MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Bleomycin

(OYVAGSVQBOHSSS-WXFSZRTFSA-O)

Structure

SMILES: OCC1OC(O[C@H]([C@@H](C(=O)N[C@@H]([C@H]([C@@H](C(=O)N[C@H](C(=O)NCCc2scc(n2)c2scc(n2)C(=O)NCCC[S+](C)C)[C@H](O)C)C)O)C)NC(=O)c2nc(nc(c2C)N)[C@H](CC(=O)N)NC[C@@H](C(=O)N)N)c2[nH]cnc2)C(C(C1O)O)OC1OC(CO)C(C(C1O)OC(=O)N)O
Type(s): Approved; Investigational
ATC code(s): L01DC01
Molecular Formula:: C55H84N17O21S3+
Molecular Weight:: 1415.550
Log P:: -1.9758
Hydrogen Bond Acceptor:: 39
Hydrogen Bond Donor:: 20
TPSA:: 708.85
CAS Number(s):: 11056-06-7

Synonym(s)

Bleomycin

BLEO-cell

Blanoxan

Blenoxane

Bleolem

Bleomicina

Bleomycin A(2)

Bleomycin A2

Bleomycin B(2)

10.

Bleomycin B2

11.

Bleomycin Sulfate

12.

Bleomycins

13.

Bleomycinum Mack

14.

Bléomycine Bellon

15.

BLEO cell

16.

BLEOcell

17.

Bellon, Bléomycine

18.

Mack, Bleomycinum

19.

Sulfate, Bleomycin

External Link(s)

MeSH	D001761
PubChem Compound	5360373
BindingDB	50122169
ChEBI	22907
CHEMBL	CHEMBL403664
DrugBank	DB00290
KEGG	cpd:C06854
Therapeutic Target Database	D06UVD

