MetaADEDB 2.0 @ LMMD
alosetron
(JSWZEAMFRNKZNL-UHFFFAOYSA-N)
Structure
SMILES
O=C1N(CCc2c1c1ccccc1n2C)Cc1nc[nH]c1C
Type(s)
Approved; Withdrawn
ATC code(s)
A03AE01
Molecular Formula:
C17H18N4O
Molecular Weight:
294.351
Log P:
2.3462
Hydrogen Bond Acceptor:
4
Hydrogen Bond Donor:
1
TPSA:
53.92
CAS Number(s):
122852-42-0
Synonym(s)
1.
alosetron
2.
2,3,4,5-tetrahydro-5-methyl-2-((5-methylimidazol-4-yl)methyl)-1H-pyrido(4,3-b)indol-1-one monohydrochloride
3.
GR 68755
4.
GR68755
5.
Lotronex
6.
alosetron hydrochloride
7.
alosetron monohydrochloride
External Link(s)
MeSHC090840
PubChem Compound2099
BindingDB50014558
50131429
93624
ChEBI253342
CHEMBLCHEMBL1110
DrugBankDB00969
DrugCentral129
IUPHAR/BPS Guide to PHARMACOLOGY2296
KEGGdr:D07129
Therapeutic Target DatabaseD06GKN
ZINC13537284
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Drug ineffectiveFAERS: 34OFFSIDES
US FAERS
2Adverse eventFAERS: 30OFFSIDES
US FAERS
3ConstipationFAERS: 3015233703CTD
SIDER
US FAERS
4Abdominal PainFAERS: 28OFFSIDES
US FAERS
5VomitingFAERS: 25SIDER
US FAERS
6Irritable Bowel SyndromeFAERS: 1411304902
11304903
16000936		CTD
US FAERS
7ColitisFAERS: 7OFFSIDES
SIDER
US FAERS
8NauseaFAERS: 7SIDER
US FAERS
9Intestinal ObstructionFAERS: 6OFFSIDES
US FAERS
10AnxietyFAERS: 4SIDER
US FAERS
11AstheniaFAERS: 4SIDER
US FAERS
12Disease complicationFAERS: 4OFFSIDES
US FAERS
13Intestinal PerforationFAERS: 4US FAERS
14Pharmaceutical product complaintFAERS: 4OFFSIDES
US FAERS
15DehydrationFAERS: 3OFFSIDES
US FAERS
16DiverticulitisFAERS: 3OFFSIDES
SIDER
US FAERS
17DiverticulumFAERS: 3OFFSIDES
US FAERS
18Drug exposure during pregnancyFAERS: 3US FAERS
19FlatulenceFAERS: 3SIDER
US FAERS
20Gastrointestinal PainFAERS: 3US FAERS
21HeadacheFAERS: 3SIDER
US FAERS
22Weight decreasedFAERS: 3US FAERS
23Back PainFAERS: 2US FAERS
24Bowel movement irregularityFAERS: 2OFFSIDES
US FAERS
25Cerebrovascular accidentFAERS: 2US FAERS
26ColectomyFAERS: 2OFFSIDES
US FAERS
27Completed SuicideFAERS: 2US FAERS
28DisabilityFAERS: 2US FAERS
29DiscomfortFAERS: 2SIDER
US FAERS
30Erectile dysfunctionFAERS: 2OFFSIDES
US FAERS
31Feeling abnormalFAERS: 2SIDER
US FAERS
32Gastric infectionFAERS: 2OFFSIDES
US FAERS
33GastritisFAERS: 2SIDER
US FAERS
34LymphomaFAERS: 2OFFSIDES
US FAERS
35MalaiseFAERS: 2SIDER
US FAERS
36MyalgiaFAERS: 2SIDER
US FAERS
37PainFAERS: 228947236CTD
SIDER
US FAERS
38Product use issueFAERS: 2US FAERS
39Septic ShockFAERS: 2OFFSIDES
US FAERS
40AcneFAERS: 1SIDER
US FAERS
41AgitationFAERS: 1US FAERS
42AlopeciaFAERS: 1SIDER
US FAERS
43Anal sphincter atonyFAERS: 1OFFSIDES
US FAERS
44AnhedoniaFAERS: 1US FAERS
45AnorexiaFAERS: 1US FAERS
46AphagiaFAERS: 1US FAERS
47Atrial FibrillationFAERS: 1US FAERS
48Blood glucose increasedFAERS: 1US FAERS
49Blood sodium decreasedFAERS: 1US FAERS
50CellulitisFAERS: 1US FAERS
51Colonic StenosisFAERS: 1OFFSIDES
US FAERS
52Deep Vein ThrombosisFAERS: 1US FAERS
53DeliriumFAERS: 1US FAERS
54Diabetes MellitusFAERS: 1US FAERS
55Disease recurrenceFAERS: 1US FAERS
56DizzinessFAERS: 1US FAERS
57Drug administration errorFAERS: 1US FAERS
58Drug dispensing errorFAERS: 1US FAERS
59Dry skinFAERS: 1US FAERS
60DysgraphiaFAERS: 1OFFSIDES
US FAERS
61Enterococcal infectionFAERS: 1US FAERS
62ErythemaFAERS: 1US FAERS
63FatigueFAERS: 1SIDER
US FAERS
64Gastric ulcerFAERS: 1US FAERS
65GastroenteritisFAERS: 1SIDER
US FAERS
66Gastrointestinal infectionFAERS: 1SIDER
US FAERS
67HypervigilanceFAERS: 1OFFSIDES
US FAERS
68HypoxiaFAERS: 1US FAERS
