MetaADEDB 2.0 @ LMMD
Dipyridamole
(IZEKFCXSFNUWAM-UHFFFAOYSA-N)
Structure
SMILES
OCCN(c1nc(N2CCCCC2)c2c(n1)c(nc(n2)N(CCO)CCO)N1CCCCC1)CCO
Type(s)
Approved
ATC code(s)
B01AC07
Molecular Formula:
C24H40N8O4
Molecular Weight:
504.626
Log P:
0.1124
Hydrogen Bond Acceptor:
12
Hydrogen Bond Donor:
4
TPSA:
145.44
CAS Number(s):
58-32-2
Synonym(s)
1.
Dipyridamole
2.
Antistenocardin
3.
Apo-Dipyridamole
4.
Cerebrovase
5.
Cléridium
6.
Curantil
7.
Curantyl
8.
Dipyramidole
9.
Kurantil
10.
Miosen
11.
Novo-Dipiradol
12.
Persantin
13.
Persantine
14.
Apo Dipyridamole
15.
Novo Dipiradol
External Link(s)
MeSHD004176
PubChem Compound3108
BindingDB23620
ChEBI4653
CHEMBLCHEMBL932
DrugBankDB00975
DrugCentral924
IUPHAR/BPS Guide to PHARMACOLOGY4807
KEGGdr:D00302
Therapeutic Target DatabaseD0F9GE
ZINC643046
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1HeadacheFAERS: 19
Canada Vigilance: 4

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CTD
SIDER
Canada Vigilance
US FAERS
2Chest PainFAERS: 17
Canada Vigilance: 6

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CTD
OFFSIDES
SIDER
Canada Vigilance
US FAERS
3NauseaFAERS: 17
Canada Vigilance: 5

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CTD
OFFSIDES
SIDER
Canada Vigilance
US FAERS
4BradycardiaFAERS: 15

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CTD
SIDER
US FAERS
5HypotensionFAERS: 15

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CTD
SIDER
US FAERS
6VomitingFAERS: 14
Canada Vigilance: 2
8412526CTD
SIDER
Canada Vigilance
US FAERS
7Pharmaceutical product complaintFAERS: 12US FAERS
8Cardiac ArrestFAERS: 11
Canada Vigilance: 2
Canada Vigilance
SIDER
US FAERS
9DizzinessFAERS: 10
Canada Vigilance: 2

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CTD
SIDER
Canada Vigilance
US FAERS
10Injection site painFAERS: 10SIDER
US FAERS
11MalaiseFAERS: 10SIDER
US FAERS
12ShockFAERS: 9SIDER
US FAERS
13InfectionFAERS: 7OFFSIDES
US FAERS
14WheezingFAERS: 7US FAERS
15BronchospasmFAERS: 6SIDER
US FAERS
16ExtravasationFAERS: 6US FAERS
17Neck PainFAERS: 6US FAERS
18Chest discomfortFAERS: 5US FAERS
19Drug ineffectiveFAERS: 5US FAERS
20Inappropriate schedule of drug administrationFAERS: 5US FAERS
21PainFAERS: 58412526
9619318
CTD
SIDER
US FAERS
22Respiratory arrestFAERS: 5US FAERS
23SyncopeFAERS: 58254386CTD
SIDER
US FAERS
24Unevaluable eventFAERS: 5US FAERS
25Adverse eventFAERS: 4US FAERS
26AnxietyFAERS: 4
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
27Cerebrovascular accidentFAERS: 4SIDER
US FAERS
28FatigueFAERS: 4SIDER
US FAERS
29Myocardial InfarctionFAERS: 4
Canada Vigilance: 2

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CTD
SIDER
Canada Vigilance
US FAERS
30Brain ContusionFAERS: 3US FAERS
31Depressed moodFAERS: 3US FAERS
32Infusion site painFAERS: 3US FAERS
33PalpitationsFAERS: 3SIDER
US FAERS
34Procedural complicationFAERS: 3US FAERS
35TachycardiaFAERS: 3SIDER
US FAERS
36Abdominal PainFAERS: 23815730CTD
SIDER
US FAERS
37Acute myocardial infarctionFAERS: 2US FAERS
38Angina PectorisFAERS: 2