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Pulmonary toxicity	FAERS: 13		OFFSIDES US FAERS
2	Respiratory Failure	FAERS: 11		US FAERS
3	Pulmonary Fibrosis	FAERS: 10	View details 11554783 12574379 12624602 14609568 14982598 15133236 15298984 15322207 15541506 15619575 16115399 16314464 16445573 17035056 17177178 17241526 17434272 18008008 18162602 18403674 19080365 19112509 19497426 20686337 20719937 21381050 21435439 21575650 21998664 22982510 23523906 23548910 23570914 23656969 23759512 24459475 24762191 25071917 25582705 25648892 25933445 26093215 26209236 26345256 26768587 26817844 27704718 28300665 28694203 28726637 28940894 29175452 29256173 29408570 29720568 30572104	CTD SIDER US FAERS
4	Pneumonitis	FAERS: 6		US FAERS
5	Pulmonary Embolism	FAERS: 5	2457470	CTD US FAERS
6	Erythema	FAERS: 4		SIDER US FAERS
7	Toxicity to various agents	FAERS: 4		US FAERS
8	Chills	FAERS: 3		SIDER US FAERS
9	Disease Progression	FAERS: 3		US FAERS
10	Headache	FAERS: 3		US FAERS
11	Hypotension	FAERS: 3	9572663	CTD SIDER US FAERS
12	Hypoxia	FAERS: 3	15782499	CTD OFFSIDES US FAERS
13	Lung Injury	FAERS: 3	View details 15684285 20686337 21998664 23523906 26093215 29256173	CTD OFFSIDES US FAERS
14	Neutropenia	FAERS: 3	7534090 10526668	CTD US FAERS
15	Pneumonia	FAERS: 3	View details 54212 16317386 17071938 18024389 19362168 25071917	CTD SIDER US FAERS
16	Akinesia	FAERS: 2		US FAERS
17	Alveolitis	FAERS: 2		US FAERS
18	Asthenia	FAERS: 2		SIDER US FAERS
19	Bone pain	FAERS: 2		OFFSIDES US FAERS
20	Drug toxicity	FAERS: 2		US FAERS
21	Ecchymosis	FAERS: 2		US FAERS
22	Fatigue	FAERS: 2		US FAERS
23	Flagellate dermatitis	FAERS: 2		US FAERS
24	Hypopituitarism	FAERS: 2		OFFSIDES US FAERS
25	Medication Error	FAERS: 2		US FAERS
26	Nausea	FAERS: 2		SIDER US FAERS
27	Osteoradionecrosis	FAERS: 2		US FAERS
28	Respiratory Depression	FAERS: 2		US FAERS
29	Skin necrosis	FAERS: 2		US FAERS
30	Sudden death	FAERS: 2		US FAERS
31	Tachycardia	FAERS: 2		US FAERS
32	Urticaria	FAERS: 2		SIDER US FAERS
33	Vomiting	FAERS: 2		SIDER US FAERS
34	Amaurosis	FAERS: 1		US FAERS
35	Atrial Fibrillation	FAERS: 1		US FAERS
36	Bacteria sputum identified	FAERS: 1		US FAERS
37	Blindness	FAERS: 1		US FAERS
38	Cellulitis	FAERS: 1		OFFSIDES US FAERS
39	Chest Pain	FAERS: 1		SIDER US FAERS
40	Cholecystitis	FAERS: 1		US FAERS
41	Cholelithiasis	FAERS: 1		US FAERS
42	Chromaturia	FAERS: 1		US FAERS
43	Clostridium difficile infection	FAERS: 1		US FAERS
44	Complex partial seizures	FAERS: 1		US FAERS
45	Deep Vein Thrombosis	FAERS: 1		US FAERS
46	Depressed Level of Consciousness	FAERS: 1		US FAERS
47	Dermatitis	FAERS: 1		SIDER US FAERS
48	Disorientation	FAERS: 1		SIDER US FAERS
49	Drug administration error	FAERS: 1		US FAERS
50	Drug dispensing error	FAERS: 1		US FAERS
51	Epilepsy	FAERS: 1		US FAERS
52	Extremity necrosis	FAERS: 1		OFFSIDES US FAERS
53	Febrile Neutropenia	FAERS: 1		OFFSIDES SIDER US FAERS
54	Feeling abnormal	FAERS: 1		SIDER US FAERS
55	Fibrosis	FAERS: 1	View details 9794163 19112509 19362168 29033951	CTD US FAERS
56	General physical health deterioration	FAERS: 1		OFFSIDES US FAERS