69Impaired work abilityFAERS: 1US FAERS
70Incorrect dose administeredFAERS: 1US FAERS
71InfectionFAERS: 1SIDER
US FAERS
72InfluenzaFAERS: 1US FAERS
73Intestinal hypomotilityFAERS: 1US FAERS
74Joint swellingFAERS: 1US FAERS
75Large intestine perforationFAERS: 1US FAERS
76Lymphoid tissue hyperplasiaFAERS: 1US FAERS
77NasopharyngitisFAERS: 1SIDER
US FAERS
78NervousnessFAERS: 1US FAERS
79OverweightFAERS: 1OFFSIDES
US FAERS
80PalpitationsFAERS: 1US FAERS
81PancreatectomyFAERS: 1OFFSIDES
US FAERS
82PancreatitisFAERS: 1US FAERS
83PeritonitisFAERS: 1US FAERS
84Postoperative ileusFAERS: 1US FAERS
85PregnancyFAERS: 1US FAERS
86Prescribed overdoseFAERS: 1OFFSIDES
US FAERS
87Product packaging issueFAERS: 1US FAERS
88Product substitution issueFAERS: 1US FAERS
89PruritusFAERS: 1US FAERS
90SinusitisFAERS: 1SIDER
US FAERS
91StressFAERS: 1US FAERS
92SyncopeFAERS: 1US FAERS
93UlcerFAERS: 1SIDER
US FAERS
94Unevaluable eventFAERS: 1US FAERS
95Abdominal AbscessOFFSIDES
96Abdominal discomfortSIDER
97AcidosisOFFSIDES
98AgoraphobiaOFFSIDES
99Alanine Aminotransferase IncreasedSIDER
100Alcohol consumptionOFFSIDES
101Allergic skin reactionSIDER
102Bilirubin abnormalSIDER
103Bladder painSIDER
104Blood alkaline phosphatase increasedOFFSIDES
105Blood bilirubin abnormalSIDER
106Blood triglycerides increasedOFFSIDES
107Bone painSIDER
108Burning sensationSIDER
109Chemical and Drug Induced Liver Injury16000936CTD
110CholecystitisOFFSIDES
SIDER
111CirrhosisOFFSIDES
112ClaustrophobiaOFFSIDES
113Congenital tricuspid valve incompetenceOFFSIDES
114Conjunctival depositOFFSIDES
115CystitisSIDER
116Depressive disorderSIDER
117DermatitisSIDER
118DiabetesOFFSIDES
119DiarrheaOFFSIDES
120DiuresisSIDER
121DiverticulosisOFFSIDES
122Drug ToleranceOFFSIDES
123Drug abuserOFFSIDES
124Drug addictOFFSIDES
125DyscheziaOFFSIDES
126DysequilibriumSIDER
127Dyspepsia15238200CTD
128Dyspeptic signs and symptomsSIDER
129Dysthymic DisorderSIDER
130EczemaSIDER
131EndometriosisOFFSIDES
132Eye painOFFSIDES
133Feeling ColdSIDER
134Feeling of body temperature changeSIDER
135FolliculitisSIDER
136Gastric pH decreasedSIDER
137GastroduodenitisSIDER
138Gastrointestinal discomfortSIDER
139Gastrointestinal motility disorderOFFSIDES
140Gastrointestinal obstructionSIDER
141Hallucinations, mixedOFFSIDES
142HepatitisSIDER
143HerniaOFFSIDES
144HydronephrosisOFFSIDES
145Hyperalgesia28947236CTD
146HyperchlorhydriaSIDER
147HypersensitivitySIDER
148HypopituitarismSIDER
149IleusSIDER
150Impaired gastric emptyingOFFSIDES
151IntussusceptionSIDER
152LaryngitisSIDER
153Lymphocyte count decreasedOFFSIDES
154Muscle RigiditySIDER
155Musculoskeletal discomfortSIDER
156Musculoskeletal stiffnessSIDER
157Nasal sinus drainageOFFSIDES
158Occult blood positiveOFFSIDES
SIDER
159PallorOFFSIDES
160ParanoiaOFFSIDES
161Pharyngolaryngeal PainOFFSIDES
162PhotodermatosisOFFSIDES
163PhotophobiaSIDER
164PolyuriaSIDER
165Postoperative infectionOFFSIDES
166ProctitisSIDER
167ProctocolitisSIDER
168Protein total increasedOFFSIDES
169Rectal fissureOFFSIDES
170Rectal polypOFFSIDES
171RegurgitationSIDER
172Reproductive system haemorrhagesSIDER
173Retinal Artery OcclusionOFFSIDES
174SweatingSIDER
175Systolic hypertensionOFFSIDES
176TachyarrhythmiaSIDER
177Testicular massOFFSIDES
178Therapeutic response unexpectedOFFSIDES
179TraumaSIDER
180TremorSIDER
181Urinary tract infectionSIDER
182Urine output increasedSIDER
183UrticariaSIDER
184jaundiceSIDER
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