MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Stavudine

(XNKLLVCARDGLGL-JGVFFNPUSA-N)

Structure

SMILES: Cc1cn([C@@H]2O[C@@H](C=C2)CO)c(=O)[nH]c1=O
Type(s): Approved; Investigational
ATC code(s): J05AF04; J05AR07
Molecular Formula:: C10H12N2O4
Molecular Weight:: 224.213
Log P:: -0.7091
Hydrogen Bond Acceptor:: 5
Hydrogen Bond Donor:: 2
TPSA:: 84.32
CAS Number(s):: 3056-17-5; 220020-60-0

Synonym(s)

Stavudine

2',3'-Didehydro-3'-deoxythymidine

D4T

2',3'-Didehydro-2',3'-dideoxythmidine

BMY-27857

Stavudine, Monosodium Salt

Zerit

2',3' Didehydro 3' deoxythymidine

BMY 27857

10.

BMY27857

External Link(s)

MeSH	D018119
PubChem Compound	18283
BindingDB	50013111
ChEBI	63581
CHEMBL	CHEMBL991
DrugBank	DB00649
DrugCentral	2478
KEGG	cpd:C07312 dr:D00445
Therapeutic Target Database	D0Z8EX
ZINC	137884

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Lipodystrophy acquired	FAERS: 18		OFFSIDES SIDER US FAERS
2	Mitochondrial toxicity	FAERS: 14		OFFSIDES SIDER US FAERS
3	Facial wasting	FAERS: 7		OFFSIDES US FAERS
4	Pancreatitis	FAERS: 7	15547198 17279048	CTD OFFSIDES SIDER US FAERS
5	treatment failure	FAERS: 4		OFFSIDES US FAERS
6	Lipoatrophy	FAERS: 3		SIDER US FAERS
7	Abdominal Pain	FAERS: 2	18261327	CTD OFFSIDES SIDER US FAERS
8	Adverse event	FAERS: 2		US FAERS
9	Diabetes Mellitus	FAERS: 2		SIDER US FAERS
10	Drug exposure during pregnancy	FAERS: 2		US FAERS
11	Drug toxicity	FAERS: 2		OFFSIDES US FAERS
12	Expired drug administered	FAERS: 2		US FAERS
13	Lipohypertrophy	FAERS: 2		OFFSIDES SIDER US FAERS
14	Medication Error	FAERS: 2		US FAERS
15	Nausea	FAERS: 2	10950090 11061656 11774091	CTD OFFSIDES SIDER US FAERS
16	Neutropenia	FAERS: 2		SIDER US FAERS
17	Pregnancy	FAERS: 2		US FAERS
18	Suicide attempt	FAERS: 2		US FAERS
19	Xanthoma	FAERS: 2		OFFSIDES US FAERS
20	jaundice	FAERS: 2		SIDER US FAERS
21	Abscess	FAERS: 1		OFFSIDES US FAERS
22	Blood cholesterol increased	FAERS: 1		US FAERS
23	Blood creatinine increased	FAERS: 1		US FAERS
24	Blood glucose increased	FAERS: 1		US FAERS
25	Blood urea increased	FAERS: 1		US FAERS
26	Chills	FAERS: 1		SIDER US FAERS
27	Creatinine renal clearance decreased	FAERS: 1		OFFSIDES US FAERS
28	Deformity	FAERS: 1		US FAERS
29	Dementia	FAERS: 1		US FAERS
30	Drug resistance	FAERS: 1		OFFSIDES US FAERS
31	Economic problem	FAERS: 1		OFFSIDES US FAERS
32	Emotional distress	FAERS: 1		US FAERS
33	Fatigue	FAERS: 1	11061656	CTD OFFSIDES SIDER US FAERS
34	Hepatotoxicity	FAERS: 1		SIDER US FAERS
35	Incorrect dose administered	FAERS: 1		US FAERS
36	Malaise	FAERS: 1		US FAERS
37	Mental status changes	FAERS: 1		US FAERS
38	Mitochondrial cytopathy	FAERS: 1		US FAERS
39	Myocardial Infarction	FAERS: 1		US FAERS
40	Neuropathy	FAERS: 1		SIDER US FAERS
41	No adverse effect	FAERS: 1		US FAERS