57	Hemiparesis	FAERS: 1		OFFSIDES US FAERS
58	Hepatitis B	FAERS: 1		US FAERS
59	Hypersensitivity	FAERS: 1		SIDER US FAERS
60	Infection	FAERS: 1		SIDER US FAERS
61	Injection site ulcer	FAERS: 1		US FAERS
62	Injection site vesicles	FAERS: 1		US FAERS
63	Leukopenia	FAERS: 1	54212 10526668	CTD SIDER US FAERS
64	Malaise	FAERS: 1		SIDER US FAERS
65	Metaplasia	FAERS: 1		OFFSIDES SIDER US FAERS
66	Myalgia	FAERS: 1		SIDER US FAERS
67	Necrosis	FAERS: 1		US FAERS
68	Oral Cavity Fistula	FAERS: 1		US FAERS
69	Oral candidiasis	FAERS: 1		US FAERS
70	Osteonecrosis of Jaw	FAERS: 1		US FAERS
71	Overdose	FAERS: 1		US FAERS
72	Pain of skin	FAERS: 1		SIDER US FAERS
73	Pain	FAERS: 1		OFFSIDES SIDER US FAERS
74	Precocious Puberty	FAERS: 1		US FAERS
75	Pulmonary function test decreased	FAERS: 1		OFFSIDES US FAERS
76	Quality of life decreased	FAERS: 1		US FAERS
77	Respiratory arrest	FAERS: 1		US FAERS
78	Restrictive pulmonary disease	FAERS: 1		OFFSIDES US FAERS
79	Skin lesion	FAERS: 1		US FAERS
80	Stomatitis	FAERS: 1		SIDER US FAERS
81	Stridor	FAERS: 1		US FAERS
82	Subcutaneous Emphysema	FAERS: 1		OFFSIDES US FAERS
83	Therapy non-responder	FAERS: 1		OFFSIDES US FAERS
84	Tinnitus	FAERS: 1		OFFSIDES US FAERS
85	Treatment related secondary malignancy	FAERS: 1		OFFSIDES US FAERS
86	Ulcer	FAERS: 1		OFFSIDES SIDER US FAERS
87	Urinary Retention	FAERS: 1		US FAERS
88	Weight decreased	FAERS: 1		SIDER US FAERS
89	Wheezing	FAERS: 1		SIDER US FAERS
90	White blood cell count decreased	FAERS: 1		US FAERS
91	Wrong technique in drug usage process	FAERS: 1		US FAERS
92	Abdominal Abscess			OFFSIDES
93	Abdominal discomfort			OFFSIDES
94	Abdominal mass			OFFSIDES
95	Abdominal rigidity			OFFSIDES
96	Abdominal symptom			OFFSIDES
97	Acne			OFFSIDES
98	Acute Coronary Syndrome			SIDER
99	Acute Lung Injury		17118201 19362168 22687607	CTD
100	Acute chest pain			SIDER
101	Adenocarcinoma			OFFSIDES
102	Adnexa uteri mass			OFFSIDES
103	Agranulocytosis		7105387	CTD
104	Alopecia			OFFSIDES SIDER
105	Amniotic fluid volume decreased			OFFSIDES
106	Amyloidosis			OFFSIDES
107	Anaphylactic shock			SIDER
108	Anemia, Hemolytic		9572663	CTD
109	Angina Pectoris		2456930	CTD
110	Anhidrosis			OFFSIDES
111	Anorexia			SIDER
112	Anosmia			OFFSIDES
113	Anticonvulsant drug level decreased			OFFSIDES
114	Anuria		9572663	CTD
115	Appendectomy			OFFSIDES
116	Arterial insufficiency			OFFSIDES
117	Arteritis			SIDER
118	Arthritis			SIDER
119	Azoospermia			OFFSIDES
120	Bacteria stool identified			OFFSIDES
121	Band neutrophil count increased			OFFSIDES
122	Bladder pain			SIDER
123	Blepharospasm			OFFSIDES
124	Blindness, Cortical		6085288 7683015	CTD
125	Body Temperature			OFFSIDES
126	Bone swelling			OFFSIDES
127	Brain Diseases		2460709	CTD
128	Bronchiectasis			OFFSIDES
129	Bronchitis			OFFSIDES
130	Bronchospasm			SIDER
131	Burning sensation			OFFSIDES
132	Cancer Pain			OFFSIDES
133	Carcinoma		7105387 12373036	CTD
134	Carotid Artery Thrombosis			OFFSIDES
135	Catheter placement			OFFSIDES
136	Catheter site infection			OFFSIDES
137	Cerebral arteritis			SIDER
138	Cerebrovascular accident			SIDER
