MetaADEDB 2.0 @ LMMD
Phenylephrine
(SONNWYBIRXJNDC-VIFPVBQESA-N)
Structure
SMILES
CNC[C@@H](c1cccc(c1)O)O
Type(s)
Approved
ATC code(s)
C01CA06; R01AA04; R01AB01; R01BA03; R01BA53; S01FB01; S01FB51; S01GA05; S01GA55
Molecular Formula:
C9H13NO2
Molecular Weight:
167.205
Log P:
1.0359
Hydrogen Bond Acceptor:
3
Hydrogen Bond Donor:
3
TPSA:
52.49
CAS Number(s):
59-42-7; 1416-03-1
Synonym(s)
1.
Phenylephrine
2.
(R)-3-Hydroxy-alpha-((methylamino)methyl)benzenemethanol
3.
Metaoxedrin
4.
Metasympatol
5.
Mezaton
6.
Neo-Synephrine
7.
Neosynephrine
8.
Phenylephrine Hydrochloride
9.
Phenylephrine Tannate
10.
Neo Synephrine
11.
Tannate, Phenylephrine
External Link(s)
MeSHD010656
PubChem Compound6041
BindingDB50067212
ChEBI8093
CHEMBLCHEMBL1215
DrugBankDB00388
DrugCentral2146
IUPHAR/BPS Guide to PHARMACOLOGY485
KEGGcpd:C07441
dr:D08365
Therapeutic Target DatabaseD0O6IU
ZINC113355
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1BradycardiaFAERS: 12
Canada Vigilance: 1

View details

1319020
1560369
1646264
1719293
1765616
2076755
2110014
2282935
2326505
2412035
2636709
2733263
2767131
3029526
3525850
6436028
8113962
8401937
8583776
9309312
9366485
9519251
10638917
10801282
15306635
15518641
18938261
 		CTD
OFFSIDES
SIDER
Canada Vigilance
US FAERS
2CyanosisFAERS: 6US FAERS
3Drug ineffectiveFAERS: 6US FAERS
4Incorrect dose administeredFAERS: 6US FAERS
5Acute myocardial infarctionFAERS: 4OFFSIDES
US FAERS
6Cardiac ArrestFAERS: 4US FAERS
7Myocardial InfarctionFAERS: 41614584
7772323		CTD
SIDER
US FAERS
8Medication ErrorFAERS: 3US FAERS
9Product label confusionFAERS: 3US FAERS
10Product label issueFAERS: 3US FAERS
11Accidental overdoseFAERS: 2US FAERS
12Circumstance or information capable of leading to medication errorFAERS: 2OFFSIDES
US FAERS
13Drug DependenceFAERS: 2US FAERS
14FlushingFAERS: 2US FAERS
15Procedural complicationFAERS: 2OFFSIDES
US FAERS
16TachycardiaFAERS: 26268123
6696128		CTD
SIDER
US FAERS
17Unresponsive to stimuliFAERS: 2OFFSIDES
US FAERS
18Accidental exposure to productFAERS: 1US FAERS
19Acute macular outer retinopathyFAERS: 1US FAERS
20Adverse eventFAERS: 1US FAERS
21Angina PectorisFAERS: 13365589
9380924
10389447		CTD
US FAERS
22Anoxic EncephalopathyFAERS: 1US FAERS
23Atrioventricular BlockFAERS: 1OFFSIDES
SIDER
US FAERS
24Atrioventricular Septal DefectFAERS: 1US FAERS
25Blood pressure fluctuationFAERS: 1US FAERS
26Carbon dioxide abnormalFAERS: 1US FAERS
27Cerebrovascular accidentFAERS: 1US FAERS
28Chemical injuryFAERS: 1US FAERS
29Chest PainFAERS: 14835748
9433094		CTD
SIDER
US FAERS
30ClaustrophobiaFAERS: 1US FAERS
31Culture positiveFAERS: 1US FAERS
32Documented hypersensitivity to administered drugFAERS: 1US FAERS
33Dose calculation errorFAERS: 1US FAERS
34Drug administration errorFAERS: 1OFFSIDES
US FAERS
35Drug exposure during pregnancyFAERS: 1OFFSIDES
US FAERS
36Drug label confusionFAERS: 1US FAERS
37Ejection Fraction DecreasedFAERS: 1OFFSIDES
US FAERS
38Electrocardiogram U-wave abnormalityFAERS: 1OFFSIDES
US FAERS
39Excessive eye blinkingFAERS: 1US FAERS
40Eye painFAERS: 1OFFSIDES
SIDER
US FAERS
41Head titubationFAERS: 1US FAERS
42HypotensionFAERS: 1