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CTD
SIDER
US FAERS
39AstheniaFAERS: 2SIDER
US FAERS
40Atrial FibrillationFAERS: 21464359CTD
SIDER
US FAERS
41Burning sensationFAERS: 2US FAERS
42Cardiac procedure complicationFAERS: 2US FAERS
43ChillsFAERS: 2SIDER
US FAERS
44DeliriumFAERS: 2US FAERS
45Drug DependenceFAERS: 2US FAERS
46DysgeusiaFAERS: 24026910CTD
SIDER
US FAERS
47EpilepsyFAERS: 2US FAERS
48EpistaxisFAERS: 2OFFSIDES
US FAERS
49FlushingFAERS: 21395766CTD
SIDER
US FAERS
50Frustration tolerance decreasedFAERS: 2US FAERS
51Granulocyte count decreasedFAERS: 2US FAERS
52HydrocephalusFAERS: 2US FAERS
53HypersensitivityFAERS: 2SIDER
US FAERS
54Medication ErrorFAERS: 2US FAERS
55MyalgiaFAERS: 2SIDER
US FAERS
56No adverse eventFAERS: 2US FAERS
57OpisthotonusFAERS: 2US FAERS
58OverdoseFAERS: 2US FAERS
59Pancreatic carcinomaFAERS: 2US FAERS
60PiloerectionFAERS: 2US FAERS
61Product substitution issueFAERS: 2US FAERS
62Respiratory distressFAERS: 2US FAERS
63SepsisFAERS: 2US FAERS
64Sinus TachycardiaFAERS: 2US FAERS
65Suicide attemptFAERS: 2US FAERS
66Unresponsive to stimuliFAERS: 2US FAERS
67Weight decreasedFAERS: 2US FAERS
68White blood cell count decreasedFAERS: 2US FAERS
69Wrong technique in product usage processFAERS: 2US FAERS
70Accidental overdoseFAERS: 1US FAERS
71Acute Coronary SyndromeFAERS: 1SIDER
US FAERS
72AgitationFAERS: 1US FAERS
73AmnesiaFAERS: 1US FAERS
74Anaphylactic shockFAERS: 1SIDER
US FAERS
75Anastomotic stenosisFAERS: 1US FAERS
76Application site irritationFAERS: 1US FAERS
77AscitesFAERS: 1US FAERS
78Aspartate Aminotransferase IncreasedFAERS: 1US FAERS
79AsthmaFAERS: 1OFFSIDES
US FAERS
80Back PainFAERS: 1SIDER
US FAERS
81Bilirubin conjugated increasedFAERS: 1US FAERS
82Bladder neoplasm surgeryFAERS: 1US FAERS
83Blood potassium decreasedFAERS: 1US FAERS
84Cardiac TamponadeFAERS: 1US FAERS
85CellulitisFAERS: 1US FAERS
86Cerebral InfarctionFAERS: 1US FAERS
87Cerebral ventricle dilatationFAERS: 1US FAERS
88CholangitisFAERS: 1US FAERS
89CholestasisFAERS: 11360065CTD
US FAERS
90Chronic tonsillitisFAERS: 1US FAERS
91Cold sweatFAERS: 1US FAERS
92CyanosisFAERS: 1US FAERS
93Deep Vein ThrombosisFAERS: 1US FAERS
94DiplopiaFAERS: 1US FAERS
95Drug abuserFAERS: 1US FAERS
96Drug administration errorFAERS: 1US FAERS
97Drug dispensing errorFAERS: 1US FAERS
98Drug exposure during pregnancyFAERS: 1US FAERS
99Drug interaction inhibitionFAERS: 1US FAERS
100Electrocardiogram abnormalFAERS: 1
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
101Electromechanical dissociationFAERS: 1US FAERS
102Eye painFAERS: 1OFFSIDES
SIDER
US FAERS
103Feeling abnormalFAERS: 1SIDER
US FAERS
104FractureFAERS: 1US FAERS
105Gastrointestinal endoscopic therapyFAERS: 1US FAERS
106GlaucomaFAERS: 1US FAERS
107Hepatic EncephalopathyFAERS: 1US FAERS
108HepatotoxicityFAERS: 1US FAERS
109HypersplenismFAERS: 1US FAERS
110HypopituitarismFAERS: 1US FAERS
111HypoxiaFAERS: 1US FAERS
112IleusFAERS: 1US FAERS
113Inappropriate schedule of product administrationFAERS: 1US FAERS
114InflammationFAERS: 1US FAERS
115Infusion Site ExtravasationFAERS: 1US FAERS
116Injection Site ReactionFAERS: 1
Canada Vigilance: 2
Canada Vigilance
SIDER
US FAERS
117Injection site extravasationFAERS: 1US FAERS
118Injection site irritationFAERS: 1US FAERS
119Intestinal ObstructionFAERS: 1US FAERS
120LaparotomyFAERS: 1US FAERS
121Lip swellingFAERS: 1US FAERS
122Malignant Atrophic PapulosisFAERS: 1US FAERS
123Memory impairmentFAERS: 1US FAERS
124Mental impairmentFAERS: 1US FAERS
125Mental status changesFAERS: 1US FAERS
126Metabolic acidosisFAERS: 1US FAERS
127Mixed hepatocellular-cholestatic injuryFAERS: 1US FAERS
128Multiple drug overdose intentionalFAERS: 1US FAERS
129Muscle tightnessFAERS: 1
Canada Vigilance: 2
Canada Vigilance
US FAERS
130Musculoskeletal PainFAERS: 1SIDER
US FAERS
131MydriasisFAERS: 1US FAERS
132NervousnessFAERS: 1SIDER
US FAERS
133OphthalmoplegiaFAERS: 1US FAERS
134Oral dischargeFAERS: 1US FAERS
135Oral mucosa atrophyFAERS: 1US FAERS
136PallorFAERS: 1US FAERS
137PancytopeniaFAERS: 1US FAERS
138PeritonsillitisFAERS: 1US FAERS
139PharyngitisFAERS: 1SIDER
US FAERS
140Pharyngolaryngeal PainFAERS: 1US FAERS
141Platelet aggregation abnormalFAERS: 1US FAERS
142PneumonitisFAERS: 1US FAERS
143Poor quality drug administeredFAERS: 1US FAERS
144Post procedural complicationFAERS: 1US FAERS
145Prescribed overdoseFAERS: 1US FAERS
146PresyncopeFAERS: 1US FAERS
147Product contaminationFAERS: 1US FAERS
148Product storage errorFAERS: 1US FAERS
149Product use in unapproved indicationFAERS: 1US FAERS
150Protein urine presentFAERS: 1US FAERS
151Prothrombin level decreasedFAERS: 1US FAERS
152Pulmonary EmbolismFAERS: 1US FAERS
153ScabFAERS: 1US FAERS
154SciaticaFAERS: 1US FAERS
155SomnolenceFAERS: 1SIDER
US FAERS
156Throat irritationFAERS: 1US FAERS
157ThrombocytopeniaFAERS: 1SIDER
US FAERS
158ThrombosisFAERS: 13496060
16382298
CTD
US FAERS
159Toxic Epidermal NecrolysisFAERS: 1US FAERS
160Toxicity to various agentsFAERS: 1US FAERS
161TremorFAERS: 1
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
162UrticariaFAERS: 1
Canada Vigilance: 2
Canada Vigilance
SIDER
US FAERS
163Uterine CancerFAERS: 1US FAERS
164Ventricle ruptureFAERS: 1US FAERS
165Ventricular FibrillationFAERS: 1OFFSIDES
SIDER
US FAERS
166Ventricular arrhythmiaFAERS: 1SIDER
US FAERS
167Waist circumference increasedFAERS: 1US FAERS
1682',5'-oligoadenylate synthetase test increasedOFFSIDES
169Abdominal AbscessOFFSIDES
170Abdominal CrampsSIDER
171Abdominal discomfortSIDER
172Abdominal distressSIDER
173Abdominal symptomOFFSIDES
174Acidosis1433833CTD
OFFSIDES
175Activities of daily living impairedOFFSIDES
176Alanine Aminotransferase IncreasedOFFSIDES
177Alcohol consumptionOFFSIDES
178Alcoholic IntoxicationOFFSIDES
179AlopeciaSIDER
180Altered state of consciousnessOFFSIDES
181Anal FistulaOFFSIDES
182Anaphylactoid ReactionCanada Vigilance: 1Canada Vigilance
SIDER
183AngiodysplasiaOFFSIDES
184AngioedemaCanada Vigilance: 17977438CTD
SIDER
Canada Vigilance
185Anorectal discomfortSIDER
186AnorexiaOFFSIDES
187Anti-HBc IgG antibody positiveOFFSIDES
188Anti-HBc antibodyOFFSIDES
189Anuria3183852CTD
190ApathyOFFSIDES
191AphoniaOFFSIDES
192Apnea8423863CTD
193ArthralgiaSIDER
194ArthritisSIDER
195Atrioventricular Block