139	Choking sensation			OFFSIDES
140	Chondrosarcoma			OFFSIDES
141	Clostridium difficile colitis			OFFSIDES
142	Cold sweat			OFFSIDES
143	Contact Dermatitis			OFFSIDES
144	Coronary Artery Disease		87274 6161700 6166992	CTD
145	Creatinine renal clearance decreased			OFFSIDES
146	Cystitis			SIDER
147	Cytokine storm			OFFSIDES
148	Cytomegalovirus proctocolitis			OFFSIDES
149	Deafness			OFFSIDES
150	Device leakage			OFFSIDES
151	Diarrhea		7534090	CTD
152	Diplopia			OFFSIDES
153	Discomfort			SIDER
154	Disseminated Intravascular Coagulation			OFFSIDES
155	Diverticulum			OFFSIDES
156	Drug withdrawal headache			OFFSIDES
157	Dry cough			SIDER
158	Dysgerminoma		7683015	CTD
159	Dysgeusia			OFFSIDES
160	Dysmenorrhea			OFFSIDES
161	Dysphonia			OFFSIDES
162	Dyspnea		28694203	CTD
163	Dystrophic calcification			OFFSIDES
164	Dysuria			OFFSIDES
165	Eczema			OFFSIDES
166	Edema		17118201	CTD
167	Ejection Fraction Decreased			OFFSIDES
168	Electrocardiogram ST segment abnormal			OFFSIDES
169	Erectile dysfunction		1690581	CTD
170	Escherichia infection			OFFSIDES
171	Extravasation			SIDER
172	Fever		6155201	CTD
173	Flushing			SIDER
174	Formication			OFFSIDES
175	Gangrene		9415644	CTD OFFSIDES
176	Hamman-Rich syndrome			SIDER
177	Head and Neck Neoplasms		6173125	CTD
178	Hematuria		9572663	CTD
179	Hemiplegia			OFFSIDES
180	Hemolytic-Uremic Syndrome		View details 1699855 2482985 6203452 7679450 9572663 10435899	CTD
181	Hemoptysis		9572663	CTD
182	Hip surgery			OFFSIDES
183	Histiocytosis haematophagic			OFFSIDES
184	Hodgkin Disease		View details 1329697 6459048 10526668 15147373 15922437 17290056 17606976 18293384 18501091	CTD
185	Hodgkin's disease mixed cellularity recurrent			OFFSIDES
186	Hodgkin's disease mixed cellularity stage III			OFFSIDES
187	Hyperbilirubinemia		54212	CTD
188	Hyperkeratosis			SIDER
189	Hyperpigmentation			OFFSIDES
190	Hyperplasia		28694203	CTD
191	Hypertension, Renovascular		6181679	CTD
192	Hypothalamo-pituitary disorder			OFFSIDES
193	Hypothyroidism		10526668	CTD
194	Idiopathic Pulmonary Fibrosis		21131602 28434932	CTD SIDER
195	Idiosyncratic drug reaction			OFFSIDES
196	Immunosuppression			OFFSIDES
197	Impetigo			OFFSIDES
198	Incision site infection			OFFSIDES
199	Induration			SIDER
200	Infectious pneumonitis			SIDER
201	Inflammation		View details 17118201 22687607 26209236 29033951 29408570	CTD
202	Infusion site mobility decreased			OFFSIDES
203	Intervertebral Disc Degeneration			OFFSIDES
204	Ischemia		2456930 6168223	CTD
205	Joint sprain			OFFSIDES
206	Keratitis sicca			OFFSIDES
207	Kidney Diseases		View details 2413982 6181679 6203452 7532742	CTD
208	Laboratory test interference			OFFSIDES
209	Legionella serology positive			OFFSIDES
210	Local reaction			SIDER
211	Locked-In Syndrome			OFFSIDES
212	Lung Diseases, Interstitial		26209236	CTD
213	Lung Neoplasms		6189445	CTD
214	Lung diseases		67817	CTD
215	Lymphoma, AIDS-Related		8697399	CTD
216	Lymphoma, Non-Hodgkin		2861395 2872506 12172056	CTD
217	Lymphoma		6155201	CTD
218	Malignant neoplasm progression			OFFSIDES
219	Metastases to adrenals			OFFSIDES
