MetaADEDB 2.0 @ LMMD
Dothiepin
(PHTUQLWOUWZIMZ-BOPFTXTBSA-N)
Structure
SMILES
CN(CC/C=C/1\c2ccccc2SCc2c1cccc2)C
Molecular Formula:
C19H21NS
Molecular Weight:
295.442
Log P:
4.6757
Hydrogen Bond Acceptor:
2
Hydrogen Bond Donor:
0
TPSA:
28.54
CAS Number(s):
113-53-1; 897-15-4; 25627-38-7
Synonym(s)
1.
Dothiepin
2.
Dosulepin
3.
Dothiepin Hydrochloride
4.
Prothiaden
5.
Hydrochloride, Dothiepin
External Link(s)
MeSHD004308
PubChem Compound5282426
BindingDB82548
ChEBI36802
36798
CHEMBLCHEMBL108947
IUPHAR/BPS Guide to PHARMACOLOGY7549
KEGGdr:D07872
Therapeutic Target DatabaseD0Q2MN
ZINC1329
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Abdominal CrampsSIDER
2Abdominal PainSIDER
3AcidosisOFFSIDES
4AcneOFFSIDES
5Acute Coronary SyndromeSIDER
6AdenocarcinomaOFFSIDES
7AgitationSIDER
8AgoraphobiaOFFSIDES
9AgranulocytosisSIDER
10Alanine Aminotransferase IncreasedOFFSIDES
11Alcohol interactionOFFSIDES
12Alcohol poisoningOFFSIDES
13AmnesiaOFFSIDES
14AngerOFFSIDES
15AngioedemaOFFSIDES
SIDER
16AnhidrosisOFFSIDES
17AnuriaOFFSIDES
18Anxiety Disorders7034025CTD
19AnxietyOFFSIDES
SIDER
20Aortic valve calcificationOFFSIDES
21Apallic syndromeOFFSIDES
22ApathyOFFSIDES
23AstheniaSIDER
24AtaxiaSIDER
25Athetosis1434066CTD
26Atrioventricular BlockSIDER
27Autoimmune hepatitisOFFSIDES
28Bacteria urine identifiedOFFSIDES
29BartholinitisOFFSIDES
30BedriddenOFFSIDES
31Biliary cancer metastaticOFFSIDES
32Black hairy tongueSIDER
33BlepharitisOFFSIDES
34BlepharospasmOFFSIDES
35Blood alkaline phosphatase increasedOFFSIDES
36Blood cortisol decreasedOFFSIDES
37Blood creatine phosphokinase increasedOFFSIDES
38Blood follicle stimulating hormone increasedOFFSIDES
39Blood potassium decreasedOFFSIDES
40Blood prolactin increasedOFFSIDES
41Blurred visionOFFSIDES
42Bone marrow depressionSIDER
43Bulbar palsyOFFSIDES
44BulimiaOFFSIDES
45Cerebrovascular accidentSIDER
46Chemotherapeutic drug level increasedOFFSIDES
47Choking sensationOFFSIDES
48CholangiolitisOFFSIDES
49Cholestasis12524417CTD
50Chorea1434066CTD
51Circumstance or information capable of leading to medication errorOFFSIDES
52CirrhosisOFFSIDES
53Clostridium difficile colitisOFFSIDES
54Colonic Pseudo-ObstructionOFFSIDES
55Completed SuicideOFFSIDES
56Concomitant disease aggravatedOFFSIDES
57ConfabulationOFFSIDES
58ConstipationSIDER
59CryingOFFSIDES
60Deafness NeurosensoryOFFSIDES
61Decreased LibidoOFFSIDES
62DependenceOFFSIDES
63Depressed moodOFFSIDES
64Depressive disorder

View details

6386793
7034025
7496659
9803478
 		CTD
65DermatitisSIDER
66Diabetes InsipidusOFFSIDES
67DiplopiaOFFSIDES
68DisorientationSIDER
69Disturbance in sexual arousalSIDER
70DizzinessOFFSIDES
SIDER
71DrowsinessSIDER
72Drug addictOFFSIDES
73Drug toxicityOFFSIDES
74Drug withdrawal headacheOFFSIDES
75DysgeusiaSIDER
76Dyskinesia, Drug-Induced1434066CTD
77DyslexiaOFFSIDES
78DyspepsiaSIDER
79Dysthymic DisorderOFFSIDES
80DystoniaOFFSIDES
81EczemaOFFSIDES
82Electroconvulsive TherapyOFFSIDES
83Electromechanical dissociationOFFSIDES
84Elevated moodOFFSIDES
85Emotional disorderOFFSIDES