42	Nodular regenerative hyperplasia	FAERS: 1		OFFSIDES US FAERS
43	Oropharyngeal cancer stage unspecified	FAERS: 1		US FAERS
44	Pain	FAERS: 1		SIDER US FAERS
45	Pneumocystis jiroveci pneumonia	FAERS: 1		OFFSIDES US FAERS
46	Portal Hypertension	FAERS: 1		OFFSIDES US FAERS
47	Pregnancy on contraceptive	FAERS: 1		US FAERS
48	Product quality issue	FAERS: 1		US FAERS
49	Pruritus	FAERS: 1		SIDER US FAERS
50	Shock	FAERS: 1		US FAERS
51	Skin Wrinkling	FAERS: 1		US FAERS
52	Virologic failure	FAERS: 1		US FAERS
53	Vomiting	FAERS: 1	11061656	CTD SIDER US FAERS
54	ACTH stimulation test abnormal			OFFSIDES
55	AIDS Dementia Complex		19139369	CTD
56	AIDS related complex			OFFSIDES
57	Abasia			OFFSIDES
58	Abdominal Compartment Syndrome			OFFSIDES
59	Abdominal Infection			OFFSIDES
60	Abdominal sepsis			OFFSIDES
61	Abdominal tenderness			OFFSIDES
62	Acid fast bacilli infection			OFFSIDES
63	Acidosis, Lactic		View details 10894300 10906833 11356442 15547198 17279048 18580619 19702629 19732926 23782481	CTD
64	Acidosis		12604378	CTD OFFSIDES
65	Acne			SIDER
66	Acquired Immunodeficiency Syndrome		7861015 7861017	CTD
67	Acquired Protein S Deficiency			OFFSIDES
68	Acute Chest Syndrome			OFFSIDES
69	Acute kidney injury		11959068	CTD
70	Acute myocardial infarction			OFFSIDES
71	Adenitis			OFFSIDES
72	Alanine Aminotransferase Increased			OFFSIDES
73	Alanine aminotransferase abnormal			OFFSIDES
74	Alopecia		18261327	CTD
75	Alveolitis			OFFSIDES
76	Anemia, Macrocytic		10476771	CTD
77	Anemia		17279048 17760739	CTD
78	Anisocytosis			OFFSIDES
79	Anogenital dysplasia			OFFSIDES
80	Anorexia			OFFSIDES SIDER
81	Anxiety			SIDER
82	Apathy			OFFSIDES
83	Aplasia Cutis Congenita			OFFSIDES
84	Appendicitis			OFFSIDES
85	Arterial fibrosis			OFFSIDES
86	Arteriogram coronary abnormal			OFFSIDES
87	Arthralgia			SIDER
88	Arthritis			OFFSIDES
89	Ascites			OFFSIDES
90	Aseptic Meningitis			OFFSIDES
91	Asterixis			OFFSIDES
92	Asthenia			SIDER
93	Asymptomatic hyperlactatemia			SIDER
94	Atrial tachycardia			OFFSIDES
95	Atrioventricular Block			OFFSIDES
96	Atrioventricular Septal Defect			OFFSIDES
97	Atypical mycobacterial lymphadenitis			OFFSIDES
98	Back Pain			SIDER
99	Bacteria stool identified			OFFSIDES
100	Base excess increased			OFFSIDES
101	Bicytopenia			OFFSIDES
102	Bilirubin conjugated increased			OFFSIDES
103	Biopsy lymph gland abnormal			OFFSIDES
104	Bipolar Disorder			OFFSIDES
105	Blepharoptosis			OFFSIDES
106	Blood Glucose			OFFSIDES
107	Blood HIV RNA decreased			OFFSIDES
108	Blood alkaline phosphatase increased			OFFSIDES
109	Blood amylase increased			OFFSIDES
110	Blood and lymphatic system disorders			SIDER
111	Blood beta-D-glucan increased			OFFSIDES
112	Blood bilirubin unconjugated increased			OFFSIDES
113	Blood cholesterol			OFFSIDES
