pitavastatin
(RHGYHLPFVJEAOC-FFNUKLMVSA-L)
Structure
- SMILES
- O[C@H](C[C@@H](/C=C/c1c(nc2c(c1c1ccc(cc1)F)cccc2)C1CC1)O)CC(=O)[O-].O[C@H](C[C@@H](/C=C/c1c(nc2c(c1c1ccc(cc1)F)cccc2)C1CC1)O)CC(=O)[O-].[Ca+2]
- Molecular Formula:
- C50H46CaF2N2O8
- Molecular Weight:
- 880.984
- Log P:
- 6.3668
- Hydrogen Bond Acceptor:
- 10
- Hydrogen Bond Donor:
- 4
- TPSA:
- 186.96
- CAS Number(s):
- 147511-69-1; 147526-32-7
Synonym(s)
1.
pitavastatin
2.
(E,3R,5S)-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoic acid
3.
NK 104
4.
NK-104
5.
P 872441
6.
P-872441
7.
itavastatin
8.
itavastatin calcium
9.
nisvastatin
10.
pitavastatin calcium
11.
pitavastatin lactone
External Link(s)
Adverse Drug Event(s)
| Name | Number of Reports | Reference(s) | Data Source | |
|---|---|---|---|---|
| 1 | Myalgia | FAERS: 82 | US FAERS | |
| 2 | Blood creatine phosphokinase increased | FAERS: 26 | US FAERS | |
| 3 | Headache | FAERS: 21 | US FAERS | |
| 4 | Arthralgia | FAERS: 20 | US FAERS | |
| 5 | Dizziness | FAERS: 17 | US FAERS | |
| 6 | Wrong technique in product usage process | FAERS: 17 | US FAERS | |
| 7 | Back Pain | FAERS: 15 | US FAERS | |
| 8 | Fatigue | FAERS: 15 | US FAERS | |
| 9 | Rhabdomyolysis | FAERS: 14 | US FAERS | |
| 10 | Asthenia | FAERS: 12 | US FAERS | |
| 11 | Myocardial Infarction | FAERS: 12 | US FAERS | |
| 12 | Malaise | FAERS: 11 | US FAERS | |
| 13 | Nausea | FAERS: 11 | US FAERS | |
| 14 | Pain | FAERS: 11 | US FAERS | |
| 15 | Alanine Aminotransferase Increased | FAERS: 9 | US FAERS | |
| 16 | Aspartate Aminotransferase Increased | FAERS: 9 | US FAERS | |
| 17 | Constipation | FAERS: 9 | US FAERS | |
| 18 | Wrong technique in drug usage process | FAERS: 9 | US FAERS | |
| 19 | No adverse event | FAERS: 8 | US FAERS | |
| 20 | Chest Pain | FAERS: 7 | US FAERS | |
| 21 | Feeling abnormal | FAERS: 7 | US FAERS | |
| 22 | Musculoskeletal Pain | FAERS: 7 | US FAERS | |
| 23 | Abasia | FAERS: 6 | US FAERS | |
| 24 | Abdominal Pain | FAERS: 6 | US FAERS | |
| 25 | Abdominal discomfort | FAERS: 6 | US FAERS | |
| 26 | Amnesia | FAERS: 6 | US FAERS | |
| 27 | Memory impairment | FAERS: 6 | US FAERS | |
| 28 | Pruritus | FAERS: 6 | US FAERS | |
| 29 | Vomiting | FAERS: 6 | US FAERS | |
| 30 | Weight decreased | FAERS: 6 | US FAERS | |
| 31 | Alopecia | FAERS: 5 | US FAERS | |
| 32 | Blood glucose increased | FAERS: 5 | US FAERS | |
| 33 | Drug ineffective | FAERS: 5 | US FAERS | |
| 34 | Dysgeusia | FAERS: 5 | US FAERS | |
| 35 | Inappropriate schedule of drug administration | FAERS: 5 | US FAERS | |
| 36 | Joint swelling | FAERS: 5 | US FAERS | |
| 37 | Nasopharyngitis | FAERS: 5 | US FAERS | |
| 38 | Tremor | FAERS: 5 | US FAERS | |