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CTD
SIDER
196Beta 2 microglobulin urine increasedOFFSIDES
197BiopsyOFFSIDES
198BlindnessCanada Vigilance: 1Canada Vigilance
199Blood GlucoseOFFSIDES
200Blood albumin decreasedOFFSIDES
201Blood alkaline phosphatase increasedOFFSIDES
202Blood and lymphatic system disordersSIDER
203Blood chloride increasedOFFSIDES
204Blood cholesterolOFFSIDES
205Blood count abnormalOFFSIDES
206Blood creatine increasedOFFSIDES
207Blood creatine phosphokinase decreasedOFFSIDES
208Blood creatinine increasedOFFSIDES
209Blood immunoglobulin A decreasedOFFSIDES
210Blood immunoglobulin G decreasedOFFSIDES
211Blood immunoglobulin M decreasedOFFSIDES
212Blood iron decreasedOFFSIDES
213Blood lactate dehydrogenase increasedOFFSIDES
214Blood urea increasedOFFSIDES
215Blood uric acid decreasedOFFSIDES
216Blood uric acidOFFSIDES
217Bone density decreasedOFFSIDES
218Brain Diseases7864009CTD
219Brain Ischemia7965160CTD
220BursitisOFFSIDES
221CalcinosisOFFSIDES
222Calcium deficiencyOFFSIDES
223Cardiac DeathSIDER
224Cardiomyopathy, Dilated9665216CTD
225Carotid artery occlusionOFFSIDES
226Cell marker increasedOFFSIDES
227Cerebellar infarctionOFFSIDES
228Cerebral artery occlusionOFFSIDES
229Chemical and Drug Induced Liver Injury24014644CTD
230Chemotherapeutic drug level increasedOFFSIDES
231CholelithiasisSIDER
232Conjunctival depositOFFSIDES
233Conjunctival erosionOFFSIDES
234Coronary Artery Disease1736603
2283188
3783931
CTD
SIDER
235Coronary heart diseaseSIDER
236Cytomegalovirus test positiveOFFSIDES
237DebridementOFFSIDES
238Dental cariesOFFSIDES
239Depressed Level of ConsciousnessOFFSIDES
240DermatitisSIDER
241Device FailureOFFSIDES
242Diarrhea3815730CTD
OFFSIDES
243DiscomfortSIDER
244Disease recurrenceOFFSIDES
245Disruptive, Impulse Control, and Conduct Disorders6093179CTD
246DistressSIDER
247DiverticulitisOFFSIDES
248Dyskinesia, Drug-Induced17377417CTD
249DyslaliaOFFSIDES
250DyspepsiaCanada Vigilance: 1Canada Vigilance
SIDER
251DysphoniaSIDER
252Dyspnea