114	Blood creatine phosphokinase increased			OFFSIDES
115	Blood electrolytes abnormal			OFFSIDES
116	Blood ketone body decreased			OFFSIDES
117	Blood lactate dehydrogenase increased			OFFSIDES
118	Blood pH decreased			OFFSIDES
119	Blood pyruvic acid decreased			OFFSIDES
120	Blood pyruvic acid increased			OFFSIDES
121	Blood thyroid stimulating hormone increased			OFFSIDES
122	Blood triglycerides increased			OFFSIDES SIDER
123	Blood uric acid			OFFSIDES
124	Body Temperature			OFFSIDES
125	Body fat disorder			OFFSIDES
126	Body height below normal			OFFSIDES
127	Bone infarction			OFFSIDES
128	Bone lesion			OFFSIDES
129	Bone marrow toxicity			OFFSIDES
130	Brain stem syndrome			OFFSIDES
131	Bronchitis			SIDER
132	Buffalo hump			SIDER
133	Bulbar palsy			OFFSIDES
134	Bursitis			OFFSIDES
135	CD4 Lymphocytes Decreased			OFFSIDES
136	CD4 lymphocytes abnormal			OFFSIDES
137	Candida serology positive			OFFSIDES
138	Candidiasis		12008857	CTD
139	Cardiac Tamponade			OFFSIDES
140	Cataract			OFFSIDES
141	Central nervous system lesion			OFFSIDES
142	Cerebral aspergillosis			OFFSIDES
143	Cerebral atrophy congenital			OFFSIDES
144	Cerebral disorder			OFFSIDES
145	Cerebral hypoperfusion			OFFSIDES
146	Cervical dysplasia			OFFSIDES
147	Chemical and Drug Induced Liver Injury		View details 10950090 11356442 15507236 15674093 28437613	CTD
148	Chest Pain			OFFSIDES
149	Choking sensation			OFFSIDES
150	Chondromatosis			OFFSIDES
151	Choroiditis			OFFSIDES
152	Cirrhosis			OFFSIDES
153	Citrobacter infection			OFFSIDES
154	Clonus			OFFSIDES
155	Concomitant disease progression			OFFSIDES
156	Congenital cystic kidney disease			OFFSIDES
157	Congenital cytomegalovirus infection			OFFSIDES
158	Congenital hydronephrosis			OFFSIDES
159	Congenital mitochondrial cytopathy			OFFSIDES
160	Conjunctivitis			SIDER
161	Consciousness fluctuating			OFFSIDES
162	Constipation			SIDER
163	Corneal Ulcer			OFFSIDES
164	Corneal abscess			OFFSIDES
165	Corynebacterium sepsis			OFFSIDES
166	Creatinine urine decreased			OFFSIDES
167	Cubital Tunnel Syndrome			OFFSIDES
168	Cyst			OFFSIDES
169	Cytomegalovirus chorioretinitis			OFFSIDES
170	Cytomegalovirus myocarditis			OFFSIDES
171	Dandy-Walker Syndrome			OFFSIDES
172	Decreased Libido			OFFSIDES
173	Demyelination			OFFSIDES
174	Depressed Level of Consciousness			OFFSIDES
175	Dermatitis			SIDER
176	Diabetes			OFFSIDES
177	Diabetic Foot			OFFSIDES
178	Diarrhea		10950090 11774091 12008857	CTD OFFSIDES
179	Diffuse Large B-Cell Lymphoma			OFFSIDES
180	Diffuse panbronchiolitis			OFFSIDES
181	Diplopia			OFFSIDES
182	Disease recurrence			OFFSIDES
183	Dizziness		11774091	CTD OFFSIDES SIDER
184	Drug abuser			OFFSIDES
185	Drug ineffective			OFFSIDES
186	Dry skin			SIDER
187	Duodenal Ulcer			OFFSIDES
188	Dysgeusia			SIDER