View details

809711
1595919
2344749
7532552
7604996
8346819
9105223
10357338
10638892
10960424
11429337
11429359
12073197
12198065
12932066
14510655
14693627
14973804
14977792
17991262
18806043
19095857
19513130
19957053
20173633
20659611
21467553
21724004
 		CTD
US FAERS
43Incision site painFAERS: 1US FAERS
44Incorrect drug administration durationFAERS: 1US FAERS
45Incorrect route of drug administrationFAERS: 1OFFSIDES
US FAERS
46Infusion Site ExtravasationFAERS: 1US FAERS
47Infusion site reactionFAERS: 1US FAERS
48Intercepted product administration errorFAERS: 1US FAERS
49Intracranial AneurysmFAERS: 1US FAERS
50LethargyFAERS: 1US FAERS
51Macular degenerationFAERS: 1US FAERS
52Memory impairmentFAERS: 1US FAERS
53Multiple use of single-use productFAERS: 1US FAERS
54NauseaFAERS: 1SIDER
US FAERS
55OverdoseFAERS: 1US FAERS
56Paradoxical drug reactionFAERS: 1US FAERS
57Product communication issueFAERS: 1US FAERS
58Product contamination microbialFAERS: 1US FAERS
59Product dispensing errorFAERS: 1US FAERS
60Product use in unapproved indicationFAERS: 1US FAERS
61Pulmonary HypertensionFAERS: 1OFFSIDES
US FAERS
62Respiratory FailureFAERS: 1OFFSIDES
US FAERS
63Serratia test positiveFAERS: 1US FAERS
64Skin test positiveFAERS: 1US FAERS
65Systemic leakageFAERS: 1US FAERS
66TremorFAERS: 1SIDER
US FAERS
67Ventricular FibrillationFAERS: 195312
5021502
6655564		CTD
US FAERS
68Wrong drug administeredFAERS: 1US FAERS
69Wrong technique in drug usage processFAERS: 1US FAERS
70Wrong technique in product usage processFAERS: 1US FAERS
71Abnormal visionOFFSIDES
72AcidosisOFFSIDES
73Acute Coronary SyndromeSIDER
74Acute kidney injury13678392CTD
75Acute otitis mediaOFFSIDES
76Acute respiratory failureOFFSIDES
77AgitationSIDER
78AgraphiaOFFSIDES
79Alcohol consumptionOFFSIDES
80Alcohol poisoningOFFSIDES
81Amnesia20064624CTD
82AngioedemaOFFSIDES
83AnhedoniaOFFSIDES
84AnisocoriaOFFSIDES
85AnuriaOFFSIDES
86Aphthous StomatitisOFFSIDES
87Apnea2331071CTD
OFFSIDES
88Arterial Occlusive Diseases17938347CTD
89Arteriovenous graft thrombosisOFFSIDES
90AsbestosisOFFSIDES
91AsphyxiaOFFSIDES
92Atrial Fibrillation19004376CTD
93Atrial tachycardiaOFFSIDES
94Autologous bone marrow transplantation therapyOFFSIDES
95Bacteremia7604996CTD
96Biliary sepsisOFFSIDES
97Blanching of skinSIDER
98BlanchingSIDER
99Blepharitis12199969
17663925		CTD
100Blood creatine phosphokinase increasedOFFSIDES
101Blood thyroid stimulating hormone increasedOFFSIDES
102Blood uric acidOFFSIDES
103Body TemperatureOFFSIDES
104Bone density decreasedOFFSIDES
105Bone lesionOFFSIDES
106Bone painOFFSIDES
107Brain Edema1711760
2375408
15815377		CTD
108Brain Injuries2375408CTD
109Brain Ischemia

View details

1614584
2375408
2815189
18340095
 		CTD
110Breakthrough PainOFFSIDES
111Cardio-respiratory distressOFFSIDES
112Cardiomegaly

View details

11179087
11754973
11940550
15728586
16170337
17124262
17287366
19299911
23939492
27094368
27094369
28822817
 		CTD
113Cataract operationOFFSIDES
114Cataract operation complicationOFFSIDES
115CataractOFFSIDES
116CellulitisOFFSIDES
117Cerebellar infarctionOFFSIDES
118Cerebral Arterial Diseases9296138CTD
119Cerebral Infarction1614584CTD
120Choking sensationOFFSIDES
121Cholecystitis infectiveOFFSIDES
122Chronic respiratory failureOFFSIDES
123Collagen-vascular diseaseOFFSIDES
124ConjunctivitisCanada Vigilance: 3Canada Vigilance
125Corneal epithelium disorderOFFSIDES
126Corneal erosionOFFSIDES
127CystOFFSIDES
128Denture wearerOFFSIDES
129Depressed moodOFFSIDES
130Dermatitis, Allergic Contact18383004CTD
131Device FailureOFFSIDES
132Diabetes InsipidusOFFSIDES
133DiverticulitisOFFSIDES
134DiverticulumOFFSIDES
135DizzinessCanada Vigilance: 1Canada Vigilance
SIDER
136Drug dispensing errorOFFSIDES
137DysmorphismOFFSIDES
138Dysthymic DisorderOFFSIDES
139Electrocardiogram ST-T changeOFFSIDES
140Endodontic procedureOFFSIDES
141EndophthalmitisOFFSIDES
142Epigastric painSIDER
143Erectile dysfunction6137152CTD
144Escherichia infectionOFFSIDES
145Euphoric moodOFFSIDES
146ExcitabilitySIDER
147ExtravasationSIDER
148Feeding disorder neonatalOFFSIDES
149Fetal Diseases18806043CTD
150Floppy iris syndromeOFFSIDES
151General physical health deteriorationOFFSIDES
152GranulocytosisOFFSIDES
153Headache9296138CTD
SIDER
154Heart Diseases8346819CTD
155Heparin-induced thrombocytopeniaOFFSIDES
156HepatosplenomegalyOFFSIDES
157Hyperalgesia18559275CTD
158Hyperemia7828311CTD
159HypersensitivitySIDER
160Hypertensive crisisSIDER
161Hypertrophy