| 39 | Urticaria | FAERS: 5 | US FAERS | |
| 40 | Low density lipoprotein increased | FAERS: 4 | US FAERS | |
| 41 | Musculoskeletal stiffness | FAERS: 4 | US FAERS | |
| 42 | Myopathy | FAERS: 4 | US FAERS | |
| 43 | Palpitations | FAERS: 4 | US FAERS | |
| 44 | Somnolence | FAERS: 4 | US FAERS | |
| 45 | Activities of daily living impaired | FAERS: 3 | US FAERS | |
| 46 | Blood alkaline phosphatase increased | FAERS: 3 | US FAERS | |
| 47 | Blood triglycerides increased | FAERS: 3 | US FAERS | |
| 48 | Chills | FAERS: 3 | US FAERS | |
| 49 | Chromaturia | FAERS: 3 | US FAERS | |
| 50 | Disorientation | FAERS: 3 | US FAERS | |
| 51 | Dry skin | FAERS: 3 | US FAERS | |
| 52 | Dyspepsia | FAERS: 3 | US FAERS | |
| 53 | Guillain-Barre Syndrome | FAERS: 3 | US FAERS | |
| 54 | Pancreatitis | FAERS: 3 | US FAERS | |
| 55 | Anxiety | FAERS: 2 | US FAERS | |
| 56 | Ascites | FAERS: 2 | US FAERS | |
| 57 | Blood cholesterol increased | FAERS: 2 | US FAERS | |
| 58 | Cerebral Infarction | FAERS: 2 | US FAERS | |
| 59 | Cold sweat | FAERS: 2 | US FAERS | |
| 60 | Diabetes Mellitus | FAERS: 2 | US FAERS | |
| 61 | Dysarthria | FAERS: 2 | US FAERS | |
| 62 | Epigastric discomfort | FAERS: 2 | US FAERS | |
| 63 | Erectile dysfunction | FAERS: 2 | US FAERS | |
| 64 | Erythema | FAERS: 2 | US FAERS | |
| 65 | Gamma-Glutamyltransferase Increased | FAERS: 2 | US FAERS | |
| 66 | Hunger | FAERS: 2 | US FAERS | |
| 67 | Hypersensitivity | FAERS: 2 | US FAERS | |
| 68 | Incorrect dose administered | FAERS: 2 | US FAERS | |
| 69 | Infection | FAERS: 2 | US FAERS | |
| 70 | Lip swelling | FAERS: 2 | US FAERS | |
| 71 | Lymphadenopathy | FAERS: 2 | US FAERS | |
| 72 | Lymphoma | FAERS: 2 | US FAERS | |
| 73 | Middle insomnia | FAERS: 2 | US FAERS | |
| 74 | Miller Fisher Syndrome | FAERS: 2 | US FAERS | |
| 75 | Myoglobin blood increased | FAERS: 2 | US FAERS | |
| 76 | Myositis | FAERS: 2 | US FAERS | |
| 77 | Neck Pain | FAERS: 2 | US FAERS | |
| 78 | Neuralgia | FAERS: 2 | US FAERS | |
| 79 | Pneumonia | FAERS: 2 | US FAERS | |
| 80 | Retinal Detachment | FAERS: 2 | US FAERS | |
| 81 | Rhinitis | FAERS: 2 | US FAERS | |
| 82 | Thrombosis | FAERS: 2 | US FAERS | |
| 83 | Transaminases increased | FAERS: 2 | US FAERS | |
| 84 | Adenosquamous cell lung cancer | FAERS: 1 | US FAERS | |
| 85 | Alanine aminotransferase abnormal | FAERS: 1 | US FAERS | |
| 86 | Amylase abnormal | FAERS: 1 | US FAERS | |
| 87 | Anaphylactic shock | FAERS: 1 | US FAERS | |
| 88 | Angioedema | FAERS: 1 | US FAERS | |
| 89 | Aphasia | FAERS: 1 | US FAERS | |
| 90 | Aphonia | FAERS: 1 | US FAERS | |
| 91 | Arthritis | FAERS: 1 | US FAERS | |
| 92 | Aspartate aminotransferase abnormal | FAERS: 1 | US FAERS | |