189	Dyslalia			OFFSIDES
190	Dyspepsia			SIDER
191	Dysuria			OFFSIDES SIDER
192	Ear discomfort			OFFSIDES
193	Electrocardiogram ST-T change			OFFSIDES
194	Enterocolitis			OFFSIDES
195	Enuresis			OFFSIDES
196	Epidermal necrosis			OFFSIDES
197	Epididymitis			OFFSIDES
198	Erectile dysfunction			OFFSIDES
199	Eructation			SIDER
200	Erythema Nodosum			OFFSIDES
201	Erythema		17279048 18261327	CTD
202	Escherichia sepsis			OFFSIDES
203	Eustachian tube disorder			OFFSIDES
204	Eye inflammation			OFFSIDES
205	Eyelid Diseases			OFFSIDES
206	Facial Neuralgia			OFFSIDES
207	Fanconi Syndrome		18580619	CTD
208	Fat redistribution			OFFSIDES SIDER
209	Fatty Liver		View details 9562777 10894300 10906833 12604378 15547198 18299183	CTD OFFSIDES
210	Feeling Cold			OFFSIDES
211	Femoral arterial stenosis			OFFSIDES
212	Fever		18261327	CTD
213	Flatulence			SIDER
214	Gamma-Glutamyltransferase Increased			OFFSIDES
215	Gamma-glutamyltransferase abnormal			OFFSIDES
216	Gastric ulcer			OFFSIDES
217	Gastroenteritis			OFFSIDES
218	Gastrointestinal Pain			SIDER
219	Gastrointestinal perforation			OFFSIDES
220	General nutrition disorder			OFFSIDES
221	General physical health deterioration			OFFSIDES
222	Genital Herpes			OFFSIDES
223	Glasgow coma scale			OFFSIDES
224	Glioma			OFFSIDES
225	Glossitis			OFFSIDES
226	Graft infection			OFFSIDES
227	Granuloma			OFFSIDES
228	Guillain-Barre Syndrome			SIDER
229	HIV Infections		View details 7861018 9007205 9317091 9562777 10320127 10476771 10534145 10534154 10708286 11061656 11141242 11303821 11356442 11442229 11486172 11741175 12473835 12799577 15547198 16135977 16288408 17259905 18261327 19328734 20232757	CTD
230	HIV Seropositivity		11110045	CTD
231	HIV Wasting Syndrome			OFFSIDES
232	HIV-Associated Lipodystrophy Syndrome		16135977	CTD
233	Haemoconcentration			OFFSIDES
234	Headache			SIDER
235	Hearing Loss, Bilateral		11774091	CTD
236	Hearing Loss, Sudden		11774091	CTD
237	Heart sounds abnormal			OFFSIDES
238	Hemothorax			OFFSIDES
239	Hepatic enzyme decreased			OFFSIDES
240	Hepatitis B Virus			OFFSIDES
241	Hepatitis B			OFFSIDES SIDER
242	Hepatitis C			OFFSIDES
243	Hepatitis		17279048	CTD SIDER
244	Hepatomegaly		10950090 15547198	CTD SIDER
245	Hepatosplenomegaly			OFFSIDES
246	Human anti-mouse antibody positive			OFFSIDES
247	Hyperalgesia		19398414 19442827	CTD
248	Hypersensitivity			SIDER
249	Hypertensive cardiomyopathy			OFFSIDES
250	Hypertrophy of Breast			SIDER
251	Hypervigilance			OFFSIDES
252	Hypogonadism			OFFSIDES
253	Hyporeflexia			OFFSIDES
254	Hypospadias			OFFSIDES
255	Ileal ulcer			OFFSIDES
256	Immune reconstitution syndrome			OFFSIDES
257	Immunosuppression			OFFSIDES
258	Impetigo			OFFSIDES
259	Incisional hernia			OFFSIDES
260	Infantile spitting up			OFFSIDES