220	Metastases to thorax			OFFSIDES
221	Metastatic Neoplasm			OFFSIDES
222	Micronuclei, Chromosome-Defective		23249641	CTD
223	Migraine Disorders		2456930	CTD
224	Monocyte percentage increased			OFFSIDES
225	Mononeuritis			OFFSIDES
226	Mouth Neoplasms		2482985	CTD
227	Muscle Weakness		5027400	CTD
228	Muscle strain			OFFSIDES
229	Muscle tightness			OFFSIDES
230	Musculoskeletal discomfort			SIDER
231	Musculoskeletal stiffness			OFFSIDES
232	Myelodysplasia			OFFSIDES
233	Myelosuppression			SIDER
234	Myocardial Infarction		1713559	CTD SIDER
235	Nail changes			SIDER
236	Neoplasms, Germ Cell and Embryonal		View details 1690581 2413982 2447295 2472472 2476531 6168223 12078977	CTD
237	Neutropenic sepsis			OFFSIDES
238	Neutrophil count abnormal			OFFSIDES
239	Nodule			OFFSIDES
240	Orchitis			OFFSIDES
241	Oropharyngeal pain			OFFSIDES
242	Osteoporosis			OFFSIDES
243	Pancytopenia			SIDER
244	Paraparesis			OFFSIDES
245	Paresthesia		2476531 5027400	CTD
246	Peripheral Nervous System Diseases		2476531	CTD
247	Pharyngolaryngeal Pain			OFFSIDES
248	Phlebitis			SIDER
249	Pilonidal Cyst			OFFSIDES
250	Platelet Transfusion			OFFSIDES
251	Pleuritic pain			SIDER
252	Pleuropericarditis			SIDER
253	Pneumocystis jiroveci pneumonia			OFFSIDES
254	Pneumopericardium			OFFSIDES
255	Pneumothorax			OFFSIDES
256	Post procedural hypothyroidism			OFFSIDES
257	Posterior Leukoencephalopathy Syndrome		12078977	CTD
258	Pruritus			SIDER
259	Psittacosis			OFFSIDES
260	Pulmonary Edema		View details 15684285 15808516 26520185 28300665 28694203	CTD
261	Pulmonary Infarction			OFFSIDES
262	Purpura, Thrombotic Thrombocytopenic		6203452	CTD
263	Purulent discharge			OFFSIDES
264	Pyelonephritis			OFFSIDES
265	Pyoderma Gangrenosum			OFFSIDES
266	Quadriparesis			OFFSIDES
267	Radiation Pneumonitis			SIDER
268	Rales			SIDER
269	Raynaud Disease		View details 70274 77726 81878 1702313 2413982 2423995 2456930 2472472 6162955 6163385 6168223 6173125 6174061 6183087 6846998 7689922 8652248 9415644	CTD
270	Reaction febrile			SIDER
271	Renal Artery Obstruction		6181679	CTD
272	Renal Artery Stenosis			OFFSIDES
273	Respiratory Insufficiency		5027400	CTD
274	Retroperitoneal fibrosis			OFFSIDES
275	Sarcoidosis			OFFSIDES
276	Scleroderma			SIDER
277	Scotoma			OFFSIDES
278	Seizures		View details 6193870 6209833 7683015 12078977	CTD
279	Sepsis		10526668	CTD
280	Sequestrectomy			OFFSIDES
281	Sinus headache			OFFSIDES
282	Sinusitis			OFFSIDES
283	Skin hypertrophy			SIDER
284	Skin laceration			OFFSIDES
285	Skin tenderness			SIDER
286	Skin toxicity			SIDER
287	Stem cell transplant			OFFSIDES
288	Synovial Cyst			OFFSIDES
289	Testicular Neoplasms		View details 54212 70274 2447295 2456930 5027400 6174061 7105387 12373036 17565539 24478030	CTD
290	Thirst decreased			OFFSIDES
291	Thrombocytopenia		54212 7105387	CTD SIDER
292	Thyroiditis			OFFSIDES
293	Tracheitis			OFFSIDES
294	Trauma			SIDER
295	Vascular Diseases		6173125	CTD
296	Wound Infection			OFFSIDES
297	anaphylaxis		65671	CTD
298	kyphosis			OFFSIDES
299	melanoma		15577320	CTD

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