86EosinophiliaSIDER
87Epigastric distressSIDER
88Erectile dysfunctionOFFSIDES
SIDER
89Erythema ab igneOFFSIDES
90Facial NeuralgiaOFFSIDES
91FatigueOFFSIDES
SIDER
92Fatty LiverOFFSIDES
93Feeling abnormalSIDER
94Fever7496659CTD
95Flight of ideasOFFSIDES
96Fluid overloadOFFSIDES
97Food AllergyOFFSIDES
98FormicationOFFSIDES
99FrustrationOFFSIDES
100Gamma-Glutamyltransferase IncreasedOFFSIDES
101Gastrointestinal hypermotilityOFFSIDES
102Gastrointestinal hypomotilityOFFSIDES
103General physical health deteriorationOFFSIDES
104Global AmnesiaOFFSIDES
105GlossitisOFFSIDES
106Hallucinations8766220CTD
107Head BangingOFFSIDES
108HeadacheSIDER
109Helicobacter pylori identification test positiveOFFSIDES
110Hepatic necrosisOFFSIDES
111HepatitisSIDER
112HepatosplenomegalyOFFSIDES
113HomicideOFFSIDES
114Hormone level abnormalOFFSIDES
115HostilityOFFSIDES
116HypersensitivitySIDER
117Hypoaesthesia facialOFFSIDES
118HypomaniaOFFSIDES
SIDER
119HypopituitarismOFFSIDES
120HypotensionSIDER
121Ileal ulcerOFFSIDES
122ImmobileOFFSIDES
123Inappropriate affectOFFSIDES
124Infusion site mobility decreasedOFFSIDES
125Intention tremorOFFSIDES
126Intentional self-injuryOFFSIDES
127IridoceleOFFSIDES
128Kidney FailureOFFSIDES
129LethargyOFFSIDES
130MacrocytosisOFFSIDES
131MalnutritionSIDER
132Mental impairmentOFFSIDES
133MesotheliomaOFFSIDES
134Metabolic acidosisOFFSIDES
135Morbid thoughtsOFFSIDES
136Multiple drug overdoseOFFSIDES
137Muscle Rigidity7496659CTD
138Musculoskeletal chest painOFFSIDES
139MydriasisSIDER
140Myocardial InfarctionSIDER
141Myoglobin blood increasedOFFSIDES
142Narcotic intoxicationOFFSIDES
143NauseaOFFSIDES
SIDER
144Negative thoughtsOFFSIDES
145NegativismOFFSIDES
146Ocular HypertensionOFFSIDES
147Ocular icterusOFFSIDES
148Oropharyngeal candidiasisOFFSIDES
149OverdoseOFFSIDES
150Pain managementOFFSIDES
151PalpitationsSIDER
152PancytopeniaSIDER
153ParanoiaOFFSIDES
154Pathogen resistanceOFFSIDES
155Percutaneous Coronary InterventionOFFSIDES
156Pericardial effusionOFFSIDES
157PhlebitisOFFSIDES
158Pleural MesotheliomaOFFSIDES
159PolymenorrheaOFFSIDES
160Poor quality sleepOFFSIDES
161Procedural complicationOFFSIDES
162Psychiatric symptomOFFSIDES
163Pulmonary congestionOFFSIDES
164PyloroplastyOFFSIDES
165Renal tubular necrosisOFFSIDES
166Rheumatoid NoduleOFFSIDES
167RhinalgiaOFFSIDES
168Seasonal Affective DisorderOFFSIDES
169Septic ShockOFFSIDES
170SomnolenceSIDER
171Spasm7496659CTD
172StomatitisSIDER
173StressOFFSIDES
174Sudden deathOFFSIDES
175SweatingSIDER
176Syncope3556944CTD
177Tachycardia9803478CTD
SIDER
178Taste peculiarSIDER
179ThrombocytopeniaSIDER
180TinnitusOFFSIDES
181Torsades de Pointes3556944CTD
182Tremor7496659CTD
SIDER
183Unresponsive to stimuliOFFSIDES
184Urinary RetentionSIDER
185UrticariaSIDER
186Vaginal mucosal blisteringOFFSIDES
187VagotomyOFFSIDES
188Ventricular Fibrillation3556944CTD
189Ventricular hypokinesiaOFFSIDES
190VomitingSIDER
191Weight decreasedSIDER
192nervous system disorderSIDER
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