261	Infection in an immunocompromised host			OFFSIDES
262	Infection			OFFSIDES
263	Inflammation			SIDER
264	Influenza			SIDER
265	Inguinal mass			OFFSIDES
266	Insulin Resistance			OFFSIDES SIDER
267	Intentional misuse			OFFSIDES
268	Intraocular inflammation			OFFSIDES
269	Intrauterine infection			OFFSIDES
270	Iridocyclitis			OFFSIDES
271	Isosporiasis			OFFSIDES
272	Joint warmth			OFFSIDES
273	Kidney Diseases		18261327	CTD
274	Kwashiorkor			OFFSIDES
275	Lactate pyruvate ratio increased			OFFSIDES
276	Lactic acidosis syndrome			SIDER
277	Left Ventricular Hypertrophy			OFFSIDES
278	Legionella			OFFSIDES
279	Leukopenia neonatal			OFFSIDES
280	Leukopenia			SIDER
281	Light chain analysis increased			OFFSIDES
282	Limb injury			OFFSIDES
283	Lip erosion			OFFSIDES
284	Lipase			OFFSIDES
285	Lipodystrophy		17362559 19732926 23782481	CTD SIDER
286	Lipomatosis		16135977	CTD
287	Liver Failure, Acute		12604378	CTD
288	Liver Failure		9317091 18299183	CTD
289	Liver diseases		18261327	CTD
290	Low set ears			OFFSIDES
291	Lung squamous cell carcinoma stage I			OFFSIDES
292	Lymph Node Tuberculosis			OFFSIDES
293	Lymphocytic infiltration			OFFSIDES
294	Lymphoma			OFFSIDES
295	Macrocytosis			OFFSIDES
296	Malnutrition			SIDER
297	Markedly reduced dietary intake			OFFSIDES
298	Meconium abnormal			OFFSIDES
299	Meningoradiculitis			OFFSIDES
300	Metabolic acidosis			OFFSIDES
301	Metastases to adrenals			OFFSIDES
302	Metastatic Neoplasm			OFFSIDES
303	Microalbuminuria			OFFSIDES
304	Microcephaly			OFFSIDES
305	Mitochondrial Diseases		10906833 15507236 20702595	CTD
306	Mitochondrial Myopathies		17545213	CTD
307	Mononeuritis			OFFSIDES
308	Monoplegia			OFFSIDES
309	Mood swings			SIDER
310	Multi-organ disorder			OFFSIDES
311	Muscle Weakness			OFFSIDES
312	Muscle necrosis			OFFSIDES
313	Muscle strain			OFFSIDES
314	Musculoskeletal discomfort			SIDER
315	Mutagenic effect			OFFSIDES
316	Myalgia			SIDER
317	Mycobacterium avium complex immune restoration disease			OFFSIDES
318	Necrotising granulomatous lymphadenitis			OFFSIDES
319	Neonatal aspiration			OFFSIDES
320	Nephrolithiasis			SIDER
321	Nephrotic Syndrome			OFFSIDES
322	Neuralgia		19801048	CTD
323	Neuritis			SIDER
324	Neurotoxicity Syndromes		12700465 19398414 19801048	CTD
325	Neutropenic sepsis			OFFSIDES
326	Neutrophil count decreased			OFFSIDES
327	Nodule			OFFSIDES
328	Nuclear magnetic resonance imaging abdominal			OFFSIDES
329	Numbness			SIDER
330	Nutritional condition abnormal			OFFSIDES
331	Nystagmus			OFFSIDES
332	Oligohydramnios			OFFSIDES
333	Ophthalmoplegia			OFFSIDES
334	Opisthotonus			OFFSIDES
335	Optic Atrophy			OFFSIDES
336	Orchitis			OFFSIDES
337	Osteopenia			OFFSIDES
338	PCO2 decreased			OFFSIDES
339	Pancreatic Insufficiency			OFFSIDES
340	Parasite DNA test positive			OFFSIDES
