hyperemia		3101516 8845006	CTD
33	Hyperglycemia		1032269	CTD
34	Hyperplasia		6203632 16112403	CTD
35	Hypertrophy		10050945 12791704	CTD
36	Hypocalcemia		21076021	CTD
37	Hypogonadism		20307649	CTD
38	Hypokalemia		View details 228309 2468922 6621246 7685286	CTD
39	Hyponatremia		6621246	CTD
40	Hypotension		View details 15525 20392 282069 1106169 1973398 2868116 2900909 2907738 3706053 3802704 6542785 6740701 7226440 7788917 7878074 8610867 9038718 10226872 10556671 11242812 15329512 17665049 19747457 20121584	CTD SIDER
41	Hypoxia		3712522 6228730 16499031	CTD
42	Infarction		22391854	CTD
43	Inflammation		19826179 24286936 29355689	CTD
44	Ischemia		View details 839834 949029 1182733 3038283 3565241 4091837 12708743 18808529 20554997	CTD
45	Long QT Syndrome		View details 8399252 10942753 11529656 12766260 16615675 18329740	CTD
46	Lung Injury		28266775	CTD
47	Mitochondrial Diseases		2546223	CTD
48	Mitral Valve Insufficiency		529546	CTD
49	Musculoskeletal Diseases		22878004	CTD
50	Myocardial Infarction		View details 453639 533011 540709 666886 895432 1008995 1129332 1170763 1170870 1208595 1427967 1432604 1506079 1521861 1588003 1701394 1874539 1875279 1879889 2015110 2401523 2628316 2854114 3021656 3224354 3715799 3756602 3833691 3964138 3996487 4039190 4273180 4426056 4582368 4817821 5410284 5494861 5524164 5780019 6272002 6534871 6539233 6545526 6676163 6832181 7070262 7106817 7161883 7184850 7234711 7309083 7349219 8276435 8377107 8389635 8534267 9043801 9055097 9580216 9736020 9753871 10404535 11395263 11829124 11897407 12557918 12635694 12841644 14121382 14499179 14527820 15185846 15225664 15233872 15261977 15678289 15740881 15934019 15951400 16259760 16259765 16444596 16538859 16567950 16584858 16635105 16639876 16640840 16697266 16716347 16757080 16820956 16906521 16906524 17027232 17052832 17084010 17135156 17188415 17275273 17289242 17366541 17467089 17623887 17848144 17994576 17994577 18294627 18384769 18426087 18513933 18528854 18697569 18786522 18806606 18844325 18949894 19058010 19067678 19146839 19172585 19288277 19294532 19296206 19298195 19306480 19352575 19352599 19445921 19466570 19494560 19559874 19595682 19667237 19672741 19728169 20024955 20039145 20196927 20307515 20376586 20391626 20554997 20693123 20846025 20979156 21322096 21469598 21472895 21671307 21762681 23261676 24026955 24842192 25794854 26277537 26721194 26995004 27527349 28177670 30088836	CTD
51	Myocardial Ischemia		View details 641628 918610 1208595 3109801 3159365 3218133 6616139 8819482 10050945 11218852 12732346 12776519 16112403 16499031 16640830 16987513 17052790 17306419 17455091 17623887 18949894 19565716 19573579 19623992 19960946 20020988 20125031 20518309 20724803 25080425	CTD
52	Myocarditis		1892950 2169911 3160411	CTD
53	Nausea		2127	CTD SIDER
54	Necrosis		View details 62047 453639 475980 656315 949029 1208595 1217150 1752259 2047568 2527639 2617945 2959998 3130838 3158047 3158144 3336205 3712522 3894677 4091837 4226214 4381147 4402017 4773536 5017287 5927953 6017708 6048021 6228730 6241897 6255219 6330819 6721878 6832181 6868085 7135265 7161883 7436998 7494559 8592101 9539862 9788755 10533957 10831235 11064274 12577380 15261977 15282950 15813973 17045618 17509559 18513933 18528854 19216232 19667237 19854236 19957885 20211217 20554997 21570962 23558518 24117263 24201307 24286936 24954035 25537132 26996544	CTD
55	Neoplasm Invasiveness		24929186	CTD
56	Nerve Degeneration		17136323	CTD
57	Nervousness			SIDER
58	Ocular Hypertension		5446045	CTD
59	Pallor			SIDER
60	Palpitations			SIDER
61	Panic Disorder		View details 2165824 3069135 3341469 3363024	CTD
62	Personality Disorders		1946713	CTD
63	Pulmonary Edema		10903255	CTD
64	Respiratory Insufficiency		5067981	CTD
65	Sepsis		10066715	CTD
66	Shock, Cardiogenic		3156367	CTD
67	Sinus Arrest, Cardiac		1983399 3954116 20601460	CTD
68	Sinus rhythm			SIDER
69	Status Asthmaticus		641628 3109801 5067981	CTD
70	Sweating			SIDER
71	Syncope		View details 7056119 7638127 8598089 8806338 10831960 11469429 18760129	CTD
72	Tachyarrhythmia			SIDER
73	Tachycardia, Atrioventricular Nodal Reentry		11752915	CTD
74	Tachycardia, Reciprocating		2727406 9092395	CTD
75	Tachycardia, Ventricular		View details 1282244 1696950 5067981 7685286 8644647 9930905 11227967 16216767 17201857 19371192 25723814	CTD
76	Tachycardia		View details 2127 3420 12778 15525 20392 22739 29117 33998 42517 204966 212150 501565 506367 789082 854479 947650 1124718 1208595 1267541 1335070 1360255 1383620 1776484 2123908 2437399 2442536 2452313 2565296 2570522 2859793 2870085 2878599 2888869 2890664 2900909 2907738 2997437 3010692 3698462 3802704 3830711 4392540 4921234 5639626 5767742 6048021 6103674 6125170 6129320 6130864 6138177 6141285 6149731 6256527 6299641 6314140 6486026 6727101 6849777 7053299 7617516 7695617 8043010 8100704 8872350 9038718 9074945 9084878 9211567 9342554 9593075 9607136 9777039 10073741 10226872 10440531 10556671 10721819 10756546 10780909 10975596 11425575 11483288 12021574 12420050 14256809 15243307 15683744 15749201 17047523 17420778 17665049 18218783 18528854 20121584 20601460 22391854	CTD SIDER
77	Tension			SIDER
78	Torsades de Pointes		View details 2416504 6465184 6842807 6849241 7056119 8189766 10819411	CTD
79	Tremor		6115732 6258838	CTD SIDER
80	Vasospasm, Intracranial		11958422	CTD
81	Ventricular Dysfunction, Left		View details 17114241 18097624 19904010 24026955 24117263 24842192 30623541	CTD
82	Ventricular Dysfunction		9234661	CTD
83	Ventricular Fibrillation		View details 95312 1209009 2023523 2465450 2730548 2869040 3038283 3704313 4019937 4079442 4457230 5348156 5768127 6103072 6330819 6621246 6655564 19215837	CTD
84	Ventricular Remodeling		18097624 25080425	CTD
85	Ventricular arrhythmia			SIDER
86	Vertigo			SIDER
87	Vomiting		2127	CTD
88	Wolff-Parkinson-White Syndrome		3830711	CTD

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