MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Digitoxin

(WDJUZGPOPHTGOT-XUDUSOBPSA-N)

Structure

SMILES: O=C1OCC(=C1)[C@H]1CC[C@]2([C@]1(C)CC[C@H]1[C@H]2CC[C@H]2[C@]1(C)CC[C@@H](C2)O[C@H]1C[C@H](O)[C@@H]([C@H](O1)C)O[C@H]1C[C@H](O)[C@@H]([C@H](O1)C)O[C@H]1C[C@H](O)[C@@H]([C@H](O1)C)O)O
Type(s): Approved; Investigational
ATC code(s): C01AA04
Molecular Formula:: C41H64O13
Molecular Weight:: 764.939
Log P:: 3.2473
Hydrogen Bond Acceptor:: 13
Hydrogen Bond Donor:: 5
TPSA:: 182.83
CAS Number(s):: 71-63-6

Synonym(s)

Digitoxin

Coramedan

Digimed

Digimerck

Digitaline Nativelle

Digitoxin AWD

Digitoxin Bürger

Digitoxin Didier

Digitoxin-Philo

10.

Digophton

11.

AWD, Digitoxin

12.

Bürger, Digitoxin

13.

Didier, Digitoxin

14.

Digitoxin Philo

15.

Nativelle, Digitaline

External Link(s)

MeSH	D004074
PubChem Compound	441207
BindingDB	46356
ChEBI	28544
CHEMBL	CHEMBL254219
DrugBank	DB01396
DrugCentral	881
IUPHAR/BPS Guide to PHARMACOLOGY	6782
KEGG	cpd:C06955 dr:D00297
Therapeutic Target Database	D0M3QP
ZINC	95862733

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Acute prerenal failure			OFFSIDES
2	Alveolitis			OFFSIDES
3	Amphetamines			OFFSIDES
4	Ascites			OFFSIDES
5	Atrial Fibrillation	Canada Vigilance: 1	4255107 17460324	CTD Canada Vigilance
6	Atrial Flutter		5654317	CTD
7	Atrial Premature Complexes		2447325	CTD
8	Atrial tachycardia			OFFSIDES
9	Atrioventricular Block		4255107 5654317 5727264	CTD
10	Aura			OFFSIDES
11	Bicytopenia			OFFSIDES
12	Bidirectional tachycardia		4781244 12145041 15674736	CTD
13	Bladder cancer recurrent			OFFSIDES
14	Blood count abnormal			OFFSIDES
15	Blood creatinine increased			OFFSIDES
16	Blood iron decreased			OFFSIDES
17	Blood sodium			OFFSIDES
18	Bradycardia		1179459 8212711	CTD OFFSIDES
19	Breast tenderness			OFFSIDES
20	Bronchopneumonia			OFFSIDES
21	Bundle-Branch Block		15674736	CTD
22	Calciphylaxis			OFFSIDES
23	Carcinoembryonic antigen increased			OFFSIDES
24	Cardiac Death			OFFSIDES
25	Cardioactive drug level increased			OFFSIDES
26	Cardiomegaly		2436403	CTD
27	Cardiomyopathies		4909201 5384065	CTD
28	Cardiovascular Diseases		19446813	CTD
29	Cirrhosis			OFFSIDES
30	Clostridium difficile colitis			OFFSIDES
31	Confabulation			OFFSIDES
32	Confusion		7361148	CTD
33	Dehydration			OFFSIDES
34	Delirium		7361148	CTD
35	Depressive disorder		5643946	CTD
36	Drug toxicity			OFFSIDES
37	Electrocardiogram PQ interval prolonged			OFFSIDES
38	Endocarditis			OFFSIDES
39	Enuresis			OFFSIDES
40	Erosive gastritis			OFFSIDES
41	Erythropenia			OFFSIDES
42	Fatty Liver			OFFSIDES
43	Gambling			OFFSIDES
44	Gamma-Glutamyltransferase Increased			OFFSIDES
45	Gastric ulcer helicobacter			OFFSIDES
46	Gastroenteritis, Transmissible, of Swine		28438630	CTD
47	Gastrointestinal ulcer			OFFSIDES
48	General physical condition			OFFSIDES
49	General physical health deterioration			OFFSIDES
50	Heart Diseases		11532201	CTD
51	Heart failure		18272488	CTD
52	Hemisensory Neglect			OFFSIDES
53	Hepatorenal Syndrome		11051385	CTD
54	Hypercapnia			OFFSIDES
55	Hypertransaminasaemia			OFFSIDES
56	Hypokinesia			OFFSIDES
57	Hypophagia			OFFSIDES
58	Hypotension		11016824	CTD
59	Hypoxia-Ischemia, Brain		14574425	CTD
60	Intestinal mucosal hypertrophy			OFFSIDES
61	Kidney Failure			OFFSIDES
62	Left Ventricular Hypertrophy			OFFSIDES
63	Left atrial dilatation			OFFSIDES
64	Lethargy		7361148	CTD
65	Lip erosion			OFFSIDES
66	Metastatic bronchial carcinoma			OFFSIDES
67	Monoparesis			OFFSIDES
68	Motor retardation			OFFSIDES
69	Movement Disorders		7146044 7361148	CTD
70	Multimorbidity			OFFSIDES
71	Nausea	Canada Vigilance: 2		Canada Vigilance
72	Neurotoxicity Syndromes		14574425	CTD
73	Oliguria			OFFSIDES
74	Overdose			OFFSIDES
75	Personality Change			OFFSIDES
76	Personality Disorders		7361148	CTD
77	Pulmonary Hypertension			OFFSIDES
78	Reflex, Abnormal		7146044	CTD
79	Rotavirus test positive			OFFSIDES
80	Seizures		5569832 5643946 7146044	CTD
81	Serositis			OFFSIDES
82	Sick Sinus Syndrome		17460324	CTD
83	Sinoatrial Block		8212711	CTD
84	Soft Tissue Infection			OFFSIDES
85	Soft tissue necrosis			OFFSIDES
86	Sudden Cardiac Death			OFFSIDES
87	Sudden onset of sleep			OFFSIDES
88	Tachycardia, Ventricular		914999 4255107	CTD
89	Thrombocytopenia		8212711	CTD
90	Tissue polypeptide antigen increased			OFFSIDES
91	Transaminases increased			OFFSIDES
92	Tremor		7146044	CTD
93	Troponin increased			OFFSIDES
94	Urinary Incontinence		7361148	CTD
95	Vasospasm, Intracranial		14574425	CTD
96	Venous thrombosis limb			OFFSIDES
97	Ventricular Dysfunction, Left		4018179	CTD
98	Ventricular Fibrillation		11808 7162976	CTD
99	Ventricular arrhythmia	Canada Vigilance: 1		Canada Vigilance
100	Vestibular Neuronitis			OFFSIDES
101	Visual disturbance			OFFSIDES
102	Vomiting	Canada Vigilance: 2		Canada Vigilance

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