341	Patellofemoral Pain Syndrome			OFFSIDES
342	Pathogen resistance			OFFSIDES
343	Penile size reduced			OFFSIDES
344	Periarthritis			OFFSIDES
345	Pericarditis			OFFSIDES
346	Peripheral Nervous System Diseases		View details 7861015 7861017 7861018 9030365 10534154 10716503 10716516 10780724 11737385 12008857 12700465 17279048 17362559 18261327 18422462 18431998 19139369 19398414 19636052 19732926	CTD
347	Pharyngeal candidiasis			OFFSIDES
348	Pharyngitis			SIDER
349	Plagiocephaly			OFFSIDES
350	Platelet Transfusion			OFFSIDES
351	Polyneuropathy			OFFSIDES SIDER
352	Polysubstance dependence			OFFSIDES
353	Porencephaly			OFFSIDES
354	Portal Vein Thrombosis			OFFSIDES
355	Portal hypertensive gastropathy			OFFSIDES
356	Precocious Puberty			OFFSIDES
357	Prenatal Exposure Delayed Effects		20702595	CTD
358	Productive Cough			OFFSIDES
359	Protein-losing gastroenteropathy			OFFSIDES
360	Pseudomonal sepsis			OFFSIDES
361	Psychomotor skills impaired			OFFSIDES
362	Pulmonary Hypertension			OFFSIDES
363	Pulmonary Infarction			OFFSIDES
364	Pyelonephritis			OFFSIDES
365	Pyonephrosis			OFFSIDES
366	Radiculitis			OFFSIDES
367	Rales			OFFSIDES
368	Respiratory Failure			SIDER
369	Retinitis			OFFSIDES
370	Rhabdomyolysis		11959068	CTD
371	Rhinitis			SIDER
372	Salmonella sepsis			OFFSIDES
373	Schizophrenia			OFFSIDES
374	Sick Sinus Syndrome			OFFSIDES
375	Sinus bradycardia			OFFSIDES
376	Sinus headache			OFFSIDES
377	Sinusitis			SIDER
378	Sjogren's Syndrome			OFFSIDES
379	Skeleton dysplasia			OFFSIDES
380	Skin lesion			OFFSIDES
381	Skin toxicity			OFFSIDES
382	Somnolence			SIDER
383	Spinal Cord Diseases		16135977	CTD
384	Sputum test			OFFSIDES
385	Stevens-Johnson Syndrome			OFFSIDES
386	Stillbirth			SIDER
387	Stomatitis			SIDER
388	Stress			OFFSIDES
389	Superinfection lung			OFFSIDES
390	Supraventricular tachycardia			OFFSIDES
391	Sweating			SIDER
392	Symptomatic hyperlactatemia			SIDER
393	Testicular mass			OFFSIDES
394	Therapy non-responder			OFFSIDES
395	Thrombocytopenia			SIDER
396	Tinea Capitis			OFFSIDES
397	Tinnitus		11774091	CTD
398	Tolosa-Hunt Syndrome			OFFSIDES
399	Tongue biting			OFFSIDES
400	Tooth Extraction			OFFSIDES
401	Tracheitis			OFFSIDES
402	Umbilical cord vascular disorder			OFFSIDES
403	Umbilical hernia			OFFSIDES
404	Upper respiratory tract inflammation			OFFSIDES
405	Urinary sediment abnormal			OFFSIDES
406	Urinary tract infection staphylococcal			OFFSIDES
407	Urinary tract infection			SIDER
408	Urticaria			SIDER
409	Vasospasm			OFFSIDES
410	Vestibular Neuronitis			OFFSIDES
411	Viral mutation identified			OFFSIDES
412	Visual disturbance			OFFSIDES
413	Wasting Syndrome		12008857	CTD
414	Weight decreased			SIDER
415	nervous system disorder			SIDER

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