| 93 | Asterixis | FAERS: 1 | US FAERS | |
| 94 | Atrial Fibrillation | FAERS: 1 | US FAERS | |
| 95 | Blood bilirubin abnormal | FAERS: 1 | US FAERS | |
| 96 | Blood lactate dehydrogenase increased | FAERS: 1 | US FAERS | |
| 97 | Blood pressure fluctuation | FAERS: 1 | US FAERS | |
| 98 | Blood urine present | FAERS: 1 | US FAERS | |
| 99 | Burning sensation | FAERS: 1 | US FAERS | |
| 100 | Chest discomfort | FAERS: 1 | US FAERS | |
| 101 | Cholecystitis | FAERS: 1 | US FAERS | |
| 102 | Cholestasis | FAERS: 1 | US FAERS | |
| 103 | Clumsiness | FAERS: 1 | US FAERS | |
| 104 | Consciousness fluctuating | FAERS: 1 | US FAERS | |
| 105 | Coronary Artery Disease | FAERS: 1 | US FAERS | |
| 106 | Crying | FAERS: 1 | US FAERS | |
| 107 | Deafness | FAERS: 1 | US FAERS | |
| 108 | Dehydration | FAERS: 1 | US FAERS | |
| 109 | Depressed Level of Consciousness | FAERS: 1 | US FAERS | |
| 110 | Device Failure | FAERS: 1 | US FAERS | |
| 111 | Diplopia | FAERS: 1 | US FAERS | |
| 112 | Discomfort | FAERS: 1 | US FAERS | |
| 113 | Drug administered to patient of inappropriate age | FAERS: 1 | US FAERS | |
| 114 | Drug effect incomplete | FAERS: 1 | US FAERS | |
| 115 | Dysuria | FAERS: 1 | US FAERS | |
| 116 | Ear discomfort | FAERS: 1 | US FAERS | |
| 117 | Electrocardiogram abnormal | FAERS: 1 | US FAERS | |
| 118 | Enteritis | FAERS: 1 | US FAERS | |
| 119 | Enterocolitis | FAERS: 1 | US FAERS | |
| 120 | Eosinophilic Fasciitis | FAERS: 1 | US FAERS | |
| 121 | Epistaxis | FAERS: 1 | US FAERS | |
| 122 | Erythema Multiforme | FAERS: 1 | US FAERS | |
| 123 | Feeling Cold | FAERS: 1 | US FAERS | |
| 124 | Flank Pain | FAERS: 1 | US FAERS | |
| 125 | Flatulence | FAERS: 1 | US FAERS | |
| 126 | Flushing | FAERS: 1 | US FAERS | |
| 127 | Gait inability | FAERS: 1 | US FAERS | |
| 128 | Gastroenteritis | FAERS: 1 | US FAERS | |
| 129 | General physical health deterioration | FAERS: 1 | US FAERS | |
| 130 | Genital erythema | FAERS: 1 | US FAERS | |
| 131 | Glaucoma | FAERS: 1 | US FAERS | |
| 132 | Heat Cramps | FAERS: 1 | US FAERS | |
| 133 | Hyperphagia | FAERS: 1 | US FAERS | |
| 134 | Hypersomnia | FAERS: 1 | US FAERS | |
| 135 | Ileus | FAERS: 1 | US FAERS | |
| 136 | Impaired driving ability | FAERS: 1 | US FAERS | |
| 137 | Impaired gastric emptying | FAERS: 1 | US FAERS | |
| 138 | Impaired work ability | FAERS: 1 | US FAERS | |
| 139 | Inability to afford medication | FAERS: 1 | US FAERS | |
| 140 | Induration | FAERS: 1 | US FAERS | |
| 141 | Inflammation | FAERS: 1 | US FAERS | |
| 142 | Initial insomnia | FAERS: 1 | US FAERS | |
| 143 | Intentional product misuse | FAERS: 1 | US FAERS | |