View details

9788975
12791704
18502941
20582486
23297412
24903162
25107896
25449040
26168186
 		CTD
162Hypotension, Orthostatic10369619CTD
163Hypoxia7532552CTD
OFFSIDES
164Impaired gastric emptyingOFFSIDES
165Intercepted medication errorOFFSIDES
166Intervertebral Disc DegenerationOFFSIDES
167Intestinal ObstructionOFFSIDES
168Intestinal infarctionOFFSIDES
169Intraocular inflammationOFFSIDES
170Intraoperative Complications1614584
3365589		CTD
171IridoceleOFFSIDES
172Iridocyclitis11037905CTD
173KeratitisSIDER
174LacrimationSIDER
175Left Ventricular HypertrophyOFFSIDES
176Loose toothOFFSIDES
177Mallory-Weiss SyndromeOFFSIDES
178Mental status changesOFFSIDES
179Metabolic acidosisOFFSIDES
180Multiple drug overdose intentionalOFFSIDES
181Muscle necrosisOFFSIDES
182Musculoskeletal discomfortOFFSIDES
183Mydriasis

View details

2620933
3920700
7074302
8780295
 		CTD
184MyelodysplasiaOFFSIDES
185Myocardial Ischemia9380924
9433094
9987052		CTD
186Myocardial Stunning7772323
9433094		CTD
187Neck PainSIDER
188Necrosis6953098CTD
189Nephrosis10406839CTD
190NervousnessSIDER
191Neurologic Manifestations19513130CTD
192Neutropenic infectionOFFSIDES
193Obstetric Labor Complications18806043CTD
194Ocular Hypertension19295368CTD
195Open reduction of fractureOFFSIDES
196PROTHROMBIN TIMEOFFSIDES
197Pain, Postoperative8610872CTD
198Pain

View details

2271928
8773445
11037905
15363882
 		CTD
SIDER
199PallorOFFSIDES
SIDER
200PalpitationsCanada Vigilance: 1Canada Vigilance
SIDER
201Personality Disorders3575346CTD
202PhotophobiaSIDER
203PiloerectionSIDER
204Platelet factor 4 increasedOFFSIDES
205Pleural decorticationOFFSIDES
206Post procedural complicationOFFSIDES
207Priapism1856926
18194188		CTD
208Procedural hypotensionOFFSIDES
209Propofol Infusion SyndromeOFFSIDES
210Prostatic Hyperplasia16784248CTD
211PruritusSIDER
212Puerperal Disorders9296138CTD
213Pulmonary Edema

View details

71637
8001214
9230324
9380923
9605701
12383833
 		CTD
214RalesSIDER
215Reflex bradycardiaSIDER
216Retinogram abnormalOFFSIDES
217RhabdomyolysisOFFSIDES
218RhinitisOFFSIDES
219Seizures7856916CTD
220Septic ShockOFFSIDES
221ShockSIDER
222Sinusitis7327846CTD
OFFSIDES
223Skin Diseases, Vascular17938347CTD
224Skin necrosisSIDER
225Sleep Apnea Syndromes1537703CTD
226SomnolenceCanada Vigilance: 1Canada Vigilance
227Spinal column stenosisOFFSIDES
228SpondylolisthesisOFFSIDES
229Stem cell transplantOFFSIDES
230Stevens-Johnson SyndromeOFFSIDES
231Subarachnoid Hemorrhage12383833
12791938
18194188		CTD
232Supraventricular tachycardiaOFFSIDES
233Syncope12528876CTD
SIDER
234Synovial CystOFFSIDES
235Tachycardia, Ventricular1280660CTD
236TendinitisOFFSIDES
237TensionSIDER
238Tetralogy of Fallot14617591CTD
239Therapeutic response unexpected with drug substitutionOFFSIDES
240Thrombosis22016802CTD
241Tongue blisteringOFFSIDES
242Tooth ExtractionOFFSIDES
243Tooth LossOFFSIDES
244Toxic anterior segment syndromeOFFSIDES
245TremblingSIDER
246UnderweightSIDER
247Vascular resistance systemic decreasedOFFSIDES
248Vasospasm, Intracranial12015837CTD
249VasospasmOFFSIDES
250Ventricular Dysfunction, Left9433094CTD
251Ventricular arrhythmiaSIDER
252Vitreous floatersSIDER
253VitritisOFFSIDES
254VomitingSIDER
255nervous system disorderSIDER
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