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CTD
253Ear tube insertionOFFSIDES
254EczemaOFFSIDES
255Electrocardiogram ST-T changeSIDER
256Electrocardiogram changeSIDER
257Emotional distressOFFSIDES
SIDER
258EmpyemaOFFSIDES
259Eosinophil percentage increasedOFFSIDES
260EpidermolysisOFFSIDES
261Epigastric discomfortSIDER
262Epstein-Barr virus associated lymphoproliferative disorderOFFSIDES
263Erectile dysfunctionOFFSIDES
264EructationSIDER
265Erythema MultiformeOFFSIDES
266ErythemaOFFSIDES
267Eustachian tube disorderOFFSIDES
268Eye Abnormalities25883026CTD
269Eyelid painOFFSIDES
270Fibroadenoma of breastOFFSIDES
271FlatulenceSIDER
272Focal glomerulosclerosisOFFSIDES
273GamblingOFFSIDES
274Gamma-Glutamyltransferase IncreasedOFFSIDES
275Gastric irritationSIDER
276Gastric ulcerOFFSIDES
277Gastrointestinal Diseases1395766
18984426
CTD
278Gastrointestinal PainSIDER
279Gastrointestinal ulcerOFFSIDES
280General physical conditionOFFSIDES
281General physical health deteriorationOFFSIDES
282Genital rashOFFSIDES
283Gingival erythemaOFFSIDES
284Glomerulonephritis9496734CTD
OFFSIDES
285GoutOFFSIDES
286Hallucinations17845733CTD
287Head discomfortCanada Vigilance: 1Canada Vigilance
288Heart Block9922805
10221063
CTD
289Heart Diseases983936CTD
290Heart failure4026910
18037770
CTD
291Heat ExhaustionOFFSIDES
292Heat illnessOFFSIDES
293Hemolytic-Uremic Syndrome2413037CTD
294Hemorrhage1722991
18198244
CTD
295HepatitisSIDER
296HirsutismCanada Vigilance: 1Canada Vigilance
297Hyperemia