| 144 | Irritable Bowel Syndrome | FAERS: 1 | US FAERS | |
| 145 | Joint stiffness | FAERS: 1 | US FAERS | |
| 146 | Large intestine perforation | FAERS: 1 | US FAERS | |
| 147 | Lethargy | FAERS: 1 | US FAERS | |
| 148 | Limb injury | FAERS: 1 | US FAERS | |
| 149 | Lipase abnormal | FAERS: 1 | US FAERS | |
| 150 | Mental impairment | FAERS: 1 | US FAERS | |
| 151 | Monoplegia | FAERS: 1 | US FAERS | |
| 152 | Muscle tightness | FAERS: 1 | US FAERS | |
| 153 | Musculoskeletal discomfort | FAERS: 1 | US FAERS | |
| 154 | Ophthalmoplegia | FAERS: 1 | US FAERS | |
| 155 | Oropharyngeal pain | FAERS: 1 | US FAERS | |
| 156 | Pancytopenia | FAERS: 1 | US FAERS | |
| 157 | Paresis | FAERS: 1 | US FAERS | |
| 158 | Partner stress | FAERS: 1 | US FAERS | |
| 159 | Peripheral swelling | FAERS: 1 | US FAERS | |
| 160 | Personality Change | FAERS: 1 | US FAERS | |
| 161 | Pharyngitis | FAERS: 1 | US FAERS | |
| 162 | Physical examination abnormal | FAERS: 1 | US FAERS | |
| 163 | Polydipsia | FAERS: 1 | US FAERS | |
| 164 | Polymyositis | FAERS: 1 | US FAERS | |
| 165 | Polyuria | FAERS: 1 | US FAERS | |
| 166 | Prescribed overdose | FAERS: 1 | US FAERS | |
| 167 | Pulmonary congestion | FAERS: 1 | US FAERS | |
| 168 | Pyelonephritis | FAERS: 1 | US FAERS | |
| 169 | Rotator cuff syndrome | FAERS: 1 | US FAERS | |
| 170 | Saliva altered | FAERS: 1 | US FAERS | |
| 171 | Sexual Dysfunction | FAERS: 1 | US FAERS | |
| 172 | Sluggishness | FAERS: 1 | US FAERS | |
| 173 | Stevens-Johnson Syndrome | FAERS: 1 | US FAERS | |
| 174 | Sudden death | FAERS: 1 | US FAERS | |
| 175 | Suicide attempt | FAERS: 1 | US FAERS | |
| 176 | Swelling | FAERS: 1 | US FAERS | |
| 177 | Syncope | FAERS: 1 | US FAERS | |
| 178 | Synovial Cyst | FAERS: 1 | US FAERS | |
| 179 | Talipes | FAERS: 1 | US FAERS | |
| 180 | Throat irritation | FAERS: 1 | US FAERS | |
| 181 | Toothache | FAERS: 1 | US FAERS | |
| 182 | Toxic Epidermal Necrolysis | FAERS: 1 | US FAERS | |
| 183 | Toxicity to various agents | FAERS: 1 | US FAERS | |
| 184 | Unevaluable event | FAERS: 1 | US FAERS | |
| 185 | Urinary Retention | FAERS: 1 | US FAERS | |
| 186 | Urinary tract infection | FAERS: 1 | US FAERS | |
| 187 | Vaginal Discharge | FAERS: 1 | US FAERS | |
| 188 | Vasculitis | FAERS: 1 | US FAERS | |
| 189 | Vertigo | FAERS: 1 | US FAERS | |
| 190 | Visual Impairment | FAERS: 1 | US FAERS | |
| 191 | White blood cell count decreased | FAERS: 1 | US FAERS | |
| 192 | colonoscopy | FAERS: 1 | US FAERS | |
| 193 | jaundice | FAERS: 1 | US FAERS | |
| 194 | muscle injury | FAERS: 1 | US FAERS | |
| 195 | nervous system disorder | FAERS: 1 | US FAERS |
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