MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Papaverine

(XQYZDYMELSJDRZ-UHFFFAOYSA-N)

Structure

SMILES: COc1ccc(cc1OC)Cc1nccc2c1cc(OC)c(c2)OC
Type(s): Approved; Investigational
ATC code(s): A03AD01; G04BE02; G04BE52
Molecular Formula:: C20H21NO4
Molecular Weight:: 339.385
Log P:: 3.8600
Hydrogen Bond Acceptor:: 5
Hydrogen Bond Donor:: 0
TPSA:: 49.81
CAS Number(s):: 58-74-2; 61-25-6

Synonym(s)

Papaverine

Cerespan

Papaverine Hydrochloride

Pavabid

Pavatym

Hydrochloride, Papaverine

External Link(s)

MeSH	D010208
PubChem Compound	4680
BindingDB	14754
ChEBI	28241
CHEMBL	CHEMBL19224
DrugBank	DB01113
DrugCentral	2056
KEGG	cpd:C06533 dr:D07425
Therapeutic Target Database	D0WV2S D0NJ3V
ZINC	56555

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Agonal death struggle	FAERS: 1		US FAERS
2	Blood creatine increased	FAERS: 1		US FAERS
3	Blood glucose increased	FAERS: 1		US FAERS
4	Blood sodium increased	FAERS: 1		US FAERS
5	Cardiac Arrest	FAERS: 1		US FAERS
6	Carotid pulse decreased	FAERS: 1		US FAERS
7	Flushing	FAERS: 1		SIDER US FAERS
8	Hepatitis	FAERS: 1	4029887	CTD SIDER US FAERS
9	PCO2 increased	FAERS: 1		US FAERS
10	Pruritus	FAERS: 1		US FAERS
11	Vomiting	FAERS: 1		US FAERS
12	Abdominal discomfort			SIDER
13	Anorexia			SIDER
14	Aphasia		8613866	CTD
15	Arterial Occlusive Diseases		3809473 8451424	CTD
16	Atrioventricular Block		1422403	CTD
17	Blindness		19901231	CTD
18	Bradycardia		19961315	CTD
19	Catalepsy		1033561	CTD
20	Cerebral Arterial Diseases		9726476	CTD
21	Chest Pain		2750660	CTD
22	Choroid Diseases		19901231	CTD
23	Constipation			SIDER
24	Dermatitis			SIDER
25	Discomfort			SIDER
26	Dizziness		3366170	CTD
27	Dyskinesia, Drug-Induced		1172755	CTD
28	Dyspareunia		1296038 1719248	CTD
29	Edema		11549511	CTD
30	Erectile dysfunction		View details 1296038 1589286 1737261 1984099 2278150 2327828 2366292 2617964 2908935 2917481 3175561 3215253 3363769 3640652 3687629 7735362 9607891 10098948 14999218	CTD
31	Exophthalmos		19901231	CTD
32	Facial Nerve Diseases		12513030	CTD
33	Facial paralysis		9918178 12513030 17977279	CTD
34	Feeling abnormal			SIDER
35	Fibrosis		11549511	CTD
36	General discomfort			SIDER
37	Headache			SIDER
38	Hematoma		3762853	CTD
39	Hemiplegia		8613866	CTD
40	Hepatitis, Chronic		3949106	CTD
41	Hepatomegaly		28108177	CTD
42	Hyperemia		View details 2358592 3881002 6240483 8287414 8601879 8892781 9840701 11249884 17351955 18568317	CTD
43	Hypotension		View details 999414 2835134 16984954 19604547 19961315	CTD
44	Impotence, Vasculogenic		1719248 2038782	CTD
45	Infarction		19901231	CTD
46	Intracranial Embolism		16283980	CTD
47	Intracranial Hypertension		9726476	CTD
48	Liver Cirrhosis		3949106	CTD
49	Long QT Syndrome		View details 2044564 2334953 2605630 7511988	CTD
50	Malaise			SIDER
51	Muscle Weakness		3366170	CTD
52	Mydriasis		12513030	CTD
53	Nausea			SIDER
54	Neurologic Manifestations		7847211	CTD
55	Paresis		3762853 11145478	CTD
56	Postoperative Complications		9918178	CTD
57	Priapism		View details 1296038 1589286 1719248 1984077 2278150 2327828 2524805 2908935 2917481 7713130 14999218	CTD
58	Respiratory Insufficiency		7847211	CTD
59	Sinus Arrest, Cardiac		19961315	CTD
60	Spasm		47907	CTD
61	Tachycardia, Ventricular		View details 2299067 7511988 8032075 8892781	CTD
62	Thrombosis		8451424	CTD
63	Torsades de Pointes		2044564 2605630	CTD
64	Tranquillisation excessive			SIDER
65	Vasospasm, Intracranial		View details 7847211 7900600 8010275 9726476 11145478 18726058 19057314 19901231	CTD
66	Ventricular Fibrillation		1772671	CTD
67	Vertigo			SIDER
68	Vestibulocochlear Nerve Diseases		18726058	CTD
69	jaundice		3949106	CTD

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