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CTD
298HyperventilationSIDER
299Implant site infectionOFFSIDES
300IncontinenceOFFSIDES
301Increased bronchial secretionOFFSIDES
302Injection site infectionOFFSIDES
303Interleukin-2 receptor increasedOFFSIDES
304Intermittent ClaudicationSIDER
305Intervertebral disc disorderOFFSIDES
306Intraoperative Complications795299
8571641
8890804
CTD
307Intraoperative HemorrhageSIDER
308Ischemia20145578CTD
309Joint sprainOFFSIDES
310Kidney FailureOFFSIDES
311Klebsiella sepsisOFFSIDES
312LaryngospasmOFFSIDES
SIDER
313LethargyOFFSIDES
314Leukocytosis1360065CTD
315Leukopenia neonatalOFFSIDES
316Life expectancy shortenedOFFSIDES
317Lung infection pseudomonalOFFSIDES
318Malignant neoplasm progressionOFFSIDES
319MeningiomaOFFSIDES
320Migraine Disorders16886928CTD
321Mitral Valve Insufficiency2738708CTD
322Mitral valve sclerosisOFFSIDES
323Moyamoya Disease16551458CTD
324MumpsOFFSIDES
325Muscle strainOFFSIDES
326Musculoskeletal discomfortCanada Vigilance: 1Canada Vigilance
SIDER
327Myocardial Ischemia

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CTD
328Myocardial Stunning11786737CTD
329Neoplasms3815730CTD
330Nephrosis9824428CTD
331OliguriaOFFSIDES
332Open woundOFFSIDES
333OsteolysisOFFSIDES
334ParaplegiaOFFSIDES
335Paresthesia8412526CTD
336Peptic UlcerSIDER
337Pericardial effusionOFFSIDES
338Perineal painSIDER
339PeriodontitisOFFSIDES
340Peritoneal DialysisOFFSIDES
341Peritoneal Fibrosis11380836CTD
342Pharyngolaryngeal discomfortOFFSIDES
343Photophobia16886928CTD
344Pleuritic painSIDER
345PoriomaniaOFFSIDES
346Postoperative wound complicationOFFSIDES
347Prenatal Injuries25883026CTD
348Protein total decreasedOFFSIDES
349Proteinuria1744988CTD
350PruritusSIDER
351Pseudomonal sepsisOFFSIDES
352Pulmonary radiation injuryOFFSIDES
353Rectal tenesmusSIDER
354Renal Artery StenosisOFFSIDES
355Renal painSIDER
356Renal tubular disorderOFFSIDES
357Renal tubular necrosisOFFSIDES
358Reperfusion Injury16003293CTD
359RhabdomyolysisOFFSIDES
360RhinitisSIDER
361SequestrectomyOFFSIDES
362Shock, Cardiogenic15944542CTD
363Shoulder PainSIDER
364Sinus Arrest, Cardiac8306773CTD
365Sinus bradycardiaOFFSIDES
366Skin lesionOFFSIDES
367Stomach acheSIDER
368StridorOFFSIDES
369Subarachnoid Hemorrhage1886315
20345728
CTD
370Substance Withdrawal Syndrome9576224
14583322
CTD
371Supraventricular tachycardiaCanada Vigilance: 1Canada Vigilance
SIDER
372Sustained ventricular tachycardiaSIDER
373Tachycardia, Ventricular1898221
8175222
10820963
CTD
374Takotsubo Cardiomyopathy20340053CTD
375TensionSIDER
376ThirstSIDER
377Throat cancerOFFSIDES
378TinnitusCanada Vigilance: 1Canada Vigilance
SIDER
379Tooth LossOFFSIDES
380Transient Cerebral IschemiaSIDER
381Troponin increasedOFFSIDES
382Urethral fistulaOFFSIDES
383Varicose vein operationOFFSIDES
384Venous Thrombosis795299CTD
385Ventricular Dysfunction, Left

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CTD
386VertigoCanada Vigilance: 12651175CTD
SIDER
Canada Vigilance
387anaphylaxis7977438CTD
388nervous system disorderSIDER
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